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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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连续过程生产调度的研究策略

系统工程理论与实践 1998年第5期18卷 40-46页

作者：王军金以慧清华大学自动化系

针对连续行业生产调度的特点，给出连续过程生产调度的一般描述、功能结构和动态调度机制。提出应用网络模型进行生产过程结构的分析和求解，阐明了生产调度系统的实现策略、并基于连续行业的生产方式及市场特征，给出了连续过程的四类... 详细信息

针对连续行业生产调度的特点，给出连续过程生产调度的一般描述、功能结构和动态调度机制。提出应用网络模型进行生产过程结构的分析和求解，阐明了生产调度系统的实现策略、并基于连续行业的生产方式及市场特征，给出了连续过程的四类基本生产模式。

关键词：连续生产过程生产调度工业企业

开裂式方向舵对某无尾飞翼布局飞机气动特性影响的实验研究

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实验流体力学 2010年第3期24卷 63-66页

作者：张子军黎军李天王晋军北京航空航天大学流体力学研究所流体力学教育部重点实验室北京100191 沈阳飞机设计研究所沈阳110035

开裂式方向舵是无尾飞翼布局飞机一种重要的阻力式偏航装置。本文在不同马赫数和舵偏下,通过风洞实验,深入研究了开裂式方向舵的作动对某无尾飞翼布局飞机气动特性的影响。研究结果表明开裂式方向舵是一种合理的偏航式操纵装置,能够在... 详细信息

开裂式方向舵是无尾飞翼布局飞机一种重要的阻力式偏航装置。本文在不同马赫数和舵偏下,通过风洞实验,深入研究了开裂式方向舵的作动对某无尾飞翼布局飞机气动特性的影响。研究结果表明开裂式方向舵是一种合理的偏航式操纵装置,能够在升力、侧力和俯仰力矩变化较小的条件下提供较大的偏航力矩,但也与滚转力矩存在一定程度的耦合。本文的研究为开裂式方向舵的工程化应用提供了一定的基础。

关键词：开裂式方向舵飞翼布局飞机偏航操纵装置阻力式方向舵偏航力矩

NACA0012翼型低雷诺数绕流的实验研究

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实验流体力学 2013年第6期27卷 32-38页

作者：吴鋆王晋军李天北京航空航天大学流体力学研究所流体力学教育部重点实验室北京100191 中航工业集团沈阳飞机设计研究所沈阳110035

通过水槽氢气泡流动显示和PIV测速实验研究了NACA0012翼型在雷诺数为8200时的流动特性,重点关注了翼型绕流结构随迎角的变化。研究发现:分离点和分离剪切层形成旋涡的位置随迎角的增大而向上游移动,同时翼型上表面流动分离后形成的回流... 详细信息

通过水槽氢气泡流动显示和PIV测速实验研究了NACA0012翼型在雷诺数为8200时的流动特性,重点关注了翼型绕流结构随迎角的变化。研究发现:分离点和分离剪切层形成旋涡的位置随迎角的增大而向上游移动,同时翼型上表面流动分离后形成的回流区尺寸随着翼型迎角的增加而增大。当流动再附于翼型上表面时,在再附点附近能够观测到展向涡的三维演化过程,并能观测到展向涡的局部配对现象。

关键词：流动显示 NACA0012翼型低雷诺数层流分离泡水洞实验

危机过程、制度结构与危机预防——一个群体性事件发生和预防机制的分析框架

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北京行政学院学报 2010年第4期 34-39页

作者：汪锦军浙江行政学院浙江杭州311121

群体性事件的发生都有自身的发展逻辑。从潜在危机发展为群体性事件,需要经历一系列的发展酝酿,在整个发展过程中都可以通过积极有效的介入防止事件的最终发生。本文由此构建了群体性事件发展过程的一般路径。而另一方面,群体性事件的... 详细信息

群体性事件的发生都有自身的发展逻辑。从潜在危机发展为群体性事件,需要经历一系列的发展酝酿,在整个发展过程中都可以通过积极有效的介入防止事件的最终发生。本文由此构建了群体性事件发展过程的一般路径。而另一方面,群体性事件的发生又与政府目前的体制和利益结构密切相关,本文从利益冲突和行政吸纳体制的角度,提出了群体性事件发生的体制原因。为此,要构建一个有效的危机预防体系,既需要遵循群体性事件的发展规律,又要考虑目前政府的体制结构的影响。本文为此提出从短期策略和长期战略两个阶段,构建危机预防的有效机制。

关键词：群体性事件危机预防策略战略

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高原低压环境小尺寸乙醇池火辐射特性的变化

燃烧科学与技术 2011年第1期17卷 62-66页

作者：涂然关劲夫王彦方俊王进军张永明中国科学技术大学火灾科学国家重点实验室合肥230026

运用火灾相似模型分析中的辐射相似模型理论,推导了低气压环境下池火辐射特性与常压环境的关系.理论分析表明,池火的辐射分数随气压降低变化不明显,火源对外的热辐射与燃烧速率近似成正比关系.利用合肥及拉萨环境气压差异,在两地开展了... 详细信息

运用火灾相似模型分析中的辐射相似模型理论,推导了低气压环境下池火辐射特性与常压环境的关系.理论分析表明,池火的辐射分数随气压降低变化不明显,火源对外的热辐射与燃烧速率近似成正比关系.利用合肥及拉萨环境气压差异,在两地开展了边长范围6～24,cm的方形乙醇池火的燃烧速率及辐射通量对比实验,对理论分析进行了验证.实验结果表明,燃烧状态受池火尺寸影响,随燃料盆尺寸的增加,燃烧状态从层流主导向湍流主导过渡,两地燃烧速率比向气压比趋近,两地池火的辐射差异也相应改变.总的来说,拉萨高原环境下池火燃烧速率要普遍低于合肥地区,辐射强度也相对较小.

关键词：辐射相似模型高原低压乙醇池火辐射分数

Research progress of socio-economic water cycle in China

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Journal of Geographical Sciences 2002年第1期12卷 114-120页

作者： JIA Shao-feng, wang Guo, ZHANG Shi-feng, YU Gui-rui, wang jin-xia, XIA jun (Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101,China) Institute of Geographic Sciences and Natural Resources Research CAS Beijing China

China has made great progress in the study of socio-economic water cycle. She has completed national water resources appraisement and medium to long-term water supply planning. She has been engaging in study on water-deficient regions in North China and Northwest China for about half a century. For solving water shortage problem in northern China, she has put forward the famous South-to-North Water Transferring Projects, which has been set as one of the four biggest national projects in the Tenth Five-Year-Plan period although there are still debates. For promoting water use efficiency, China has been reforming her water management system, including water right system and water price system. There has already been a case of water right purchase. China has also done a lot of research on the interaction between human activity, water and ecosystem. For meeting the need of sustainability and coordinating water resources development and environmental protection, the study of ecological water requirement became very hot in recent years. There are three focuses of socio-economic water cycle study now in China: water transfer projects from the south to the north, water resources management and ecological water requirement.

关键词： water cycle socio-economic water cycle sustainable water resources management water security

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： wang Shuang MU Lin LI Xue XIE jun DONG Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia William Yi wang jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy