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GPU-accelerated OCT imaging: Real-time data processing and artifact suppression for enhanced monitoring of 3D bioprinted tissues and vascular-like networks

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 67-82页

作者： Shanshan yang Jinhao Zhou Hao Guo ling wang Mingen Xu Hangzhou Dianzi University Automation College HangzhouZhejiangP.R.China Zhejiang Provincial Key Laboratory of Medical Information and Biological 3D Printing Hangzhou ZhejiangP.R.China

Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological ***,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization *** technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data *** the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data ***,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further ***,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact ***,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data ***,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic ***,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like *** imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network ***,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.

关键词： SS-OCT GPU acceleration artifact noise 3D bioprinted microfluidic chip.

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Two thin middle-crust low-velocity zones imaged in the Chuan-Dian region of southeastern Tibetan Plateau and their tectonic implications

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Science China Earth Sciences 2024年第5期67卷 1675-1686页

作者： Long LI Xin wang Guangbing HOU Yuan ling Yinshuang AI Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

Intracrustal low-velocity zones(LVZs)indicate a mechanically weak crust and are widely observed in the southeast margin of the Tibetan ***,their spatial distributions and formation mechanisms remain *** investigate their distribution and detailed morphology of the LVZs in the southeastern Tibetan Plateau,here we used teleseismic events and continuous waveform data recorded by 40 broadband seismic stations newly deployed in the Sichuan-Yunnan region from December 2018 to October 2020.A total of 12,924 high-quality P-wave receiver functions and 5–40 s fundamental Rayleigh surface wave phase velocity dispersion curves from ambient noise cross-correlation functions were *** Swave velocity model at a depth interval of 0–100 km in the study area was inverted by using the trans-dimensional Markov chain Monte Carlo strategy to jointly invert the complementary data of the receiver function waveform and Rayleigh surface wave phase velocity *** results show that there are two separate LVZs(~3.5 km/s)surrounding the rigid Daliangshan subblock at crustal depths of approximately 30–40 km,providing new constraints on the geometry of the LVZs in our study *** two LVZs obtained in this study may represent the middle crustal flow channels,through which the material in the center of the Tibetan Plateau extrudes to its southeast *** by the rigid Sichuan Basin and the spindle-like Daliangshan subblock,the material continues to flow southward through the mechanically weak middle crustal channels surrounding the Daliangshan *** addition,the existence of thin LVZs in the middle crust plays an important role in understanding the decoupling between the upper and lower crust in the study *** also provides new constraint on the complex tectonic deformation process of the southeastern margin of the Tibetan Plateau caused by the collision and compression of the Indian and the Eurasian plates.

关键词： Southeastern Tibetan Plateau Joint inversion Intracrustal low-velocity zone Mid-crustal channel flow

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Possible Habitats for NH_(3),NH_(2)D,H^(13)CN,HC^(15)N,SO,and C^(18)O in the Initial Conditions of High-mass Star Formation

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Research in Astronomy and Astrophysics 2024年第4期24卷 237-252页

作者： Quan-ling Cui Chuan-Peng Zhang Jun-Jie wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Science Qiqihar UniversityQiqihar 161006China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China

The initial condition of high-mass star formation is a complex area of study because of the high densities(n_(H_(2))>106cm^(-3))and low temperatures(T_(dust)<18 K)*** such conditions,many molecules become depleted from the gas phase by freezing out onto dust ***,the N-bearing and deuterated species could remain gaseous under these extreme conditions,suggesting that they may serve as ideal *** this paper,using the Plateau de Bure Interferometer and Very Large Array observations at 1.3 mm,3.5 mm,and 1.3 cm,we investigate the possible habitats for NH_(3),NH_(2)D,H^(13)CN,HC^(15)N,SO,and C^(18)O in eight massive precluster and protocluster clumps G18.17,G18.21,G23.97N,G23.98,G23.44,G23.97S,G25.38,and *** found that the NH3cores are in good agreement with the 3.5 mm peak emission,but the NH_(3)is much more extended than the 3.5 mm emission *** SO distributions agree well with the 3.5 mm peaks for the evolved star formation stage,but we did not detect any SO emission in the four earliest star formation sources.C^(18)O is a poor tracer in conditions of the cold(■18 K)and dense(■10^(4)cm^(-3))cores,e.g.,the prestellar *** also found that the NH_(2)D cores are mainly located in the temperature range of 13.0-20.0 K,and the NH_(2)D lines may be strongly depleted above 20 K.

关键词： galaxies:star formation techniques:interferometric methods:observational

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北宋定州军事特质农业发展管窥

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河北大学学报（哲学社会科学版） 2009年第3期34卷 28-32页

作者：米玲王彦岭河北大学卫生职业技术学院河北保定071000 保定职业技术学院河北保定071051

定州在宋代政治军事中有着重要的地位。军事的作用对定州农业经济的影响很大,使之具有很鲜明的军事特质。无论在土地的使用,还是在劳动力的使用以及农作物种植方面都具有军事色彩。对定州这一时期军事农业的成因、农业的相关问题进行了... 详细信息

定州在宋代政治军事中有着重要的地位。军事的作用对定州农业经济的影响很大,使之具有很鲜明的军事特质。无论在土地的使用,还是在劳动力的使用以及农作物种植方面都具有军事色彩。对定州这一时期军事农业的成因、农业的相关问题进行了历史的考量和思索。

关键词：宋代定州军事农业

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Six types of spin solitons in three-component Bose-Einstein condensates

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Communications in Theoretical Physics 2024年第6期76卷 57-65页

作者： Yu-Hao wang ling-Zheng Meng Li-Chen Zhao School of Physics Northwest UniversityXi'an 710127China School of Science Xi'an Technological UniversityXi'an 710032China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

Exact analytical solutions are good candidates for studying and explaining the dynamics of solitons in nonlinear *** further extend the region of existence of spin solitons in the nonlinearity coefficient space for the spin-1 Bose-Einstein *** types of spin soliton solutions can be obtained,and they exist in different *** analysis and numerical simulation results indicate that three types of spin solitons are stable against weak *** non-integrable properties of the model can induce shape oscillation and increase in speed after the collision between two spin *** results further enrich the soliton family for non-integrable models and can provide theoretical references for experimental studies.

关键词： Bose-Einstein condensate non-integrable spin soliton exact analytical solution

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Investigation of formaldehyde sources and its relative emission intensity in shipping channel environment

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Journal of Environmental Sciences 2024年第8期142卷 142-154页

作者： Jiaqi Liu Shanshan wang yan Zhang Yuhao yan Jian Zhu Sanbao Zhang Tianyu wang Yibing Tan Bin Zhou Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Institute of Eco-Chongming(IEC) No.20 Cuiniao RoadShanghai 202162China Institute of Atmospheric Sciences Fudan UniversityShanghai 200433China National Observations and Research Station for Wetland Ecosystems of the yangtze Estuary Fudan UniversityShanghai 200438China Institute of Digitalized Sustainable Transformation Big Data InstituteFudan UniversityShanghai 200433China

Formaldehyde(HCHO)is considered one of the most abundant gas-phase carbonyl compounds in the atmosphere,which can be directly emitted through transportation ***-Path Differential Optical Absorption Spectroscopy(LP-DOAS)was used to observe HCHO in the river channel of Wusong Wharf in Shanghai,China for the whole year of *** to the impact of ship activity,the annual average HCHO level in the channel is about2.5 times higher than that in the nearby campus *** explain the sources of HCHO under different meteorological conditions,the tracer-pair of CO and O_(x)(NO_(2)+O_(3))was used on the clustered air *** results of the source appointment show that primary,secondary and background account for 24.14%(3.34±1.19 ppbv),44.78%(6.20±2.04ppbv)and 31.09%(4.31±2.33 ppbv)of the HCHO in the channel when the air masses were from the mixed direction of the city and channel,*** performing background station subtraction at times of high primary HCHO values and resolving the plume peaks,directly emitted HCHO/NO_(2)in the channel environment and plume were determined to be mainly distributed between 0.2 and *** cargo ships with higher sailing speeds or main engine powers tend to have higher HCHO/NO_(2)*** the knowledge of NO_(2)(or NO_(x))emission levels from ships,this study may provide data support for the establishment of HCHO emission factors.

关键词： HCHO LP-DOAS Channel environment Ship emissions

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Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP

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Chinese Medical Journal 2010年第22期123卷 3299-3303页

作者： wang yan-ling yan Yun-li ZHOU Na-jing HAN Shuo ZHAO Jun-xia CAO Cui-li LUE Yu-hong Cell Biology Division Institute of Basic Medicine Hebei Medical University Shijiazhuang Hebei 050017 China

Background Small cell lung cancer （SCLC） is the most aggressive form of lung cancer. This study aimed to investigate the mechanism of human small cell lung cancer cell line resistance to etoposide （VP-16）, H446NP. Methods The cell viability was measured by MTT assay. Immunocytochemistry, reverse transcription-polymerase chain reaction （RT-PCR） and Western blotting methods were used to detect the multidrug resistance gene （MDR1）, bcl-2, bax and the topoisomerase Ⅱ （TopoⅡ） expressions in H446 and H446NP cells after treated with or without VP-16. Results The 50% inhibition concentration （IC50） of VP-16 on H446 cells was 49 mg/L, and 836 mg/L was for H446NP cells. The expressions of MDR1 and bcl-2 were up-regulated, while the amounts of bax and Topo II were reduced in H446NP cells. After treated with 49 mg/L of VP-16, it showed that the drug could significantly inhibit bcl-2 and Topo fl expressions, and increase bax expression in H446 cells compared with that of H446NP cells. Conclusions The H446NP cell was stably resistant to VP-16. The decreased expression of Topo II was correlated with the H446NP multidrug resistance. The elevated expressions of MDR1, and the altered apoptotic pathways also played an important role in VP-16 induced multidrug resistance of SCLC.

关键词： small cell lung cancer etoposide topoisomerase II, multidrug resistance

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Synthesis,Style Editing,and Animation of 3D Cartoon Face

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Tsinghua Science and Technology 2024年第2期29卷 506-516页

作者： Ming Guo Feng Xu Shunfei wang Zhibo wang Ming Lu Xiufen Cui Xiao ling School of Software and BNRist Tsinghua UniversityBeijing 100084China Department of Multimedia and Smart Guangdong OPPO Mobile Telecommunications Corp.Ltd.Dongguan 523860China Intel Labs IntelBeijing 100089China

As a popular kind of stylized face,cartoon faces have rich application *** is challenging to create personalized 3D cartoon faces directly from 2D real ***,in order to adapt to more application scenarios,automatic style editing,and animation of cartoon faces is also a crucial problem that is urgently needed to be solved in the industry,but has not yet had a perfect *** solve this problem,we first propose“3D face cartoonizer”,which can generate high-quality 3D cartoon faces with texture when fed into 2D facial *** contribute the first 3D cartoon face hybrid dataset and a new training strategy which first pretrains our network with low-quality triplets in a reconstruction-then-generation manner,and then finetunes it with high-quality triplets in an adversarial manner to fully leverage the hybrid ***,we implement style editing for 3D cartoon faces based on k-means,which can be easily achieved without retrain the neural *** addition,we propose a new cartoon faces'blendshape generation method,and based on this,realize the expression animation of 3D cartoon faces,enabling more practical *** dataset and code will be released for future research.

关键词： cartoon 3D face animation computer graphics

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OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity

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Journal of Integrative Plant Biology 2024年第7期66卷 1459-1480页

作者： Yuqing yan Hui wang yan Bi Jiajing wang Muhammad Noman Dayong Li Fengming Song National Key Laboratory for Rice Biology and Breeding Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Ubiquitination-mediated protein degradation is integral to plant immunity,with E3 ubiquitin ligases acting as key factors in this ***,we report the functions of OsATL32,a plasma membrane-localized Arabidopsis Tóxicos En Levadura(ATL)-type E3 ubiquitin ligase,in rice(Oryza sativa)immunity and its associated regulatory *** found that the expression of OsATL32 is downregulated in both compatible and incompatible interactions between rice and the rice blast fungus Magnaporthe *** OsATL32 protein level declines in response to infection by a compatible *** strain or to chitin ***32 negatively regulates rice resistance to blast and bacterial leaf blight diseases,as well as chitin-triggered *** and genetic studies revealed that OsATL32 suppresses pathogen-induced reactive oxygen species(ROS)accumulation by mediating ubiquitination and degradation of the ROS-producing OsRac5–OsRbohB module,which enhances rice immunity against *** protein phosphatase PHOSPHATASE AND TENSIN HOMOLOG enhances rice blast resistance by dephosphorylating OsATL32 and promoting its degradation,preventing its negative effect on rice *** study provides insights into the molecular mechanism by which the E3 ligase OsATL32 targets a ROS-producing module to undermine rice immunity.

关键词： E3 ligase OsATL32 OsRac5-OsRbohB module phosphatase OsPTEN reactive oxygen species rice immunity

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Determination of drug concentration in aqueous humor of cataract patients administered gatifloxacin ophthalmic gel

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Chinese Medical Journal 2010年第15期123卷 2105-2110页

作者： LIU Xuan wang Ning-li wang yan-ling MA Chen MA Li GAO Li-xin HUANG Ying-xiang XIONG Shi-hong wang Kang Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Eye Friendship Hospital Capital Medical University Beijing 100050 China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050China

Background Ophthalmic gel has been developed to increase the drug concentration in aqueous humor and to retard the loss of drug from the conjunctival *** research was to compare the drug concentration in aqueous humor of cataract patients administered 0.3% gatifloxacin ophthalmic gel with that in patients administered 0.3% gatifloxacin ophthalmic *** Ninety-six patients with cataract （96 eyes） were randomly assigned to 8 *** patients in groups 1-4received topical gatifloxacin 0.3% ophthalmic gel and those in groups 5-8 received gatifloxacin 0.3% ophthalmic *** dose regimen was 1 drop, 4 times a day for 3 consecutive days prior to cataract *** the day of surgery, 1drop was applied at 15, 30, 60 or 120 minutes before commencement of cataract surgery in groups 1 and 5, groups 2 and 6, goups 3 and 7, and groups 4 and 8, *** humor was extracted during the cataract surgery for the analysis of gatifloxacin concentration..Results The concentrations of gatifloxacin in aqueous humor were （0.24±0.25） μg/ml, （1.11±0.74） μg/ml, （2.32±2.01）μg/ml and （1.85±1.14） μg/ml in groups 1 to 4, and （0.16±0.25） μg/ml, （0.31±0.24） μg/ml, （0.75±0.28） μg/ml and （0.33±0.22） μg/ml in groups 5 to 8, *** receiving gatifloxacin ophthalmic gel showed greater mean values of gatifloxacin concentration in aqueous humor than those receiving gatifloxacin solution, and such differences were significant with P 〈0.05 for all comparisons except that between groups 1 and *** Topical gatifloxacin ophthalmic gel can attain significantly greater drug concentrations in human aqueous humor than gatifloxacin ophthalmic solution.

关键词： gatifloxacin ophthalmic gel endophthalmitis cataract surgery quinolones

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