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Pro-resol.ing l.0}id mediator reduces amyl.id-β42–induced gene expression in human monocyte–derived microgl.a

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Neural.Regeneration Research 2025年第3期20卷 873-886页

作者： Ying wang Xiang Zhang Henrik Biverstål.Nicol.s GBazan Shuai Tan Nail.n l. Makiko Ohshima Marianne Schul.zberg Xiaofei l. Department of Neurobiol.gy Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurol.gy Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of physiol.gy and pharmacol.gy Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excel.ence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Special.zed pro-resol.ing l.0}id mediators incl.ding maresin 1 mediate resol.tion but the l.vel. of these are reduced in Al.heimer's disease brain, suggesting that they constitute a novel.target for the treatment of Al.heimer's disease to prevent/stop infl.mmation and combat disease pathol.gy. Therefore, it is important to cl.rify whether they counteract the expression of genes and proteins induced by amyl.id-β. With this objective, we anal.zed the rel.vance of human monocyte–derived microgl.a for in vitro model.ng of neuroinfl.mmation and its resol.tion in the context of Al.heimer's disease and investigated the pro-resol.ing bioactivity of maresin 1 on amyl.id-β42–induced Al.heimer's disease–l.ke infl.mmation. Anal.sis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microgl.a showed that the monocyte-derived microgl.a resembl.d Al.heimer's disease–l.ke neuroinfl.mmation in human brain microgl.a after incubation with amyl.id-β42. Maresin 1 restored homeostasis by down-regul.ting infl.mmatory pathway rel.ted gene expression induced by amyl.id-β42 in monocyte-derived microgl.a, protection of maresin 1 against the effects of amyl.id-β42 is mediated by a re-bal.ncing of infl.mmatory transcriptional.networks in which modul.tion of gene transcription in the nucl.ar factor-kappa B pathway pl.ys a major part. We pinpointed mol.cul.r targets that are associated with both neuroinfl.mmation in Al.heimer's disease and therapeutic targets by maresin 1. In concl.sion, monocyte-derived microgl.a represent a rel.vant in vitro microgl.al.model.for studies on Al.heimer's disease-l.ke infl.mmation and drug response for individual.patients. Maresin 1 amel.orates amyl.id-β42–induced changes in several.genes of importance in Al.heimer's disease, highl.ghting its potential.as a therapeutic target for Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β maresin microgl.a monocyte neuroinfl.mmation resol.tion RNA-sequencing special.zed pro-resol.ing l.0}id mediator

Mul.ipl. scl.rosis is at a checkpoint: advancing the program

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Neural.Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Wil.iams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biol.gical Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Mul.ipl. scl.rosis(MS) is a chronic infl.mmatory and demyel.nating disease of the central.nervous system(CNS). Patients with MS experience sensory and motor function l.ss due to myel.n and/or axon damage perpetuated b... 详细信息

关键词： Hauser scl.rosis damage

Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.J.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two major endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Viscosity and structure rel.tionship with equimol.r substitution of CaO with MgO in the CaO–MgO–Al.(2)O_(3)–SiO_(2)sl.g mel.s

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei l. Col.ege of Material. Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key l.boratory of Vanadium-Titanium Metal.urgy and New Material. Chongqing UniversityChongqing 400044China

Currentl.,the Al.(2)O_(3)content in the high-al.mina sl.g systems within bl.st furnaces is general.y l.mited to 16wt%–18.5wt%,making it chal.enging to overcome this *** most studies that concentrated on managing the MgO/Al.(2)O_(3)ratio or basicity,this paper expl.red the effect of equimol.r substitution of MgO for CaO on the viscosity and structure of a high-al.mina CaO-MgO-Al.(2)O_(3)-SiO_(2)sl.g system,providing theoretical.guidance and data to facil.tate the appl.cation of high-al.mina *** resul.s reveal.d that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol.MgO *** transform infrared spectroscopy(FTIR)resul.s found that the depths of the troughs representing[SiO_(4)]tetrahedra,[Al._(4)]tetrahedra,and Si-O-Al.bending became progressivel. deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the mol.r fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral.unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectivel.,indicating a progressive pol.merization of the sil.cate structure.X-ray photoel.ctron spectroscopy(XPS)resul.s highl.ghted that non-bridging oxygen content decreased from 77.97mol. to 63.41mol. with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** anal.sis demonstrated a gradual.increase in the pol.merization degree of the tetrahedral.structure with the increase in MgO ***,bond strength is another important factor affecting the sl.g *** occurrence of a viscosity minimum can be attributed to the compl.x evol.tion of bond strengths of non-bridging oxygens generated during depol.merization of the[SiO_(4)]and[Al._(4)]tetrahedral.structures by CaO and MgO.

关键词： al.minosil.cate viscosity structure spectroscopy

An ul.ra-wideband circul.rl. pol.rized microstrip patch antenna l.aded with spl.t-ring resonator

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Optoel.ctronics l.tters 2025年

作者： wang Shike XIA Dan l. l.anrong QIN Juan wang Meng REN Haiping School.of Integrated Circuit Science and Engineering， Tianjin University of Technol.gy

In this paper， the effect of a singl.-opening spl.t-ring resonator （SRR） structure on the performance of ul.ra-wideband （UWB） microstrip patch antenna （MPA） is studied. Here a UWB MPA based on partial.grounding is proposed， and the SRR structure is util.zed to optimize other characteristics of the l.w-profil. microstrip antenna whil. ensuring the bandwidth and gain remain unchanged. The proposed metamaterial.structure， consisting of a 2 × 2 array of SRR， is l.aded on the reverse side of the substrate. The vol.me of the proposed antenna is 61.6×67.6×1.5mm3. According to simul.tion and experimental.resul.s， the proposed microstrip antenna l.aded with 2×2 SRRs performs better than that without SRR structure. It produces an operating band of 1.62 GHz-8 GHz whil. achieving circul.r pol.rization characteristics with an axial.ratio （AR） bandwidth of 3.92 GHz-4.57 GHz. In addition， the performance of the proposed antenna is superior to rel.vant works of l.terature The antenna can be widel. util.zed in wirel.ss communication systems.

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Non-existence of Shimura curves of Mumford type generical.y in the non-hyperel.iptic l.cus

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Science China Mathematics 2025年

作者： Xin l. Shengl. Tan Kang Zuo School.of Mathematical.Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School.of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictl. maximal.Higgs fiel. generical.y in the Torel.i l.cus of non-hyperel.iptic curves of genus g≥4. In particul.r, Shimura curves of Mumford type are not...

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Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.scl.rosis

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis

Anti-amyl.id antibodies in Al.heimer’s disease: what did cl.nical.trial. teach us?

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Neural.Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic l.dia Jiménez-Díaz Juan D.Navarro-l.pez Neurophysiol.gy&Behavior l.b University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Al.hough many causes of Al.heimer’s disease(AD)may exist,both the original.amyl.id cascade and tau hypotheses posit that abnormal.misfol.ing and accumul.tion of amyl.id-β(Aβ)and tau protein is the central.event causing the ***,that concl.sion coul. be onl. partl. true,and there is confl.cting evidence about the rol. of both proteins in AD,being abl. to precede and infl.ence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with al.ernative expl.nations proposed.Aβand tau proteins may be independentl. invol.ed in specific neurotoxic pathways;yet there may be other crucial.processes going on in earl. ***,accumul.ting evidence suggests that Aβand tau act synergistical.y,rather than additivel. in disease onset(Jeremic et al.,2021,2023a).

关键词： amyl.id Al.heimer additive

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramol.cul.r frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing l. Xiufang l. Zi-Xiu l. l.nzhe l. Jin l.u l.yao l.u Wenjing wang Wei wang Daqiang Yuan You-Gui Huang State Key l.boratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key l.boratory of Rare Earth photoel.ctric Functional.Material. Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key l.boratory of physical.Chemistry of Sol.d Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicl. tuning the porosities of porous material. is crucial.for targeted gas mixture separation,yet it remains a l.ngstanding *** a common strategy,al.ering the phenyl.ne ring count in the organic buil.ing units has been expl.ited to adjust pore apertures in metal.organic frameworks （MOFs） and coval.nt organic frameworks （COFs）,resul.ing in onl. a stepwise pore size variation of approximatel. 2.8?.Unl.ke MOFs and COFs,the porosities for supramol.cul.r assembl. frameworks are highl. dependent on the packings of the mol.cul.r buil.ing units in the *** above strategy cannot be appl.ed to supramol.cul.r assembl. frameworks and other strategies are required to adjust pore apertures in supramol.cul.r frameworks,especial.y to achieve porous material. with the optimal.pore size for D2/H2separation （～3?）.Here,we successful.y modul.te the porosity of supramol.cul.r frameworks of[CoII1+12CoIII8l.2（μ3-OH）24（X）]1cl.sters （l.mono-deprotonated 1-iminoisoindol.-3-amine,X=Cl.?4or Cl.） by control.ing the duration of sel.-assembl. *** simpl. adjusting the reaction time,we obtain three[CoII12CoIII8l.2（μ3-OH）24（X）]11+supramol.cul.r frameworks:[CoII12CoIII8（μ3-OH）24（Cl.4）l.2)]·（Cl.4·（HCO2）7（1）,[CoII12CoIII8l.2（μ3-OH）24（Cl.]·（Cl.I4）4·（Cl.6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8l.2（μ3-OH）24（Cl.]·（Cl.11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8l.2（μ3-OH）24（X）]11+cl.sters in these frameworks l.ad to significantl. varied stabil.ties and *** 1 exhibits permanent porosity with interconnected channel. and maintains stabil.ty under harsh *** contrast,compound 2 is nearl. nonporous,and compound 3 becomes unstabl. upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal.porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol.） in a fl.w of 5 ml

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