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Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

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Chinese Chemical Letters 2006年第9期17卷 1177-1180页

作者： Fei DENG Fu Jun ZHANG Ming ZHAO Yi Ping wang jin sheng ZHANG State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 （IC50 = 3.7 μg/mL）. The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.

关键词： Synthesis sapriparaquinone antioxidant activity.

NUMERICAL MODELLING OF FREE-SURFACE FLOWS WITH BOTTOM AND SURFACE-LAYER PRESSURE TREATMENT

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Journal of Hydrodynamics 2009年第3期21卷 352-359页

作者： wang Kun State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

A new non-hydrostatic numerical model with the three-dimensional Navier-Stokes equations on structured grids was constructed and discussed. The algorithm is based upon a staggered finite difference Crank-Nicholson scheme on a Cartesian grid. The eddy viscosity coefficient was calculated by the efficient k-ε turbulence model. A new surface-layer non-hydrostatic treatment and a local cell bottom treatment were introduced so that the three-dimensional model is fully non-hydrostatic and is free of any hydrostatic assumption. The developed model is second-order accuracy in both time and space when semi-implicit coefficient is set to 0.5. The validity of the present solution algorithm was demonstrated from its application to the three-dimension channel flow and the wave propagation over a submerged bar problems.

关键词： Navier-Stokes equations implicit k -ε turbulence model surface-layer non-hydrostatic treatment local cell bottom treatment

Preparation, Characterization, and Application of Antiharpin_(xoo) Antibody

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Agricultural Sciences in China 2006年第7期5卷 512-516页

作者： SHAO Mini LI Ming PAN Xiao-mei wang jin-sheng Key Laboratory of Monitoring and Management of Plant Diseases and Insects Ministry of Agriculture/Nanjing Agricultural UniversityNanjing 210095 P.R.China

Polyclonal antiharpinxoo rabbit antibody has been prepared successfully using purified harpinxoo protein as an immunogen. The ELISA titer of the antiserum against harpinxoo was about 1：2 000. Western blot analysis showed that the antiserum could bind to the expression harpinxoo protein in particular, hrfl, encoding harpinxoo, is an expression in transgenic rice, detected by antiharpinxoo rabbit antibody. The rabbit antibody against harpinxoo can be used to study further about the biological function, harpinxoo localization, and hrfl gene expression in other plants.

关键词： harpinxoo polyclonal antibody Western blot expression analysis in transgenic plants

Recognition of 3-D objects based on Markov random field models

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Frontiers of Electrical and Electronic Engineering in China 2006年第2期1卷 125-129页

作者： HUANG Ying DING Xiao-qing wang sheng-jin Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

The recognition of 3-D objects is quite a difficult task for computer vision *** paper presents a new object framework,which utilizes densely sampled grids with different resolutions to represent the local information of the input image.A Markov random field model is then created to model the geometric distribution of the object key *** matching,which aims to find the accurate correspondence map between the key points of two images,is performed by combining the local similarities and the geometric relations together using the highest confidence first ***,a global similarity is calculated for object *** results on Coil-100 object database,which consists of 7200 images of 100 objects,are *** the numbers of templates vary from 4,8,18 to 36 for each object,and the remaining images compose the test sets,the object recognition rates are 95.75%,99.30%,100.0%and 100.0%,*** excellent recognition performance is much better than those of the other cited references,which indicates that our approach is well-suited for appearance-based object recognition.

关键词： Pattern recognition 3-D object recognition Markov random field Highest confidence first

Clinical Research on Alzheimer's Disease: Progress and Perspectives

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Neuroscience Bulletin 2018年第6期34卷 1111-1118页

作者： Bin-Lu Sun Wei-Wei Li Chi Zhu wang-sheng jin Fan Zeng Yu-Hui Liu Xian-Le Bu Jie Zhu Xiu-Qing Yao Yan-Jiang wang Department of Neurology Daping Hospital Third Military Medical University State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Surgery Research Daping Hospital Third Military Medical University

Alzheimer’s disease(AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of *** this review, we summarize the latest achievements,including diagnostic biomarkers, polygenic hazard score,amyloid and tau PET imaging, clinical trials targeting amyloid-beta(Ab), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.

关键词： Alzheimer's disease Amyloid-beta Tau Immunotherapy BACE1 inhibitor 5-HT6 receptor antagonist Primary prevention Positron emission tomographic imaging Biomarker

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma Xin-Li sheng Qun wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort

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Neuroscience Bulletin 2020年第7期36卷 696-704页

作者： Wei-Wei Li Zhen wang Dong-Yu Fan Ying-Ying Shen Dong-Wan Chen Hui-Yun Li Ling Li Heng Yang Yu-Hui Liu Xian-Le Bu wang-sheng jin Fan Zeng Zhi-Qiang Xu jin-Tai Yu Li-Yong Chen Yan-Jiang wang Department of Neurology and Centre for Clinical Neuroscience Duping HospitalThird Military Medical UniversityChongqing 400042China Department of Anaesthesiology Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Diseases Chongqing 400042China Centre for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with ***,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic *** operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at *** measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the *** found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our *** PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at ***,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and *** study suggests that PRS models hold promise for assessing the genetic risk and development of *** genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice.

关键词： Alzheimer's disease Single nucleotide polymorphism Polygenic risk score Cerebrospinal fluid Biomarker Amyloid-beta Tau

Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation

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Stroke & Vascular Neurology 2023年第5期8卷 405-412,I0017-I0023页

作者： Yaning Xu Chengchun Liu Wei Li Ximing Nie Shuhan Huang Xiaoshu Li Ya Wu wang-sheng jin Jiaojin Jiang Jun Dong Yi Yang Zhiqiang Sun Wenjun Han Yanjiang wang Liping Liu Meng Zhang Department of Neurology Army Medical Center of PLAArmy Medical UniversityChongqingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Background The timing for initiating anticoagulant therapy in acute ischaemic stroke(AIS)patients with atrial fibrillation who recanalised after endovascular treatment(EVT)is *** objective of this study was to evaluate the effect of early anticoagulation after successful recanalisation in AIS patients with atrial *** Patients with anterior circulation large vessel occlusion and atrial fibrillation who were successfully recanalised by EVT within 24 hours after stroke in the Registration Study for Critical Care of Acute Ischemic Stroke after Recanalization registry were *** anticoagulation was defined as the initiation of unfractionated heparin(UFH)or low-molecular-weight heparin(LMWH)within 72 hours after ***-early anticoagulation was defined if it was initiated within 24 *** primary efficacy outcome was the score on the modified Rankin Scale(mRS)at day 90,and the primary safety outcome was symptomatic intracranial haemorrhage within 90 *** Overall,257 patients were enrolled,of whom 141(54.9%)initiated anticoagulation within 72 hours after EVT,including 111 within 24 hours.A significant shift towards better mRS scores at day 90 was associated with early anticoagulation(adjusted common OR 2.08(95%CI 1.27 to 3.41)).Symptomatic intracranial haemorrhage was comparable between patients treated with early and routine anticoagulation(adjusted OR 0.20(95%CI 0.02 to 2.18)).Comparison of different early anticoagulation regimens showed that ultra-early anticoagulation was more significantly associated with favourable functional outcomes(adjusted common OR 2.03(95%CI 1.20 to 3.44))and reduced the incidence of asymptomatic intracranial haemorrhage(OR 0.37(95%CI 0.14 to 0.94)).Conclusions In AIS patients with atrial fibrillation,early anticoagulation with UFH or LMWH after successful recanalisation is associated with favourable functional outcomes without increasing the risk of symptomatic intracranial haemorrhages.

关键词： patients fibrillation routine

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先排矸三产品重介质旋流器流场的数值模拟

煤炭学报 2007年第12期32卷 1307-1311页

作者：刘峰王金生煤炭科学研究总院唐山分院河北唐山063012

使用3种湍流模型对先排矸三产品重介质旋流器的流场进行了数值模拟和实验研究.采用RSM模型进行的流场数值模拟结果表明,在旋流器密度场中,一段旋流器流场中存在着完整的空气柱,二段空气柱是气水混合中心低密度区;在旋流器压力场中,以轴... 详细信息

使用3种湍流模型对先排矸三产品重介质旋流器的流场进行了数值模拟和实验研究.采用RSM模型进行的流场数值模拟结果表明,在旋流器密度场中,一段旋流器流场中存在着完整的空气柱,二段空气柱是气水混合中心低密度区;在旋流器压力场中,以轴线为中心存在着负压区,沿径向负压逐渐升高至0,然后达到正压力;在旋流器速度场中,轴向速度沿轴线向下形成内旋流,沿半径加大到0,形成了零速包络面,一段的切向速度和DWP旋流器相近,二段的切向速度比DWP旋流器更高.

关键词：先排矸三产品重介质旋流器数值模拟 RSM湍流模型