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Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

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Chinese Medical Journal 2024年第8期137卷 936-948页

作者： Wanlin Ye Kun Han Maodi Xie Sheyu li guo Chen Yanyan wang Tao li Department of Anesthesiology Laboratory of Mitochondria and MetabolismNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Anesthesiology West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengduSichuan 610041China Department of Endocrinology and Metabolism Division of Guideline and Rapid RecommendationCochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Nursing Key Laboratory of Sichuan Province West China HospitalSichuan UniversityChengduSichuan 610041China

Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the *** blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic *** the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic *** this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

关键词： Mitochondria Mitochondrial energy metabolism Diabetic cardiomyopathies Physiology Physiological adaption Pathogenesis Therapeutics

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A unified stochastic damage model for concrete based on multi-scale energy dissipation analysis

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Science China(Technological Sciences) 2024年第3期67卷 863-877页

作者： guo ChengGong li Jie College of Civil Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai 200092China

This work proposes a unified damage model for concrete within the framework of stochastic damage mechanics. Based on the micro-meso stochastic fracture model(MMSF), the nonlinear energy dissipation process of the microspring from nanoscale to microscale is investigated. In nanoscale, the rate process theory is adopted to describe the crack growth rate;therefore, the corresponding energy dissipation caused by a representative crack propagation can be obtained. The scale gap from nanoscale to microscale is bridged by a crack hierarchy model. Thus, the total energy dissipated by all cracks from the nanoscale to the microscale is gained. It is found that the fracture strain of the microspring can be derived from the above multi-scale energy dissipation analysis. When energy dissipation is regarded as some microdamage to the microspring, the constitutive law of the microspring is no longer linearly elastic, as previously assumed. By changing the expression of the damage evolution law from fracture strain to energy dissipation threshold, the new damage evolution model is derived. The proposed model can not only replicate the original static model but also extend to cases of rate dependence. By deriving the fracture strain under different strain rates, the rate sensitivity of concrete materials can be reflected. The model parameters can be conveniently obtained by identifying them with experimental data. Finally, several numerical examples are presented to verify the proposed model.

关键词： concrete damage model stochastic damage rate dependent energy dissipation

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Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： Zhen li Wei Zhao Kedong Yu Ning guo Guangchun Xiao Zhiming wang Hui Zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Shandong Institute of Mechanical Design and Research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

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Experimental and computational investigation on flow characteristics of rotating cavities with high inlet pre-swirl axial throughflow

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Chinese Journal of Aeronautics 2024年第4期37卷 276-293页

作者： Sipeng wang Xiang LUO linji guo Zeyu WU Yang BAI Zongchao li lichun MA School of Energy and Power Engineering Beihang UniversityBeijing 100191China Research Institude of Aero-Enigine Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China Shenyang Aeroengine Research Institute Aero Engine Corporation of ChinaShenyang 110015China

As an integral part of the internal air system of aero-engines,the axial throughflow of the cooling air can interact with the cavity flow between the rotating compressor disks,forming a threedimensional,unsteady,and unstable flow *** flow characteristics in an engine-like rotating multi-stage cavity with throughflow were investigated using particle image velocimetry,flow visualization technology and three-dimensional unsteady Reynolds-Averaged Navier-Stokes (RANS)*** focus of current research was to understand the distribution of the mean swirl ratio and its variation with a wide range of non-dimensional parameters in the co-rotating cavity with high inlet pre-swirl axial *** maximum axial Reynolds number and rotational Reynolds numbers could reach 4.41×10^(4)and 1.24×10^(6),*** velocity measurement results indicate that the mean swirl ratio is greater than 1 and decreases with an increase in the radial *** flow structure is dominated by the Rossby number,and two different flow patterns (flow penetration and flow stratification) are identified and confirmed by flow visualization *** the absence of buoyancy,the flow penetration caused by the precession of the throughflow makes it easier for the throughflow to reach a high radius *** consistency of results between measurements and numerical calculations is *** study provides a theoretical basis and data support for toroidal vortex breakdown,which is of practical significance for the design of high-pressure compressor cavities.

关键词： Compressor Axial throughflow Rotating cavity flow Particle image velocimetry Unsteady RANS Flow pattern

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New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study

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Petroleum Science 2024年第1期21卷 694-704页

作者： Jun Zhang Hai-Qiang Fu Mu-Zhi guo Zhao wang li-Wen li Qi Yin You-guo Yan Wei Wei Wei-Feng Han Jie Zhong School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007HebeiChina

Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low *** hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH *** studies suggested the water film can greatly increase hydrate adhesion in gas-dominant ***,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion ***,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film *** water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate *** absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Feliquid layer,the process of which becomes harder as liquid layer *** a result,contrary to gas-dominant system,the water film plays the weakening roles on hydrate adhesion in water-dominant ***,our results can help to better understand the hydrate deposition mechanisms on Fe and its corrosion surfaces and suggest hydrate deposition can be adjusted by changing water affinities on pipeline surfaces.

关键词： Deposition Natural gas hydrate Pipelines Water affinity Adhesion strength

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Rational Design of Cost-Effective Metal-Doped ZrO_(2)for Oxygen Evolution Reaction

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Nano-Micro Letters 2024年第9期16卷 385-396页

作者： Yuefeng Zhang Tianyi wang liang Mei Ruijie Yang Weiwei guo Hao li Zhiyuan Zeng Department of Materials Science and Engineering and State Key Laboratory of Marine PollutionCity University of Hong Kong83 Tat Chee AvenueKowloon 999077Hong KongPeople’s Republic of China Advanced Institute for Materials Research(WPI‑AIMR) Tohoku UniversitySendai 980‑8577Japan Shenzhen Research Institute City University of Hong KongShenzhen 518057People’s Republic of China Shanxi Supercomputing Center Lvliang 033000ShanxiPeople’s Republic of China

The design of cost-effective electrocatalysts is an open challenging for oxygen evolution reaction(OER)due to the“stable-oractive”*** dioxide(ZrO_(2)),a versatile and low-cost material that can be stable under OER operating conditions,exhibits inherently poor OER activity from experimental ***,we doped a series of metal elements to regulate the ZrO_(2)catalytic activity in OER via spin-polarized density functional theory calculations with van der Waals *** modeling as a function of the OER activity descriptor(G_(O*)-G_(HO*))displays that 16 metal dopants enable to enhance OER activities over a thermodynamically stable ZrO_(2)surface,among which Fe and Rh(in the form of single-atom dopant)reach the volcano peak(*** optimal activity of OER under the potential of interest),indicating excellent OER *** energy diagram calculations,density of states,and ab initio molecular dynamics simulations further showed that Fe and Rh are the effective dopants for ZrO_(2),leading to low OER overpotential,high conductivity,and good *** cost-effectiveness,single-atom Fe doped ZrO_(2)emerged as the most promising catalyst for *** finding offers a valuable perspective and reference for experimental researchers to design cost-effective catalysts for the industrial-scale OER production.

关键词： Oxygen evolution reaction Metal oxide Electrocatalysis Surface Pourbaix analysis Doping

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Reinforcement Learning Navigation for Robots Based on Hippocampus Episode Cognition

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Journal of Bionic Engineering 2024年第1期21卷 288-302页

作者： Jinsheng Yuan Wei guo Zhiyuan Hou Fusheng Zha Mantian li Pengfei wang lining Sun State Key Laboratory of Robotics and System Harbin Institute of Technology(HIT)Harbin 150001China Shenzhen Academy of Aerospace Technology Shenzhen 518057China School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050China

Artificial intelligence is currently achieving impressive success in all ***,autonomous navigation remains a major challenge for *** learning is used for target navigation to simulate the interaction between the brain and the environment at the behavioral level,but the Artificial Neural Network trained by reinforcement learning cannot match the autonomous mobility of humans and *** hippocampus–striatum circuits are considered as key circuits for target navigation planning and *** paper aims to construct a bionic navigation model of reinforcement learning corresponding to the nervous system to improve the autonomous navigation performance of the *** ventral striatum is considered to be the behavioral evaluation region,and the hippocampal–striatum circuit constitutes the position–reward *** this paper,a set of episode cognition and reinforcement learning system simulating the mechanism of hippocampus and ventral striatum is constructed,which is used to provide target guidance for the robot to perform autonomous *** with traditional methods,this system reflects the high efficiency of learning and better Environmental *** research is an exploration of the intersection and fusion of artificial intelligence and neuroscience,which is conducive to the development of artificial intelligence and the understanding of the nervous system.

关键词： Episode cognition Reinforcement learning Hippocampus Robot navigation

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Development review and the prospect of oil shale in-situ catalysis conversion technology

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Petroleum Science 2024年第2期21卷 1385-1395页

作者： li wang Chen-Hao Gao Rui-Ying Xiong Xiao-Jun Zhang Ji-Xiang guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism

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Synthesis and Enhanced Acetone-sensing Properties of Ordered Large-pore Mesoporous Nickel Oxides with Ultrathin Crystalline Frameworks

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Chemical Research in Chinese Universities 2024年第3期40卷 521-528页

作者： SHAO Chen guo Ru li Hui wang Xiaozhong YANG Qingfeng LAI Xiaoyong State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021P.R.China

Acetone is a tracer for monitoring air quality and a potential breath maker for diabetes. It remains a great challenge for current portable sensors to sensitively and selectively detect acetone at low-ppb (part per billion) level. Herein, we present an ordered mesoporous nickel oxide (NiO) with both large mesopores and ultrathin crystalline frameworks for the detection of low-ppb acetone. The ordered mesoporous NiO replicas with predominant large mesopores of 11 nm, high specific surface areas of 121–128 m2/g and ultrathin crystalline frameworks of 5 nm were synthesized by the nanocasting method and the crystalline properties of NiO frameworks were adjusted by changing the annealing temperature from 300℃ to 750℃, which resulted in different contents of oxygen deficient on the surface of ultrathin frameworks. The gas-sensing properties for all the NiO samples were investigated and the ordered large-pore mesoporous NiO (NiO-600) with maximum oxygen deficient obtained at 600℃ exhibited the highest response (R_(gas)/R_(air)−1=2.9) toward acetone (1 ppm, ppm: part per million), which is 3.4 and 30 times larger than those for common mesoporous NiO obtained at 300℃ and bulk NiO. Notably, a low detection limit (2 ppb), good selectivity and cycling stability were also observed in NiO-600.

关键词： Mesoporous semiconductor NiO Gas sensing Acetone

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The effects of deformation parameters and cooling rates on the aging behavior of AZ80+0.4%Ce

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Journal of Magnesium and Alloys 2024年第2期12卷 639-658页

作者： Yongbiao Yang Jinxuan guo Cuiying wang Ting Yan Zhang Wenxuan Jiang Zhimin Zhang Qiang wang guojun li Jun wang College of Materials Science and Engineering North University of ChinaLane 3Xueyuan RoadTaiyuanShanxiChina030051 State Key Laboratory of Advanced Stainless Steel Materials Taiyuan Iron Steel(Group)Co.Ltd.Taiyuan 030003China Technology Center Shanxi Taigang Stainless Steel Co.Ltd.Taiyuan 030003China

The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion *** deformed cylindrical specimens were cooled at a cooling rate of 10℃/s or 0.1℃/s,respectively,and aged at 170℃.The microstructure analysis results showed that the grain size decreased with increasing specimen radial position from center(SRPC),and that the strong initial basal texture of the extruded magnesium alloy was *** continuous and discontinuous dynamic recrystallization mechanisms were involved in contributing to the grain refinement for all specimens *** a novel extension twinning induced dynamic recrystallization mechanism was proposed for specimen deformed at 300℃.For the specimens deformed at 300℃and 340℃followed by a slow cooling rate(0.1℃/s),precipitates of various shapes(β-Mg_(17)Al_(12)),with the dominant precipitates being on the grains boundaries,appeared on the surface *** specimen deformed at 380℃,lamellar precipitates(LPS)in the interiors of the grains were *** aging,the LPS still dominated for specimens twisted at 380℃;however,the LPS gradually decreased with decreasing deformation temperatures from 380℃to 300℃.Dynamically precipitatedβ,especially those decorating the grain boundaries,changed the competition pictures for the LPS and precipitates of other shapes after ***,LPS dominated the areas for the center section of the specimens after aging regardless of deformation *** temperature deformation with high SRPC followed by rapid cooling rate increased the micro hardness of the alloy after aging due to refined grain,reduced precipitates size,decreased lamellar spacing as well as strain hardening.

关键词： AZ80+0.4%Ce magnesium alloy Hot torsion Deformation parameters Cooling rate Aging Micro hardness

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