检索结果-南通市图书馆

Gefitinib(an EGFR tyrosine kinase inhibitor)plus anlotinib(an multikinase inhibitor)for untreated,EGFR-mutated,advanced non-small cell lung cancer(FL-ALTER):a multicenter phase III trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第9期9卷 4091-4102页

作者： hua-Qiang zhou Ya-Xiong zhang Gang Chen Qi-Tao yu hua zhang Guo-Wu Wu Di Wu Ying-Cheng lin jun-Fei Zhu jian-hua Chen xiao-hua Hu Bin Lan Ze-Qiang zhou hai-Feng lin Zi-Bing wang xiao-lin Lei Suo-Ming Pan li-Ming Chen jian zhang Tian-dong Kong Ji-Cheng Yao Xin Zheng Feng li li zhang Wen-Feng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Medical Oncology of Respirotary Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Urogenital Oncology the First People’s Hospital of FoshanFoshan 52800China Department of Medical Oncology Meizhou People’s Hospital(Huangtang Hospital)Meizhou 514031China Department of Respiratory and Critical Care Medicine Shenzhen people’s HospitalShenzhen 518020China Department of Medical Oncology of Respirotary Cancer Hospital of Shantou University Medical CollegeShantou 515031China Department of Respiratory and Critical Care Medicine Taizhou Central HospitalTaizhou 318000China Department of Medical Oncology Hunan Provincial Cancer HospitalChangsha 410031China Department of Medical Oncology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Cardiothoracic Surgery Shantou Central HospitalShantou 515031China Department of Oncology the 2nd People’s Hospital of ShenzhenShenzhen 518025China Department of Medical Oncology the Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450003China Department of Oncology Affiliated Hospital of Panzhihua UniversityPanzhihua 617099China Department of Radiotherapy Yuebei People’s HospitalShaoguan 512099China Department of Oncology the First Affiliated Hospital of Shantou University Medicine CollegeShantou 515041China Department of Oncology ZhuJiang Hospital of Southern Medical University(The Second Clinical Medical College)Guangzhou 510280China Department of Respiratory Oncology the Third People’s Hospital of ZhengzhouZhengzhou 450001China shanghai OrigiMed Co. LtdShanghaiChina

Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor(EGFR)signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted *** this phase 3 study(***:NCT04028778),315 patients with treatment-naïve,EGFR-mutated,advanced non-small cell lung cancer(NSCLC)were randomized(1:1)to receive anlotinib or placebo plus gefitinib once daily on days 1–14 per a 3-week *** the prespecified final analysis of progression-free survival(PFS),a significant improvement in PFS was observed for the anlotinib arm over the placebo arm(hazards ratio[HR]=0.64,95%CI,0.48–0.80,P=0.003).Particularly,patients with brain metastasis and those harboring EGFR amplification or high tumor mutation load gained significant more benefits in PFS from gefitinib plus *** incidence of grade 3 or higher treatment-emergent adverse events was 49.7%of the patients receiving gefitinib plus anlotinib versus 31.0%of the patients receiving gefitinib plus *** plus gefitinib significantly improves PFS in patients with treatment-naïve,EGFR-mutated,advanced NSCLC,with a manageable safety profile.

关键词： cancer lung treatment

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun jian-Wei Zhao Xue-Heng zhang li-Na Sheng Zhi-yu Sun Isao Tanihata Satoru Terashima Yong Zheng li-hua Zhu li-Min Duan liu-Chun He Rong-jiang Hu Guang-Shuai li Wen-jian lin Wei-Ping lin Chuan-Ye liu Zhong liu Chen-Gui Lu Xin-Wen Ma li-jun Mao Yi Tian Feng wang Meng wang Shi-Tao wang Jia-Wen Xia xiao-dong Xu Hu-shan Xu Zhi-Guo Xu jian-Cheng Yang Da-yu Yin You-jin yuan Wen-Long Zhan yu-Hu zhang xiao-Hong zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

Repair, protection and regeneration of peripheral nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第11期10卷 1777-1798页

作者： shan-lin Chen Zeng-gan Chen Hong-lian Dai jian-xun Ding Jia-song Guo Na Han Bao-guo jiang hua-jun jiang Juan li Shi-pu li Wen-jun li jing liu Yang liu jun-xiong Ma jiang Peng yun-dong Shen Guang-wei Sun Pei-fu Tang Gu-heng wang Xiang-hai wang liang-bi Xiang Ren-guo Xie jian-guang Xu Bin yu li-cheng zhang Pei-xun zhang Song-lin zhou Department of Hand Surgery Beijing Jishuitan Hospital Department of Orthopedic Surgery Zhongshan Hospital Fudan University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Biomedical Materials and Engineering Research Center of Hubei Province Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Department of Histology and Embryology Southern Medical University Key Laboratory of Tissue Construction and Detection of Guangdong Province Institute of Bone Biology Academy of Orthopedics Peking University People's Hospital Department of Orthopedics First Affiliated Hospital of Dalian Medical University The First Affiliated Hospital of Dalian Medical University Laboratory of Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Orthopedics General Hospital of Shenyang Military Area Command of Chinese PLA Rescue Center of Severe Wound and Trauma of Chinese PLA Institute of Orthopedics Chinese PLA General Hospital The Neural Regeneration Co-innovation Center of jiangsu Province Department of Hand Surgery Huashan Hospital Fudan University Department of Hand and Upper Extremity Surgery Jing’an District Centre Hospital Department of Orthopedics General Hospital of People's Liberation Army Department of Hand Surgery Affiliated Hospital of Nantong University Trauma Center Department of Orthopedic Surgery Shanghai First People’s Hospital Shanghai Jiao Tong University School of Medicine jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of Neuroregeneration Nantong University

Reading guide 1778Repair of long-segment peripheral nerve defects1779Bionic reconstruction of hand function after adult brachial plexus root avulsion1780Optimized design of regeneration material for the treatment of peripheral nerve injury1781Synergism of electroactive polymeric materials and electrical stimulation promotes peripheral nerve repair1783Schwann cell effect on peripheral nerve repair and regeneration .

关键词： cell protection and regeneration of peripheral nerve injury Repair

SAPT:a synchrotron-based proton therapy facility in shanghai

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-zhou zhang De-Ming li li-Ren Shen hai-Rong zhang Zhi-ling Chen Han-Wen Du Ming Gu Rui li De-Kang liu yue-Hu Pu jun-Feng yu jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang jiang Zhi-Qiang jiang lin jin Wen-jing li xiu-Fang li Ye lin Ming liu Yong-Hao liu Ya-Juan liu Ming Lv Qing-Ru Mi lian-hua Ouyang Wei-Guo Shi Hang Shu Qi-Sheng Tang Kun wang Zhi-shan wang jun Wu xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng yu Ren-Xian yuan Qi-Bing yuan hai-Qun zhang Miao zhang Wen-Zhi zhang li-Ying Zhao Wei-Min zhou Shou-Xian Fang Xi-dong Sun Zhen-Tang Zhao shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Genetic dissection of the grain-filling rate and related traits through linkage analysis and genome-wide association study in bread wheat

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2022年第10期21卷 2805-2817页

作者： yu hai-xia DUAN Xi-xian SUN Ai-qing SUN xiao-xiao zhang jing-juan SUN hua-qing SUN Yan-yan NING Tang-yuan TIAN Ji-chun wang dong-xue li Hao FAN Ke-xin wang Ai-ping MA Wu-jun CHEN jian-sheng State Key Laboratory of Crop Biology/Key Laboratory of Crop Water Physiology and Drought-tolerance Germplasm Improvement Minstry of Agriculture and Rural Affairs/Group of Wheat Quality BreedingCollege of AgronomyShandong Agricultural UniversityTai’an 271018P.R.China Dezhou Agricultural Protection and Technological Extension Center Dezhou 253000P.R.China Zhongnong Tiantai Seed Co. Ltd.Pingyi 273300P.R.China School of Veterinary and life Sciences Murdoch UniversityMurdochWA 6150Australia

Wheat grain yield is generally sink-limited during grain *** grain-filling rate(GFR)plays a vital role but is poorly studied due to the difficulty of phenotype *** study explored the grain-filling traits in a recombinant inbred population and wheat collection using two highly saturated genetic maps for linkage analysis and genome-wide association study(GWAS).Seventeen stable additive quantitative trait loci(QTLs)were identified on chromosomes 1B,4B,and *** linkage interval between IWB19555 and IWB56078 showed pleiotropic effects on GFR_(1),GFR_(max),kernel length(KL),kernel width(KW),kernel thickness(KT),and thousand kernel weight(TKW),with the phenotypic variation explained(PVE)ranging from 13.38%(KW)to 33.69%(TKW).198 significant marker-trait associations(MTAs)were distributed across most chromosomes except for 3D and *** major associated sites for GFR included IWB44469(11.27%),IWB8156(12.56%)and IWB24812(14.46%).linkage analysis suggested that IWB35850,identified through GWAS,was located in approximately the same region as QGFR_(max)2B.3-11,where two high-confidence candidate genes were *** important grain weight(GW)-related QTLs colocalized with grain-filling *** findings contribute to understanding the genetic architecture of the GFR and provide a basic approach to predict candidate genes for grain yield trait QTLs.

关键词： wheat grain-filling rate linkage analysis genome-wide association study

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun liu Dan-Dan li Wei dong yu-Qi liu Yang Wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi hua jing-yu He jun li Bai Du Ting-hai Du lin-lin Niu Xue-jun jiang Bo Cui jiang-Bin Chen Yang-Gan wang hai-Rong wang Qin yu jing He Yi-lin Mao xiao-Fang Bin yue Deng yu-Dan Tian Qing-hua Han Da-jin liu li-Qin Duan Ming-jun Zhao Cui-Ying zhang hai-Ying Dai Ze-hua li Ying xiao You-Zhi Hu xiao-yu huang Kun Xing Xin jiang Chao-Feng liu jing An Feng-Chun li Tao Tao jin-Fa jiang Ying Yang Yao-Rong dong Lei zhang Guang Fu Ying li Shu-Wei huang li-Ping Dou Lan-jun Sun Ying-Qiang Zhao Jie li yun Xia jun liu Fan liu Wen-jin He Ying li jian-Cong Tan Yang lin Ya-Bin zhou jian-Fei Yang Guo-Qing Ma Hui-jun Chen He-Ping liu Zong-Wu liu jian-Xiong liu xiao-Jia Luo xiao-Hong Bin Ya-Nan yu hai-Xia Dang Bing li Fei Teng wang-Min Qiao xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan wang yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU dong shan CHEN Ren Bo SHI Nan Nan liU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI jiang Feng CHEN Hong CHEN li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU yun Hong huaNG jin huaNG Qiu hua huaNG Shao Zhen JI liang jin hai Hao LEI xiao li Chun Yan li Min Qing li Qun Tang li Xian Yong liU Hong De liU jin Ping liU zhang MA yu Ting MAO Ya MO liu Fen NA Hui wang jing Wei SONG Fang li SUN Sheng wang dong Ting wang Ming Xuan wang xiao Yan wang Yin Zhen wang yu dong WU Wei WU Lan Ping xiao Yan hua XIE hai jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai jun yuAN Sheng li zhang Gong Qi zhang jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai zhou Ying Chun ZHU jun Teng ZHU Tian Qing zhang hua Min wang Yan Ping wang Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-Jie li Wen-xiao Tu xiao-Chun wang Guo-Qing Shi Zun-dong Yin hai-jun Su Tao Shen Da-Peng zhang jian-dong li shan Lv Chun-li Cao Rui-Qian Xie Hong-zhou Lu Rong-Meng jiang Zheng Cao Zhi-Jie An Lei-Lei li Jie Xu Yan-Wen Xiong Wei Zang Wei zhang Hong-Wei zhang Wen-Sen Chen hua ling Wen Xu jian Cai huan-jin Luo Xue-Sheng Xing Can-jun Zheng Qiang Wei Xin-Xu li Mei li hai jiang li-Quan Deng Ming-Quan Chen Xiang Huo Feng Xu Xue-Hui Lai Xi-Chen Bai Long-Jie Ye jian-Yi Yao Wen-Wu Yin Jiao-jin Sun lin xiao Fu-Qiang liu xiao-Qiang liu Hong-Wei Fan Zeng-Qiang Kou Ji-Kun zhou Hao zhang Da-Xin Ni Thomas TSamba Qun li Hong-Jie yu yu wang xiao-Feng liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Health Education BeijingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Chongqing Municipal Center for Disease Control and Prevention ChongqingChina yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： hai-dong Zhu hai-liang li Ming-Sheng huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong jun-Hui Sun Zhi-Cheng jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui li jin-hua huang Wei Mu shan-Zhi Gu Jia-Ping li Hui Zhao Shu-Wei Wen Yan-Ming Lei yu-Sheng Song Chun-wang yuan Wei-dong wang Ming huang Wei Zhao jian-Bing Wu Song wang Xu Zhu jian-jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan hai-Lan lin Zi-Shu zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang jin-Wei Zhao Ai-Bing Xu jian Xu Qing-hua Wu huan-zhang Niu jian wang Feng Dai Dui-Ping Feng Qing-dong li Rong-Shu Shi Jia-Rui li Guang Yang hai-Bin Shi jian-Song Ji yu-E liu Zheng Cai Po Yang Yang Zhao xiao-li Zhu li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching