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Nonvolatile resistive switching memories-characteristics,mechanisms and challenges

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Progress in Natural Science:Materials International 2010年第1期20卷 1-15页

作者： Feng PAN,Chao CHEN,Zhi-shun wang,Yu-chao YANG,jing YANG,Fei zeng Laboratory of Advanced Materials,department of Materials Science and Engineering, tsinghua university,beijing 100084,china Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

This review presents a summary of current understanding of the resistive switching materials and devices which have inspired extraordinary interest all over the *** various switching behaviors and different conductive mechanisms are involved in the field,the resistive switching effects can be roughly classified into filament type and interface type according to their conducting behavior in low resistance *** those filament based systems,the migration of metallic cations and oxygen vacancies, characterization of the filament as well as the role of Joule heating effects are discussed in *** to the interface based system, we describe the methods of modulating interface barrier height such as using different electrodes,inserting a tunnel *** is demonstrated that the switching mechanism can transform from one to another along the change of some specific *** also give an overview on the latest developments in multilevel storage and the resistive switching in organic *** this paper,the solutions to address the sneak current problems in crossbar structure are discussed.

关键词： resistive switching nonvolatile memory RRAM filament redox reaction

Interface diffusion of sputtered CoZrNb films on silicon substrate

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Rare Metals 2006年第Z2期25卷 36-40页

作者： LI Xiaowei wang Leyun YANG jing zeng Fei PAN Feng Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The amorphous CoZrNb films were deposited by DC magnetron *** depth distributions of the elements were analyzed by Rutherford backscattering spectrometry(RBS).The results indicate that when the deposition time is longer than 37 min,the film composition keeps constant along the *** the deposition time is longer than 45 min,the Co concentration at the interface of the silicon substrate is higher than the average value in the whole *** the deposition time is longer than 52 min,the Co atoms diffuse into the substrate during the *** to the Co composition profile in the substrate,which were determined from the RBS spectra,the Co diffusion coefficients in the substrate were calculated using the solution of Fick′s second law corresponding to an infinite source with a constant diffusion *** calculated diffusion coefficients indicate an interstitial assisted diffusion mechanism.

关键词： CoZrNb films interface diffusion RBS

Promoting hepatic growth factor in the treatment of heavy type hepatitis and severe chronic hepatitis: a multicenter clinical study

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 381-385页

作者： jing-Hang Xu, Yan-Yan Yu, Chong-Wen Si, Zheng zeng, Qin-Huan wang, Duan-De Luo,Yong-Xing Zhou, Min-De zeng, Guang-Yan Qiao, Ji-Lu Yao and Wei-Lun Lu department of Infectious Diseases, First Hospital ofbeijing university, beijing 100034, china department of Gastroenterology, Wuhan UnionHospital, Wuhan 430022, china department of Gastroentero-logy , Affiliated Tangdu Hospital, Fourth Military Medical university, Xi’an 710038, china department of Gastroenterology, RenjiHospital, Shanghai 200001 , china department of InfectiousDiseases, Second Affiliated Hospital, china Medical university, Shenyang110004, china department of Gastroenterology, Third Affilia-ted Hospital, china Medical university, Shenyang 110004 , china department of Infectious Diseases First Hospital of Beijing University Beijing 100034 China. ddcatjh@***

BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hepatic growthfactor (PHGF) in the treatment of heavy type hepatitis andsevere chronic ***: 347 patients with heavy type hepatitis and 324with severe chronic hepatitis were subjected to administra-tion of 120 μg of PHGF per day for 4 weeks on the basis ofgeneral treatment. Those who were being effectively treat-ed would last additional 2 to 4 weeks. Blood routine, urineroutine, blood urea nitrogen (BUN), blood creatinine(Cr), blood ammonia, alpha fetoprotein (AFP), electro-lyte, alanine transaminase (ALT), aspartate transaminase(AST), serum total bilirubin (TBIL), serum direct biliru-bin (DBIL), prothrombin time activity (PTA), total pro-tein (TP) and albumin (ALB) were detected in the pa-tients before treatment, 2 weeks after treatment, and at theend of the treatment. Any side-effect would be ***: In the patients with severe chronic hepatitis, thetotal effective rate of the treatment was 88. 9% The levelsof ALT, AST and TBIL decreased significantly (P<0.001),whereas those of PTA and ALB increased significantly (P <0.001), and the level of AFP increased slightly. In patientswith heavy type hepatitis, the total effective rate of thistreatment was 78.4%, and patients at different stage showeddifferent results. The total effective rates of patients withearly, medium and terminal stage heavy type hepatitis were89.9%, 84.8% and 27.5%, respectively. No severe side-effect was ***: PHGF is effective and safe in the treat-ment of patients with heavy type hepatitis and severe chro-nic hepatitis. But it should be administered early in patientswith heavy type hepatitis so as to get better curative effects.

关键词： promoting hepatic growth factor hepatitis safety efficacy

Human papillomavirus DNA and P16～(INK4A) expression in concurrent esophageal and gastric cardia cancers

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World Journal of Gastroenterology 2010年第46期16卷 5901-5906页

作者： Guang-Cheng Ding,Tao Guo,department of Gastroenterology,The First Affiliated Hospital and The Fifth Affiliated Hospital,Zhengzhou university,Zhengzhou 450052,Henan Province,china jing-Li Ren,Xin Song,Sheng-Li Zhou,Zong-Min Fan,LiDong wang,Henan Key Laboratory for Esophageal Cancer Research,department of Gastroenterology,The First Affiliated Hospital,College of Basic Medicine,Zhengzhou university,Zhengzhou 450052,Henan Province,china Fu-Bao Chang,department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456500,Henan Province,china Ji-Lin Li,department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456500,Henan Province,china Ling Yuan,department of Oncoradiotherapy,Henan Province Tumor Hospital,Zhengzhou 450003,Henan Province,china Yi zeng,Institute of Virology,Chinese Academy of Preventive Medicine,beijing 100052,china Henan Key Laboratory for Esophageal Cancer Research Department of Gastroenterology The First Affiliated Hospital College of Basic Medicine Zhengzhou University Zhengzhou 450052 Henan Province China.

AIM:To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16 INK4A protein ***:Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16).The expression of P16 INK4A protein was detected using ***:Among the CC specimens,HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA),respectively (47% vs 29%),and two of both ESCC and GCA.P16 INK4A was highly expressed in both ESCC and *** the HPV-associated positive CC,higher P16 INK4A expression was observed in the GCA than in the ESCC (75% vs 25%,P < 0.05).CONCLUSION:HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA.P16 INK4A may be a screening index in the HPVassociated carcinoma of gastric cardia.

关键词： Esophageal squamous cell carcinoma Gastric cardia adenocarcinoma Human papillomavirus Polymerase chain reaction Immunohistochemistry

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支持异常处理的柔性工作流可信赖性分析

计算机科学 2010年第4期37卷 41-44页

作者：张静乐杨扬曾明王元卓北京科技大学信息工程学院北京100083 清华大学计算机系北京100084

随着人们对柔性工作流认识的不断增强,柔性工作流管理系统的可信赖性变得越来越重要。异常作为影响工作流柔性的主要原因之一,对系统的可信赖性有很大的影响。提出了一种基于随机Petri网的支持异常处理的柔性工作流建模与性能分析方法,... 详细信息

随着人们对柔性工作流认识的不断增强,柔性工作流管理系统的可信赖性变得越来越重要。异常作为影响工作流柔性的主要原因之一,对系统的可信赖性有很大的影响。提出了一种基于随机Petri网的支持异常处理的柔性工作流建模与性能分析方法,并以电子商务系统中的物流系统为例,在随机Petri网模型建模的基础上着重分析了柔性工作系统的可用性、可靠性等性能参数。

关键词：异常柔性工作流随机Petri网电子商务

Convolutional Neural Networks Based Indoor Wi-Fi Localization with a Novel Kind of CSI Images

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china Communications 2019年第9期16卷 250-260页

作者： Haihan Li Xiangsheng zeng Yunzhou Li Shidong Zhou jing wang beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China department of Electronic Engineering Tsinghua UniversityBeijing 100084China

Indoor Wi-Fi localization of mobile devices plays a more and more important role along with the rapid growth of location-based services and Wi-Fi mobile *** this paper,a new method of constructing the channel state information(CSI)image is proposed to improve the localization *** with previous methods of constructing the CSI image,the new kind of CSI image proposed is able to contain more channel information such as the angle of arrival(AoA),the time of arrival(TOA)and the *** construct three gray images by using phase differences of different antennas and amplitudes of different subcarriers of one antenna,and then merge them to form one RGB *** localization method has off-line stage and on-line *** the off-line stage,the composed three-channel RGB images at training locations are used to train a convolutional neural network(CNN)which has been proved to be efficient in image *** the on-line stage,images at test locations are fed to the well-trained CNN model and the localization result is the weighted mean value with highest output *** performance of the proposed method is verified with extensive experiments in the representative indoor environment.

关键词： convolutional neural network indoor Wi-Fi localization channel state information CSI image

Spatio-temporal variation in rock exhumation linked to large-scale shear zones in the southeastern Tibetan Plateau

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Science china Earth Sciences 2020年第4期63卷 512-532页

作者： Yukui GE jing LIU-zeng Jinyu ZHANG Wei wang Yuntao TIAN Matthew FOX Lingsen zeng Xiaoming SHEN Heng wang Ze SU Kejia XIE State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Surface-Earth System Science Tianjin UniversityTianjin 300072China Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityGuangzhou 510275China department of Earth Sciences University College LondonWC1E 6BTUK Key Laboratory of Deep-Earth Dynamics Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of Crustal Dynamics Institute of Crustal DynamicsChina Earthquake AdministrationBeijing 100085China Henan Province Non-ferrous Metals Geological Mineral Resources Bureau Zhengzhou 450016.China

Crustal-scale shear zones are believed to have played an important role in the tectonic and landscape evolution of orogens. However, the variation of long-term rock exhumation between the interior of shear zones and adjacent regions has not been documented in detail. In this study, we obtained new zircon U-Pb, biotite ^(40)Ar/^(39)Ar, zircon and apatite(U-Th)/He data, and conducted inverse thermal history modeling from two age-elevation profiles(the Pianma and Tu'er profiles) in the southeastern Tibetan Plateau. Our goal is to constrain the exhumation history of the Gaoligong and Chongshan shear zones and adjacent regions, so as to explore the effect of the shear zones on exhumation and their thermal effect on cooling that should not be ignored. Our results suggest that during the interval of 18–11 Ma the exhumation rates of rocks within the Gaoligong shear zone are anomalously high compared with those outside of. The rapid cooling during 18–11 Ma appears to be restricted to the shear zone, likely due to localized thermal effects of shearing and exhumation. After 11 Ma, both the areas within and outside of the shear zones experienced a similar two-stage exhumation history: slower cooling until the early Pliocene, and then a rapid increase in cooling rate since the early Pliocene. Our results indicate a synchronized exhumation but with spatially varied exhumation rates. Our study also highlights the important role of large-scale shear zones in exposing rocks, and thus the importance of the structural context when interpreting thermochronological data in the southeastern margin of the Tibetan Plateau.

关键词： Southeastern Tibetan Plateau Exhumation (U-Th)/He Low-temperature thermochronometry Shear zone

A combination extract of Renshen(Panax Ginseng),Yinyanghuo(Herba Epimedii Brevicornus),Yuanzhi(Radix Palygalae) and Jianghuang(Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3β expression in brain cortex of APPV717I transgenic mice

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Journal of Traditional Chinese Medicine 2013年第2期33卷 211-217页

作者： jing Shi Jinzhou Tian Xuekai Zhang Chuiyou zeng Mingqing Wei Pengwen wang Yongyan wang department of Neurology Dongzhimen HospitalBeijing University of Chinese Medicine Clinical Neuroscience Research Group The University of ManchesterHope HospitalStott LaneSalfordManchester M6 8HDUK Key Laboratory of Chinese Internal Medicine Ministry of EducationBeijing University of Chinese Medicine Institute of Clinical Medicine China Academy of Chinese Medical Sciences

OBJECTIVE： To investigate the neuroprotective mechanism of combination extract of Renshen （Ponax Ginseng）, Yinyanghuo （Herba Epimedii Brevi-comus）, Yuanzhi （Radix Palygalae） and Jianghuang （Rhizoma Curcumae Longae）（GEPT） in treating AI- zheimer＇s disease on the target of glycogen syn- thase kinase 3β（GSK-3β）. METHODS： Three-month-old APPV7171 transgenic mice were randomly divided into ten groups （n=12 per group） and intragastrically administrated vehi- cle or medicines： APP group was given 0.5% CMC, donepezil group was given donepezil （APP ＋ D group）（0.92 mg/kg-1. day-1）, and GEPT groups were given small dose of GEPT （APP＋Gs group）（0.075 g/ kg-1. day-1）, medium dose （APP＋Gm group）（0.15 g/ kg-1. day-1）, and large dose （APP＋GI group）（0.30 g/ kg-1. day-1） for 4 or 8 months, respectively. Three-month-old C57BL/6J mice as vehicle controls （n=12） were given 0.5% CMC for 4 or 8 months as well. The GSK-3β expression in the cortex of 7- and 11-month-old APPV7171 transgenic mice with and without GEPT or donepezil treatment and normal C57BL/6J mice were measured via Western blotting and Immunohistochemistry. RESULTS： Immunohistochemistry analysis showed significant increase of GSK-3β in the cerebral cortex of 7-month-old APP group （compare to control group P=0.003）, while the GSK-313 expression of donepezil or OEPT group were all significantly de-creased （Donepezil vs APP： P=0.041; GI vs APP： P=0.049, Gm vs APP： P=0.029, Gh vs APP： P=0.036）. Western blot analysis showed similar results. The densitometric measures of GSK-3β in APP mice in- creased significantly as compared with the control group （P=0.008）. And the GSK-3β expression indonepezil and GEPT groups were all decreased. There was significant difference between Gh group or donepezil group and the control group （P=0.05）. Similar findings were shown in the 11-month-old mice in each group, except for greater decrease of GSK-3β in the GEPT group. CONCLUSION： GEPT can effectively decrease the level of GSK-3β expression

关键词： Alzheimer disease Mice, transgenic Glycogen synthase kinase 3 Traditional ChineseMedicine Chinese medical formula

The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease

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Neural Regeneration Research 2022年第4期17卷 898-904页

作者： jing wang Xiao-Na Zhang Jin-Ni Fang Fei-Fei Hua jing-Yang Han zeng-Qiang Yuan An-Mu Xie department of Neurology the Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Brain Science Center Academy of Military Medical Sciences of PLABeijingChina

Previous studies have shown that the ATP-P2 X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3(NLRP3)*** NLRP3 inflammasome may promote renal interstitial inflammation in diabetic *** inflammation also plays an important role in the pathogenesis of Parkinson's disease,we hypothesized that the ATP-P2 X4 receptor signaling pathway may activate the NLRP3 inflammasome in Parkinson's disease.A male rat model of Parkinson's disease was induced by stereotactic injection of 6-hydroxydopamine into the pars compacta of the substantia *** P2 X4 receptor and the NLRP3 inflammasome(interleukin-1βand interleukin-18)were *** injection of the selective P2 X4 receptor antagonist 5-(3-bromophenyl)-1,3-dihydro-2 H-benzofuro[3,2-e]-1,4-diazepin-2-one(5-BDBD)or knockdown of P2 X4 receptor expression by si RNA inhibited the activation of the NLRP3 inflammasome and alleviated dopaminergic neurodegeneration and *** results suggest that the ATP-P2 X4 receptor signaling pathway mediates NLRP3 inflammasome activation,dopaminergic neurodegeneration,and dopamine *** findings reveal a novel role of the ATP-P2 X4 axis in the molecular mechanisms underlying Parkinson's disease,thus providing a new target for *** study was approved by the Animal Ethics Committee of Qingdao university,china,on March 5,2015(approval *** 26119).

关键词： ATP neurodegenerative disorder neuroinflammation neuroinflammatory response NLRP3 P2X4 Parkinson's disease