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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying wang xiang Zhang Henrik Biverstål nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthnic electrochromic materials).Additionally,the resulting device exhibited impressive electrochromic performance,such as fast response(3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities

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Genes & Diseases 2023年第1期10卷 101-112页

作者： jin xiang Kai wang ni Tang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

The last few decades have witnessed an advancement in our understanding of multiple cancer cell pathways related to metabolic *** of the most important cancer hallmarks,including aerobic glycolysis(the Warburg effect),the central carbon pathway,and multiple-branch metabolic pathway remodeling,enables tumor growth,progression,and *** carboxykinase1(PCK1),a key rate-limiting enzyme in gluconeogenesis,catalyzes the conversion of oxaloacetate to ***1 expression in gluconeogenic tissues is tightly regulated during *** tumor cells,PCK1 is regulated in a cell-autonomous manner rather than by hormones or nutrients in the extracellular ***,PCK1has ananti-oncogenic role in gluconeogenic organs(the liver and kidneys),but a tumor-promoting role in cancers arising from non-gluconeogenic *** studies have revealed that PCK1 has metabolic and non-metabolic roles in multiple signaling networks linking metabolic and oncogenic *** PCK1 expression results in the activation of oncogenic pathways,accompanied by metabolic reprogramming,to maintain *** this review,we summarize the mechanisms underlying PCK1 expression and regulation,and clarify the crosstalk between aberrant PCK1 expression,metabolic rewiring,and signaling pathway *** addition,we highlight the clinical relevance of PCK1 and its value as a putative cancer therapeutic target.

关键词： Gluconeogenesis Metabolism Oncogenesis PCK1 Tumor

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Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年

作者： xiang wang Guang-Hui YU Yakov KUZYAKOV Bo-Hao YIN Andreas KAPPLER Cong-Qiang LIU Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System Science School of Earth System Science Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin University Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil Science University of G?ttingen Agro-Technological Institute Peoples Friendship University of Russia (RUDN University) Geomicrobiology Center for Applied Geosciences University of Tübingen Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infection University of Tübingen

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues (necromass). Yet, it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across biomes. Here, this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes. A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global level. High spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered nanoparticles. We propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i) fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces, and (ii) fungi stabilize their residues on mineral surfaces, leading to millennial scale persistence of soil C. Concluding, fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent carbon. They are crucial in stabilizing carbon on mineral surfaces, thereby facilitating the long-term removal of carbon from rapid biotic cycling.

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： xiang-Tian Bai Li-Hui Cao Xu-Yong Chen Jia-Yu wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Research on Resilience Assessment and Improvement Methods of New Energy Bases Under Strong Sandstorm

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Dianwang Jishu/Power System Technology 2025年第1期49卷 124-135页

作者： wang, jinyan Ding, Kun Sun, Yalu wang, xiang Dong, Haiying College of New Energy and Power Engineering Lanzhou Jiaotong University Gansu Province Lanzhou 730070 China State Grid Gansu Electric Power Company Gansu Province Lanzhou 730000 China Tsinghua Sichuan Energy Internet Research Institute Sichuan Province Chengdu 610213 China

The natural endowments of wind and solar resources in the desert and Gobi Desert areas of our country, as well as the reverse distribution of energy and load, make it of great significance to develop large-scale new energy bases and large-scale transmission of AC/DC hybrid power grids in the desert and Gobi Desert areas. The frequent occurrence of extreme sandstorms in the desert and Gobi Desert areas has seriously affected the centralized development and long-distance safe and stable transmission of new energy power generation bases. This article first quantifies the impact of two disaster-causing factors of sandstorms on new energy bases, establishes a mathematical model that reflects the relationship between sandstorms and new energy output, strong winds, and line failure rates, uses Monte Carlo sampling combined with system information entropy to select typical fault scenarios and construct a recovery model, obtains the system elasticity curve based on operating conditions, considers the entire process of system disaster, and adopts the Analytic Hierarchy Process (AHP) method Establish elasticity evaluation indicators;Secondly, a flexible improvement method is proposed from a planning perspective, to minimize the equivalent annual investment cost of the line and energy storage and the system's loss of load cost. A joint planning model for line expansion and energy storage configuration for flexible improvement is established, which is transformed into a mixed integer linear programming (MILP) problem, and the expansion plan of the new energy baseline and the optimal configuration of energy storage are solved. Finally, taking the improved IEEE36 node system as an example for simulation analysis, the elasticity indicators before and after adopting improvement measures are compared to verify the effectiveness and accuracy of the proposed elasticity evaluation and improvement methods. © 2025 Power System Technology Press. All rights reserved.

关键词： Charge storage

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Rangeland Grasshoppers in Relation to Soils in the Qinghai Lake Region, China

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Pedosphere 2007年第1期17卷 84-89页

作者： ni shao-xiang wang Jie-Chen JIANG Jian-Jun ZHA Yong College of Geographical Science Nanjing Normal University Nanjing 210097 （China） Department of Urban and Resources Science Nanjing UniversityNanjing 910093 （China）

The relationship between rangeland grasshopper density and soil type as well as topsoil moisture content was analyzed with in situ soil data collected in the Qinghai Lake region of China. Grasshoppers were confined mainly to the areas with light chestnut soil or chestnut soil, and very few were found in areas with subalpine meadow soil. Grasshoppers were almost absent from other types of soil, such as aeolian soil. In addition, analysis of 14 soil samples collected in the study area revealed that a soil moisture content between 18 and 32 g kg-1 coincided spatially with a higher density of grasshoppers, with the grasshopper density averaging 15 head m-2. In areas with a soil moisture content above 42 g kg-1 or below 10 g kg-1, grasshopper density dropped to less than 5 head m-2. These indicated that for the study area, soils with very high or very low moisture contents were not conducive to the survival of grasshoppers.

关键词： Qinghai Lake rangeland grasshopper soil type soil moisture

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Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina nie Weijie Yang Xin wang xiang Li Lele Wei Xiaolin Bai Lin Liu Feng Fu Jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Solitary Wave Solutions of a Generalized Derivative Nonlinear Schrdinger Equation

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Communications in Theoretical Physics 2008年第7期50卷 39-42页

作者： wang Ming-liang ZHANG jin-liang LI xiang-Zheng Science College Henan University of Science and Technology Luoyang 471003 China Department of Mathematics Lanzhou University Lanzhou 730000 China

With the aid of a class of nonlinear ordinary differential equation （ODE） and its various positive solutions, four types of exact solutions of the generalized derivative nonlinear Sehrodinger equation （GDNLSE） have been found out, which are the bell-type solitary wave solution, the algebraic solitary wave solution, the kink-type solitary wave solution and the sinusoidal traveling wave solution, provided that the coefficients of GDNLSE satisfy certain constraint conditions. For more general GDNLSE, the similar results are also given.

关键词： generalized derivative nonlinear Schrodinger equation bell-type solitary wave kink-type solitary wave sinusoidal traveling wave

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Solitary Waves for Cubic-Quintic Nonlinear Schroedinger Equation with Variable Coefficients

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Communications in Theoretical Physics 2006年第2期45卷 343-346页

作者： ZHANG jin-liang wang Ming-liang LI xiang-Zheng Department of Mathematics and Physics Henan University of Science and Technology Luoyang 471003 China Department of Mathematics Lanzhou University Lanzhou 730000 China

The cubic-quintic nonlinear Schroedinger equation （CQNLS） plays important parts in the optical fiber and the nuclear hydrodynamics. By using the homogeneous balance principle, the bell type, kink type, algebraic solitary waves, and trigonometric traveling waves for the cubic-quintic nonlinear Schroedinger equation with variable coefficients （vCQNLS） are derived with the aid of a set of subsidiary high-order ordinary differential equations （sub-equations for short）. The method used in this paper might help one to derive the exact solutions for the other high-order nonlinear evolution equations, and shows the new application of the homogeneous balance principle.

关键词： cubic-quintic nonlinear Schroedinger equation with variable coefficients homogeneous balance principle solitary wave

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