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肺纤维化脂质代谢研究概况

中国药理学通报 2024年第9期40卷 1612-1616页

作者：王靖颖徐泳许伟辰谢彤时晨单进军南京中医药大学儿童健康与中医药江苏省高校重点实验室江苏南京210023 南京中医药大学医学代谢组学中心江苏南京210023 南京中医药大学中西医结合学院江苏南京210023

肺纤维化是一种预后较差的弥漫性、间质性肺病,其发病机制尚未完全明确。脂质作为构成细胞结构以及参与信号转导的一类关键成分,对维持肺部功能起着重要作用。越来越多的研究表明,脂质变化与肺纤维化的进展密切相关。该文对脂质组学在... 详细信息

肺纤维化是一种预后较差的弥漫性、间质性肺病,其发病机制尚未完全明确。脂质作为构成细胞结构以及参与信号转导的一类关键成分,对维持肺部功能起着重要作用。越来越多的研究表明,脂质变化与肺纤维化的进展密切相关。该文对脂质组学在肺纤维化中的研究进展,以及各类脂质在肺纤维化中的作用进行简要概述。

关键词：肺纤维化脂质代谢脂质组学甘油磷脂特发性肺纤维化脂肪酸

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新形势下我国低碳钢材需求分析与发展建议

冶金经济与管理 2024年第3期 25-28页

作者：卢宇迪王晶莹冶金工业规划研究院北京100013

在我国钢铁行业发展环境和消费需求的新变化和新形势下,绿色、低碳、高质量成为发展新主题,市场需求进入减量调整期,房地产领域消费需求快速下滑,但新兴产业需求明显增长,低碳消费成为市场新动能。根据我国低碳钢材发展现状和典型供给... 详细信息

在我国钢铁行业发展环境和消费需求的新变化和新形势下,绿色、低碳、高质量成为发展新主题,市场需求进入减量调整期,房地产领域消费需求快速下滑,但新兴产业需求明显增长,低碳消费成为市场新动能。根据我国低碳钢材发展现状和典型供给案例分析,结合国际、国内政策导向,判断低碳钢材在打破国际贸易壁垒、支撑“碳达峰”“碳中和”战略实施、引导消费升级等方面具有重要意义,但也存在碳足迹工作基础薄弱、低碳消费需求不足、标准体系亟待完善等问题;从政府、企业层面,针对未来低碳钢材的推广应用,提出有关建议。

关键词：新形势低碳钢材低碳消费标准体系

透过宏观经济形势看2024年我国成品钢表观消费量

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冶金经济与管理 2024年第2期 4-6页

作者：王晶莹卢宇迪周勋冶金工业规划研究院北京100013

钢铁工业是实体经济的筋骨,在我国经济发展过程中起着重要作用。同样,宏观经济形势的变化对我国钢铁工业亦有深刻的影响。在此背景下,通过建立多元线性回归模型进行评估、检验和优化,得到回归系数和截距;根据该模型计算结果,认为我国成... 详细信息

钢铁工业是实体经济的筋骨,在我国经济发展过程中起着重要作用。同样,宏观经济形势的变化对我国钢铁工业亦有深刻的影响。在此背景下,通过建立多元线性回归模型进行评估、检验和优化,得到回归系数和截距;根据该模型计算结果,认为我国成品钢表观消费量将保持边际放缓的趋势,并就此提出钢铁行业应抓住结构性机会等建议。

关键词：宏观经济成品钢表观消费量多元线性回归预测

A decoupled procedure for convection-radiation simulation in scramjets

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Science China(Technological Sciences) 2014年第12期57卷 2551-2566页

作者： wang jing ying GAO Zhen Xun LEE Chun Hian ZHANG Hui Qiang School of Aeronautical Science and Engineering Beihang University School of Aerospace Tsinghua University

Following an order analysis of key parameters, a decoupled procedure for simulation of convection-radiation heat transfer problems in supersonic combustion ramjet(scramjet) engine was developed. The radiation module of the procedure consisted of Perry 5GG weighted sum gray gases model for spectral property calculation and discrete ordinates method S4 scheme for radiative transfer computation, while the flow field was computed using the Favrè average conservative Navier-Stokes(N-S) equations, in conjunction with Menter's k-ω SST two-equation model. A series of 2D supersonic nonreactive turbulent channel flows of radiative participants with selective parameters were simulated for validation purpose. Radiative characteristics in DLR hydrogen fueled and NASA SCHOLAR ethylene fueled scramjets were numerically studied using the developed procedure. The results indicated that the variations of spatial distributions of the radiative source and total absorption coefficient are highly consistent with those of the temperature and radiative participants, while the spatial distribution of the incident radiation spreads wider. It also demonstrated that the convective heating is significantly affected by the complexity of the flow field, such as the shock wave/boundary layer interactions, while the radiative heating is simply an integral effect of the whole flow field. Although the radiative heating in the combustion chambers reaches a certain level, an order of magnitude of 10 k W/m2, it still contributes little to the total heat transfer(<7%).

关键词： scramjet radiative heating convective heating turbulent combustion decoupled procedure

Development of Fixture Layout Optimization for Thin-Walled Parts:A Review

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 15-39页

作者： Changhui Liu jing wang Binghai Zhou Jianbo Yu ying Zheng Jianfeng Liu School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Jiaotong University Shanghai 200240China Shanghai Waigaoqiao Shipbuilding Co. Ltd.Shanghai 200137China

An increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past ***,few papers systematically review these *** analyzing existing literature,this paper summarizes the process of fixture layout optimization and the methods *** process of optimization is made up of optimization objective setting,assembly variation/deformation modeling,and fixture layout *** paper makes a review of the fixture layout for thin-walled parts according to these three ***,two different kinds of optimization objectives are *** usually consider in-plane variations or out-of-plane deformations when designing ***,modeling methods for assembly variation and deformation are divided into two categories:Mechanism-based and data-based *** common methods are discussed *** that,optimization algorithms are reviewed *** are two kinds of optimization algorithms:Traditional nonlinear programming and heuristic ***,discussions on the current situation are *** research direction of fixture layout optimization in the future is discussed from three aspects:Objective setting,improving modeling accuracy and optimization ***,a new research point for fixture layout optimization is *** paper systematically reviews the research on fixture layout optimization for thin-walled parts,and provides a reference for future research in this field.

关键词： Thin-walled parts Assembly quality Fixture layout optimization Modeling methods Optimization algorithms

Optimization of Fixture Number in Large Thin-Walled Parts Assembly Based on IPSO

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 213-227页

作者： Changhui Liu jing wang ying Zheng Ke Jin Jianbo Yu Jianfeng Liu School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Jiaotong University Shanghai 200240China Shanghai Waigaoqiao Shipbuilding Co. Ltd.Shanghai 200137China

There are lots of researches on fixture layout optimization for large thin-walled *** researches focus on the positioning problem,i.e.,optimizing the positions of a constant number of ***,how to determine the number of fixtures is *** most cases,the number of fixtures located on large thin-walled parts is determined based on engineering experience,which leads to huge fixture number and extra ***,this paper constructs an optimization model to minimize the number of *** constraints are set in the optimization model to ensure that the part deformation is within the surface profile *** addition,the assembly gap between two parts is also *** conduct the optimization,this paper develops an improved particle swarm optimization(IPSO)algorithm by integrating the shrinkage factor and adaptive inertia *** the algorithm,particles are encoded according to the fixture *** dimension of the particle is assigned to a sub-region by constraining the optional position range of each fixture to improve the optimization ***,a case study on ship curved panel assembly is provided to prove that our method can optimize the number of fixtures while meeting the assembly quality *** research proposes a method to optimize the number of fixtures,which can reduce the number of fixtures and achieve deformation control at the same time.

关键词： Assembly quality Large thin-walled parts Fixture layout PSO FEM

基于物理情境的九年级学生科学思维测试工具编制及验证

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教学研究 2024年第4期47卷 10-16页

作者：田雪葳尹子娟刘文科王晶莹青岛大学师范学院山东青岛266017 北京师范大学教育学部北京100875

科学思维是2022版新课程标准中核心素养的重要组成部分。为评估九年级学生的科学思维能力,特设计了一套测评工具,并基于Rasch模型从评分者信度、单维性、试题评分结构、试题拟合度、分离度、误差统计、怀特图等方面评估工具的整体质量... 详细信息

科学思维是2022版新课程标准中核心素养的重要组成部分。为评估九年级学生的科学思维能力,特设计了一套测评工具,并基于Rasch模型从评分者信度、单维性、试题评分结构、试题拟合度、分离度、误差统计、怀特图等方面评估工具的整体质量。经分析,测评工具整体信效度较高,试题拟合度和分离度符合要求,误差在可接受范围内。怀特图的分析结果显示,学生们的科学思维水平普遍有待提高。总体上看,这套测评工具符合要求,可信度比较强。基于Rasch模型的测试质量分析也为进一步优化测试工具提供了参考。

关键词：科学思维质量分析九年级学生 Rasch模型

Dynamic properties of rumor propagation model induced by L´evy noise on social networks

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Chinese Physics B 2024年第9期33卷 223-237页

作者： ying jing Youguo wang Qiqing Zhai Xianli Sun School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China

Social networks are inevitably subject to disruptions from the physical world,such as sudden internet outages that sever local connections and impede information *** Gaussian white noise,commonly used to simulate stochastic disruptions,only fluctuates within a narrow range around its mean and fails to capture large-scale variations,L´evy noise can effectively compensate for this ***,a susceptible–infected–removed rumor propagation model with L´evy noise is constructed on homogeneous and heterogeneous networks,***,the existence of a global positive solution and the asymptotic path-wise of the solution are derived on heterogeneous networks,and the sufficient conditions of rumor extinction and persistence are ***,theoretical results are verified through numerical calculations and the sensitivity analysis related to the threshold is conducted on the model *** simulation experiments on Watts–Strogatz(WS)and Barab´asi–Albert networks,it is found that the addition of noise can inhibit the spread of rumors,resulting in a stochastic resonance phenomenon,and the optimal noise intensity is obtained on the WS *** validity of the model is verified on three real datasets by particle swarm optimization algorithm.

关键词： rumor propagation model L´evy noise extinction and persistence stochastic resonance

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： jing-jing Yang ying-Xin Liu Yan-Fang wang Bi-ying Ge ying wang Qing-Shan wang Sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong Sheng-Ming Yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose