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Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, china

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Biomedical and Environmental Sciences 2020年第5期33卷 306-314页

作者： DONG Shi Rui HAN Ya jing WU jing zeng Cheng Li ZHU Ke Hui CHEN Xiao jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan wang Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei wang Huan Yu GUO Shu jing Chun Xia YANG Guang department of Pathogen Biology School of MedicineJinan UniversityGuangzhou 510632GuangdongChina Guangdong Key Laboratory of Environmental Pollution and Health Jinan UniversityGuangzhou 510632GuangdongChina Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655GuangdongChina department of Epidemiology School of MedicineJinan UniversityGuangzhou 510632GuangdongChina Zhuhai Precision Medical Center Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai 519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou 510632GuangdongChina department of Viral Encephalitis National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The Key Laboratory for Virology of Guangzhou College of Life Science and TechnologyJinan UniversityGuangzhou 510632GuangdongChina

Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very *** study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in *** In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h *** 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput *** Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in *** In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics.

关键词： china. Guangzhou Particulate

Theoretical Simulation on a Nonlinear Photonics Process of Er(1%)Yb(8%):FOV Oxyfluoride Nanophase Vitroceramics

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Communications in Computational physics 2010年第3期7卷 580-596页

作者： Ce wang Xiaobo Chen Gregory J.Salamo Naruhito Sawanobori Chenjuan He Hongyu Zhou Hongmei jing Yongzhi zeng Song Li Xiaoling Xu Applied Optics beijing Area Major Laboratory Beijing Normal UniversityBeijing100875China Applied Optics beijing Area Major Laboratory Department of Physics&Material CollegeBeijing Normal UniversityBeijing100875China department of physics University ArkansasFayettevilleAR 72701USA Sumita Optical Glass Inc.4-7-25 HarigayaUrawaSaitama338Japan department of physics Fuzhou UniversityFuzhouFujian350002China

We numerically simulate a photonics phenomenon of what we call intensity inversion between red and green fluorescence in oxyfluoride nanophase vitroceramics Er(1%)Yb(8%):FOV through the integration of whole fluorescence’s *** found that it is essential to introduce a coefficient presenting the difference between the Stokes energy transfer and anti-Stokes energy transfer processes in nano-material when calculating the energy transfer *** this consideration,and with the total crystallized volume ratio set to be 17.6%,the simulation results of the population probabilities values of all energy levels of Er^(3+) ion are coincident with the experimental result perfectly.

关键词： Energy transfer theoretical simulation Stokes and anti-Stokes processes rare earth ions oxyfluoride nanophase vitroceramics

信息化麻醉质控指标上报体系在麻醉质控管理中的应用

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麻醉安全与质控 2024年第1期6卷 28-31页

作者：韩彬杜海明张静周阳王军曾鸿郭向阳韩永正北京大学第三医院麻醉科北京100191 北京市临床麻醉质量控制和改进中心北京100191

目的探讨运用信息化麻醉质控指标上报体系优化围术期麻醉质控管理工作,提高麻醉科医疗安全与质控管理水平。方法针对麻醉质控专员进行信息化麻醉质控指标上报系统的培训,分发调查问卷并进行分析,对质控指标实行动态管理,探讨信息化麻醉... 详细信息

目的探讨运用信息化麻醉质控指标上报体系优化围术期麻醉质控管理工作,提高麻醉科医疗安全与质控管理水平。方法针对麻醉质控专员进行信息化麻醉质控指标上报系统的培训,分发调查问卷并进行分析,对质控指标实行动态管理,探讨信息化麻醉质控指标上报系统在麻醉质控管理领域的应用。结果北京市辖区内159名麻醉质控专员接受信息化麻醉质控指标上报系统的培训,共发放问卷159份,回收有效问卷157份,质控专员对系统培训相关内容满意度较高。临床麻醉质量核心控制指标由最初的17项增加至40项,使用信息化麻醉质控指标上报系统可显著提高质控数据的真实性,数据上报率显著升高。结论通过信息化质控指标上报体系的运用,有助于快速达到麻醉质控标准化管理、提高临床麻醉安全、强化医疗服务的目的,确保患者围术期安全。

关键词：麻醉质控质控指标上报系统质控管理

Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection

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World Journal of Gastroenterology 2021年第37期27卷 6248-6261页

作者： jing-jing Nie Ya-Ya Pian Ji-Hong Hu Guo-Qing Fan Lv-Tao zeng Qiu-Geng Ouyang Zhen-Xiang Gao Zhen Liu Chen-Chen wang Qian Liu Jian-Ping Cai department of Microbiology National Center for Clinical LaboratoriesBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyNational Health CommissionInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Pharmacy Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Shigella flexneri(***)is a major pathogen causing acute intestinal infection,but the systematic oxidative damage incurred during the course of infection has not been *** To investigate the incurred systemic RNA oxidative damage and the diagnostic value of RNA oxidative metabolites during ***-induced intestinal *** In this study,a Sprague-Dawley rat model of acute intestinal infection was established by oral gavage with *** *** changes in white blood cells(WBCs)and cytokine levels in blood and the inflammatory response in the colon were *** also detected the RNA and DNA oxidation in urine and *** *** infection induced an increase in WBCs,C-reactive protein,interleukin(IL)-6,IL-10,IL-1β,IL-4,IL-17a,IL-10,and tumor necrosis factorα(TNF-α)in *** note,a significant increase in urinary 8-oxo-7,8-dihydroguanosine(8-oxo-Gsn),an important marker of total RNA oxidation,was detected after intestinal infection(P=0.03).The urinary 8-oxo-Gsn level returned to the baseline level after recovery from *** addition,the results of a correlation analysis showed that urinary 8-oxo-Gsn was positively correlated with the WBC count and the cytokines IL-6,TNF-α,IL-10,IL-1β,and IL-17α.Further detection of the oxidation in different tissues showed that *** infection induced RNA oxidative damage in the colon,ileum,liver,spleen,and *** Acute infection induced by *** causes increased RNA oxidative damage in various tissues(liver,spleen,and brain)and an increase of 8-oxo-Gsn,a urinary *** 8-oxo-Gsn may be useful as a biomarker for evaluating the severity and prognosis of infection.

关键词： 8-oxo-7,8-dihydroguanosine Shigella flexneri Infection Oxidative damage

Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau

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Science china(Life Sciences) 2023年第7期66卷 1554-1568页

作者： Liandong Yang Ning Sun Honghui zeng Ying wang Wenjun Chen Zufa Ding Yang Liu jing wang Minghui Meng Yanjun Shen jingliang Kang Xiuhui Ma Wenqi Lv Juan Chen Axel Meyer Baocheng Guo Shunping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan430072China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing100101China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXining810016China Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin School of Life SciencesJianghan UniversityWuhan430056China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming650223China university of Chinese Academy of Sciences Beijing100049China department of Biology University of Konstanz78457KonstanzGermany Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650223China

The uplift of the Tibetan Plateau significantly altered the geomorphology and climate of the Euroasia by creating large mountains and *** are more likely to be affected relative to other organisms,as they are largely restricted to river *** with the rapidly flowing water in the Tibetan Plateau,a group of catfish has evolved greatly enlarged pectoral fins with more numbers of fin-rays to form an adhesive ***,the genetic basis of these adaptations in Tibetan catfishes remains *** this study,we performed comparative genomic analyses based on the chromosome-level genome of Glyptosternum maculatum in family Sisoridae and detected some proteins with conspicuously high evolutionary rates in particular in genes involved in skeleton development,energy metabolism,and hypoxia *** found that the hoxd12a gene evolved faster and a loss-of-function assay of hoxd12a supports a potential role for this gene in shaping the enlarged fins of these Tibetan *** genes with amino acid replacements and signatures of positive selection included proteins involved in low temperature(TRMU)and hypoxia(VHL)*** assays reveal that the *** TRMU allele generates more mitochondrial ATP than the ancestral allele found in low-altitude *** assays of VHL alleles suggest that the *** allele has lower transactivation activity than the low-altitude *** findings provide a window into the genomic underpinnings of physiological adaptations that permit *** to survive in the harsh environment of the Tibetan Himalayas that mirror those that are convergently found in other vertebrates such as humans.

关键词： Glyptosternum maculatum enlarged fins adaptation Tibetan Plateau

新辅助直肠评分在局部晚期直肠癌新辅助短程放疗后巩固化疗模式中的预后及辅助化疗决策作用

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中华肿瘤杂志 2024年第4期46卷 335-343页

作者：曾强唐源周海涛李宁刘文扬陈司霖李帅卢宁宁房辉王淑莲刘跃平宋永文李晔雄金晶国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院、北京协和医学院肿瘤医院放疗科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院、北京协和医学院肿瘤医院结直肠外科北京100021 福建医科大学附属协和医院放疗科、福建省肿瘤智能影像与精准放疗重点实验室福建省消化、血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心福州350001 血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心北京100142 北京大学肿瘤医院放疗科、北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科深圳518116

目的探讨新辅助直肠(NAR)评分在新辅助短程放疗加巩固化疗模式下对局部晚期直肠癌(LARC)预后的影响及对辅助化疗决策的价值。方法选取2015年8月至2018年8月入组STELLARⅢ期试验(NCT02533271)接受新辅助短程放疗加巩固化疗并可计算NAR评... 详细信息

目的探讨新辅助直肠(NAR)评分在新辅助短程放疗加巩固化疗模式下对局部晚期直肠癌(LARC)预后的影响及对辅助化疗决策的价值。方法选取2015年8月至2018年8月入组STELLARⅢ期试验(NCT02533271)接受新辅助短程放疗加巩固化疗并可计算NAR评分的LARC患者。按照NAR评分,分为低(16分)组。生存分析采用Kaplan-Meier法和Log rank检验,影响因素分析采用Cox比例风险回归模型。结果232例LARC患者,低、中和高NAR评分患者分别为56例(24.1%)、113例(48.7%)和63例(27.2%)。中位随访37个月,低、中和高NAR评分患者的3年无病生存(DFS)率分别为87.3%、68.3%和53.4%(P<0.001)。多因素分析显示,NAR评分(中NAR评分:HR=3.10,95%CI:1.30~7.37,P=0.011;高NAR评分:HR=5.44,95%CI:2.26~13.09,P<0.001)、切除状态(HR=3.00,95%CI:1.64~5.52,P<0.001)及辅助化疗(HR=3.25,95%CI:2.01~5.27,P<0.001)为DFS的独立预后因素,高NAR评分者DFS显著较低。R0切除患者中,低、中NAR评分者接受辅助化疗的3年DFS率分别为97.8%、78.0%,高于未接受辅助化疗的患者(分别为43.2%和50.6%,均P<0.05)。高NAR评分者接受或未接受辅助化疗的3年DFS差异无统计学意义(分别为54.2%和53.3%,P=0.214)。结论NAR评分是LARC新辅助短程放疗加巩固化疗策略中的有效预后指标,在后续辅助化疗决策方面具有潜在作用,其值得在更大样本量的研究中进一步验证其价值。

关键词：直肠肿瘤新辅助直肠评分短程放疗巩固化疗预后

Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome

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Chinese Medical Journal 2019年第10期132卷 1194-1201页

作者： Xin Li Cheng zeng jing Shang Sheng wang Xue-Lian Gao Qing Xue department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Background: Estradiol, as an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization embryo transfer (IVF-ET) cycles. The aim of this retrospective study was to evaluate the association between elevated serum estradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and IVF-ET pregnancy and birth outcomes. Methods: A total of 1771 infertile patients with their first fresh IVF-ET cycles were analyzed retrospectively between January 2011 and January 2016 in Peking university First Hospital. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels 5000 pg/mL, n — 137). The retrieved oocyte and Mil oocyte numbers and implantation and clinical pregnancy rates of the groups were compared as the first objective of the study. For the 360 women with singleton births among all patients, the area under the corresponding receiver operating characteristic curve (ROC curve) was calculated to assess the predictive value of the E2 change for the probability of low birth weight (LBW) infants as the second objective. Results: The retrieved oocyte and Mil oocyte numbers and implantation and clinical pregnancy rates gradually increased from groups 1 to 5 but decreased in group 6. The parameters of group 1 were statistically worse than those of the other groups, from group 2 to group 6 (the number of retrieved oocytes, t = 13.096, t = 23.307, t = 23.086, t = 26.376, t = 19.636, P < 0.003;the number of retrieved Mil oocytes, t = 10.856, t = 20.868, t = 21.874, t = 23.374, t = 19.092, P < 0.003;the implantation rate,χ^2= 12.179,χ^2= 22.239,χ^2= 23.993,

关键词： Estradiol in vitro fertilization Clinical pregnancy rate Low birth weight

Changes in Plasma Angiotensin II and Circadian Rhythm of Blood Pressure in Hypertensive Patients with Sleep Apnea Syndrome Before and After Treatment

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Chinese Medical Sciences Journal 2011年第1期26卷 9-13页

作者： Hai-ling wang Yu wang Ying Zhang Yun-dai Chen Xin-chun wang Zhi-xuan Liu Guo-li jing Hai-feng Tong Yuan Tian Qing-zeng Liu department of Heart and Circulation 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China department of Otolaryngology-Head and Neck Surgery 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China department of Cardiology Chinese PLA General Hospital Beijing 100853 China department of Emergency the 2nd Affiliated Hospital of Harbin Medical University Harbin 150001 China

Objective To explore the changes in plasma angiotensin II （Ang Ⅱ） and circadian rhythm of blood pressure among hypertensive patients with sleep apnea syndrome （SAS） before and after continuous positive airway pressure （CPAP） or surgical treatment. Methods A total of 180 essential hypertension patients were enrolled in our study. The determination of plasma Ang Ⅱ concentration, ambulatory blood pressure （ABP）, and polysomnography （PSG） monitoring were performed before and 3 months after CPAP or surgical treatment. Results Patients were classified into three groups by their apnea-hypopnea index （AHI）： essential hypertension group （EH group, n=72; AHI〈5）, essential hypertension with mild SAS group （EH＋mild SAS group, n=60, 5≤AHI〈20）, and essential hypertension with moderate and severe SAS group （EH＋moderate-severe SAS group, n=48, AHI_〉20）. The concentrations of plasma AngⅡ in the above three groups were 13.42±3.27, 16.17±3.82, and 18.73±4.05 ng/mL respectively before treatment, and AngⅡ concentration in EH patients combined with SAS was significantly higher than that in EH group （all P〈0.05）. After treatment the values in the latter two groups significantly decreased to 14.67±2.56 and 15.03±3.41 ng/mL respectively （P〈0.05）. The incidence of non-dipper blood pressure curve in EH patients was 31.9%, and those in hypertensive patients with mild SAS and moderate-severe SAS were 51.7% and 58.3%, respectively before treatment. The incidence of non-dipper blood pressure curve in the EH patients with mild SAS was significantly higher than that of patients with EH alone （P〈0.05）. After CPAP treatment or surgery, the incidence of non-dipper blood pressure curve in the two SAS groups was significantly decreased to 38.3% and 39.6%, respectively （P〈0.05）. Conclusions Ang Ⅱ might play a role in blood pressure variability in patients with obstructive SAS. CPAP or surgical treatment can improve blood pressure disorder and decrease plasma Ang Ⅱ level in patients with obstructive SA

关键词： hypertension sleep apnea syndrome circadian rhythm of blood pressure angiotensin Ⅱ continuous positive airway pressure surgery

龙柴降血方治疗骨髓增殖性肿瘤多中心随机对照研究

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中国中西医结合杂志 2024年第8期44卷 921-927页

作者：邹吉轩王德好王子卿丁晓庆邸海侠曾英坚付海英孙岸弢李雨蒙杨二鹏牛继聪王明镜谌海燕王国姿邓少兰王贺张明辉胡晓梅北京中医药大学研究生院北京100029 中国中医科学院西苑医院血液科北京100091 北京中医药大学附属东方医院血液科北京100029 廊坊市中医医院血液科河北065000 江西省中医院血液科南昌330006 福建中医药大学附属第三人民医院血液科福州350122 中国中医科学院广安门医院血液科北京100053

目的评价龙柴降血方治疗骨髓增殖性肿瘤(MPN)的临床疗效和安全性.方法采用多中心随机双盲对照研究设计,将100例MPN患者随机分为试验组和对照组,每组50例.两组均采用西医基础治疗+异功散治疗,试验组加用龙柴降血方治疗,治疗4个月.观察两... 详细信息

目的评价龙柴降血方治疗骨髓增殖性肿瘤(MPN)的临床疗效和安全性.方法采用多中心随机双盲对照研究设计,将100例MPN患者随机分为试验组和对照组,每组50例.两组均采用西医基础治疗+异功散治疗,试验组加用龙柴降血方治疗,治疗4个月.观察两组有效率、血细胞计数、骨髓增殖性肿瘤总症状评估量表(MPN-10)症状积分、疾病进展及血栓或出血事件.记录治疗过程中不良反应.结果试验组40例、对照组41例完成研究并纳入统计分析.与对照组比较,试验组有效率升高(86.5%vs.56.1%,P<0.05),血小板计数、红细胞压积水平降低(P<0.05),MPN-10总积分、早饱感以及夜间盗汗症状积分降低(P<0.05).两组患者治疗期间均未发生疾病进展及血栓或出血事件.与对照组比较,试验组肝功能异常比例降低(5.0%vs.9.7%,P<0.05),两组患者均未观察到除轻度肝功能异常外的不良反应.结论龙柴降血方可提高MPN患者治疗有效率,降低MPN患者血细胞计数,改善患者症状,且不增加不良反应,有较好的疗效和安全性.

关键词：骨髓增殖性肿瘤原发性血小板增多症真性红细胞增多症中医药龙柴降血方中西医结合