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Synthesis and Antitumor Activity of Capecitabine Derivatives

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Chemical Research in Chinese Universities 2015年第1期31卷 78-83页

作者： JIA Xuedong LIU Xlujun wang Jian wang minghua GUO Huiyuan LIU Mingliang Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 P. R. China The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 P. R. China No.5 Hospital of Harbin Harbin 150040 P. R. China

A series of capecitabine derivatives with a Boc group at the N4-position was synthesized and their in vitro antitumor activities against HepG2（liver hepatocellular carcinoma） were primarily evaluated. Some compounds were chosen for further evaluation of their in vivo efficacy on nude mice xenografted human hepatoma HepG2. The results showed that compounds 3 and 6 had considerable in vivo activity against HepG2, with tumor growth inhibition rates of 70% and 64% on day 21, respectively, and 56% and 55% on day 35, respectively, which are roughly comparable to capecitabine（74% and 59% on days 21 and 35, respectively）.

关键词： Capecitabine Derivative Antitumor activity

Proteomic analysis of a toxic dinoflagellate Alexandrium catenella under different growth phases and conditions

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Chinese Science Bulletin 2012年第25期57卷 3328-3341页

作者： wang DaZhi LIN Lin wang minghua LI Cheng HONG HuaSheng State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology Xiamen UniversityXiamen 361005China

Alexandrium is a widely spread dinoflagellate genus throughout many regions of the world,which not only causes the harmful algal blooms(HABs) but also results in the paralytic shellfish poisoning(PSP) throughout the *** study compared protein profiles of *** grown under different growth phases and conditions using a proteomic approach,and identified the differentially expressed *** results showed that the expressions of proteins identified in three different regions of the gels,the groups 1,2 and 3 proteins,varied significantly with the growth phases and *** 1 proteins and six Group 2 proteins were highly expressed at the initial,exponential and stationary growth phases,eight Group 2 proteins were highly expressed only at the initial phase,and Group 3 proteins were highly expressed at the exponential and/or stationary ***,all these proteins were expressed at low levels or were barely visible at the dissipation *** expressions of groups 1 and 2 proteins were low or barely visible in various growth conditions except in continuous darkness they were highly *** 3 proteins,on the other hand,were overexpressed in continuous illumination and expressed at low levels or barely visible in continuous darkness or under *** data from MALDI-TOF-TOF mass spectrometry demonstrated that these differentially expressed proteins were associated with macromolecular biosynthesis,photosynthesis,tRNA synthesis and DNA stability,stress response and cell division *** was the major component of the altered *** is one of the first comprehensive proteomic study of a dinoflagellate,***,that provides a fundamental understanding of the proteins involved in *** growth and response to environmental stresses,and potential physiological indicator proteins related to growth and environmental stress have been identified.

关键词：蛋白质组学生长阶段亚历山大学分差异表达生物合成环境压力 TOF质谱

Investigation on the particle loss and applicability of aviation nvPM measurement methodology for wide particle size ranges

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Particuology 2024年第12期95卷 154-165页

作者： minghua wang Liuyong Chang Xuehuan Hu Meiyin Zhu Bin Zhang Guangze Li Zheng Xu Hangzhou International Innovation Institute Beihang UniversityHangzhou311115China School of Energy and Power Engineering Beihang UniversityBeijing100083China

The precise measurement of non-volatile Particulate Matter(nvPM)is outlined in aviation engine emissions regulations by the International Civil Aviation Organization(ICAO).However,assessing particle losses in the sampling and transfer unit presents challenges,raising concerns about the system's ***,nvPM emissions from small and medium aircraft engines,with thrust not exceeding 26.7 kN,vary widely in size,adding complexity to the measurement *** provide a comprehensive analysis of particle losses in the sampling and transfer subsystems,this study established a test bench equipped with a nanoparticle *** generator simulates nvPM emissions from medium and small aircraft engines and can consistently produce nvPMs with a wide range of concentrations(103–107/cm^(3))and size distributions(20–160 nm).Thermophoretic loss verification experiments were conducted within the sampling pipeline under significant temperature differences,investigating the effects of particle size,temperature gradient,and airflow rate on thermophoretic particle *** experimental results demonstrated good agreement with the predictions of the model proposed by United Technologies Research Centre(UTRC).After correcting for temperature,the experimental data showed a maximum disparity of 2%under typical engine exhaust conditions,validating the predictability of the thermophoretic loss model for various engine ***,verification experiments for particle diffusion and bending losses were *** analysis with the UTRC model revealed nvPM inertial deposition under laminar flow conditions with low Reynolds numbers(Re).As the Re increased,the measured data more closely aligned with the *** losses due to secondary flow patterns ranged from 1%to 10%,depending on particle size and flow *** finding supports the applicability of aviation nvPM measurement methods across a wide particle size *** research provides theoretic

关键词： Non-volatile particulate matter Thermophoretic loss Transfer loss Particle number concentration Particle size distribution

Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine

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Journal of Environmental Sciences 2022年第1期34卷 153-163页

作者： Beibei Gao Giulia Poma Govindan Malarvannan Catalina Dumitrascu Michiel Bastiaensen minghua wang Adrian Covaci Toxicological Centre University of AntwerpWilrijk 2610Belgium Department of Pesticide Science College of Plant ProtectionState and Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjing Agricultural UniversityNanjing 210095China

Pyrethroids,organophosphorus pesticides and fipronil have been listed as priority chemicals in human biomonitoring studies because of their wide use and potential health effects in *** determination of 13 pesticides,including pyrethroids(deltamethrin,cypermethrin,permethrin,cyfluthrin,bifenthrin),organophosphorus(chlorpyrifos,chlorpyrifosmethyl,and malathion),fipronil,neonicotinoids(imidacloprid,acetamiprid and thiacloprid)and triazole(prothioconazole),together with 13 corresponding metabolites in human urine samples was achieved by solid-phase extraction and analysis by liquid chromatography coupled to tandem mass *** targeted compounds,except malathion dicarboxylic acid,were measured with a mean within-accuracy(n=5)of 71%–114%(RSD:1%–14%)and between-run(n=15)accuracy of 80%–118%(RSD:2%–14%).Limits of quantitation of the targeted analytes ranged from 0.1 to 16 pg/m *** detection result of urine samples from 25 volunteers indicated that the detection frequencies of 3,5,6-trichloro-2-pyridinol(median:448 pg/m L),6-chloropyridine-3-carboxylic acid(median:193 pg/m L),2-methyl-3-phenylbenzoic acid(median:181 pg/m L),3-phenoxybenzoic acid(median:99 pg/m L),2-isopropyl-6-methyl-4-pyrimidinol(median:77 pg/m L),cyfluthrin(median:59 pg/m L),cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid(cis-DCCA,median:53 pg/m L),trans-DCCA(median:25 pg/m L),prothioconazole(median:21 pg/m L),imidacloprid(median:7 pg/m L),and prothioconazole-desthio(median:1 pg/m L)were>50%.The obtained results show that the validated method is suitable for the human biomonitoring of these currentuse pesticides and their metabolites.

关键词： Pyrethroids Organophosphorus Fipronil Neonicotinoids Urine Biomonitoring

Research of high speed optical switch based on compound semiconductor

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Chinese Science Bulletin 2009年第20期54卷 3679-3684页

作者： wang minghua QI Wei YU Hui JIANG XiaoQing YANG JianYi Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China School of Information and Electrical Engineerig Zhejiang University City College Hangzhou 310014 China

High-speed optical switch and its array are the crucial components of all-optical switching *** paper presents the analytical model of a total-internal-reflection(TIR) optical *** employing the carrier injection effect in GaAs and the GaAs/AlGaAs double heterojunction structure,the X-junction TIR switch and the Mach-Zehnder interference(MZI) switch are demonstrated at 1.55 μ*** measured results show that the extinction ratio of both switches exceeds 20 *** switching speed reaches the scale of 10 ns.

关键词：光开关化合物半导体 AlGaAs 公路货运载流子注入双异质结构关键部件交换系统

Multi-antenna synchronized global navigation satellite system receiver and its advantages in high-precision positioning applications

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Frontiers of Earth Science 2016年第4期10卷 772-783页

作者： Danan DONG Wen CHEN Miaomiao CAI Feng ZHOU minghua wang Chao YU Zhengqi ZHENG Yuanfei wang Engineering Center of SHMEC for Space Information and GNSS East China Normal University Shanghai 200241 China Shanghai Key Laboratory of Multidimensional Information Processing East China Normal University Shanghai 200241 China Key Laboratory of Geographic Information Science Ministry of Education East China Normal University Shanghai 200241 China College of Surveying and Geo-informatics Tongji University Shanghai 200092 China

The multi-antenna synchronized global navi- gation satellite system receiver is a high precision, low cost, and widely used emerging receiver. Using this type of receiver, the satellite and receiver clock errors can be eliminated simultaneously by forming between antenna single-differences, which is equivalent to the conventional double-difference model. However, current multi-antenna synchronized global navigation satellite system receiver products have not fully realized their potential to achieve better accuracy, efficiency, and broader applications. This paper introduces the conceptual design and derivable products of multi-antenna synchronized global navigation satellite system receivers involving the aspects of attitude determination, multipath effect mitigation, phase center variation correction, and ground-based carrier phase wind- up calibration. Through case studies, the advantages of multi-antenna synchronized global navigation satellite system receivers in high-precision positioning applications are demonstrated.

关键词： multi-antenna synchronized global navigationsatellite system receiver high-precision positioning attitudedetermination multipath effect mitigation phase centervariation correction ground-based carrier phase wind-upcalibration

CeO_2-ZrO_2-La_2O_3-Al_2O_3 composite oxide and its supported palladium catalyst for the treatment of exhaust of natural gas engined vehicles

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Journal of Natural Gas Chemistry 2009年第2期18卷 139-144页

作者： Xiaoyu Zhang Enyan,Long Yile Li Jiaxiu Guo Lijuan Zhang Maochu Gong minghua wang Yaoqiang Chen Key Laboratory of Green Chemistry ＆ Technology of the Ministry of Education College of Chemistry Sichuan University Chengdu 610064 Sichuan China College of Architecture and Environment Sichuan University Chengdu 610064 Sichuan China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning China Sichuan Tianyi Science ＆ Technology Co. Ltd. Chengdu 610225 Sichuan China

Composite supports CeO2-ZrO2-Al2O3（CZA） and CeO2-ZrO2-Al2O3-La2O3（CZALa） were prepared by co-precipitation method. Palladium catalysts were prepared by impregnation and their purification ability for CH4, CO and NOx in the mixture gas simulated the exhaust from natural gas vehicles （NGVs） operated under stoichiometric condition was investigated. The effect of La2O3 on the physicochemical properties of supports and catalysts was characterized by various techniques. The characterizations with X-ray diffraction （XRD） and Raman spectroscopy revealed that the doping of La2O3 restrained effectively the sintering of crystallite particles, maintained the crystallite particles in nanoscale and stabilized the crystal phase after calcination at 1000 ℃. The results of N2-adsorption, H2-temperatnre-programmed reduction （H2-TPR） and oxygen storage capacity （OSC） measurements indicated that La2O3 improved the textural properties, reducibility and OSC of composite supports. Activity testing results showed that the catalysts exhibit excellent activities for the simultaneous removal of methane, CO and NOx in the simulated exhaust gas. The catalysts supported on CZALa showed remarkable thermal stability and catalytic activity for the three pollutants, especially for NOx. The prepared palladium catalysts have high ability to remove NOx, CH4 and CO, and they can be used as excellent catalysts for the purification of exhaust from NGVs operated under stoichiometric condition. The catalysts reported in this work also have significant potential in industrial application because of their high performance and low cost.

关键词： Pd catalysts natural gas vehicles exhaust methane oxidation NOx conversion CeO2-ZrO2-Al2O3 La2O3

Recovery of Titanium from the Rich Titanium Slag by H2SO4 Method

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Journal of Materials Science & Technology 2003年第2期19卷 191-192页

作者： Zhenqi HUANG, minghua wang, Xinghong DU and Zhitong SUISchool of Materials and Metallurgy, Northeastern University, Shenyang 110006, China Sch. of Mat. and Metall. Northeastern Univ. Shenyang 110006 China

The blast furnace slag bearing Ti02 in Panzhihua, China, is an important resource to be utilized. In the present paper, the effects of the ratio of slag to H2S04, the reaction temperature, the particle size of the slag, and the concentration of H2S04 on the reaction rate and the acidolysis ratio of Ti were studied. The results indicated that the maximum acidolysis ratio reached 98%, which can serve as an experimental basis for the production of titania from the slag.

关键词： Slag bearing TiO2 H2SO4 Acidolysis Titanium recovery

Influence of doping position on the extinction ratio of Mach-Zehnder-interference based silicon optical modulators

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Journal of Semiconductors 2012年第1期33卷 77-79页

作者： Zhao Yong wang Wanjun Shao Haifeng Yang Jianyi wang minghua Jiang Xiaoqing Department of Information Science and Electronics Engineering Zhejiang University Hangzhou 310027China

The extinction ratio （ER） ofa Mach-Zehnder-interference （MZI） based silicon optical modulator can be strongly influenced by carrier absorption. Moreover, different doping positions can induce different distributions of injected carriers, leading to different ERs. This effect has been experimentally investigated based on the devices fabricated on silicon-on-insulator （SOl） by using a 0.18μm CMOS process. Our experiments indicate that a device with a doping position of about 0.5μm away from the edge of the rib waveguide has optimal ER.

关键词： silicon photonics modulator carrier dispersion effect carrier absorption doping position