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Rare Metals 2024年第1期43卷 395-401页

作者： Chen-Yang Zhang Xiao-Nan niu Yan-Feng Wei Shu-Xing Zhou Da-Qing Yang Ying wang Jian wang Bing-Bing Zhang College of Chemistry and Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsHebei UniversityBaoding 071002China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Hubei Longzhong Laboratory Xiangyang 441000China Department of Chemistry and Biochemistry Wichita State UniversityKansas 67260USA

High-performance nonlinear optical(NLO)crystals are crucial devices to convert wavelength of solid-state *** play an indispensable role in the research of infrared NLO *** this work,ternary chalcogenide ZnGa_(2)S_(4) ... 详细信息

关键词： optical nonlinear harmonic

A duplex TaqMan probe-based real-time PCR method for rapid detection and differentiation of the classical and VB strains of human immunodeficiency virus

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Science China(Life Sciences) 2024年第1期67卷 208-210页

作者： Aiping wang Haili wang Jianguo Zhao Yumei Chen Hongliang Liu Peiyang Ding Yan niu Gaiping Zhang Longhu Laboratory Zhengzhou 450046China School of Advanced Agricultural Sciences Peking UniversityBeijing 100871China

Dear Editor,Human immunodeficiency virus(HIV)is a lentivirus that,if left untreated,can lead to acquired immunodeficiency syndrome(AIDS).The virus can be divided into two types based on genetic differences:HIV-1 and ***-1 is widely distributed worldwide and is the primary strain responsible for the global AIDS epidemic due to its high replication capacity,greater likelihood of transmission,and more severe clinical symptoms(Oeschger et al.,2021).

关键词： immunodeficiency untreated

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning niu Tianyi Tian Lu wang Yinmei Tian Tian Tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

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Genes & Diseases 2024年第1期11卷 49-52页

作者： Yumei Liu Haiyue niu Jie Ren Zhiqin wang Li Yan Limin Xing Zonghong Shao Rong Fu Zhigang Cai Huaquan wang Department of Hematology Tianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300070China

Pure red cell aplasia(PRCA)is a bone marrow failure syndrome characterized by severe anemia,reticulocytopenia,selective reduction,and even the absence of bone marrow erythroid precursors,while leukocyte and platelet counts are normal.1 Acquired PRCA can be divided into primary and *** are mediated by immune *** in the quantity and dysfunction of committed erythroid progenitors(EPs),including burst forming uniterythroid(BFU-E)and colony forming unit-erythroid(CFU-E),may be the source of reduced erythropoiesis and needs to be elucidated.

关键词： progenitor anemia leukocyte

A New Robot Manipulator Uncalibrated Visual Serving Control Method

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A New Robot Manipulator Uncalibrated Visual Serving Control ...

Transcriptome analysis suggests broad jejunal alterations in Linghu’s obesity-diarrhea syndrome:A pilot study

2015年中国智能自动化学术会议

作者： wang niu Liu Lang Qiu Jing College of Automation Chongqing University

This paper presents a new robot manipulator uncalibrated visual serving control method, which can conduct visual feedback control under the situation that the internal and external of camera parameters and the robot manipulator model are unknown, as well as without real-time computing the inverse of image ***, the dual cameras biaxial parallel vision configuration is applied to detect the posture of the characteristics of robot manipulator end. Then, we select the specific feature points and lines in the image plane in order to represent the five degrees of freedom of the robot manipulator in cartesian space and design a PI ***, we realized the five degrees of freedom of the robot manipulator uncalibrated visual serving control in the actual physical platform, and the experiment results show that the effectiveness of the proposed control method under the dual cameras biaxial parallel vision configuration.

关键词： Robot manipulator Uncalibrated visual Biaxial parallel vision configuration Five degrees of freedom PI controller

来源： cnki会议评论

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World Journal of Gastroenterology 2024年第21期30卷 2777-2792页

作者： Xiao-Tong niu Xiang-Yao wang Yan wang Ke Han Nan Ru Jing-Yuan Xiang En-Qiang Linghu Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Obesity is associated with a significantly increased risk for chronic diarrhea,which has been proposed as Linghu’s obesity-diarrhea syndrome(ODS);however,its molecular mechanisms are largely *** To reveal the transcriptomic changes in the jejunum involved in *** In a cohort of 6 ODS patients(JOD group),6 obese people without diarrhea(JO group),and 6 healthy controls(JC group),high-throughput sequencing and bioinformatics analyses were performed to identify jejunal mucosal mRNA expression alterations and dysfunctional biological *** another cohort of 16 ODS patients(SOD group),16 obese people without diarrhea(SO group),and 16 healthy controls(SC group),serum diamine oxidase(DAO)and D-lactate(DLA)concentrations were detected to assess changes in intestinal barrier *** The gene expression profiles of jejunal mucosa in the JO and JC groups were similar,with only 1 differentially expressed gene(DEG).The gene expression profile of the JOD group was significantly changed,with 411 DEGs compared with the JO group and 211 DEGs compared with the JC group,129 of which *** enrichment analysis of these DEGs showed that the biological processes such as digestion,absorption,and transport of nutrients(especially lipids)tended to be up-regulated in the JOD group,while the biological processes such as rRNA processing,mitochondrial translation,antimicrobial humoral response,DNA replication,and DNA repair tended to be down-regulated in the JOD *** DEGs(CDT1,NHP2,EXOSC5,EPN3,NME1,REG3A,PLA2G2A,and PRSS2)may play a key regulatory role in the pathological process of ODS,and their expression levels were significantly decreased in ODS patients(P<0.001).In the second cohort,compared with healthy controls,the levels of serum intestinal barrier function markers(DAO and D-LA)were significantly increased in all obese individuals(P<0.01),but were higher in the SOD group than in the SO group(P<0.001).CONCLUSION Compared with health

关键词： Obesity Chronic diarrhea Jejunum Transcriptome Intestinal barrier

A Fault-Tolerant Mobility-Aware Caching Method in Edge Computing

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 907-927页

作者： Yong Ma Han Zhao Kunyin Guo Yunni Xia Xu wang Xianhua niu Dongge Zhu Yumin Dong School of Computer Information Engineering Jiangxi Normal UniversityNanchang330000China School of Digital Industry Jiangxi Normal UniversityShangrao334000China The College of Computer Science Chongqing UniversityChongqing400044China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China School of Computer and Software Engineering Xihua UniversityChengdu610039China Electric Power Research Institute of State Grid Ningxia Electric Power Company Ltd. Yinchuan750002China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a technology designed for the on-demand provisioning of computing and storage services,strategically positioned close to *** the MEC environment,frequently accessed content can be deployed and cached on edge servers to optimize the efficiency of content delivery,ultimately enhancing the quality of the user ***,due to the typical placement of edge devices and nodes at the network’s periphery,these components may face various potential fault tolerance challenges,including network instability,device failures,and resource *** the dynamic nature ofMEC,making high-quality content caching decisions for real-time mobile applications,especially those sensitive to latency,by effectively utilizing mobility information,continues to be a significant *** response to this challenge,this paper introduces FT-MAACC,a mobility-aware caching solution grounded in multi-agent deep reinforcement learning and equipped with fault tolerance *** approach comprehensively integrates content adaptivity algorithms to evaluate the priority of highly user-adaptive cached ***,it relies on collaborative caching strategies based onmulti-agent deep reinforcement learningmodels and establishes a fault-tolerancemodel to ensure the system’s reliability,availability,and *** results unequivocally demonstrate that FTMAACC outperforms its peer methods in cache hit rates and transmission latency.

关键词： Mobile edge networks mobility fault tolerance cooperative caching multi-agent deep reinforcement learning content prediction

Industry-Oriented Detection Method of PCBA Defects Using Semantic Segmentation Models

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1438-1446页

作者： Yang Li Xiao wang Zhifan He Ze wang Ke Cheng Sanchuan Ding Yijing Fan Xiaotao Li Yawen niu Shanpeng Xiao Zhenqi Hao Bin Gao Huaqiang Wu Department of Internet of Things Technology and Application China Mobile Research InstituteBeijing 100053China Beijing Advanced Innovation Center for Integrated Circuits the School of Integrated CircuitTsinghua UniversityBeijing 100084China SigmaStar Technology Limited Xiamen 361199China IEEE

Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in *** AOI equipment has several deficiencies including low throughput,large computation cost,high latency,and poor flexibility,which limits the efficiency of online PCBA *** this paper,a novel PCBA defect detection method based on a lightweight deep convolution neural network is *** this method,the semantic segmentation model is combined with a rule-based defect recognition algorithm to build up a defect detection *** improve the performance of the model,extensive real PCBA images are collected from production lines as *** optimization methods have been applied in the model according to production demand and enable integration in lightweight computing *** results show that the production line using our method realizes a throughput more than three times higher than traditional *** method can be integrated into a lightweight inference system and pro-mote the flexibility of *** proposed method builds up a general paradigm and excellent example for model design and optimization oriented towards industrial requirements.

关键词： Automated optical inspection(AOI) deep learning defect detection printed circuit board assembly(PCBA) semantic segmentation.

The first chiral cerium halide towards circularly-polarized luminescence in the UV region

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Science China Chemistry 2024年第6期67卷 1961-1968页

作者： Xinyi niu Zhichao Zeng Zhaoyu wang Haolin Lu Bing Sun Hao-Li Zhang Yongsheng Chen Yaping Du Guankui Long Tianjin Key Lab for Rare Earth Materials and Applications Renewable Energy Conversion and Storage CenterSmart Sensing Interdisciplinary Science CenterSchool of Materials Science and EngineeringNational Institute for Advanced MaterialsNankai UniversityTianjin300350China Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsHaihe Laboratory of Sustainable Chemical TransformationsSmart Sensing Interdisciplinary Science CenterSchool of Materials Science and EngineeringNational Institute for Advanced MaterialsNankai UniversityTianjin300350China State Key Laboratory of Applied Organic Chemistry Key Laboratory of Special Function Materials and Structure Design(Ministry of Education)College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China The Centre of Nanoscale Science and Technology and State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China

Chiral organic-inorganic hybrid metal halides(OIHMHs)have attracted broader scientific community recently in spin lightemitting diodes,and circularly polarized light-emitting ***,the emission peaks of the reported chiral OIHMHs mainly locate in the visible region,and chiral OIHMH with ultraviolet(UV)circularly polarized luminescence(CPL)has been rarely *** fill this gap,cerium,a unique rare-earth(RE)element with tunable luminescence from UV to the visible region owing to the 4 f-related electronic transition,was introduced to construct the first RE-based chiral OIHMHs,R/*** chirality is successfully transferred from the chiral organic cations to the inorganic cerium chloride framework in R/S-MCC,as confirmed by the single crystal structures,circular dichroism,and *** emission spectra of R/S-MCC are in the UV region,originating from the characteristic d-f transition of Ce^(3+),which making the Ce-based metal halides are ideal candidates towards CPL light sources in the UV ***,R-and S-MCC are the first RE-based OIHMHs,also the first chiral metalhalides with UV *** work opens a new avenue for the development of the chiral OIHMH family towards RE-based chiral *** RE-based chiral metal halides couple the unique and superior optical,electrical,magnetic,and spintronic properties of RE elements with chirality could accelerate the development of chiral optoelectronics and spintronics toward real applications.

关键词： chiral rare-earth halide ultraviolet circularly-polarized luminescence d-f transition rare-earth halide perovskite chiral perovskite

Fabrication of dense SiBCN monolith at a lower temperature and its high-temperature performance

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Journal of Advanced Ceramics 2024年第8期13卷 1198-1211页

作者： Zi-Bo niu Daxin Li Dechang Jia Zhihua Yang Kunpeng Lin Yan wang Paolo Colombo Ralf Riedel Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structural-Function Integrated Materials and Green Manufacturing Technology Ministry of Industry and Information TechnologyHarbin 150080China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150080China Department of Industrial Engineering University of PadovaPadova 3513iItaly Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity Park 16802USA Institute of Materials Science Darmstadt University of TechnologyDarmstadt 64287Germany School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

In this study,a crack-free pyrolysis process of partially cured precursor powder compacts was developed to prepare dense silicon boron carbonitride(SiBCN)monoliths at much lower temperatures(1300℃),thereby circumventing the challenges of sintering densification(>1800℃).Unlike the elastic fracture in over-cured precursors or the viscoelastic deformation in under-cured precursors,the partially cured precursor,exhibiting elastic-plastic deformation behavior,facilitates limited nanoscale pore formation in a dense structure,achieving a balance between crack-free pyrolysis and *** to SiBCN derived from the over-cured precursor(σ=~159 MPa,K_(IC)=1.9 MPa:m^(1/2),Vickers hardness(HV)=7.8 GPa,and E=122 GPa),the resulting SiBCN monolith exhibited significantly improved mechanical properties(σ=~304 MPa,K_(IC)=3.7 MPa-m12,HV=10.6 GPa,and E=161 GPa)and oxidation *** addition,this study investigated the high-temperature performance of SiBCN monoliths,including crystallization and oxidation,and determined the oxidation kinetics induced by pore structure healing and the different oxidation mechanisms of Si-C-N and B-C-N clusters in the amorphous *** to its unique composition and structure,the SiBCN ceramic oxide layer exhibits exceptional self-healing effects on repairing the nanoporous system in the initial stage and shows outstanding high-temperature stability during prolonged oxidation,mitigating adverse effects from bubble formation and *** to the nanoporous structure,the oxidation rate is initially controlled by gas diffusion following a linear law before transitioning to oxide layer diffusion characterized by a parabolic ***,due to different valence bond configurations,Si-C-N transforms into an amorphous SiCNO structure after phase separation,unlike the nucleation and growth of residual B-N-C.

关键词： silicon boron carbonitride(SiBCN)ceramics crack-free pyrolysis amorphous structure oxidation mechanisms kinetic law