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Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： Lan-mei wang Wei-Wei Zhang Ying-Yang Qiu Fang wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

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A polarized^(3)He system based on metastability-exchange optical pumping

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 72-81页

作者： Yuting wang Liangyong Wu Kaiyuan Zhang mei Peng Siyu Chen Haiyang Yan State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Key Laboratory of Neutron Physics Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyang 621900China

Hyperpolarized^(3)He nuclei have emerged as a significantly important approach in quantum precision measurement techniques,with extensive applications in fundamental physics,magnetometry,metrology,and *** this study,we report on the design and implementation of a^(3)He polarization system at the China Mianyang Research Reactor(CMRR),utilizing the metastabilityexchange optical pumping(MEOP)*** employed a Merritt coil system consisting of four square coils to furnish a uniform holding *** deployed a 2 W fiber laser to pump the metastable^(3)He atoms and conducted free induction decay(FID)detection of the polarized^(3)He nuclei using both pickup coil and optical *** the optical method,we used a50 m W linearly polarized distributed Bragg reflector(DBR)laser as the *** applied transverse light absorption polarimetry to measure the absolute nuclear polarization of the ground-state^(3)*** have developed cell fabrication capabilities at the CMRR,and cells at various pressures ranging from 100 to 1000 Pa have been fabricated and *** a typical borosilicate cell with 100 Pa pressure,the absolute polarization is measured as Pn≈70%,and the transverse relaxation time is estimated as T2≈0.5 ***,we constructed a few aluminosilicate cells,each carefully filled with pure^(3)He at a pressure of 100 ***,we conducted a comprehensive evaluation of their performance in the context of MEOP.

关键词： metastability exchange optical pumping polarized^(3)He magnetic resonance

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Charge-controlled compositional/microstructural regulations and electrochemical actuation performance of bulk nanoporous Ni-Pd alloys

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Rare Metals 2024年第10期43卷 5305-5317页

作者： Fu-quan Tan Qing-Guo Bai Bin Yu Jian-Feng wang Zhong-Hua Zhang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University School of Applied Physics and Materials Wuyi University Ira A.Fulton School of Engineering Arizona State University

Bulk nanoporous （np） metallic actuators have attracted increasing attention due to their large strain and low stimulation ***,studies focusing upon the combined effect of composition and structure on the actuation performance of metallic actuators are relatively scarce,and its underlying mechanism needs to be clarified Herein,a series of bulk np-NiPd samples with differen compositions and microstructures were fabricated using a dealloying-coarsening-dealloying strategy and chargecontrolled electrochemical dealloying,and the process involves only one component of precursor *** has been found that the np-NiPd cubes show a composition/structure-dependent mechanical property and electrochemical actuation ***,the npNi70Pd30sample with a homogeneously porous structure and good network connectivity exhibits significantly larger strain amplitude and faster strain rate than other hierarchically porous NiPd samples (np-Ni50Pd50and npNi20Pd80).Moreover,the np-Ni70Pd30sample demonstrates good actuation stability with high strain retention after hundreds of ***,the maximum strain amplitude （1.17%） is even comparable to that of advanced leadfree piezoceramic,and the maximum strain rate exceeds those of many reported metallic actuator *** work indicates that good network connectivity plays a vita role in facilitating large/fast strain response in metallic actuators.

关键词： Actuation stability Bulk nanoporous NiPd Electrochemical dealloying Good network connectivity Metallic actuators

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Tetherless Optical Neuromodulation:Wavelength from Orange-red to Mid-infrared

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Neuroscience Bulletin 2024年第8期40卷 1173-1188页

作者： Chao Sun Qi Fan Rougang Xie Ceng Luo Bingliang Hu quan wang Key Laboratory of Spectral Imaging Technology Xi'an Institute of Optics and Precision Mechanics(XIOPM)Chinese Academy of SciencesXi'an 710119China Key Laboratory of Biomedical Spectroscopy of Xi'an Key Laboratory of Spectral Imaging TechnologyXIOPMChinese Academy of SciencesXi'an 710119China Department of Neurobiology School of Basic MedicineFourth Military Medical UniversityXi'an 710032China

Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type ***,visible light,particularly blue and green light,commonly used in conventional optogenetics,has limited penetration in biological *** limitation necessitates the implantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue damage and experimental *** overcome these challenges,the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical *** this review,we provide an overview of the development and applications of tetherless optical neuromodulation methods with long *** first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical ***,we summarize two novel tetherless neuromodulation methods using near-infrared light:upconversion nanoparticle-mediated optogenetics and photothermal *** addition,we discuss recent advances in mid-infrared optical neuromodulation.

关键词： Optical neuromodulation Tetherless Orange-red wavelength responding rhodopsins Upconversion nanoparticle-mediated optogenetics Photothermal neuromodulation

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Excitonic optical properties in monolayer SnP_(2)S_(6)

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Chinese Physics B 2024年第10期33卷 371-375页

作者： Peng-Yuan Chen Zhen quan Shu-Dong wang School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China

quantum confinement effect and reduced dielectric screening in two-dimensional(2D)dramatically enhance theelectron-hole *** this work,we use many-body perturbation theory and Bethe-Salpeter equation(BSE)toinvestigate the electronic and excitonic optical properties of monolayer SnP_(2)S_(6).Our findings reveal that the excitoniceffect dominates the optical absorption spectra in the visible light range,and the lowest-energy exciton X0 in monolayerSnP_(2)S_(6)is optically bright with the binding energy of 0.87 eV and the radiative lifetime of~10^(-11)s,which is highly advantageousto the *** importantly,the absence of optically forbidden states below the bright statesX0 would give rise to a high quantum efficiency of 2D SnP_(2)S_(6).We also find that applied biaxial strain can further shortenthe radiative lifetime of the bright *** results imply that 2D SnP_(2)S_(6)is a promising candidate for the optoelectronicdevices.

关键词： excitons radiative lifetime SnP_(2)S_(6)

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Food poisoning due to money tree seeds:a case report of toxic encephalopathy

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Emergency and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Yue Zhao Xiaojiao quan Tao wang Department of Emergency Medicine Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina The Center of Heat Stroke Prevention and Treatment of Peoples’Liberation Army SanyaHainanChina

Background:The money tree is a favored indoor potted plant in *** seeds resemble chestnuts in both shape and flavor when cooked,which are generally considered non-toxic and safe for *** presentation:This report presents the first published case of food poisoning due to the ingestion of large amounts of money tree seeds.A 67-year-old man exhibited toxic encephalopathy symptoms and dyspnea after consuming the seeds for approximately 6 *** empirical mechanical ventilation,therapeutic plasma exchange,and other medical interventions,the patient’s clinical status improved *** was subsequently discharged from the ***:Consuming a substantial quantity of money tree seeds within a limited timeframe can lead to poisoning,resulting in adverse outcomes,particularly toxic ***,plasma exchange may have some therapeutic effect.

关键词： Case report Money tree Pachira macrocarpa Respiratory failure Toxic encephalopathy

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A deep learning-based approach for flow field prediction in a dual-mode combustor

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Propulsion and Power Research 2024年第2期13卷 178-193页

作者： Chen Kong Ziao wang Fuxu quan Yunfei Li Juntao Chang Harbin Institute of Technology Harbin 150001China

Accurate acquisition of the distribution ofﬂow parameters inside the supersonic combustor is of great signiﬁcance for hypersonicﬂight *** is an interesting attempt to introduce a data-driven model to a supersonic combustor forﬂowﬁeld *** paper proposes a novel method for predicting theﬂowﬁeld in a dual-mode combustor.Aﬂowﬁeld prediction convolutional neural network with multiple branches is *** investiga-tions for a strut variable geometry combustor have been conducted to obtainﬂowﬁeld data for training the network as aﬂowﬁeld prediction ***ﬂowﬁeld data are obtained by changing the equivalent ratio,incomingﬂow condition and geometry of the supersonic *** Mach number distribution can be obtained from the trainedﬂowﬁeld predic-tion model using the combustor wall pressure as input with high *** accuracy ofﬂowﬁeld prediction is discussed in several ***,the combustion mode detection is im-plemented on the predictionﬂowﬁeld.ª2024 The *** services by Elsevier *** behalf of KeAi Communications ***.

关键词： Flowﬁeld prediction Deep learning(DL) Convolutional neural networks(CNNs) Data-driven model Dual-mode combustor Variable geometry combustor

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Response of maize growth and soil biological characteristics to planting density under fertigation in a semi-arid region

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 186-192页

作者： Peng Jiang Lei Li Dejia Xu Rui wang quan Sun School of Forestry and Prataculture Ningxia UniversityYinchuan 750021China Institute of Agricultural Resources and Environment Ningxia Academy of Agriculture and Forestry SciencesYinchuan 750002China School of Agriculture Ningxia UniversityYinchuan 750021China

Increasing the planting density can exacerbate crop competition for water,nutrients and space which results in a decline in the crop ***,the effect of increasing planting density on crop growth and soil biological characteristics in barren sandy land in the semi-arid regions are still *** this study,we investigated the effects of six planting densities(5.4×10^(4),6.45×10^(4),7.95×10^(4),9.5×10^(4),9.75×10^(4) and 10.5×10^(4) plants/hm^(2))on maize growth,photosynthesis characteristics,yield and soil biological characteristics in barren sandy soil in the semi-arid region of Ningxia,*** results indicated that the stem diameter and spike length decreased linearly with increasing planting *** plant height,spike weight,grain weight and 100-grain weight decreased with increasing plating ***,the root length increased with increasing planting *** diameter,volume and activity increased and then decreased with increasing planting *** was no significant difference(p>0.05)in the effect of planting density on transpiration rate intercellular CO_(2) *** well,the soil microbial biomass carbon and microbial biomass nitrogen decreased with increasing planting *** soil catalase activities increased and then decreased with increasing planting *** alkaline phosphatase activity,the amounts of soil bacteria and actinomycetes increased with increasing planting ***,a moderately increasing planting density can improve maize yield when water and nutrients are *** optimal planting density was 8.29×10^(4) plants/hm^(2) and the highest yield was 15.84 t/hm^(2) in barren sandy soil in semi-arid region of Ningxia,*** study provides a theoretical basis for high yield and high efficiency of maize.

关键词： maize growth planting density yield fertigation soil enzyme activity

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New record of the feather star Palaeocomatella hiwia(Echinodermata:Crinoidea:Comatulida)from Zhenbei Seamount in South China Sea:new insights into the taxonomic position of Palaeocomatella

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Journal of Oceanology and Limnology 2024年第1期42卷 244-251页

作者： Shao’e SUN Zijie mei Zhongli SHA Jing wang Nansheng CHEN Department of Marine Organism Taxonomy and Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July *** on the morphological characters,the specimen was identified as Palaeocomatella hiwia McKnight,*** is first recorded from China Sea and redescribed in *** specimen differs from the original description from New Zealand for never showing syzygy at br4+5 or br5+6 on interior and br1+2 on exterior ***,it is much conform to the redescription to specimens from Indonesia,with only differences in position of the second syzygy and distalmost pinnule *** is deposited in the Institute of Oceanology,Chinese Academy of *** analyses based on the mitochondrial c oxidase subunit I(COI)and 16S rRNA genes indicated that *** was nested within the tribe Phanogeniini and clustered with Aphanocomaster ***,*** showed same morphological features in terms of mouth placement,comb location,and number of comb teeth rows as other genera of ***,we suggest that the genus Palaeocomatella should be put in the tribe Phanogeniini.

关键词： new record Palaeocomatella hiwia McKnight 1977 South China Sea phylogenetic relationship taxonomy

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Strain tunable excitonic optical properties in monolayer Ga_(2)O_(3)

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Chinese Physics B 2024年第10期33卷 366-370页

作者： Hao-Lei Cui Zhen quan Shu-Dong wang School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China

Two-dimensional(2D)Ga_(2)O_(3)has been confirmed to be a stable structure with five atomic layer thickness *** this work,we study the quasi-particle electronic band structures and then access the excitonic optical properties through solving the Bethe-Salpeter equation(BSE).The results reveal that the exciton dominates the optical absorption in the visible light region with the binding energy as large as~1.0 eV,which is highly stable at room ***,both the dominant absorption P_(1)and P_(2)peaks are optically bright without dark exciton between them,and thus is favorable for luminescence *** calculated radiative lifetime of the lowest-energy exciton is 2.0×10^(-11)s at 0 ***,the radiative lifetime under+4%tensile strain is one order of magnitude shorter than that of the strainfree case,while it is less insensitive under the compressive *** findings set the stage for future theoretical and experimental investigation on monolayer Ga_(2)O_(3).

关键词： excitons radiative lifetime Ga_(2)O_(3)

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