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近40年内蒙古近地表土壤冻融状态时空演变特征解析

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水土保持研究 2025年第1期32卷 148-159页

作者：田鑫萨楚拉孟凡浩罗敏王牧兰张翔张昊琛内蒙古师范大学地理科学学院内蒙古自治区遥感与地理信息系统重点实验室内蒙古自治区土地储备中心

[目的]解析内蒙古近地表土壤冻融状态的时空分异及变化规律并量化驱动因素的影响，为区域生态环境保护及基础设施建设提供理论依据。[方法]基于ERA5-LAND土壤温度数据，利用Sen趋势分析(Theil-Sen median)、Mann-Kendall检验和多元回归... 详细信息

[目的]解析内蒙古近地表土壤冻融状态的时空分异及变化规律并量化驱动因素的影响，为区域生态环境保护及基础设施建设提供理论依据。[方法]基于ERA5-LAND土壤温度数据，利用Sen趋势分析(Theil-Sen median)、Mann-Kendall检验和多元回归残差分析，对内蒙古地区近40年地表土壤冻融状态的时空演变特征及其驱动因素进行了分析。[结果](1)近40年内蒙古地区秋冬始冻期和完全冻结期起始日期呈推迟趋势，变化速率分别为0.54 d/10 a和0.45 d/10 a;在空间分布上，随着经纬度的增加逐渐提前。冬春解冻期和完全融化期起始日期呈提前趋势，变化速率分别为2.17 d/10 a和2.15 d/10 a;空间上随着经纬度的增加逐渐推迟。(2)秋冬始冻期、完全冻结期和冬春解冻期的发生天数呈减少趋势，变化速率分别为0.10 d/10 a, 2.61 d/10 a和0.27 d/10 a,而完全融化期的发生天数则以2.68 d/10 a的速率在增加。空间分布上，除完全冻结期呈东北向西南逐渐减少的趋势，其余3个阶段均呈东北向西南逐渐增加的趋势。(3)不同土壤冻融状态受气候变化和人类活动共同驱动影响的面积占比最大，其次为单独由气候变化驱动影响的面积占比，单独由人类活动驱动影响的面积占比最小。[结论]近地表土壤冻融状态的时空分异及变化规律明显，不同区域不同土壤冻融状态的驱动力各不相同，对内蒙古地区生态环境保护及基础设施建设意义重大，未来应更加深入分析气候变化及人类活动对其的影响。

关键词：地表土壤冻融时空演变特征内蒙古气候变化人类活动

Postmarketing studies on safety of Dengfeng~ shenmai injection

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Journal of Traditional Chinese Medicine 2013年第6期33卷 827-831页

作者： Lianxin wang Wen Zhang Yanming Xie Yang Bai mulan wang Qinghua Ai Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Marketing Department Research Department of Chiatai Qingchunbao Pharmaceutical Company Ltd.

OBJECTIVE: To systematically research the postmarketing safety of Dengfeng shenmai injection, identify potential risk factors, and ensure its clinical safety. METHODS: We investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction(ADR) case analysis and systematic review. Data from the hospital information system(HIS) and spontaneous reporting system(SRS) were also analyzed. RESULTS: The approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain. CONCLUSION: This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection.

关键词： Product surveillance, postmarketing Medicine, Chinese traditional Safety Shenmai in-jection

Submergence induced changes of molecular species in membrane lipids in Arabidopsis thaliana

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Plant Diversity 2016年第3期38卷 156-162页

作者： mulan wang Yunmei Shen Faqing Tao Shengchao Yang Weiqi Li Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials Yunnan Agriculture University Kunming 650201 China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China Department of Biology Honghe University Mengzi 661100 China Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China

The composition of membrane lipids is sensitive to environmental *** is a type of stress often encountered by ***,how the molecular species of membrane lipids respond to submergence has not yet been *** this study,we used a lipidomic approach to profile the molecular species of membrane lipids in whole plants of Arabidopsis thaliana that were completely submerged for three *** plants survived one day of submergence,after which,we found that the total membrane lipids were only subtly decreased,showing significant decreases of monogalactosyldiacylglycerol(MGDG)and phosphatidylcholine(PC)and an increase of phosphatidic acid(PA);however,the basic lipid composition was *** contrast,three days of submergence caused plants to die,and the membranes deteriorated via the rapid loss of 96% of lipid content together with a 229% increase in *** turnover of molecular species from PG and MGDG to PA indicated that submergenceinduced lipid changes occurred through PA-mediated *** addition,molecular species of extraplastidic PG degraded sooner than plastidic ones,lyso-phospholipids exhibited various patterns of change,and the double-bond index(DBI)remained unchanged until membrane *** results revealed the unique changes of membrane lipids upon submergence and suggested that the major cause of the massive lipid degradation could be anoxia.

关键词： Submergence Anoxia stress Membrane lipids Lipidomics Arabidopsis thaliana

Spatiotemporal variation in snow cover and its effects on grassland phenology on the Mongolian Plateau

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Journal of Arid Land 2021年第4期13卷 332-349页

作者： SA Chula MENG Fanhao LUO Min LI Chenhao wang mulan ADIYA Saruulzaya BAO Yuhai College of Geographical Science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Key Laboratory of Remote Sensing and Geographic Information System Inner Mongolia Normal UniversityHohhot 010022China Institute of Geography and Geoecology Mongolian Academy of ScienceUlaanbaatar 15170Mongolia

Snow cover is an important water source for vegetation growth in arid and semi-arid areas,and grassland phenology provides valuable information on the response of terrestrial ecosystems to climate *** Mongolian Plateau features both abundant snow cover resources and typical grassland *** recent years,with the intensification of global climate change,the snow cover on the Mongolian Plateau has changed correspondingly,with resulting effects on vegetation *** this study,using MOD10A1 snow cover data and MOD13A1 Normalized Difference Vegetation Index(NDVI)data combined with remote sensing(RS)and geographic information system(GIS)techniques,we analyzed the spatiotemporal changes in snow cover and grassland phenology on the Mongolian Plateau from 2001 to *** correlation analysis and grey relation analysis were used to determine the influence of snow cover parameters(snow cover fraction(SCF),snow cover duration(SCD),snow cover onset date(SCOD),and snow cover end date(SCED))on different types of grassland *** results showed wide snow cover areas,an early start time,a late end time,and a long duration of snow cover over the northern Mongolian ***,a late start,an early end,and a short duration were observed for grassland phenology,but the southern area showed the opposite *** SCF decreased at an annual rate of 0.33%.The SCD was shortened at an annual rate of 0.57 *** SCOD and SCED in more than half of the study area advanced at annual rates of 5.33 and 5.74 DOY(day of year),*** grassland phenology,the start of the growing season(SOS)advanced at an annual rate of 0.03 DOY,the end of the growing season(EOS)was delayed at an annual rate of 0.14 DOY,and the length of the growing season(LOS)was prolonged at an annual rate of 0.17 *** SCF,SCD,and SCED in the snow season were significantly positively correlated with the SOS and negatively correlated with the EOS and *** SCOD was significantly negative

关键词： snow cover fraction snow cover phenology vegetation phenology grey relation grade climate change Mongolian Plateau

Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1694-1708页

作者： Chongjin Zhong Chao Jiang Suiying Ni Qizhi wang Lingge Cheng Huan wang Qixiang Zhang Wenyue Liu Jingwei Zhang Jiali Liu mulan wang Min Jin Peiqiang Shen Xuequan Yao Guangji wang Fang Zhou Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai Qingchunbao Pharmaceutical Co. Ltd.Hangzhou 310023China

Shenmai injection(SMI)is a well-defined herbal preparation that is widely and clinically used as an adjuvant therapy for ***,we found that SMI synergistically enhanced the activity of chemotherapy on colorectal cancer by promoting the distribution of drugs in xenograft ***,the underlying mechanisms and bioactive constituents remained *** the present work,the regulatory effects of SMI on tumor vasculature were determined,and the potential anti-angiogenic components targeting tumor endothelial cells(TECs)were *** pharmacokinetic profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** results showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD-type ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** vivo bioactivity results showed that Rd suppressed neovascularization in tumors,normalized the structure of tumor vessels,and improved the anti-tumor effect of 5-fluorouracil(5 FU)in xenograft ***,Rd inhibited the migration and tube formation capacity of endothelial cells in *** conclusion,Rd may be an important active form to exert the anti-angiogenic effect on tumor after SMI treatment.

关键词： Shenmai injection Ginsenoside Rd Multidimensional pharmacokinetics Anti-angiogenic Tumor endothelial cell

Establishment and Application of Allergenic Cell Model Using Mouse Basophil Activation Test

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Establishment and Application of Allergenic Cell Model Using...

中国药理学会药检药理专业委员会第十六届（2019年）学术年会

作者： Sang Jing Duan Mingyang wang mulan wang Jiawei Jiang Nan Kuang Rong Zhejiang Institute for Food and Drug Control Zhejiang University of Technology Yangtze River Delta Region Green Pharmaceutical Collaborative Innovation Center ChiaTai QingChunBao Pharmaceutical Co Ltd.

OBJECTIVE:To establish a allergenic cell model of mouse basophil activation and investigate the potential sensitization of two Chinese herbal ***:Normal mouse peripheral blood basophils were used as target cells and fMLP as sensitizer to stimulate target *** of CD203,CD123,CD63 and CD200 R on bas ophils surface were *** allergenic cell model was established,and the potential sensitization of Danshen injection and Shenmai injection was investigated by the ***:The percentage of CD63 and CD200 R positive cells in peripheral blood of mice increased significantly after 20 pM positive substance of fMLP treatment for 30 min. CONCLUSION:fMLP-induced basophil model can be used as an allergic cell *** changes of percentage of CD63 and CD200 R positive cells could be used evaluate the potential sensitization of *** Injection and Shenmai Injection were evaluated using the *** was no potential hypersensitivity detected from the two kinds of traditional Chinese medicine injections.

关键词： mouse basophil allergenic cell model traditional Chinese medicine injection

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水环境中溶解有机物对铜生物可利用性的影响

科学通报 2018年第23期63卷 2348-2360页

作者：王木兰沙聪姜玥璐清华大学深圳研究生院深圳518055 清华大学环境学院北京100084

具有生物毒性的铜是水体重要的金属污染物之一,而溶解有机物(dissolved organic matter,DOM)的存在能够降低金属铜对生物的危害.本文综述了水环境DOM的来源、特征和形成消耗过程,并归纳了已知组成、细菌和浮游植物3种不同来源的DOM与金... 详细信息

具有生物毒性的铜是水体重要的金属污染物之一,而溶解有机物(dissolved organic matter,DOM)的存在能够降低金属铜对生物的危害.本文综述了水环境DOM的来源、特征和形成消耗过程,并归纳了已知组成、细菌和浮游植物3种不同来源的DOM与金属铜之间的络合作用,探讨了水环境DOM影响金属铜生物可利用性的因素及机制.已有研究表明DOM对金属铜生物可利用性的影响主要体现在两方面:(1)DOM能够降低或提高铜的生物毒性,海洋环境存在DOM维持铜生物毒性的平衡机制;(2)DOM通过降低食物链底端对金属铜的吸收,限制铜进入食物链.DOM对金属铜生物可利用性影响主要通过与自由铜离子(Cu2+)产生络合或螯合作用实现,同时还受DOM自身特征以及分子大小的影响.随着研究技术的发展,现在研究可以从分子结构或官能团的角度更准确地评价DOM对金属的影响.本文最后总结了目前DOM对金属铜生物可利用性影响研究中新技术的应用、面临的问题和挑战以及未来的发展方向.

关键词：水环境溶解有机物铜浮游植物细菌生物可利用性

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基于权重粒子群算法的工件铣削温度研究

机械工程学报 2014年第19期50卷 205-212页

作者：冯勇汪木兰王保升侯军明南京工程学院机械工程学院南京211167 南京工程学院江苏省先进制造技术重点建设实验室南京211167

为研究铣削加工中工件的温度分布规律,推导其热传导数学模型,提出应用权重粒子群算法(Weighted particle swarm optimization,WPSO)开展时变热流密度辨识的方法,并结合试验数据对AISI1045钢在特定工况下的温度分布情况进行分析。结果表... 详细信息

为研究铣削加工中工件的温度分布规律,推导其热传导数学模型,提出应用权重粒子群算法(Weighted particle swarm optimization,WPSO)开展时变热流密度辨识的方法,并结合试验数据对AISI1045钢在特定工况下的温度分布情况进行分析。结果表明,铣削过程中的界面热流密度呈3个阶段的非线性变化;切削初期存在缓慢温升的平台期,渡过平台期后,工件与刀具相接触部分的温度急剧上升,最高温度可达到860℃左右;从试验结果与解析结果的对比来看,两者误差的最大值约为11.06%,结果基本吻合。研究表明所提出的方法可以较为准确研究铣削加工过程中工件的温度分布情况。

关键词：工件铣削温度权重粒子群算法热传导 AISI1045钢

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面向大型机床再制造的进给系统动态特性

机械工程学报 2011年第3期47卷 135-140页

作者：丁文政黄筱调汪木兰南京工业大学机械与动力工程学院南京210009 南京工程学院先进制造技术工程中心南京211167

大型机床进给系统的再制造必须考虑大型部件的空间分布特性对进给系统动态响应的影响。针对某大型铣齿机床,采用分布参数建模方法描述细长滚珠丝杠副的传递子系统,采用集中参数建模方法描述交流伺服驱动子系统和工作台驱动子系统,并通... 详细信息

大型机床进给系统的再制造必须考虑大型部件的空间分布特性对进给系统动态响应的影响。针对某大型铣齿机床,采用分布参数建模方法描述细长滚珠丝杠副的传递子系统,采用集中参数建模方法描述交流伺服驱动子系统和工作台驱动子系统,并通过转速关系将3个子系统耦合起来,形成进给系统的分布集中参数模型。通过理论模型仿真与试验结果比较,证明建立的分布集中参数模型符合物理系统的真实性,能够准确地描述大型机床进给系统的动态响应特性。在此基础上进一步讨论不同分布特性影响下,分布集中参数模型和单纯集中参数模型动态响应的变化,结果表明,两种模型的动态响应差异会随着系统惯量的变化而改变,这为大型机床进给系统的设计、控制提供了参考依据。

关键词：再制造大型机床动态响应分布参数