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A preliminary study on the response of marine primary production to monsoon variations in the South China Sea Basic characteristics

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Acta Oceanologica Sinica 2008年第5期27卷 21-35页

作者： wang hui jin Qihua GAO Shan Chinese Academy of Meteorological Sciences Beijing 100081 China

Seasonal, interannual and interdecadal variations of monsoon over the South China Sea （SCS） directly influence the ocean circulation and the mass transport process, etc. , especially the changes of horizontal circulation pattern and upwelling area. These changes directly influence the nutrient transport and the photosynthesis of phytoplankton, which induce the change of the marine ecosystem in the SCS, including the change of marine primary production in this sea area. On the basis of climatic data for long-time series and primary production estimated by remote sensing, the multi-time scale variations of monsoon, seasonal and interannual variations of primary production, and the response of primary production to monsoon variations were analyzed. Furthermore, the spatio-temporal variations of primary production in different sea areas of the SCS and their relations to the monsoon variations were given. The results showed that the strong southwesterly prevailed over the SCS in summer whereas the vigorous northeasterly in winter. The seasonal primary production in the entire sea area of the SCS also produced a strong peak in winter and a suhpeak in summer. And the seasonal primary production distributions displayed different characteristics in every typical sea area. The variations of the annual and summer averaged primary production in the entire sea area of the SCS showed almost the same rising trend as the intensity of the summer monsoon. Especially for 1998, the summer monsoon reached almost the minimum in the past 54 a when the primary production was also found much lower than any other year （ 1999--2005 ）. The responses of annual primary production to monsoon variation were displayed to different extent in different sea areas of the SCS ; especially it was better in the deep sea basin. Such research activities could be very important for revealing the response of marine ecosystem to the monsoon variations in the SCS.

关键词： South China Sea monsoon primary production

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Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine

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Chinese Chemical Letters 2010年第2期21卷 155-158页

作者： Yuan, Lei wang, jin hui Sun, Tie Min Shenyang Pharmaceut Univ Sch Pharmaceut Engn Shenyang 110016 Peoples R China Shenyang Pharmaceut Univ Sch Traditt Chinese Mat Med Shenyang 110016 Peoples R China

All stereoisomers of asperphenamate 1a and patriscabratine 2a were achieved with a high yield,and total synthesis of 2a is firstly described *** absolute configuration of patriscabratine was determined as(S,S).The compounds 1a-d and 2a-d have been tested by MTT assay in T47D,MDA-MB231,HL60,Hela and SGC-7901 cell lines in *** them,the(R,S) stereoisomer shows the strongest anticancer effects,while the(S,R) shows the weakest one.

关键词： N N -substituted phenylalanine-phenylalaninol ester Asperphenamate Patriscabratine Total synthesis Anticancer activity

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Characterization of the hot deformation behavior of a Al-Si alloy using processing maps

Characterization of the hot deformation behavior of a Al-Si ...

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第八届中国功能材料及其应用学术会议

作者： wang Ming-liang jin Pei-peng wang jin-hui HAN Li Qinghai Provincial Key Laboratory of New Light Alloys Qinghai University

The compression tests of solution treatment ZL109 alloy have been performed in the compression temperature range from 250℃ to 450℃ and the strain rate range from 0.0005s

ISBN: (纸本)9783037859698

The compression tests of solution treatment ZL109 alloy have been performed in the compression temperature range from 250℃ to 450℃ and the strain rate range from 0.0005s

关键词： Al-Si alloy Hot deformation Processing map Dynamic recrystallization Flow instability

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Whisker Tactile Adaptation Is Encoded by Inactivity and Asynchrony of Network Neurons and Astrocytes in Barrel Cortex Through AMPAR Desensitization

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生物化学与生物物理进展 2014年第8期41卷 804-817页

作者： Zhao Jun wang jin-hui Chinese Acad Sci Inst Biophys State Key Lab Brain & Cognit Sci Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Adaptation to sensory inputs in animals influences their awareness and reactions to environment changes. The attenuated activities at all of the levels in sensory pathways, such as sensory receptors, afferent nerves and central nervous system, are likely associated with sensory adaptation. The signal encodings in cortical network neurons and astrocytes for sensory adaptation remain unclear. With the methods of two-photon cellular calcium imaging, electrophysiology and pharmacology in mice, we analyzed the dynamics of the barrel cortical neurons and astrocytes in response to repetitive inputs from whisker tactile. The paired stimuli in identical features to the mouse whiskers induced the activities of neurons and astrocytes in the barrel cortex to be spatially attenuated and temporally asynchronized. The interaction between these neurons and astrocytes became less coordinated. The dowuregulation in the spatial and temporal activities of the neurons and astrocytes was significantly reversed by locally using an inhibitor of glutamatergic AMPA-receptor(AMPAR) desensitization. Therefore, the inactivity and asynchrony of network neurons and astrocytes in barrel cortex through AMPAR desensitization are associated with encoding the adaptation of whisker tactile sensation.

关键词：摘要编辑部编辑工作读者

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Giant Magnetic Entropy Change in Manganese Perovskites near Room Temperature

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Chinese Physics Letters 2001年第8期18卷 1114-1116页

作者： ZHONG Wei CHEN Wei wang jin-hui DU You-Wei National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093 Department of Physics Hebei Normal UniversityShijiazhuang 050091

A large magnetic entropy change about twice as high as that of pure gadolinium metal near room temperature has been discovered in manganese perovskites La_(0.837)Ca_(0.098)Na_(0.038)Mn_(0.987)O_(3.00)(8.3 J·kg^(-1)·K^(-1),at 256K)and La_(0.822)Ca_(0.096)K_(0.043)Mn_(0.974)O_(3.00)(6.8 J·kg^(-1)·K^(-1),at 265 K)under a magnetic field of 1.5 *** phenomenon indicates that manganese perovskites have potential applications for magnetic refrigerants in an extended temperature range even near room temperature.

关键词： temperature. manganese magnetic

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Natural history of liver cirrhosis in south China based on a large cohort study in one center： a follow-up study for up to 5 years in 920 patients

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Chinese Medical Journal 2012年第12期125卷 2157-2162页

作者： wang Shu-bin wang jin-hui CHEN Jie Ram Krishna Giri CHEN Min-hu Department of Gastroenterology and Hepatology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Background The natural history of the profile and development of the miscellaneous complications. iver cirrhosis in China has not been we complications of liver cirrhosis as we understood. This study aimed to elucidate as the mortality of those cirrhotics with Methods We assembled data from the clinical characteristics, especially from the profile complications of cirrhosis on admission, and collected information by telephone or interview with patients and/or their family members in clinic to evaluate the development of complications in 920 patients enrolled in a prospective non-randomized cohort study, and followed up from June 2006 to October 2010. Mortality was calculated using Kaplan-Meier analysis and Cox regress analysis. We employed both of the Child-Pugh scoring system and model for end-stage liver disease （MELD） scoring system to compare with the accordance and veracity between liver function and the long-term outcome. Results On admission, only 7.4% patients had no complications, 44.5% patients with one complication （ascites, esophageal/gastric varices or hepatocellular carcinoma）, 33.8% patients with two coexisting complications, and 7.5% patients had complications concurrently with ascites, esophageal/gastric varices and hepatocellular carcinoma. During the follow-up （mean follow-up time was 17 months, ranging from 1.0 to 52.2 months） of all the patients, 37.5% patients survived without new complications, 62.5% patients had new complications, and the overall mortality was 53.9%. Patients with one or more complications had higher mortality （total mortality, 1-year or 3-year mortality） and shorter mean survival time than those without any complication; the major cause of mortality of these cirrhotic patients was hepatocellular carcinoma （59%）. Evaluated with the Child-Pugh score system, the total mortality in those with the scores more than 12 （class C） was 71.4%, the 1-year and 3-year mortalities were 57.1% and 71.4% respectively; while evaluated with the

关键词： cirrhosis mortality complications

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Kanglexin, a novel anthraquinone compound,protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

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中国药理学与毒理学杂志 2019年第10期 770-771页

作者： BIAN Yu LI Xin PANG Ping wang Ning wang jin-hui XIAO Wei DU Wei-jie YANG Bao-feng Department of Pharmacology Harbin Medical University Department of Medicinal Chemistry and Natural Medicine Chemistry Harbin Medical University Jiangsu Kanion Pharmaceutical Co. Ltd.

OBJECTIVE To investigate the myocardial protection effect of a novel anthraquinone compound（4,5-dihydroxy-7-methyl-9,10-anthraquinone-2-ethyl succinate） named Kanglexin（KLX） in vivo and in vitro. METHODS Male C57 BL/6 mice were pre-treated either with KLX(20, 40 mg·kg;·d;, ig) or vehicle for 7 consecutive days prior to ligation of coronary artery to induce permanent MI. Neonatal mouse cardiomyocytes（NMCMs） were exposed to hypoxia or LPS to detect the myocardial protection effect of KLX. Echocardiographic and myocardial infarct size were used to evaluate the effect of KLX on MI treated mice. Electron microscopic examination and H&E staining were preformed to determine morphological changes of each group. Western blotting and q PCR were used to detect the expressions of pyroptosis relative proteins. The numbers of TUNEL and PI-positive cells were measured to assess pyroptotic cell *** KLX reduced myocardial infarct size and LDH release and improved cardiac function as compared to vehicle-treated mice 24 h after MI. We found that MI triggered NLRP3 inflammasome activation leading to conversion of IL-1β and IL-18 into their active mature forms in the heart. We also showed that MI induced pyroptosis, as evidenced by increased DNA fragmentation, mitochondrial swelling and cell membrane rupture as well as increased levels of several pyroptosis-related proteins, including GSDMD, N-GSDMD and cleaved caspase-1. All these detrimental alterations were prevented by KLX administration. In hypoxia-or LPS-treated NMCMs,we showed that 10 μmol·L;KLX decreased the elevated levels of TUNEL-and PI-positive cel s as wel as pyroptosisrelated proteins. CONCLUSION KLX prevents MI-induced cardiac damages and cardiac dysfunction at least partly through attenuating NLRP3 and subsequent cardiomyocyte pyroptosis, and it is worthy of more rigorous investigations for its potential for alleviating ischemic heart disease.

关键词： myocardial infarction anthraquinone Kanglexin ischemic injury NLRP3 inflammasome pyroptosis

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GmDRR1,a dirigent protein resistant to Phytophthora sojae in Glycine max (L.) Merr.

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Journal of Integrative Agriculture 2018年第6期17卷 1289-1298页

作者： CHEN Qing-shan YU Guo-long ZOU Jia-nan wang jing QIU Hong-mei ZHU Rong-sheng CHANG hui-lin JIANG Hong-wei HU Zhen-bang LI Chang-yu ZHANG Yan-jiao wang jin-hui wang Xue-ding GAO Shan LIU Chun-yan QI Zhao-ming FU Yong-fu XIN Da-wei Key Laboratory of Soybean Biology Ministry of Education/College of AgricultureNortheast Agricultural University Key Laboratory of Soybean Biology (Beijing) Ministry of Agriculture/National Key Facility of Crop Gene Resource and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural Sciences

Soil-borne pathogen Phytophthora sojae is an oomycete that causes devastating damage to soybean yield. To mine original resistant genes in soybean is an effective and environmentally-friend approach controlling the disease. In this study, soybean proteins were extracted from the first trifoliolates infected by predominant P. sojae race 1 and analyzed by twodimensional gel electrophoresis. Nineteen differently-expressed protein spots were detected, and 10 of them were further applied for Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry Assay. One protein containing a dirigent （DIR） domain was identified and belonged to the DIR-b/d family. Therefore, it was named as GmDRR1 （Glycine max Disease Resistance Response 1）. Then, GmDRR1 gene was pathologically confirmed to be involved in the resistant to P. sojae in soybean. GmDRR1-GFP （green fluorescent protein） fusion proteins localized in the cell membrane. qRTPCR results showed GmDRR1 gene expressed differently in P. sojae resistant- and susceptible-soybean cultivars. By the promoter analysis, we found a haplotype H8 was existing in most resistant soybean varieties, while a haplotype H77 was existing in most susceptible soybean varieties. The H77 haplotype had seven SNPs （C to A, G to C, C to A, T to A, T to C, T to C, and T to A） and two single nucleotide insertions. The results supported that the expression difference of GmDRR1 genes between P. sojae resistant- and susceptible-soybean cultivars might depend on the GmDRR1 promoter SNPs. The results suggested that GmDRR1 was a dirigent protein involved in soybean resistant to P. sojae and paved a novel way for investigation of the molecular regulatory mechanism of the defense response to P. sojae in soybean.

关键词： dirigent domain GmDRR1 soybean Phytophthora sojae oomycete proteomics

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脑功能原理:神经细胞编程和信息储存

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生物化学与生物物理进展 2016年第4期43卷 367-373页

作者：王晋辉崔珊中国科学院生物物理研究所北京100101

大脑采集感觉信息、整合认知和控制行为过程,这些任务的实现依赖于神经细胞及其环路的信息储存与编程.澄清神经信息编程与储存的原理是研制拟脑计算机的基础.本文将基于神经细胞的模拟-数字信号转换、数字信号兼容式输出以及新信息储存... 详细信息

大脑采集感觉信息、整合认知和控制行为过程,这些任务的实现依赖于神经细胞及其环路的信息储存与编程.澄清神经信息编程与储存的原理是研制拟脑计算机的基础.本文将基于神经细胞的模拟-数字信号转换、数字信号兼容式输出以及新信息储存与提取等方面的研究揭示脑认知原理.

关键词：神经元编码记忆细胞神经元突触和神经环路

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胶西北金成矿区He、Ar同位素组成及成矿流体来源研究

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岩石矿物学杂志 2020年第2期39卷 172-182页

作者：王金辉山东省地质调查院山东济南250014

胶东半岛西北地区是我国重要的金成矿区,主要受三山岛断裂、焦家断裂、招平断裂带控制。为探讨3条主要成矿带成矿流体的来源与区别,对成矿带内典型矿床载金黄铁矿中流体包裹体进行了He、Ar同位素测试。结合前人数据表明三山岛成矿带3He/... 详细信息

胶东半岛西北地区是我国重要的金成矿区,主要受三山岛断裂、焦家断裂、招平断裂带控制。为探讨3条主要成矿带成矿流体的来源与区别,对成矿带内典型矿床载金黄铁矿中流体包裹体进行了He、Ar同位素测试。结合前人数据表明三山岛成矿带3He/4He均值为1.95 Ra,焦家成矿带^3He/^4He均值为1.74 Ra,招平成矿带^3He/^4He均值为1.54 Ra,从西往东逐渐降低,说明地幔流体参与成矿自西往东逐渐降低。黄铁矿流体包裹体中放射性成因Ar所占比例范围三山岛成矿带1.17%~87.12%,平均33.04%,焦家成矿带15.57%~90.00%,平均55.75%,招平成矿带7.94%~92.69%,平均44.23%,说明在成矿过程中,地壳成矿流体参与成矿作用焦家成矿带最高,招平成矿带次之,三山岛成矿带最低。结合H、O稳定同位素研究,认为成矿流体主要来源于地壳,并有地幔流体加入,具地壳流体和地幔流体混合特征,上升过程中可能还有少量大气降水的参与。

关键词： He、Ar同位素成矿流体金成矿区胶西北

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