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Significant risk factors for intensive care unit-acquired weakness:A processing strategy based on repeated machine learning

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World Journal of Clinical Cases 2024年第7期12卷 1235-1242页

作者： ling wang Deng-yan Long Intensive Care Unit People's Hospital of Qiandongnan Miao and Dong Autonomous PrefectureKaili 556000Guizhou ProvinceChina

BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse ***,there is a lack of effective preventive *** To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and *** Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU *** data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were *** relationships between these variables and ICU-AW were *** iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic *** Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW ***,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical *** most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechani

关键词： Intensive care unit-acquired weakness Risk factors Machine learning Prevention Strategies

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Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

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Chinese Journal of Natural Medicines 2020年第1期18卷 75-80页

作者： XIA Gui-yang wang ling-yan ZHANG Jing-Fang WU Yu-Zhuo GE Guang-Bo wang Ya-Nan LIN Peng-Cheng LIN Sheng State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 1Q0050China Institute of Interdisciplinaty Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China

Purpurolides D–F(1–3),three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system,were isolated from the endophytic fungus Penicillium purpurogenum IMM *** structures were unambiguously elucidated based on extensive spectroscopic data analyses,13 C NMR chemical shifts calculations coupled with the DP4+probability method,and the calculated and experimental electronic circular dichroism(ECD)*** 1–3 showed significant inhibitory activity against pancreatic lipase(PL).The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.

关键词： Penicillium purpurogenum Sesquiterpene lactones Pancreatic lipase inhibitors

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Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-yan HU yan-ling wang Zhen-Xing FAN Xi-Peng SUN Shuai wang Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

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Comparative results of corneal curvature measurements with three different keratometers after radial keratotomy

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Chinese Medical Journal 2011年第24期124卷 4260-4263页

作者： ZHAO Lu ZHANG Li wang yan-ling wang Wei yan yan Department of Ophthalmology Beijing Friendship HospitalCapital Medical University Beijing 100050 China Hankou Aier Eye Hostital Wuhan Hubei 430000 China School of Biological Engineering Capital Medical UniversityBeiiing100069 China

Background Corneal curvatures measured by conventional instruments after refractive surgeries were greater than the real values. This study on the instruments and methods for measuring corneal curvature was carried out with the aim of determining an accurate, simple and effective method to evaluate corneal refractive power after radial keratotomy （RK）. Methods A retrospective study was carried out on 52 eyes of 42 patients with a history of RK. The postoperative measurements after RK were performed with a manual keratometer （Rodenstock, Munchen-Hamburg, Germany）, a corneal topographer （Tomey TMS-1） and an automated IOLMaster keratometer （Carl Zeiss GmbH, USA）. The results obtained from analyzing clinical histories （clinical history method, CHM） were compared to the postoperative measurements with a two-way analysis of variance. Adjusted keratometry was used to correct the corneal central refractive power （K） values of the three keratometers. The CHM results were also compared to the corrected K values obtained with the three keratometers using the same statistical method. Results The smallest mean value was found for the CHM （（36.61±2.23） diopters）. The K values obtained with the CHM were very different from the results obtained with the three different instruments. The corrected K values obtained with the IOLMaster were the closest to the K values from the CHM. Conclusions It was shown that K values from measurements with the three instruments were higher. When the power of the intraocular lens of the patients after RK was calculated, the errors of the K values measured with the instruments should be taken into consideration.

关键词： radial keratotomy corneal curvature keratometer corneal topography

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芒果-紫苏油功能性风味酸奶的工艺优化及品质测定

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食品安全质量检测学报 2024年第13期15卷 318-326页

作者：田春美王艳领刘琳琳潘永波重庆工贸职业技术学院健康学院涪陵408000 海南省检验检测研究院食品检验检测中心国家市场监管重点实验室(热带果蔬质量与安全) 海口570314

目的探究芒果、紫苏油不同添加量对风味酸奶品质的影响,开发一种富含α-亚麻酸的功能性风味酸奶。方法通过运用旋转黏度计测量黏度、酸度计评估酸度以及离心机分析持水力等实验手段,探究芒果泥与紫苏油的不同添加量对风味酸奶的黏度... 详细信息

目的探究芒果、紫苏油不同添加量对风味酸奶品质的影响,开发一种富含α-亚麻酸的功能性风味酸奶。方法通过运用旋转黏度计测量黏度、酸度计评估酸度以及离心机分析持水力等实验手段,探究芒果泥与紫苏油的不同添加量对风味酸奶的黏度特性、酸度水平以及保水能力等方面所产生的影响。在此基础上,以感官评价为响应值,采用单因素试验和Box-Behnken响应面试验优化得到芒果-紫苏油功能性风味酸奶的最佳加工工艺,并通过蛋白质含量、酸度、α-亚麻酸含量、乳酸菌活菌数等指标分析其品质。结果确定了芒果-紫苏油功能性风味酸奶的最佳制备工艺参数,即芒果泥添加比例为16%、紫苏油添加比例为5%、白砂糖添加比例为7%。在此最优工艺条件下制备出的酸奶,其感官评分达88.39分,与预测值88.65分极为接近,同时对其品质进行分析可知:该酸奶中蛋白质含量为3.06%,非脂乳固体含量为8.70%,脂肪含量为4.31%(其中α-亚麻酸含量为2.20%),酸度为85.72oT,乳酸菌活菌数为2.1×10~8 CFU/m L,大肠杆菌和致病菌均未检出,最终产品的感官指标、理化指标和微生物指标均符合GB 19302—2010《食品安全国家标准发酵乳》中的各项要求。结论本研究开发出了一种果香与油香交融,营养与保健兼备的新型酸奶,引领了酸奶风味新趋势,为新型酸奶的开发提供了理论与技术支持。

关键词：芒果紫苏油功能性风味酸奶工艺优化响应面品质测定

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布地奈德治疗新生儿呼吸窘迫综合征的研究进展

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赣南医学院学报 2024年第8期44卷 852-855,866页

作者：张珂汪凌燕仇鹏业雷自成饶兴愉赣南医科大学第一临床医学院江西赣州341000 赣南医科大学第一附属医院儿童医学中心江西赣州341000

新生儿呼吸窘迫综合征(Neonatal respiratory distress syndrome,NRDS)的发病率、病死率均较高,是新生儿死亡的主要原因之一。NRDS早产儿目前主要的治疗方法为呼吸循环支持、肺表面活性物质(Pulmonary surfactant,PS)替代疗法等,但机械... 详细信息

新生儿呼吸窘迫综合征(Neonatal respiratory distress syndrome,NRDS)的发病率、病死率均较高,是新生儿死亡的主要原因之一。NRDS早产儿目前主要的治疗方法为呼吸循环支持、肺表面活性物质(Pulmonary surfactant,PS)替代疗法等,但机械通气会增加患支气管肺发育不良(Bronchopulmonary dysplasia,BPD)或慢性肺病的风险。随着对NRDS的发病机制及治疗方法的不断深入研究,关于布地奈德(Budesonide,BUD)治疗NRDS的给药方式、用药剂量、用药频率没有统一的标准,且不同严重程度的NRDS治疗效果不同。本文就BUD治疗NRDS的研究进展进行综述,为NRDS治疗的基础及临床研究提供依据。

关键词：布地奈德新生儿呼吸窘迫综合征支气管肺发育不良炎症

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Relationship between community type of wetland plants and site elevation on sandbars of the East Dongting Lake,China

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Forestry Studies in China 2009年第1期11卷 44-48页

作者： ZHENG Jing-ming wang ling-yan LI Su-yan ZHOU Jin-xing SUN Qi-xiang Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 E R. China Key Laboratory for Forest Tree Breeding of State Forestry Administration Chinese Academy of Forestry Beijing 100091 P. R. China

Plant communities on sandbars were important, and restoration of degraded wetland were significant to biological conservation in the East Dongting Lake region. In this study, typical wetland community types on sandbars and their site elevation were surveyed to explore relationship between community distribution and site elevation. Results show that eight major communities in this region were wetland communities dominated by Juncus effusus, Carex brevicuspis, Polygonum hydropiper, Salix triandra, Oenanthe Javanica, Phalaris arundinacea, Miscanthus sacchariflorus and Phragmites communis respectively. These communities had obvious constructive species and companion species, while site elevation could affect community composition and their species diversity. On sandbars in the East Dongting Lake, vegetation was largely composed of hygrophytes companied with a few mesophytes. The higher the site elevation was, the nearer the site was to the water, and the lower community diversity became. Except soil humidity and site elevation, growth period of plants after inundation could also affect species richness in the communities.

关键词： wetland restoration sandbar elevation the East Dongting Lake

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Bioactive neolignans and lignans from the roots of Paeonia lactiflora

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Chinese Journal of Natural Medicines 2022年第3期20卷 210-214页

作者： XIA Huan ZHANG Jing-Fang wang ling-yan XIA Gui-yang wang Ya-Nan WU Yu-Zhuo LIN Peng-Cheng XIONG Liang LIN Sheng Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

Two new neolignans and one new lignan(1-3)were obtained from the roots of Paeonia *** structures were unambiguously elucidated based on extensive spectroscopic analysis,single-crystal X-ray crystallography,and the calculated and experimental electronic circular dichroism(ECD)*** 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase *** 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1(hCES2Al)with an IC_(50) value of 7.28±0.94 μmol·L^(-1).

关键词： Paeonia lactiflora Neolignan Lignan Human carboxylesterase 2A1

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Insight into the microbial community of denitrification process using different solid carbon sources: Not only bacteria

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Journal of Environmental Sciences 2024年第10期144卷 87-99页

作者： Congyu Li Yu ling yanjie Zhang Haiyan wang Huan wang Guokai yan Weiyang Dong yang Chang Liang Duan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China College of Water Sciences Beijing Normal UniversityBeijing 100875China Research Center of Environmental Pollution Control Technology Chinese Research Academy of Environmental ScienceBeijing 100012China State Environmental Protection Key Laboratory of Estuarine and Coastal Environment Chinese Research Academy of Environmental SciencesBeijing 100012China

There is a lack of understanding about the bacterial,fungal and archaeal communities’composition of solid-phase denitrification(SPD)*** investigated four SPD systems with different carbon sources by analyzing microbial gene sequences based on operational taxonomic unit(OTU)and amplicon sequence variant(ASV).The results showed that the corncob-polyvinyl alcohol sodium alginate-polycaprolactone(CPSP,0.86±0.04 mg NO_(3)^(−)-N/(g·day))and corncob(0.85±0.06 mg NO_(3)^(−)-N/(g·day))had better denitrification efficiency than polycaprolactone(PCL,0.29±0.11 mg NO_(3)^(−)-N/(g·day))and polyvinyl alcoholsodium alginate(PVA-SA,0.24±0.07 mg NO_(3)^(−)-N/(g·day)).The bacterial,fungal and archaeal microbial composition was significantly different among carbon source types such as Proteobacteria in PCL(OTU:83.72%,ASV:82.49%)and Rozellomycota in PVA-SA(OTU:71.99%,ASV:81.30%).ASV methods can read more microbial units than that of OTU and exhibit higher alpha diversity and classify some species that had not been identified by OTU such as Nanoarchaeota phylum,unclassified_f_Xanthobacteraceae genus,etc.,indicating ASV may be more conducive to understand SPD microbial *** co-occurring network showed some correlation between the bacteria fungi and archaea species,indicating different species may collaborate in SPD *** KEGG function prediction results were obtained in two bioinformatic methods generally and some fungi and archaea functions should not be ignored in SPD *** results may be beneficial for understanding microbial communities in SPD systems.

关键词： Solid-phase denitrification Solid carbon source Microbial community ASV analysis OTU analysis

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Improved circulation in ocular ischemic syndrome after carotid artery stenting

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Chinese Medical Journal 2011年第21期124卷 3598-3600页

作者： wang yan-ling ZHAO Lu LI Ming-ming Department of Ophthalmology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Ocular ischemic syndrome is a chronic ischemic eye disease including a series of ischemic ocular and brain syndromes caused by carotid artery occlusion or stenosis. Because of the different degrees of ischemia, clinical manifestations of ocular ischemic syndrome are diverse, and it is difficult to diagnose in the initial stage. The main strategy to treat ocular ischemic syndrome is elimination of carotid stenosis. We presented a patient who recovered dramatically after carotid artery stenting. The pre-stenting arm-retinal circulation time of the patient＇s left eye was prolonged, and a large amount of microaneurysm appeared at the posterior polar and mid-peripheral aspects of the left retina. The post-stenting arm-retinal circulation time of the left eve decreased to 16.3 seconds, and the microaneurvsm almost disappeared.

关键词： ocular ischemic syndrome retinal microaneurysm carotid artery stenosis stent

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