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Composition Engineering Opens an Avenue Toward Efficient and Sustainable Nitrogen Fixation

Energy & Environmental Materials 2024年第1期7卷 313-325页

作者： Xiaolin wang Liming yang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationWuhan 430074China Hubei Key Laboratory of Materials Chemistry and Service Failure Wuhan 430074China Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Wuhan 430074China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Wuhan 430074China school of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China

In this work,we open an avenue toward rational design of potential efficient catalysts for sustainable ammonia synthesis through composition engineering strategy by exploiting the synergistic effects among the active sites as exemplified by diatomic metals anchored graphdiyne via the combination of hierarchical high-throughput screening,first-principles calculations,and molecular dynamics *** 43 highly efficient catalysts feature ultralow onset potentials(|U_(onset)|≤0.40 V)with Rh-Hf and Rh-Ta showing negligible onset potentials of 0 and-0.04 V,*** high catalytic activities of Rh-Hf and Rh-Ta can be ascribed to the synergistic *** forming heteronuclears,the combinations of relatively weak(such as Rh)and relatively strong(such as Hf or Ta)components usually lead to the optimal strengths of adsorption Gibbs free energies of reaction *** origin can be ascribed to the mediate d-band centers of Rh-Hf and Rh-Ta,which lead to the optimal adsorption strengths of intermediates,thereby bringing the high catalytic *** work provides a new and general strategy toward the architecture of highly efficient catalysts not only for electrocatalytic nitrogen reduction reaction(eNRR)but also for other important *** expect that our work will boost both experimental and theoretical efforts in this direction.

关键词： composition engineering strategy diatomic catalysts electrocatalytic nitrogen reduction reaction first-principles calculations graphdiyne hierarchical high-throughput screening synergistic effects

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The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

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International Journal of Oral Science 2024年第2期16卷 322-332页

作者： Wenhao zheng Xiaofeng Lu Guangjin Chen Yufeng Shen Xiaofei Huang Jinfeng Peng Jiajia wang Ying Yin Wencheng Song Mengru Xie Shaoling Yu {2. Chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina school of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanChina Department of Stomatology The First Affiliated HospitalSchool of MedicineShihezi UniversityShiheziChina

The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic ***,the sensitivity of existing detection techniques is not sufficient,and the criteria for evaluating optimal force have not been yet ***,by employing 3D finite element analysis methodology,we found that the apical distal region(A-D region)of mesial roots is particularly sensitive to orthodontic force in ***-resistant acidic phosphatase(TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams(g),leading to alveolar bone resorption and tooth *** the force reached 80 g,TRAP-positive osteoclasts started appearing on the root surface in the A-D ***,micro-computed tomography revealed a significant root resorption at 80 ***,the A-D region was identified as a major contributor to whole root *** was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement,inclination,and *** findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat ***,our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’orthodontic treatment.

关键词： movement roots offering

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Enhanced quality of Al2.3/SiC gate stack via microwave plasma annealing

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Rare Metals 2024年第10期43卷 5362-5371页

作者： Nan-Nan You Xin-Yu Liu Qian Zhang Zhen wang Jia-Yi wang {2. Xu Xiu-Yan Li Yu-zheng Guo Sheng-Kai wang High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of the Chinese Academy of Sciences school of Integrated Circuits University of Chinese Academy of Sciences school of Electrical Engineering and Automation Wuhan University Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong University

The high-quality gate dielectric on silicon carbide （SiC） surface is critical to fabricate high-performance SiC metal-oxide-semiconductor field-effect transistors（MOSFETs）.This research employs microwave plasma annealing （MPA） to obtain high-quality Al2.3/SiC gate *** designing MPA atmosphere and optimizing the plasma power,the SiC MOS capacitor with a Al2.3dielectric film shows the enhanced *** interface state density is reduced by 1 order of magnitude to 6×1011cm-2.eV-1,the breakdown electric field is increased,and the voltage shift is effectively suppressed Besides,the mechanism of MPA process is discussed in terms of the thermal effect and reactant species.X-ray photoelectron spectroscopy （XPS） results unveil oxygen plasma plays the main *** plasma power during the MPA process results in defect repairs of the firstneighbor Al-O bonding and partial removal of Al-O-H bond from the interface *** study demonstrates that MPA process is an effective option to realize highquality dielectric and interface on SiC.

关键词： Al2.3 Defect repairs Metal–oxide–semiconductor Microwave plasma annealing Silicon carbide X-ray photoelectron spectroscopy

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COLLECTIVELY COMPACT COMPOSITION OPERATOR SEQUENCES BETWEEN BERGMAN AND HARDY SPACES

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Acta Mathematica Scientia 2004年第2期24卷 206-212页

作者：王茂发刘培德 schoolofMathematicsandStatistics WuhanUniversityWuhan430072China

This paper studies the collective compactness of composition operator sequences between the Bergman and Hardy spaces. Some sufficient and necessary conditions involving the generalized Nevanlinna counting functions fo... 详细信息

关键词： Bergman space Hardy space composition operator collectively compact operator sequence

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Real-World Treatment Adherence to Smoking Cessation Medications and Association with Treatment Outcome—2. Centers,china,2.17–2.2.

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china CDC weekly 2024年第22期6卷 522-529,I0001-I0003页

作者： Anqi Cheng Zhao Liu Xinmei Zhou zheng Su Dan Xiao Chen wang the {2. National Tobacco Cessation Cohort Study(CNTCCS)Study Group Department of Tobacco Control and Prevention of Respiratory Disease Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/National Center for Respiratory Medicine/National Clinical Research Center for Respiratory Diseases/Institute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/China National Center for Respiratory Medicine/China National Clinical Research Center for Respiratory DiseasesBeijingChina Chinese Academy of Medical Sciences and Peking Union Medical College BeijingChina 不详

What is already known about this topic?Medication non-adherence significantly impedes smoking cessation *** effective smoking cessation medications are accessible in china,realworld adherence and its correlation with treatment outcomes remain largely *** is added by this report?From December 2.17 to January 2.2.,1,12. participants were recruited from 2. centers in all seven geographical regions of *** revealed that only 38.2.of smokers adhered to the prescribed 12.week smoking cessation treatment and those with a higher education level were more likely to be *** addition,smokers with good adherence were more likely to successfully quit *** are the implications for public health practice?The data obtained could enhance our understanding of smoking cessation practices in *** adherence is a crucial strategy to enhance the effectiveness of smoking cessation treatments and management provided to smokers.

关键词： china smoke likely

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Exosome-Transmitted miR-2.4-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2.in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： yang Le Mei zheng Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO Zhong Hua {2. Shu yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-2.4-5p in colorectal cancer(CRC).Methods The miR-2.4-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2.ULK2.in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-2.4-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-2.4-5p mainly in an exosome-dependent manner,and then miR-2.4-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2.was characterized as a direct target of miR-2.4-5p and was downregulated in CRC ***,ULK2.inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-2.4-5p partially reversed the proliferation regulation of ULK2.on CRC *** Our findings demonstrate that exosome-transmitted miR-2.4-5p promotes p53-dependent cell proliferation by targeting ULK2.in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-2.4-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Imitating and exploring the human brain's resting and task-performing states via brain computing: scaling and architecture

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National Science Review 2024年第5期11卷 17-28页

作者： Wenlian Lu Longbin Zeng Jiexiang wang Shitong Xiang yang Qi Qibao {2. Ningsheng Xu Jianfeng Feng DTB Consortium Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of Education Fudan University Shanghai Center for Mathematical Sciences Fudan University Department of Computer Science University of Warwick Zhangjiang Fudan International Innovation Center Fudan University

A computational human brain model with the voxel-wise assimilation method was established based on individual structural and functional imaging data. We found that the more similar the brain model is to the biological counterpart in both scale and architecture, the more similarity was found between the assimilated model and the biological brain both in resting states and during tasks by quantitative metrics. The hypothesis that resting state activity reflects internal body states was validated by the interoceptive circuit's capability to enhance the similarity between the simulation model and the biological brain. We identified that the removal of connections from the primary visual cortex(V1) to downstream visual pathways significantly decreased the similarity at the hippocampus between the model and its biological counterpart,despite a slight influence on the whole brain. In conclusion, the model and methodology present a solid quantitative framework for a digital twin brain for discovering the relationship between brain architecture and functions, and for digitally trying and testing diverse cognitive, medical and lesioning approaches that would otherwise be unfeasible in real subjects.

关键词： digital twin brain computational cortico-subcortical model fMRI data assimilation interoceptive circuit

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Conductive catalysis by subsurface transition metals

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National Science Review 2024年第1期11卷 86-93页

作者： Xin Deng Caiyan zheng yangsheng Li Zeyu Zhou Jiamin {2. Yihua Ran Zhenpeng Hu Fan yang Landong Li Frontiers Science Center for New Organic Matter College of ChemistryNankai University school of Physics Nankai University school of Physical Science and Technology Shanghai Tech University school of Materials Science and Engineering Nankai University Haihe Laboratory of Sustainable Chemical Transformations

The nature of catalysis has been hotly pursued for over a century, and current research is focused on understanding active centers and their electronic structures. Herein, the concept of conductive catalysis is proposed and verified by theoretical simulations and experimental observations. Metallic systems containing buried catalytically active transitional metals and exposed catalytically inert main group metals are constructed, and the electronic interaction between them via metallic bonding is disclosed. Through the electronic interaction, the catalytic properties of subsurface transitional metals(Pd or Rh) can be transferred to outermost main group metals(Al or Mg) for several important transformations like semi-hydrogenation,Suzuki-coupling and hydroformylation. The catalytic force is conductive, in analogy with the magnetic force and electrostatic force. The traditional definition of active centers is challenged by the concept of conductive catalysis and the electronic nature of catalysis is more easily understood. It might provide new opportunities for shielding traditional active centers against poisoning or leaching and allow for precise regulation of their catalytic properties by the conductive layer.

关键词： electronic interaction conductive catalysis subsurface transition metal

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LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells

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Genes & Diseases 2024年第4期11卷 69-72页

作者： Jia-Ni Xing Yi-Ni Shang zheng-Ling Yu Shun-Heng Zhou wang-{2. Chen Li-Hong wang Department of Pathophysiology Medical College of Southeast UniversityNanjingJiangsu 210009China Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 211106China school of Medicine Taizhou UniversityTaizhouZhejiang 318000China Jiangsu Provincial Key Laboratory of Critical Care Medicine NanjingJiangsu 210009China

Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to ***,improving the curative effect of ADR remains an urgent problem to be *** is a complex catabolic process;normal living cells break down damaged organelles or aggregated molecules and absorb energy to maintain homeostasis through autophagy.

关键词： breast cancer homeostasis

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Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury

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Research 2024年第1期2023卷 17-32页

作者： Bolin zheng Yijing He Shuai Yin Xu Zhu Qing Zhao Huiyi yang Zhaojie {2. Rongrong Zhu Liming Cheng Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationDepartment of OrthopedicsTongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Frontier Science Center for Stem Cell Research School of Life Science and TechnologyTongji UniversityShanghai 200092China Clinical Center for Brain and Spinal Cord Research Tongji UniversityShanghai 200092China

Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue *** formation is generally considered a barrier for regeneration in the central nervous ***,the intrinsic mechanism of scar formation after spinal cord injury has not been fully ***,we report that excess cholesterol accumulates in phagocytes and is inefficiently removed from spinal cord lesions in young adult ***,we observed that excessive cholesterol also accumulates in injured peripheral nerves but is subsequently removed by reverse ***,preventing reverse cholesterol transport leads to macrophage accumulation and fibrosis in injured peripheral ***,the neonatal mouse spinal cord lesions are devoid of myelin-derived lipids and can heal without excess cholesterol *** found that transplantation of myelin into neonatal lesions disrupts healing with excessive cholesterol accumulation,persistent macrophage activation,and *** internalization suppresses macrophage apoptosis mediated by CD5L expression,indicating that myelin-derived cholesterol plays a critical role in impaired wound *** together,our data suggest that the central nervous system lacks an efficient approach for cholesterol clearance,resulting in excessive accumulation of myelin-derived cholesterol,thereby inducing scar formation after injury.

关键词： healing Spinal impaired

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