检索结果-南通市图书馆

Research progress in genomics of environmental and industrial microorganisms

Science china(Life sciences) 2009年第1期52卷 64-73页

作者： wang lei1,2,liu bin1,2 & zhou zhemin1,2 1 teda school of biological sciences and biotechnology,nankai university,tianjin 300457,china 2 tianjin Research Center for Functional Genomics and Biochip,tianjin 300457,china 1. teda school of biological sciences and biotechnology Nankai University Tianjin 300457 China 2. tianjin Research Center for Functional Genomics and Biochip Tianjin 300457 China

Microbes contribute to geochemical cycles in the *** also play important roles in biodegradation and bioremediation of contaminated environments,and have great potential in energy conversion and *** to date,at least 150 genomes of non-pathogenic microbes have been sequenced,of which,the majority are bacteria from various environments or of industrial *** emerging field 'metagenomics' in combination with the high-throughput sequencing technology offers opportunities to discover new functions of microbes in the environment on a large scale,and has become the 'hot spot' in the field of environmental *** genomes of bacteria from various extreme environments,including high temperature,high and low pressure,and extreme acidic regions,have been sequenced by researchers in china,leading to the discovery of metabolic pathways,genetic functions and new enzymes,which are related to the niches those bacteria *** results were published in Nature,PNAS,Genome Research and other top international *** the meantime,several groups in china have started 'metagenomics' *** outcomes of these researches are expected to generate a considerable number of novel findings,taking Chinese researchers to the frontier of genomics for environmental and industrial microorganisms.

关键词： genomics microbiology and metagenomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Orexin-A excites lateral vestibular nucleus neurons and promotes vestibular-mediated motor behaviors in rats

Orexin-A excites lateral vestibular nucleus neurons and prom...

引用

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jun ZHANG,lei YU,bin LI,Jing-Ning ZHU~*,Jian-Jun wang~* Department of biological Science and Technology and State Key Laboratory of Pharmaceutical biotechnology,school of Life sciences,Nanjing university,Nanjing 210093,china

Central orexinergic system,originating solely from the hypothalamus but projecting widely in the brain,has been traditionally implicated in many basic physiological functions,such as wake/sleep cycle,feeding behavior,and ***,its function on motor control has still been little *** the present study,effect of orexin-A on the lateral vestibular nucleus(LVN),which holds a key position in control of the vestibulo-spinal reflexes and posture,were ***-PCR and immunofluorescence histochemical results both showed that orexin 1 receptors(OX1R) and orexin 2 receptors(OX2R) were presented in the LVN in *** brain slice preparations and whole-cell patch clamp recordings,a dose-dependent inward current and a increased neuronal firing elicited by orexin-A were observed in giant LVN neurons(diameter > 35μm,Deiter’s neurons).The orexin-A-elicited inward currents on the LVN neurons were not only partly blocked by selective OX1R antagonist SB334867 but also mimicked by selective OX2R agonist[Ala11,D- Leu15]-orexin B,indicating that the orexin-A-induced excitation was mediated by both OX1R and ***, tetrodotoxin did not block the excitations evoked by orexin-A,suggesting the actions of the peptide on LVN neurons are *** with the inward current,a slight decrease of membrane conductance of the neurons elicited by orexin-A was observed and also was not blocked by tetrodotoxin,suggesting activities of ion channels on postsynaptic membrane *** I-V curves before and after application of orexin-A on LVN neurons showed that more than one ionic basis was involved in the orexin-A-induced ***-R7943 and Ba,blockers for Na-Ca exchangers and inward rectifier K channels respectively,together totally blocked the orexin-A-elicited inward *** results demonstrate that orexin-A excites the LVN neurons via both activation of Na-Ca exchangers and closure of inward rectifier K ***,orexin-A was unilat

关键词： orexin-A orexin receptors lateral vestibular nucleus motor control

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Orexin-A excites rat lateral vestibular nucleus neurons and improves vestibular-mediated motor behaviors

Orexin-A excites rat lateral vestibular nucleus neurons and ...

引用

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Jun ZHANG,bin LI,lei YU,Jing-Ning ZHU~*,Jian-Jun wang~* Department of biological Science and Technology and State Key Laboratory of Pharmaceutical biotechnology,school of Life sciences,Nanjing university,Nanjing 210093,china

Central orexinergic system,originating solely from the hypothalamus but projecting widely in the brain, has been traditionally implicated in many basic physiological functions,such as wake/sleep cycle,feeding behavior, and *** deficiency results in cataplexy,a sudden and transient loss of muscle tone often triggered by emotions and closely related to narcolepsy,and the function of central orexinergic system in sleep has been well ***,role of orexin in somatic motor control has been largely *** we show that orexin-A directly depolarizes neurons in the rat lateral vestibular nucleus(LVN),a key subcortical motor center for body balance and posture control,and enhances their sensitivities,via postsynaptic orexin 1 and orexin 2 receptors coupled with a dual ionic mechanism involving both activation of Na-Ca exchangers and closure of inward rectifier K ***,the increase of activity and sensitivity of LVN neurons by orexin-A consequently elicits postural change and promotes motor balance and negative *** results reveal a novel function of orexin on central vestibular-mediated posture and motor *** orexin also participates in regulation of nonsomatic activities such as sleep/wake states,energy homeostasis and reward processes,we suggest that the central orexinergic system may contribute to somatic-nonsomatic integration via its parallel innervations on both nonsomatic and somatic structures of the brain and its dysfunction may induce simultaneous somatic and nonsomatic disorders,including cataplexy.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans

引用

Journal of Genetics and Genomics 2018年第12期45卷 651-662页

作者： Emmanuel Enoch Dzakah Ahmed Waqas Shuai Wei bin Yu Xiaolin wang Tao Fu lei liu Ge Shan Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscalethe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Department of Molecular Biology and biotechnology School of Biological SciencesCollege of Agriculture and Natural SciencesUniversity of Cape Coast Cape Coast 03321Ghana CAS Centre for Excellence in Molecular Cell Science.Shanghai Institutes for biological sciences Chinese Academy of SciencesShanghai 200031China Department of Molecular Cellularand Developmental BiologyUniversity of ColoradoBoulderColorado 80309USA

MicroRNAs(miRNAs) are short non-coding RNAs that are involved in the post-transcriptional regulation of protein-coding genes. miRNAs modulate lifespan and the aging process in a variety of organisms. In this study, we identified a role of miR-83 in regulating lifespan of Caenorhabditis elegans. mir-83 mutants exhibited extended lifespan, and the overexpression of miR-83 was sufficient to decrease the prolonged lifespan of the mutants. We observed upregulation of the expression levels of a set of miR-83 target genes in young mir-83 mutant adults; while different sets of genes were upregulated in older mir-83 mutant adults. In vivo assays showed that miR-83 regulated expression of target genes including din-1,spp-9 and col-178, and we demonstrated that daf-16 and din-1 were required for the extension of lifespan in the mir-83 mutants. The regulation of din-1 by miR-83 during aging resulted in the differential expression of din-1 targets such as gst-4 and gst-10. In daf-2 mutants, the expression level of miR-83 was significantly reduced compared to wild-type animals. We identified a role for miR-83 in modulating lifespan in C. elegans and provided molecular insights into its functional mechanism.

关键词： C. elegans miR-83 daf-2 din-1 Longevity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A role for orexin in central vestibular motor control

A role for orexin in central vestibular motor control

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun ZHANG~(**),bin LI~(**),lei YU,Ye-Cheng HE,Hong-Zhao LI,Jing-Ning ZHU~*,Jian-Jun wang~* Department of biological Science and Technology and State Key Laboratory of Pharmaceutical biotechnology,school of Life sciences,Mailbox 426,Nanjing university,22 Hankou Road,Nanjing 210093,china

The last decade has witnessed significant advances in our understanding of the physiological roles of orexin (also known as hypocretin),a novel neuropeptide first identified in *** a neurotransmitter system originating uniquely from the lateral hypothalamus/perifornical area but projecting extensively to almost the whole brain,the central orexinergic system has been implicated in many basic nonsomatic functions,including the sleep/wake states, feeding,and reward ***,whether the central orexinergic system has a role in somatic motor control remains ***,orexin deficiency in humans,dogs,and rodents results in cataplexy,a motor deficit characterized by sudden loss of muscle tone,highlighting the possibility of a modulatory role for orexin in motor ***,since cataplexy is closely related to narcolepsy and often triggered by strong emotions,whether the effect of orexin on motor system is secondary to its actions on the neural circuits controlling sleep or emotions is not *** the present study,to reveal the exact relationship between the central orexinergic system and motor control, the effects of orexin on the lateral vestibular nucleus(LVN),which holds a key position in control of muscle tone and posture and receives orexinergic innervation,and the underlying mechanisms were investigated at molecular, cellular,and behavioral ***,RT-PCR and immunofluorescence results both showed that orexin 1(OX,) and orexin 2(OX) receptors are presented in the LVN in *** brain slice preparations and whole-cell patch clamp recordings,a dose-dependent inward current elicited by orexin-A were observed in giant LVN neurons(diameter > 35μm,Deiters’ neurons).The orexin-A-elicited inward currents on the LVN neurons were not only partly blocked by selective OX,receptor antagonist SB334867 but also mimicked by selective OX receptor agonist[Ala,Z)-Leu]orexin -B,indicating that the orexin-A-induced excitation is mediated by both OX,an

关键词： orexin central orexmergic system lateral vestibular nucleus motor control cataplexy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

农业基因回路设计合成技术发展动态与策略

引用

中国农业科技导报 2022年第12期24卷 101-111页

作者：林敏王磊谷晓峰燕永亮刘柱涂涛姚斌河南大学农学院中原食品实验室河南开封475004 中国农业科学院生物技术研究所北京100081 海南大学生命科学学院海口570100 中国农业科学院北京畜牧兽医研究所北京100091

随着生物组学、系统生物学和合成生物学等前沿学科的高度交叉融合,推动新一代基因工程技术不断取得新突破。基因回路设计与合成是新一代基因工程的技术核心,具有颠覆性、智能性和精准性三大技术特征。加快农业生物基因回路设计与合成技... 详细信息

随着生物组学、系统生物学和合成生物学等前沿学科的高度交叉融合,推动新一代基因工程技术不断取得新突破。基因回路设计与合成是新一代基因工程的技术核心,具有颠覆性、智能性和精准性三大技术特征。加快农业生物基因回路设计与合成技术等创新,将为创制新一代农业生物新品种和促进我国农业高质量绿色发展提供重要技术支撑。简要总结了农业生物基因回路设计与合成技术国际发展动态,深入探讨了我国农业生物基因智能设计与精准表达技术的发展策略与优先领域。

关键词：农业生物基因回路智能设计精准表达生物合成

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fungal diversity notes 1611-1716: taxonomic and phylogenetic contributions on fungal genera and species emphasis in south china

引用

Fungal Diversity 2023年第5期122卷 161-403页

作者： Indunil C.Senanayake Walter Rossi Marco Leonardi Alex Weir Mark McHugh Kunhiraman C.Rajeshkumar Rajnish K.Verma Samantha C.Karunarathna Saowaluck Tibpromma Nikhil Ashtekar Sreejith K.Ashtamoorthy Sanjay Raveendran Gurmeet Kour Aishwarya Singh Saúl De la Peña-Lastra Antonio Mateos Miroslav Kolařík Vladimír Antonín HanaŠevčíková Fernando Esteve-Raventós Ellen Larsson Fermín Pancorbo Gabriel Moreno Alberto Altés Yolanda Turégano Tian-Ye Du Li Lu Qi-Rui Li Ji-Chuan Kang Sugantha Gunaseelan Kezhocuyi Kezo Malarvizhi Kaliyaperumal Jizhen Fu Milan C.Samarakoon Yusufjon Gafforov Shakhnoza Teshaboeva Pradeep C.Kunjan Arya Chamaparambath Adam Flakus Javier Etayo Pamela Rodriguez-Flakus Mikhail P.Zhurbenko Nimali Ide Silva Danushka S.Tennakoon KPDeepna Latha Patinjareveettil Manimohan KNAnil Raj Mark S.Calabon Abdollah Ahmadpour Zeinab Heidarian Zahra Alavi Fatemeh Alavi Youbert Ghosta Razmig Azizi Mei Luo Min-Ping Zhao Nuwan D.Kularathnage Li Hua Yun-Hui Yang Chun-Fang Liao Hai-Jun Zhao Anis S.Lestari Subashini C.Jayasiri Feng-Ming Yu lei lei Jian-Wei liu Omid Karimi Song-Ming Tang Ya-Ru Sun Yong wang Ming Zeng Zin H.Htet Benedetto T.Linaldeddu Artur Alves Alan J.L.Phillips Carlo Bregant Lucio Montecchio AndréDe Kesel Vincent P.Hustad Andrew N.Miller Anna G.Fedosova Viktor Kučera Mubashar Raza Muzammil Hussain Yan-Peng Chen Vinodhini Thiyagaraja Deecksha Gomdola Achala R.Rathnayaka Asha J.Dissanayake Nakarin Suwannarach Sinang Hongsanan Sajeewa S.N.Maharachchikumbura Lakmali S.Dissanayake Nalin N.Wijayawardene Rungtiwa Phookamsak Saisamorn Lumyong E.B.Gareth Jones Neelamanie Yapa Dhanushka N.Wanasinghe Ning Xie Mingkwan Doilom Ishara S.Manawasinghe Jian-Kui(Jack)liu Qi Zhao Biao Xu Kevin D.Hyde Jiage Song Innovative Institute for Plant Health/Key Laboratory of Green Prevention and Control On Fruits and Vegetables in South china Ministry of Agriculture and Rural AffairsZhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225GuangdongChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518055GuangdongChina Sect.Environmental sciences Department MeSVAUniversity of L’AquilaVia Vetoio67100 CoppitoAQItaly Department of Environmental Biology SUNY-ESF241 Illick Hall1 Forestry DriveSyracuseNY 13210USA National Fungal Culture Collection of India MACS Agharkar Research InstitutePuneMaharashtra 411004India Department of Plant Pathology Punjab Agricultural UniversityLudhianaPunjab 141004India Center for Yunnan Plateau biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanChina Department of Forest Ecology Kerala Forest Research InstitutePeechiThrissurKerala 680653India Department of Botany The American CollegeTallakkulamMaduraiTamil Nadu 625002India Department of Zoology Savitribai Phule Pune UniversityGaneshkhind RdGaneshkhindPuneMaharashtra 411007India university of Santiago de Compostela 15782 Santiago de CompostelaSpain Sociedad Micológica Extremeña C/Sagitario 1410001 CáceresSpain Institute of Microbiology of the Czech Academy of sciences Vídeňská108314220 Prague 4Czech Republic Department of Botany Moravian MuseumZelnýtrh 665937 BrnoCzech Republic Department of Life sciences(Botany Unit) University of Alcalá28805 Alcaláde HenaresMadridSpain biological and Enviromental sciences University of Gothemburgand Gothemburg Global Biodiversity CentreBox 46140530 GöteborgSweden Madrid Mycological Society Real Jardín BotánicoC/Claudio Moyano 128014 MadridSpain State Ke

This article is the 15th contribution in the Fungal Diversity Notes series,wherein 115 taxa from three phyla,nine classes,28 orders,48 families,and 64 genera are *** taxa described and illustrated in the present study include a new family,five new genera,61 new species,five new combinations,one synonym,one new variety and 31 records on new hosts or new geographical *** *** introduced and accommodated in *** new genera introduced in this study are Ageratinicola,Kevinia,Pseudomultiseptospora(Parabambusicolaceae),Marasmiellomycena,and Vizzinia(Porotheleaceae).Newly described species are Abrothallus altoandinus,Ageratinicola kunmingensis,Allocryptovalsa aceris,Allophoma yuccae,Apiospora cannae,***,***,Boeremia wisteriae,Calycina papaeana,Clypeo-coccum lichenostigmoides,Coniochaeta riskali-shoyakubovii,Cryphonectria kunmingensis,Diaporthe angustiapiculata,***,***,Diatrypella guangdongense,Dothiorella franceschinii,Endocalyx phoenicis,Epicoc-cum terminosporum,Fulvifomes karaiensis,***,Ganoderma ghatensis,Hysterobrevium baoshanense,Inocybe avellaneorosea,***,Jahnula oblonga,Kevinia lignicola,Kirschsteiniothelia guangdongensis,Laboulbenia caprina,***,***,***,***,***,***,***,***,Laccaria rubriporus,Lasiodiplodia morindae,Lyophyllum agnijum,Marasmiellomycena pseudoomphaliiformis,Melomastia beihaiensis,Nemania guangdongensis,Nigrograna thailandica,Nigrospora ficuum,Oxydothis chinensis,***,Petriella thailandica,Phaeoacremonium chinensis,Phialocephala chinensis,Phytophthora debattistii,Polyplosphaeria nigrospora,Pronectria loweniae,Seriascoma acutispora,Setoseptoria bambusae,Stictis anomianthi,Tarzetta tibetensis,Tarzetta urceolata,Tetraploa obpyriformis,Trichoglossum beninense,and Tricoderma *** provide an emendation for Urnula ailaoshanensis Agaricus duplocingulatoides *** i

关键词： Agaricomycetes Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Fungal diversity Geoglossomycetes Geographical distribution Host records Incertae sedis Laboulbeniomycetes Lecanoromycetes Leotiomycetes Novel taxa New combination Oomycota Peronosporea Pezizomycetes Phylogeny Sordariomycetes South Chinese fungi Taxonomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：