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Chinese Science Bulletin 2007年第21期52卷 2919-2924页

作者： wang jing he shiying xu lina gu ning Jiangsu Laboratory for Biomaterials and Devices National Laboratory of Molecular and Biomolecular Electronics Department ofBiological Science and Medical Engineering Southeast University Nanjing 210096 China

Recently bacterial cells have become attractive biological templates for the fabrication of metal nano- structures or nanomaterials due to their inherent small size, various standard geometrical shapes and abundant source. In this paper, nickel-coated bacterial cells (gram-negative bacteria of Escherichia coli) were fabricated via electroless chemical plating. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) characterization results reveal evident morphological difference between bacterial cells before and after deposition with nickel. The bare cells with smooth surface presented transverse outspreading effect at mica surface. Great changes took place in surface roughness for those bacterial cells after metallization. A large number of nickel nanoparticles were observed to be equably distributed at bacterial surface after activation and subsequent metallization. Furthermore, ultra thin section analytic results validated the presence and uniformity of thin nickel coating at bacte- rial surface after metallization.

关键词：原子粒显微镜电子显微镜金属化细菌细胞

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao wang Xiang‑Biao Qiu jing‑Wen Li Wei xu Tao Li Ze‑Bin Lin Chang‑Jun ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong Zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao gu Chang‑Cai Han Zi‑Jie Han guo‑Zhu he Yong‑Cheng he Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑guang Wu xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao wang jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun ning Kai Pan Wei xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao gu Chang‑Cai Han Zi‑Jie Han guo‑Zhu he Yong‑Cheng he Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑guang Wu xuan Wu Cong Xia Yong‑Ji Yu guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-12页

作者： wang, Jin-Cheng Ren, Jie Jiang, Wei Ruan, Xi-Chao Liu, Ying-Yi Yang, Hao-Lan xu, Kuo-Zhi Pan, Xin-Yi Sun, Qi Bao, Jie Huang, Han-Xiong Bai, Hao-Fan Bai, Jiang-Bo Cao, Ping Chen, Qi-Ping Chen, Yong-Hao Duan, Wen-Hao Fan, An-Chuan Fan, Rui-Rui Feng, Chang-Qing gu, Min-Hao Han, Chang-Cai Han, Zi-Jie he, guo-Zhu he, Yong-Cheng Hong, Yang Hu, Yi-Wei Jiang, Zhi-Jie Kang, Ling Lan, Chang-Lin Li, Bo Li, Feng Li, Qiang Li, Xiao Li, Yang Liu, Jie Liu, Rong Liu, Shu-Bin Liu, Yi-Na Luan, guang-Yuan ning, Chang-Jun Qiu, Yi-Jia Ren, Wen-Kai Ren, Zhi-Zhou Song, Zhao-Hui Sun, Kang Tan, Zhi-Xin Tang, jing-Yu Tang, Sheng-Da wang, Li-Jiao wang, Peng-Cheng wang, Zhao-Hui Wen, Zhong-Wei Wu, Xiao-guang Wu, xuan Wu, Ze-Peng Xia, Cong Xie, Li-Kun Yi, Han Yu, Tao Yu, Yong-Ji Zhang, guo-Hui Zhang, Hang-Chang Zhang, Qi-Wei Zhang, Xian-Peng Zhang, Yu-Liang Zhang, Zhi-Yong Zhao, Mao-Yuan Zhou, Zhi-Hao Zhu, Ke-Jun Zou, Chong China Inst Atom Energy Key Lab Nucl Data Beijing 102413 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Spallat Neutron Source Sci Ctr Dongguan 523803 Peoples R China Chinese Acad Sci Inst High Energy Phys State Key Lab Particle Detect & Elect Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Peking Univ Sch Phys State Key Lab Nucl Phys & Technol Beijing 100871 Peoples R China Fudan Univ Inst Modern Phys Shanghai 200433 Peoples R China Univ Sci & Technol China State Key Lab Particle Detect & Elect Hefei 230026 Peoples R China Univ Sci & Technol China Sch Nucl Sci & Technol Hefei 230026 Peoples R China Univ Sci & Technol China Dept Modern Phys Hefei 230026 Peoples R China China Acad Engn Phys Inst Nucl Phys & Chem Mianyang 621900 Peoples R China Univ Sci & Technol China USTC Archaeometry Lab Hefei 230026 Peoples R China Northwest Inst Nucl Technol Xian 710024 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Univ Sci & Technol China Inst Adv Technol Hefei 230027 Peoples R China

The back-streaming white-neutron beamline (Back-n) of the China Spallation Neutron Source is an essential neutron- research platform built for the study of nuclear data, neutron physics, and neutron applications. Many types of cross-sectional neutron-reaction measurements have been performed at Back-n since early 2018. These measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron beam. These gamma rays, commonly referred to as in-beam gamma rays, can induce a non-negligible experimental background in neutron-reaction measurements. Studying the characteristics of in-beam gamma rays is important for understanding the experimental background. However, measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons; thus, discriminating between neutron-induced signals and those from in-beam gamma rays is difficult. In this study, we propose the use of the black resonance filter method and a CeBr3 scintillation detector to measure the characteristics of the in-beam gamma rays of Back-n. Four types of black resonance filters, Ta-181, Co-59, Ag-nat, and Cd-nat, were used in this measurement. The time-of-flight (TOF) technique was used to select the detector signals remaining in the absorption region of the TOF spectra, which were mainly induced by in-beam gamma rays. The energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr3 scintillation detector and using Monte Carlo simulations. Based on the results of this study, the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated, which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n Black filter resonance technique In-beam gamma rays Back-n CeBr3 scintillator Black filter resonance technique C6D6 DETECTOR SYSTEM LINE

Self-assembly of Gold Nanoparticle Chains between Nanoelectrodes

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Chinese Chemical Letters 2006年第6期17卷 845-847页

作者： ning gu Jian Hui LIAO Lan HUANG Zhi Rui guO Wei YU Li Na xu jing wang Key Laboratory of Molecular and Biomolecular Electronics Department of Biological Science and Medical Engineering Southeast University Nanjing 210096

A novel strategy has been developed for construction of nanoparticle chains between nanoelectrodes with bifunctional molecules by taking advantage of linear aggregation of colloidal particles in organis solvents. As confirmed by scanning electron microscopy （SEM）,an individual nanoparticle chain bridged the electrode pair. The present approach makes this technique to be cheap and may be applicable in microelectronic industry.

关键词： Self-assembly nanoparticle chain nanoelectrode.

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儿童食物过敏临床特点分析

中国现代医生 2024年第27期62卷 70-74页

作者：于桂花杨宁谷明月石小娟赵静苏然陈孟利徐友宁王美燕周婷北京市昌平区医院儿科北京102200

目的调查北京市昌平区儿童食物过敏情况,探讨过敏性家族史、性别、分娩方式对儿童食物过敏的影响,不同年龄段食物过敏的分布,本地区容易导致食物过敏的种类、食物过敏共患疾病。方法选取2023年4月至11月就诊于北京市昌平区医院儿科门急... 详细信息

目的调查北京市昌平区儿童食物过敏情况,探讨过敏性家族史、性别、分娩方式对儿童食物过敏的影响,不同年龄段食物过敏的分布,本地区容易导致食物过敏的种类、食物过敏共患疾病。方法选取2023年4月至11月就诊于北京市昌平区医院儿科门急诊及住院的0~14岁儿童515例。采用免疫印迹法对患儿血清进行特异性免疫球蛋白E检测,采用SPSS26.0统计学软件对性别、分娩方式非参数进行二项式检验;采用Excel自定义函数对过敏性家族史、不同年龄组人数及各组过敏食物频次进行统计;用自编小程序对共患过敏性疾病组合进行统计。结果(1)男童食物过敏人数(306例)多于女童(209例),差异有统计学意义(P<0.05)。(2)父母均无过敏性疾病史的患儿109例,占总病例数的21.17%;父母至少一方有过敏性家族史的共406例,占总病例数的78.83%。其中228例(44.27%)父母一方有过敏史,178例(34.56%)父母双方均有过敏史。(3)515例食物过敏原阳性儿童中,婴儿期10例(1.94%),幼儿期37例(7.19%),学龄前期235例(45.63%),学龄期192例(37.28%),青春期41例(7.96%)。食物过敏原阳性率最高的是牛奶(444次),其次是鸡蛋白(70次)、腰果(57次)、蟹(37次)、牛肉(26次)、杧果(24次)、虾(21次)、菠萝(6次)、贝(1次)。牛奶蛋白在各年龄段中均为最主要的过敏原。(4)515例食物过敏患儿中,单一食物过敏399例,占77.47%;多重食物过敏(2种及2种以上食物过敏)116例,占22.53%。(5)食物过敏合并疾病以食物过敏相关消化道疾病合并过敏性鼻炎为最多,共267例;其次为过敏性鼻炎合并慢性咳嗽(共192例)、食物过敏性相关消化道疾病合并慢性咳嗽(共124例)。结论14岁及以下儿童中,牛奶是食物过敏的主要致敏原,食物过敏患儿以胃肠道症状最常见。

关键词：食物过敏儿童特异性免疫球蛋白E 过敏原

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen xun Chen xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Toward Earth system modeling with resolved clouds and ocean submesoscales on heterogeneous many-core HPCs

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National Science Review 2023年第6期10卷 153-167页

作者： Shaoqing Zhang Shiming xu Haohuan Fu Lixin Wu Zhao Liu Yang Gao Chun Zhao Wubing Wan Lingfeng Wan Haitian Lu Chenling Li Yanfei Liu Xiaojing Lv Jiayu Xie Yangyang Yu Jun gu xuantong wang Yan Zhang Chenhui ning Yunlong Fei Xiuwen guo Zhaoying wang xue wang Zhenming wang Binglin Qu Mingkui Li Haoran Zhao Yingjing Jiang guang Yang Lv Lu Hong wang Hong An Xin Zhang Yu Zhang Wentao Ma Fujiang Yu jing xu Xiaopei Lin xueshun Shen Key Laboratory of Physical Oceanography Ministry of Education/Institute for Advanced Ocean Study/Frontiers Science Center for Deep Ocean Multispheres and Earth System (DOMES) College of Oceanic and Atmospheric Sciences Ocean University of China Laoshan Laboratory Ministry of Education Key Lab for Earth System Modeling and Department of Earth System Science Tsinghua University National Supercomputing Center in Wuxi Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Environment and Ecology Ministry of Education Ocean University of China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of China School of Computer Science and Technology University of Science and Technology of China CEAKJ ADPRhexa Inc. National Marine Environmental Forecasting Center State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography Ministry of Natural Resources Chinese Academy of Meteorological Sciences The Center of Earth System Modeling and Prediction China Meteorological Administration

With the aid of the newly developed ’Sunway’ heterogeneous-architecture supercomputer,which has world-leading HPC(high-performance computer) capability,a series of high-resolution coupled Earth system models(SW-HRESMs) with up to 5 km of atmosphere and 3 km of ocean have been *** models can meet the needs of multiscale interaction studies with different computational *** we describe the progress of SW-HRESMs development,with an overview of the major advancements made by the international Earth science community in *** also show the preliminary results of SW-HRESMs with regard to capturing major weather-climate extremes in the atmosphere and ocean,stressing the importance of permitted clouds and ocean submesoscale eddies in modeling tropical cyclones and eddy-mean flow interactions,and paving the way for further model development to resolve finer scales with even higher resolution and more realistic ***,in addition to increasing model resolution,the development procedure for a non-hydrostatic cloud and ocean submesoscale resolved ESM is discusse d,laying out the major scientific directions of such a huge modeling advancement.

关键词： high-resolution Earth system models heterogeneous supercomputer cloud and submesoscale resolving weather-climate extremes finer cross-scale interactions

A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

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Journal of Molecular Cell Biology 2022年第2期14卷 56-71页

作者： Lianju Qin jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai jing guo Qiang wang Bin Sun Yifei Ge Chun Ouyang xueqiang xu jing wang Yaoyu Huang Hongqing Cui jing Zhou Meilian wang Zhonglan Su Yan Lu Di Wu jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng gu Xiaojun Zhuang Xiaolin Lv Hui wang Yanyan Pan Ling wang Xianrong xu jing Zhao Xiuqin wang Cuiping Liu ningxia Liang Changying Xing Jiayin Liu ningning wang State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Rheumatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Dermatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Burn and Plastic Surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Infection The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Anesthesiology and Pain Management The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First People’s Hospital of LianyungangLianyungang 222061China Department of Nephrology Northern Jiangsu People’s HospitalYangzhou 225001China Department of General Medicine Geriatric Hospital of Nanjing Medical UniversityNanjing 210024China Department of Nephrology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical Uni

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven ***,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified *** of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was *** release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were *** further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude *** the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the *** followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear *** biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged *** infusion or local treatment-related adverse events ***,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.

关键词： calciphylaxis chronic kidney disease vascular calcification multidisciplinary rescue human amnion-derived mesenchymal stem cells preclinical research regenerative medicine

The Effect of PCDH15 Gene Variations on the Risk of Noise-induced hearing Loss in a Chinese Population

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Biomedical and Environmental Sciences 2017年第2期30卷 143-146页

作者： xu Xiang Rong wang jing jing YANG Qiu Yue JIAO Jie he Li Hua YU Shan Fa gu gui Zhen CheN guo Shun ZHOU Wen Hui WU Hui LI Yan Hong ZHANG Huan Ling ZHANG Zeng Rui JIN Xian ning Department of Occupational and Environmental health School of Public HealthPeking University Health Science CenterBeijing 100191China National Center of Occupational Safety and health Beijing 102308China henan Provincial Institute for Occupational health Zhengzhou 450052HenanChina Wugang Institute for Occupational health Wugang 462500HenanChina

Noise-induced hearing loss （NIHL） is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 （PCDH15） und... 详细信息

关键词：基因人口听觉丧失噪声性亚洲大陆世系人群胰岛素