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安徽水利水电职业技术学院学报 2006年第2期6卷 19-20,23页

作者：王自明阜阳市茨淮新河插花枢纽管理所安徽阜阳236136

文章分析了阜阳市城区防洪存在问题,对提高城区综合防洪能力提出了建议。

关键词：城区防洪现状建议

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恒阻吸能材料及锚固体力学特性研究与应用

Journal of Central South University 2023年第10期30卷 3361-3373页

作者：王琦辛忠欣江贝王鸣子何满潮魏华勇 State Key Laboratory for Geo-mechanics and Deep Underground Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Geotechnical and Structural Engineering Research Center Shandong UniversityJi’nan 250061China

锚固支护作为地下工程围岩控制的主体,与围岩联合承载形成锚固体,共同抵抗动力灾害释放的能量。传统锚杆(索)支护强度、延伸率不足,在抵抗动力灾害时易破断失效。恒阻吸能材料是一种具有高强、高延伸的新型支护材料。为明确恒阻吸能新... 详细信息

锚固支护作为地下工程围岩控制的主体,与围岩联合承载形成锚固体,共同抵抗动力灾害释放的能量。传统锚杆(索)支护强度、延伸率不足,在抵抗动力灾害时易破断失效。恒阻吸能材料是一种具有高强、高延伸的新型支护材料。为明确恒阻吸能新材料及其锚固体的力学特性,本文开展了恒阻吸能支护材料与现场常用支护材料MG335、MG500的静力拉伸与动力冲击试验。在此基础上,对MG335、MG500与恒阻吸能支护材料锚固下的岩体开展了霍普金森冲击对比试验,研究了高速冲击下锚固体的变形破坏特征。相比于MG335、MG500锚固体,通过霍普金森冲击试验得到恒阻汲能锚固体的峰值应力提高了42.2%与63.9%,所能吸收的动力冲击能量提高了42.0%与63.2%。恒阻吸能支护技术能够增强锚固体的抗冲承载能力与吸能能力。结合上述试验成果,提出了强扰动下围岩恒阻吸能支护的工程建议,并在千米冲击地压矿井中应用。

关键词：恒阻吸能锚固岩体力学性能试验研究现场应用

Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

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Petroleum Science 2024年第3期21卷 1915-1927页

作者： Pan wang Yu-Hang Hu Liao-Yuan Zhang Yong Meng Zhen-Fu Ma Tian-Ru wang zi-Lin Zhang Ji-Chao Fang Xiao-Qiang Liu Qing You Yan Zhang Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences(Beijing)Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Petroleum Engineering Technology Research Institute Sinopec Shengli Oilfield CompanyDongying257000ShandongChina Hekou Oil Production Plant Sinopec Shengli Oilfield CompanyDongying257200ShandongChina Petroleum Exploration and Production Research Institute SINOPECBeijing102206China CNPC Engineering Technology R&D Company Limited Beijing102206China

Nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability *** are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their *** study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core *** pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and ***,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability *** work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

关键词： Nanoparticle Pressure reduction Augmented injection Ultra-low permeability reservoir

Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome

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Protein & Cell 2024年第9期15卷 704-709页

作者： Jing wang Hui-Juan Jin Yi Lu zi-Han wang Teng-Yan Li Lan Xia Hong-Jun Li Bin-Bin wang Su-Ren Chen Department of Medical Genetics and Developmental Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Key Laboratory of Cell Proliferation and Regulation Biology Ministry of EducationDepartment of BiologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Urology Peking Union Medical College HospitalBeijing 100005China Center for Genetics National Research Institute of Family PlanningBeijing 100081China NHC Key Laboratory of Reproductive Health Engineering Technology Research(NRIFP) Beijing 100081China

Dear Editor,Male infertility is a widespread health problem and affects approximately 6%–8%of the male population(Jiao et al.,2021).Acephalic spermatozoa syndrome(ASS),a rare but severe type of teratozoospermia,is ch... 详细信息

关键词： al. infertility finally

Property evolution and service life prediction of novel metallic materials for future lunar bases

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Rare Metals 2024年第10期43卷 5318-5331页

作者： Sen-Kuan Meng Rui-Song Zhu Hong-Liang Zheng Tong Gao Shi-Hao Jiang Wen-Hao wang Shu-Hao Zhang zi-Yuan Zhao Xuan Ge Wei-Min wang Li-Na Hu Zheng wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University Department of Chemistry and Bioscience Aalborg University

While lunar bases have been a focus of development in recent years, the complex and extreme environment of the lunar surface remains a considerable challenge for lunar exploration. Unlike those on Earth,lunar day and night temperature variations cause the properties of materials, especially metallic materials, to evolve in completely different manners. In this study, we investigated the property evolution of nine typical highperformance metallic materials using laboratory simulations of the extremely long-period lunar temperature environment. While lunation treatment improves the properties of all metallic materials, the microscopic mechanisms vary for amorphous and crystalline alloys with different structures. The treatment reduces both the loosely packed regions and heterogeneity in amorphous alloys while causing significant phase changes in crystalline alloys. Furthermore, a conservative prediction of the service life of metallic materials on lunar bases is provided based on analyzing microplastic events, followed by the practical material selection recommendations in various lunar application scenarios.

关键词： Lunar exploration Metallic glass Metallic material Property evolution

Riemann-Hilbert Problem and Multiple High-order Poles Solutions of the Focusing MKdV Equation with Nonzero Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2024年

作者： zi-yi wang Shou-fu TIAN Jin-jie YANG School of Mathematics China University of Mining and Technology

The focusing modified Korteweg-de Vries (mKdV) equation with multiple high-order poles under the nonzero boundary conditions is first investigated via developing a Riemann-Hilbert(RH) approach. We begin with the asymptotic property, symmetry and analyticity of the Jost solutions, and successfully construct the RH problem of the focusing mKdV equation. We solve the RH problem when 1/S11(k) has a single highorder pole and multiple high-order poles. Furthermore, we derive the soliton solutions of the focusing mKdV equation which corresponding with a single high-order pole and multiple high-order poles, respectively. Finally,the dynamics of one-and two-soliton solutions are graphically discussed.

关键词：

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管窜影响下的复杂碳酸盐岩油藏产水特征分析

科学技术与工程 2018年第24期18卷 72-78页

作者：王自明程亮杨赤宸中国石油川庆钻探工程公司地质勘探开发研究院成都610500

针对伊拉克Ahdeb油田下白垩统复杂碳酸盐岩油藏因套管外窜流、高渗条带及多层合采等因素造成出水情况复杂,含水上升率较高的问题,建立了精细复杂碳酸盐岩油藏精细模型。在此基础上,采用实际典型产水曲线标定数模曲线的方式,结合无因次... 详细信息

针对伊拉克Ahdeb油田下白垩统复杂碳酸盐岩油藏因套管外窜流、高渗条带及多层合采等因素造成出水情况复杂,含水上升率较高的问题,建立了精细复杂碳酸盐岩油藏精细模型。在此基础上,采用实际典型产水曲线标定数模曲线的方式,结合无因次时间得到不同管窜情况下(水泥环与储层间的第二界面破损位置位于纯水层、油水过渡带和纯油层)的套管外窜流&底水锥进和纯套管外窜流的产水特征曲线。根据建立的产水特征曲线对油藏出水类型和机理进行了识别与分析。结果表明:产水特征曲线能够有效判明油藏出水类型,避免过多进行井下PLT测试等工作;出水机理分析与现场先导试验结果一致,研究结果为油藏稳油控水提供了可靠的措施对策依据。

关键词：伊拉克 Ahdeb油田下白垩统产水特征出水机理

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze wang Lei Shen Xiu-Hai Wu Bo Fu Peng-Yu Guo zi-Qi wang Dong-Bing Cheng Hao wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury

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Neural Regeneration Research 2024年第11期19卷 2499-2512页

作者： Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu wang Chaoqin Wu Sheng Zhang Hongtao Chen zi wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Trauma Surgery Subei People’s Hospital of JiangsuClinical Medical College of Yangzhou UniversityYangzhouJiangsu ProvinceChina Department of Orthopedics Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina Department of Orthopedic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina

The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord ***,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine *** studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains *** address this gap,we established a mouse model of T10 spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord *** sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory ***,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic ***,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury.

关键词： astrocytes EAAT2 excitotoxicity glutamate homeostasis JAK-STAT pathway locomotor function neurotoxicity ruxolitinib spinal cord injury transcriptome analysis

Characteristics and geological significance of carbon and oxygen isotopes of the Permian Lucaogou Formation dolomite in the southern Junggar Basin, northwestern China

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Journal of Palaeogeography 2024年第4期13卷 862-882页

作者： Gang Liu Guo-Zhi wang Na Li Hong-Ling He Nan-Nan Lu Qing Lei zi-Ang wang College of Earth and Planetary Sciences Chengdu University of Technology National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Hebei Survey Institute of Coal Geology Sichuan Earthquake Agency

Anomalously positive δ13C values in ancient dolomites are very *** gray argillaceous rocks of the lacustrine sediments of the Permian Lucaogou Formation are important source rocks in the Junggar Basin,and dolomites of varying thicknesses from 10 cm to 150 cm are often interspersed in argillaceous *** on the study of petrographic sections,this paper systematically analyzes the carbon and oxygen isotopes of dolomite and discusses the causes of abnormally high carbon isotope values and their significance in reconstructing paleoenvironment and *** results show that carbon isotope values are abnormally high in the dolomite of Lucaogou Formation,and the δ13C value is between+3.2‰PDB and+19.6‰PDB,with an average of+9.7‰*** δ18O values range from-17.4‰PDB to-1.7‰PDB,with an average of-8.1‰*** the lower part to the upper part of the Lucaogou Formation,the carbon isotope value gradually increases and becomes increasingly positive,and the carbon isotope of the dolomite deposited near the shore is more positive than that of the dolomite deposited far from the *** anomalously positive δ13C of the dolomite is mainly caused by microbial methanogenesis,with some contribution from *** are mainly distributed at the redox *** controls the salinity and fluctuation of the redox interface in sedimentary *** positive deviation difference in carbon isotopes between nearshore and offshore sedimentary dolomites may be related to the location of the redox interface during ***,the petrographic features and carbon and oxygen isotope signatures of the sections reflect the gradual evolution of the paleolake from a hydrologically open environment to a hydrologically closed one and the possible transition of the paleoclimate from a relatively warm to an arid condition,which is possibly a geochemical response to global climate change in the Permian period.

关键词： Junggar Basin Lucaogou Formation Dolomite Positive carbon isotope anomaly Paleoenvironment