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OH regulator of highly dispersed Ru sites on host Pd nanocrystals for selective ethanol electro-oxidation

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Nano Research 2024年第5期17卷 3863-3871页

作者： Zhihe Xiao Yueguang chen Renjie wu Yuwei He Chunfeng {3. Leyu wang State key laboratory of chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Research institute of Petroleum Processing SINOPECBeijing 100083China

The ethanol oxidation reaction(EOR)is crucial in direct alcohol fuel cells and chemical ***,the electro-oxidation of ethanol molecules to produce acetaldehyde and carbon monoxide can poison the active sites of nanocatalysts,resulting in reduced performance and posing challenges in achieving high activity and selectivity for ethanol *** this study,we employed a dynamic seed-mediated method to precisely modify highly dispersed Ru sites onto well-defined Pd *** oxyphilic Ru sites serve as"OH valves",regulating water dissociation,while the surrounding Pd atomic arrangements control electronic states for the oxidation dehydrogenation of carbonaceous ***,Ru0.040@Pd nanocubes(Ru:Pd=0.04 at.%),featuring(100)facets in Ru-Pd4 configurations,demonstrate an outstanding mass activity of 6.53.A·mgPd^(-1) in EOR under alkaline conditions,which is 6.05 times higher than that of the commercial Pd/C catalyst(1.08 A·mgPd-1).Through in-situ experiments and theoretical investigations,we elucidate that the hydrophilic Ru atoms significantly promote the dynamic evolution of H_(2)O dissociation into OHads species,while the electron redistribution from Ru to adjacent Pd concurrently adjusts the selective oxidation of C_(2) *** host-guest interaction accelerates the subsequent oxidation of carbonaceous intermediates(CH_(3.CO_(ads))to acetate,while preventing the formation of toxic*CHx and*CO species,which constitutes the rate-determining step.

关键词： OH regulator atomic sites ethanol electro-oxidation host-guest interaction

Ligand effect in surface atomic sites of group VI B transition metals on ultrathin Pt nanowires for enhanced oxygen reduction

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Nano Research 2024年第6期17卷 5298-5304页

作者： Yuwei He Yueguang chen Renjie wu Zhihe Xiao mengxian Li Chun{3. shi Leyu wang State key laboratory of chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China State key laboratory of Petroleum Molecular and Process Engineering SINOPEC Research Institute of Petroleum Processing Co.Beijing 100083China

Increasing the utilization efficiency of platinum is critical for advancing proton exchange-membrane fuel cells(PEMFCs).Despite extensive research on catalysts for the cathodic oxygen reduction reaction(ORR),developing highly active and durable Pt-based catalysts that can suppress surface dealloying in corrosive acid conditions remains ***,we report a facile synthesis of bimetallic ultrathin PtM(M=Mo,W,and Cr)nanowires(NWs)composed of group VI B transition metal atomic sites anchored on the *** NWs possess uniform sizes and well-controlled atomic *** to PtW and PtCr catalysts,the PtMo0.05 NWs exhibit the highest half-wave potential of 0.93. V and a mass activity of 1.43.A·mgPt^(−1).Remarkably,they demonstrate a remarkable 23.8-fold enhancement in mass activity compared to commercial Pt/C for ORR,surpassing previously reported Pt-based ***,the PtMo NWs cathode in membrane electrode assembly tests achieves a remarkable peak power density of 1.443.W·cm^(−2)(H_(2)-O_(2)conditions at 80℃),which is 1.09 times that of commercial Pt/*** ligand effect in the bimetallic surface not only facilitates strong coupling between Mo(4d)and Pt(5d)atomic orbitals to hinder atom leaching but also modulates the d-states of active site,significantly optimizing the adsorption of key oxygen(*O and*OH)species and accelerating the rate-determining step in ORR pathways.

关键词： ligand effect oxygen reduction reaction group VI B transition metal ultrathin nanowires multiple oxygen species

Dynamic gut microbiome-metabolome in cationic bovine serum albumin induced experimental immune-complex glomerulonephritis and effect of losartan and mycophenolate mofetil on microbiota modulation

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Journal of Pharmaceutical Analysis 2024年第4期14卷 562-577页

作者： Wenying shi Zhaojun Li Weida wang Xikun Liu Haijie wu Xiaoguang {3. Xunrong Zhou Sen Zhang State key laboratory of Bioactive substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China State key laboratory of Functions and Applications of Medicinal Plants College of PharmacyGuizhou Provincial Engineering Technology Research Center for Chemical Drug R&DGuizhou Medical UniversityGuiyang550004China Department of Medicine Solna Center for Molecular MedicineKarolinska University Hospital and Karolinska InstituteStockholm17176Sweden Department of Pharmacy The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550001China

Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis(ICGN).However,an in-depth study on this topic is currently ***,we report an ICGN model to address this *** was induced via the intravenous injection of cationized bovine serum albumin(c-BSA)into Sprague-Dawley(SD)rats for two weeks,after which mycophenolate mofetil(MMF)and losartan were administered *** and six weeks after ICGN establishment,fecal samples were collected and 16S ribosomal DNA(rDNA)sequencing and untargeted metabolomic were *** microbiota transplantation(FMT)was conducted to determine whether gut normali-zation caused by MMF and losartan contributed to their renal protective effects.A gradual decline in microbial diversity and richness was accompanied by a loss of renal *** 18 genera were found to have significantly different relative abundances between the early and later stages,and Marvinbryantia and Allobaculum were markedly upregulated in both *** metabolomics indicated that the tryptophan metabolism was enhanced in ICGN,characterized by the overproduction of indole and kynurenic acid,while the serotonin pathway was *** of losartan and MMF ameliorated microbial dysbiosis and reduced the accumulation of indoxyl conjugates in *** using feces from animals administered MMF and losartan improved gut dysbiosis by decreasing the Firmicutes/Bacteroidetes(F/B)ratio but did not improve renal *** findings indicate that ICGN induces serous gut dysbiosis,wherein an altered tryptophan metabolism may contribute to its *** and losartan significantly reversed the gut microbial and metabolomic dysbiosis,which partially contributed to their renoprotective effects.

关键词： Immune-complex glomerulonephritis Gut microbiome Metabolomics Fecal microbiota transplant Tryptophan metabolism

Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species

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Chinese Journal of Natural Medicines 2024年第4期22卷 375-384页

作者： ZENG Zhen ZHANG chen HU Jiadong wang Feiyan wu Ziding wang Jing ZHANG Jun YANG Shuda chen Junfeng LI Mingming TONG Qi QIU shi chen Wansheng The SATCM key laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Second Affiliated Hospital of Navy Medical UniversityShanghai 200003China Kunming Plant Classification Biotechnology Co. Ltd.Kunming 650500China school of Pharmaceutical Sciences and Yunnan key laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China State key laboratory for Quality Ensurance and sustainable Use of Dao-di Herbs Beijing100700China

The aerial parts of Mosla chinensis *** Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as ***,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and *** challenge in distinguishing between these genera arises from their similar morphological and metabolic *** address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based *** detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203.identified compounds,as reliable {3. markers for distinguishing Xiang-ru from closely related Elsholtzia *** methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal *** findings underscore the importance of non-volatile compounds as dependable {3. markers in the authentication process of aromatic traditional medicinal plants.

关键词： Genus Elsholtzia Genus Mosla Traditional Chinese medicine Xiang-ru Non-volatile phenolic compounds Liquid chromatography-mass spectrometry

Biomimetic MXene membranes with negatively thermo-responsive switchable 2D nanochannels for graded molecular sieving

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Green Energy & environment 2024年第6期9卷 1058-1067页

作者： Yi wang Yangyang wang Chang Liu Dongjian shi Weifu Dong Baoliang Peng Liangliang Dong Mingqing {3. The key laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China International Research Center for Photo-responsive Molecules and Materials Jiangnan UniversityWuxiJiangsu214122China Research institute of Petroleum Exploration&Development(RIPED) PetroChina/Key Laboratory of Oilfield ChemistryCNPCBeijing100083China

Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation ***,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature ***,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene *** uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different *** expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D ***,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary *** strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.

关键词： Thermo-responsive 2D membrane MXene nanosheets PNIPAm Temperature-tunable 2D nanochannels Graded molecular sieving

Mechanical Behavior of Bamboo,and Its Biomimetic Composites and Structural Members:A Systematic Review

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Journal of Bionic Engineering 2024年第1期21卷 56-73页

作者： Shanyu Han Yuyuan He Hanzhou Ye Xueyong Ren Fuming chen Kewei Liu Sheldon Q.shi Ge wang institute of Biomaterials for Bamboo and Rattan Resources International Centre for Bamboo and RattanBeijing 100102China key laboratory of National Forestry and Grassland Administration/beijing for Bamboo&Rattan Science and {3. Beijing 100102China National Forestry and Grassland Engineering technology Center for Wood Resources Recycling College of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083China International Bamboo and Rattan Organization Beijing 100102China school of Civil Engineering Tsinghua UniversityBeijing 100084China Mechanical Engineering Department University of North TexasDentonTX 762077102USA

Bamboo is a typical biological material widely growing in nature with excellent physical and mechanical *** is lightweight with high strength and *** naturally optimized bamboo structure,which has inspired global material scientists and engineers for decades,is significantly important for the bionic design of novel structural materials with ultra-light,ultra-strong,or ultra-tough and comprehensive *** literature on innovative composite materials and structural members inspired by bamboo are reviewed in this paper,and the research progress and prospects in this field are expounded in three ***,the structural characteristics of the bamboo wall layer along the thickness and height directions are described in terms of chemical composition,gradient structure,pore structure,and hollow structure with variable ***,this paper summarizes the research progress on new composite materials and structural components by applying bamboo’s structural features from the perspective of sustainability,designability,and ***,given the limitations of current research,the biomimetic scientific research on bamboo’s structural characteristics is prospected from the interpretation of bamboo structure,new bamboo-like materials,and structural design optimization perspectives,providing a reference for future research on biomimetic aspects of biomass.

关键词： Bamboo Structural characteristics-Bamboo-like material Physical and mechanical properties

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： shi-Qi wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei chen Jin-Lin Zhang Bao-cheng wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei shi Jiangsu institute for Food and Drug Control Nanjing210019China school of Pharmacy China Pharmaceutical UniversityNanjing211112China school of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China school of environmental and chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 13.9 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1467-1471页

作者： chenyu Ye Qingtong Zhou shi Lin Wensheng Yang Xiaoqing Cai Yiting Mai Yanyan chen Dehua Yang Ming-Wei {3. Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Pharmacy Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghai 201102China State key laboratory of chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry School of Sciencethe University of TokyoTokyo 113-0033Japan school of Pharmacy Hainan Medical UniversityHaikou 571199China

To the Editor:G protein-coupled receptors(GPCRs)are the largest group of membrane proteins with over 800 members,characteristic of a seven transmembrane *** playing crucial roles in regulation of various physiological processes,GPCRs have been implicated in many diseases including diabetes,obesity,depression and *** initiate different intracellular responses,GPCRs mainly interact with three families of effector proteins upon agonist binding:the heterotrimeric G proteins,G protein-coupled receptor kinases(GRKs)and arrestins1.

关键词： GPR160 CARTp Prostate cancer Signaling pathway

The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

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environmental Science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang Zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo chen Renjie chen shi chen Wenhui chen Jing cheng Xiyuan Chi Hancheng Dai Xiangzhao feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin Dan Tong Xuhui wang Xuying wang Rui wu Qingyang Xiao Yang Xie Xiaolong Xu Tao Xue Haipeng Yu Da Zhang Ning Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Xin Zhang Zengkai Zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China key laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State key Joint laboratory of environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education key laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State key Joint laboratory for environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China school of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China school of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu key laboratory of Atmospheric {3. Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air