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Expression of a novel dipeptidyl peptidase 8(DPP8)transcript variant,DPP8-v3,in human testis

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Asian Journal of Andrology 2005年第3期7卷 245-255,页

作者： Hui Zhu Zuo-min Zhou li Lu min Xu Hui wang Jian-min li Jia-Hao Sha Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical UniversityNanjing 210029 China

Aim： To investigate the role of a novel dipeptidyl peptidase 8 transcript variant （DPP8-v3） gene in testis development and/or spermatogenesis. Methods： A human testis cDNA microarray was hybridized with mRNA of human adult and fetal testes. Differentially expressed clones were sequenced and characterized and their expression was analyzed by real-time reverse transcription polymerase chain reaction （RT-PCR） and Southern-blot analysis. Results： A new transcript variant of the human dipeptidyl peptidase （DPP8）, exhibiting a 5-fold higher expression level in human adult than that in fetal testes, was cloned and was named DPP8 variant 3 （DPP8-v3）. The full-length sequence of DPP8-v3 was 3,030 bp, encoding a protein of 898 amino acids. Conclusion： DPPS-v3 is a novel human DPP8 transcript variant highly expressed in the adult testis. Similar to DPPIV, DPP8-v3 may play a key role in the immunoregulation of testes and accordingly may influence spermatogenesis and male fertility. （Asian J Androl 2005 Sep; 7： 245-255）

关键词： DPP8 dipeptidyl peptidase IV (DPPIV) DPP8-v3 immunoregulation spermatogenesis testis

Theoretical Design of High-spin Organic Molecules with —~* N—S— as a Spin-containing Fragment and Heterocycle as End Groups

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Chemical Research in Chinese Universities 2006年第5期22卷 631-634页

作者： wang li-min CHU De-qing ZHANG Jing-ping wang Rong-shun Faculty of Material and Chemical Engineering Tianfin Polytechnic University Tianjin 300160 P. R. China Faculty of Chemistry Northeast Normal University Changchun 130024 P. R. China

Novel stable high-spin molecules possessing three different arranging fashions were designed with —^＊N—S— as a spin-containing （SC） fragment, an aromatic group, such as benzene （ 1 ）, pyridine （2）, pyridazine （3） , pyrimidine （4）, pyrazine （5） or triazine （6） as end groups （EG）, and phenyl as a ferromagnetic coupling （FC） unit. The effects of different EG on the spin multiplicities of the ground states and their stabilities were investigated by means of the AM1-CI approach. All the investigated molecules corresponded to the FC and possessed high-spin ground states. The spin on the two atoms of the SC fragment was not in agreement with the delocalization results in the specific stability of —^＊N—S—. In those molecules, the stabilities of the triplet states decreased when the distance between the atoms of central SC fragments （—N—） increased. The stabilities of the triplet states of compounds 1a-n, 1b-n and 1c-n, with heterocycles as EG were higher than those of the triplet states of those compounds with phenyl as EG. Furthermore, the stahilities of the triplet states of the compounds with pyrimidine and triazine as EG were higher than those with pyridine, pyridazine or pyrasine as EG.

关键词： Heterocycle End group Biradical High-spin AM1-CI

Study on the influence of humic acid of different molecular weight on basic ion exchange resin's adsorption capacity

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Chinese Chemical Letters 2009年第12期20卷 1478-1482页

作者： Jin Nan wang Ai min li Yang Zhou li Xu State Key Laboratory of Pollution Control and Resource Reuse & School of the Environment Nanjing University Nanjing 210093 China

In this paper, humic acid （HA） was ultra-filtered into different molecular weight sections and was characterized by multielement analysis, UV254/TOC, FT-IR and three-dimensional fluorescence spectrometric. Since humic acids of different molecular weights have different hydrophilic and molecular size, the maximum adsorption capacity of basic ion exchange resins appears on the humic acid whose molecular weight ranges from 6000 to 10,000 Da.

关键词： Humic acid Molecular weight Basic ion exchange resin Adsorption

Evaluation on Effectiveness and Safety of Chinese Herbs inTreatment of Sub-health: A Systematic Review andMeta-Analysis of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2019年第6期25卷 471-480页

作者： ZHAO Jun liAO Xing ZHAO Hui li Zhi-geng wang Nan-yue wang li-min China Academy of Chinese Medical Science Beijing (100700) China Beijing University of Chinese Medicine Beijing (100029) China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Science Beijing (100700) China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences Beijing (100700) China Experimental Research Center China Academy of Chinese Medical Sciences Beijing (100700) China

Objective: To evaluate the effectiveness and safety of Chinese herbs in the treatment of sub-health systematical y. Methods: Nine databases were systematicaly and extensively searched to col ect randomized control ed trials(RCTs) about Chinese herbs in the treatment of sub-health. The outcomes included overal effective rate, main symptoms, quality of life, etc. literature screening, data extraction and quality assessment were conducted according to Cochrane Handbook 5.1. Meta-analysis was conducted to the included literature with Review Manager ***: Seventy-two studies involving 9,296 patients with sub-health were included with 4,908 patients in experimental groups and 4,387 patients in control groups. The overal quality of included clinical research was not high. In the aspect of improving overall effective rate, relieving main symptoms, Pittsburgh sleep quality index(PSQI) score, Athens Insomnia Scale(AIS) score, Fatigue Scale-14(FS-14), Cornel Medical Index(CMI) score and discontinuation rate, the effects of experimental groups were better than that of control groups. According to available research reports, adverse reactions in Chinese herb groups were mainly mild gastrointestinal symptoms, which did not affect the ***: Chinese herbs have a curative effect in the treatment of sub-health. However, there are no clear criteria for diagnosis and curative effectiveness judgment global y, which would affect the accuracy of curative effect evaluation.

关键词： sub-health randomized controlled trials Chinese medicine systematic review

Prevalence of Major Cardiovascular Risk Factors and Cardiovascular Disease in Women in China: Surveillance Efforts

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Biomedical and Environmental Sciences 2016年第3期29卷 205-211页

作者： li Jian Hong wang li min li Yi Chong ZHANG Mei wang lin Hong National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and Prevention

In this study, we aimed to assess the relationship of socioeconomic status and acculturation with cardiovascular disease （CVD） risk profiles and CVD and examine the CVD risk factors associated with CVD. We used data from the 2010 China Chronic Disease and Risk Factor Surveillance surveys, which consisted of a nationally representative sample of women. The following prevalence was found： myocardial infarction （MI）：

关键词： CVD Surveillance Efforts Prevalence of Major Cardiovascular Risk Factors and Cardiovascular Disease in Women in China

Elasto-Plastic Test of Q235 Steel Bending Beam With Cracking Resistance

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Journal of Iron and Steel Research International 2013年第11期20卷 57-66页

作者： wang li-min FENG Ying CHEN Fan-xiu wang Hai-ying wang Dong-xu Science School Qingdao Technological University Institute of Mechanics Chinese Academy of Sciences

More than 30 bending beams with rectangular cross-section and different thicknesses and heights were pre- pared from Q295 steel. The specimen dimensions were about 240 mm （length） × 60 mm （height） ×70 mm （thick ness）. Flaws were cut along its middle line with a wire cutter, with lengths ranging from 6 to 35 mm. Each specimen was tested with three-point bend loading, and a process curve was obtained between load and the displacement of the loading point, in order to analyze the fracture process when opening the crack. A deformation near the prefabricated crack was observed in the testing period, and the variation of the fracture characteristic parameters was analyzed for different sizes. For a comprehensive understanding of carbon steel fracture resistance behavior, its elasticity and plas- ticity were established by determining its Young＇s modulus and Poisson＇s ratio with an optical strain gauge. This gauge was also used for the loading process test. It was found that the fracture toughness varied with the dimensions, and the toughness of the elastic limit loading was almost constant. Using the relationship of crack resistance stress intensity factor and fracture criterion, the bearing capacity of the material structure could be estimated, which shows a good agreement with the experimental test data.

关键词： elasto-plastic property fracture toughness elastic limit loading bearing capacity cracking resistance Q235 steel bending beam

Studies on Effect of Conformation on Spin Multiplicity of m-Phenylene Type of Biradicals by Different Approaches

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Chemical Research in Chinese Universities 2003年第4期19卷 489-493页

作者： wang li-min ZHANG Jing-ping wang Rong-shun Faculty of Chemistry Northeast Normal UniversityChangchun 130024P.R.China

The effect of the conformation on the spin multiplicity of the ground state and the stability of the ground state were investigated for m-phenylene type of biradicals by means of comparative study with DFT, CASSCF and AM1-CI approaches. It was found that AM1-CI approach is reliable in dealing with the stability of the high-spin ground state with the change of conformation; DFT method can give the reasonable results of the spin density of the high-spin state. Furthermore, when one or two radical centers are twisted sufficiently out of the conjugation with the benzene ring, m-phenylene turns into weak ferromagnetic and weak antiferromagnetic coupling units, respectively.

关键词： m-Phenylene High-spin Conformation DFT CASSCF AM1-CI

Theoretical Design of High-spin Organic Molecules with Heterocycles as Ferromagnetic Coupling Units

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Chemical Research in Chinese Universities 2003年第4期19卷 508-511页

作者： wang li-min ZHANG Jing-ping wang Rong-shun Faculty of Chemistry Northeast Normal UniversityChangchun 130024P.R.China

Novel stable high spin molecules possessing three different arranged fashions are designed with - · N-N< as a spin-containing(SC) fragment, phenylene as an end group and various aromatic molecules, such as benzene(1)... 详细信息

Novel stable high spin molecules possessing three different arranged fashions are designed with - · N-Nling(FC) unit. The effects of the different coupling units on the spin multiplicities of the ground states and their stabilities were investigated by means of AM1-CI approach. It has been found that the spin densities on the two atoms of the SC fragment are different from delocalization results in the specific stability of - · N-Nlities of the triplet states decrease when the distance between the atoms of central SC(-N-) increases. It is shown that the heterocycles as the coupling units have influence on the stabilities of the high-spin ground states. That the heteroatom lying in m -phenyl can improve ferromagnetic coupling, while the heteroatom lying in o -phenyl or p -phenyl is not in favor of the ferromagnetic coupling.

关键词： Heterocycle Coupling unit Biradical High-spin AM1-CI B3LYP

Effects of meteorological factors on different grades of winter wheat growth in the Huang-Huai-Hai Plain, China

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Journal of Integrative Agriculture 2016年第11期15卷 2647-2657页

作者： HUANG Qing wang li-min CHEN Zhong-xin liU Hang Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

The sown area of winter wheat in the Huang-Huai-Hai（HHH） Plain accounts for over 65% of the total sown area of winter wheat in China. Thus, it is important to monitor the winter wheat growth condition and reveal the main factors that influence its dynamics. This study assessed the winter wheat growth condition based on remote sensing data, and investigated the correlations between different grades of winter wheat growth and major meteorological factors corresponding. First, winter wheat growth condition from sowing until maturity stage during 2011–2012 were assessed based on moderate-resolution imaging spectroradiometer（MODIS） normalized difference vegetation index（NDVI） time-series dataset. Next, correlation analysis and geographical information system（GIS） spatial analysis methods were used to analyze the lag correlations between different grades of winter wheat growth in each phenophase and the meteorological factors that corresponded to the phenophases. The results showed that the winter wheat growth conditions varied over time and space in the study area. Irrespective of the grades of winter wheat growth, the correlation coefficients between the winter wheat growth condition and the cumulative precipitation were higher than zero lag（synchronous precipitation） and one lag（pre-phenophase precipitation） based on the average values of seven phenophases. This showed that the cumulative precipitation during the entire growing season had a greater effect on winter wheat growth than the synchronous precipitation and the pre-phenophase precipitation. The effects of temperature on winter wheat growth varied according to different grades of winter wheat growth based on the average values of seven phenophases. Winter wheat with a better-than-average growth condition had a stronger correlation with synchronous temperature, winter wheat with a normal growth condition had a stronger correlation with the cumulative temperature, and winter wheat with a worse-than-average growth

关键词： growth condition meteorological factors remote sensing spatiotemporal correlation winter wheat HuangHuai-Hai(HHH) Plain region China