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Nurse anesthetists’perceptions and experiences of managing emergence delirium:A qualitative study

World Journal of Psychiatry 2024年第4期14卷 553-562页

作者： Yi Xin Fu-Cai Lin Chen Huang Bin He Ya-ling Yan Shuo wang Guang-Ming {2. Rui Li Wuxi Medical College Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium(ED),a common and complex postoperative complication in the post-anesthesia care *** role of nurses in managing ED is critical,yet research on their understanding and management strategies for ED is *** To investigate anesthetic nurses’cognition and management experiences of ED in hopes of developing a standardized management *** This study employed a descriptive phenomenological approach from qualitative research *** sampling was utilized to select 12.anesthetic nurses from a tertiary hospital in Shanghai as research ***-structured interviews were conducted,and the data were organized and analyzed using Colaizzi’s seven-step analysis method,from which the final themes were *** After analyzing the interview content,four main themes and eight subthemes were distilled:Inefficient cognition hinders the identification of ED(conceptual ambiguity,empirical identification),managing diversity and challenges(patientcentered safe care,low level of medical-nursing collaboration),work responsibilities and pressure coexist(heavy work responsibilities,occupational risks and stress),demand for high-quality management(expecting the construction of predictive assessment tools and prevention strategies,and pursuing standardized management processes to enhance management effectiveness).CONCLUSION Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes.

关键词： Anesthetic nurse Emergence delirium Postoperative complications Cognition Disease management Qualitative research

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Appropriate Supply of Ammonium Nitrogen and Ammonium Nitrate Reduces Cadmium Content in Rice Seedlings by Inhibiting Cadmium Uptake and Transport

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Rice science 2024年第5期31卷 587-602,I0062-I0064页

作者： HU Yunchao YAN Tiancai GAO zhenyu wang Tiankang LU Xueli YANG Long SHEN Lan {2. Qiang HU Jiang REN Deyong {2. Guangheng ZHU Li LI Li ZENG Dali QIAN Qian LI Qing State Key Laboratory for Rice Biology and Breeding China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 311401China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterHunan Academy of Agricultural SciencesChangsha 410125China The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province College of Advanced Agricultural SciencesZhejiang A&F UniversityHangzhou 311300China

Reasonable nitrogen(N) application is a promising strategy for reducing crop cadmium(Cd) toxicity. However, the specific form of N and the required amount that affect Cd tolerance and accumulation in rice remain unclear. This study explored the influence of different N-fertilizer forms(NH_(4)NO_(3), NH_4Cl, and KNO_(3)) and dosages on Cd tolerance and uptake in Cd-stressed N-sensitive and N-insensitive indica rice accessions. The results indicated that the Cd tolerance of N-sensitive indica accessions is more robust than that of N-insensitive ones. Furthermore, the shoot Cd content and Cd translocation rate in both N-sensitive and N-insensitive indica accessions decreased with an appropriate supply of NH_(4)NO_(3) and NH_4Cl, whereas they were comparable or slightly increased with increased KNO_(3). Unfortunately, we did not find significant and regular differences in Cd accumulation or translocation between N-sensitive and N-insensitive rice accessions. Consistent with the reduction of shoot Cd content, the addition of NH_(4)NO_(3) and NH_4Cl also inhibited the instantaneous root Cd^(2.) uptake. The expression changes of Cd transport-related genes under different N forms and dosages suggested that the decreased shoot Cd content, caused by the increased supply of NH_(4)NO_(3) and NH_4Cl, is likely achieved by reducing the transcription of OsNRAMP1 and OsIRT1. In summary, our findings reveal that an appropriate supply of NH_(4)NO_(3) and NH_4Cl could reduce Cd uptake and transport in rice seedlings, suggesting that rational N management could reduce the Cd risk in rice production.

关键词： Oryza sativa cadmium nitrogen ammonium nitrate ammonium chloride

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High-timing-precision detection of single X-ray photons by superconducting nanowires

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National Science Review 2024年第1期11卷 194-203页

作者： Shuya Guo Jingrou Tan Hengbin zhang Jinguang wang Tianhao Ji Labao zhang Xiaolong Hu Jian Chen Jun Xie Kai Zou Yun Meng Xiaomin Bei ling-An Wu Qi Chen Hao wang Xuecou Tu Xiaoqing Jia Qing-Yuan Zhao Lin Kang Peiheng Wu Research institute of Superconductor Electronics Nanjing University Qian Xuesen Laboratory of Space Technology Beijing National Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Hefei National Laboratory School of Precision Instrument and Optoelectronic Engineering Tianjin University Key Laboratory of Optoelectronic Information Science and Technology Ministry of Education

Precisely acquiring the timing information of individual X-ray photons is important in both fundamental research and practical applications. The timing precision of commonly used X-ray single-photon detectors remains in the range of one hundred picoseconds to microseconds. In this work, we report on high-timing-precision detection of single X-ray photons through the fast transition to the normal state from the superconductive state of superconducting nanowires. We successfully demonstrate a free-running X-ray single-photon detector with a timing resolution of 2..1 ps made of 100-nm-thick niobium nitride film with an active area of 50 μm by 50 μm. By using a repeated differential timing measurement on two adjacent X-ray single-photon detectors, we demonstrate a precision of 0.87 ps in the arrival-time difference of X-ray photon measurements. Therefore, our work significantly enhances the timing precision in X-ray photon counting, opening a new niche for ultrafast X-ray photonics and many associated applications.

关键词： single-photon detection timing precision superconductor ultrafast phenomenon pulsar X-ray navigation

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2.Low Expression in chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing LIU Li Qun HUANG De Qin wang Yu Tong LI Jing Jie zhang Zheng wang Xi Xi LIU Chuan ling zhang Ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical School of chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of chinese patients with human epidermal growth factor receptor 2.HER2.-low early breast cancer(BC)and HER2.IHC0 *** Patients diagnosed with HER2.negative BC(N=999)at our institution between January2.11 and December 2.15 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2.low,and evolution of HER2.immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2.IHC0 and HER2.low *** HER2.low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2.IHC0 BC group(P2.low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2.test,P2.low BC group than in HER2.IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2.IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2.low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2.low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2.related factor 2.heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-ling wang Chen Chen Yi-Jia Zhu Wen-Wen Tang Yu-Ji wang Ze-Peng Chen Lin-Hai He Yu-Gen Chen Wei zhang Jiangsu Province Hospital of chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key Laboratory of Tumor Systems Biology and chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Collaborative Innovation Center of chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 2. h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2.related factor 2.Nrf2.,and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2.and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX52.,into constipated ***460 cells were induced with H2.2.and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 2. h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

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Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A Retrospective Study

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Current Medical Science 2024年第3期44卷 568-577页

作者： Fen wang Xiao-ling {2. Jing {2. Song GONG Jing TAO Hui XIANG Xiao-qing FU Xu-na BIAN Xue-feng YU An-hui XU Cheng-la YI Shi-ying SHAO Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical Research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of ***-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich *** study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical *** Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2.18 to 2.19 in Tongji Hospital were *** clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2.days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was *** Totally,2. patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)*** severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2.6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2.*** initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)*** median number of L-PRF doses was 3(2.5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh *** overall wound-healing rate was 1.47(0.63,3.2.)cm3/week,and the healing rate was faster in the first 2.weeks than in the remaining *** treatment did not change the percentage of complete epithelialization or healing *** Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for D

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

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Modulating selective interaction of NiOOH with Mg ions for high-performance aqueous batteries

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eScience 2024年第5期4卷 160-169页

作者： Bing He Ying ling Zhixun wang Wenbin Gong Zhe wang Yanting Liu Tianzhu Zhou Ting Xiong Shuai wang Yonggang wang Qingwen Li Qichong zhang Lei Wei School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang Avenue 639798Singapore Key Laboratory of Multifunctional Nanomaterials and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Department of Chemistry Fudan UniversityShanghai 200438China School of Physics and Energy Xuzhou University of TechnologyXuzhou 221018China

Aqueous Mg-ion batteries(AMIBs)featuring advantages of good safety,low cost,and high specific energy have been recognized as a promising energy-storage ***,the performance of AMIBs is consistently limited by sluggish diffusion kinetics and structural degradation of cathode materials arising from the strong electrostatic interactions between high-charge-density Mg2.and host ***,layered-structured NiOOH,as traditional cathodes for alkaline batteries,is initially demonstrated to realize proton-assisted Mg-(de)intercalation chemistry with a high discharge platform(0.57V)in neutral aqueous *** from the unique core/shell structure,the resulting NiOOH/CNT cathodes achieve a high capacity of 12..5 mAh g−1 and long cycle *** theoretical calculations reveal that the binding energy of hydrated Mg2.is higher than that of Mg2.with NiOOH,resulting in that Mg2.is easily intercalated/de-intercalated into/from *** from the freestanding design,the assembled fiber-shaped“rocking-chair”NaTi2.PO4)3//NiOOH AMIB shows a high energy density and satisfactory mechanical flexibility,which could be woven into a commercial fabric and power for fiber-shaped photoelectric sensors.

关键词： NiOOHAqueous electrolyte Mg-intercalation chemistry Rocking-chair Mg-ion batteries Fiber electronics

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Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National Science Review 2024年第3期11卷 215-226页

作者： Jian-Hong Xiao Zhen-Bang zhang JiaHao Li Si-Ming Chen Huai-ling Gao YinXiu Liao Lu Chen ZiShuo {2. YiFan Lu YuanZhen Hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine institute of Innovative Materials(I2.) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2.-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and *** HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

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Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang wang Yi Yan Jian zhang Ping Yuan Ci-Jun Luo Hong-{2. Qiu Hui-Ting Li Jian Xu Lan wang Tian-Lan Li Rong Jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2.,were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:2..2. m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2.,95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2.,95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.92.).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2.,95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

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Advances in the Research Application of Ultrasound Non-Invasive Stress-Strain Loop Technology in Cardiovascular Diseases

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Journal of Biosciences and Medicines 2024年第9期12卷 1-12页

作者： Jinshu wang Qiang zhang {2. Guo Xinyu Hao Jingzhou Hospital of Yangtze University Jingzhou China

The ultrasound pressure-strain loop (PSL) technique is a non-invasive method of examining myocardial work, which takes into account the effect of cardiac afterload on deformation and combines the overall longitudinal strain force of the left ventricle with the changes in the left ventricular pressure, allowing earlier detection of possible subclinical cardiac damage in patients, and a more accurate and non-invasive assessment of the patient’s myocardial work performance. In this article, we will discuss the progress of PSL applications in cardiovascular diseases.

关键词： Echocardiography Speckle Tracking Non-Invasive Myocardial Work Pressure-Strain Loop Left Ventricular Pressure

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