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缩尺效应对砂砾石料力学特性及其本构模型的影响

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浙江大学学报（工学版） 2024年第6期58卷 1198-1208页

作者：崔熙灿张凌凯王建祥新疆农业大学水利与土木工程学院新疆乌鲁木齐830052 新疆水利工程安全与水灾害防治重点实验室新疆乌鲁木齐830052 贵州民族大学建筑工程学院贵州贵阳550025

针对三轴仪受颗粒尺寸的限制而存在缩尺效应的问题,以新疆阿尔塔什筑坝料为研究对象,通过大型三轴数值模拟试验,从宏细观角度开展缩尺效应对砂砾石料力学特性及其非线性本构模型影响的研究.结果表明,随着围压的增加,试样偏应力极值增大... 详细信息

针对三轴仪受颗粒尺寸的限制而存在缩尺效应的问题,以新疆阿尔塔什筑坝料为研究对象,通过大型三轴数值模拟试验,从宏细观角度开展缩尺效应对砂砾石料力学特性及其非线性本构模型影响的研究.结果表明,随着围压的增加,试样偏应力极值增大,剪缩程度显著而剪胀特性被抑制;随着试样尺寸的增大,其峰值强度提高,试样由剪缩向剪胀过渡.随着试样尺寸的增大,邓肯模型的内摩擦角分量、弹性模量参数、体积模量参数均明显增大,其他参数的影响可忽略不计.砂砾石料的内摩擦角分量与颗粒粒径呈对数型函数关系,弹性模量参数、体积模量参数与颗粒粒径均呈线性函数关系.随着试样尺寸的增大,变形集中区的范围更广泛,其形式逐渐由“X”型变为“X+x”或“X+x+x”型变形集中区.初始阶段配位数随着试样尺寸的增大而增加;加载过程中配位数增加,试样以剪缩为主,随着试样尺寸的增大其配位数逐渐呈减小趋势,剪缩性被抑制.

关键词：砂砾石料离散元分析三轴试验模拟缩尺效应邓肯模型

Ivosidenib in Chinese patients with relapsed or refractory isocitrate dehydrogenase 1 mutated acute myeloid leukemia:a registry study

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Blood Science 2024年第3期6卷 33-41页

作者： Mingyuan Sun Qingsong Yin Yang Liang Chunkang Chang Jing Zheng Jian Li Chunyan Ji Huiying Qiu Junmin Li Yuping Gong Sheng Luo Yan Zhang Rumei Chen Zhenwei Shen Zenglian Yue Siyuan wang Qingmei Shi Jason Yang Jie Jin jianxiang wang State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseaseInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina Department of Hematology Henan Cancer HospitalZhengzhouChina Department of Hematologic Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Department of Hematology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina Department of Hematology Fujian Medical University Union HospitalFuzhouChina Department of Hematology Peking Union Medical College HospitalBeijingChina Department of Hematology Qilu Hospital of Shandong UniversityJinanChina Department of Hematology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Hematology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology West China Hospital of Sichuan UniversityChengduChina Department of Hematology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina CStone Pharmaceuticals(Suzhou)Co.Ltd. SuzhouChina Department of Hematology The First Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhouChina

Ivosidenib,an isocitrate dehydrogenase 1(IDH1)inhibitor,has demonstrated clinical benefits in a pivotal study(AG120-C-001)in patients with IDH1-mutated(mIDH1)acute myeloid leukemia(AML).A registry study(CS3010-101:NCT04176393)was conducted to assess the pharmacokinetic(PK)characteristics,safety,and efficacy of ivosidenib in Chinese patients with relapsed or refractory(R/R)mIDH1 *** received ivosidenib 500 mg once daily for 28-day cycles until disease *** subjects underwent intensive PK/progressive disease(PD)*** subjects had the clinical response assessed at screening,every 28 days through month 12,and then every 56 *** November 12,2019,and April 2,2021,30 patients were enrolled;26(86.7%)had de novo AML and 18(60.0%)were transfusion-dependent at *** single and repeated doses of ivosidenib,median time to maximum plasma concentration(T_(max))was 4.0 and 2.0 hours,*** inter-individual variability of pharmacokinetic exposure was moderate to high(coefficient of variation[CV],25%–53%).No obvious accumulation was observed after repeated doses at cycle 2 day *** the clinical response,the CR+CRh rate was 36.7%(95%confidence interval[CI]:19.9%–56.1%),the median duration of CR+CRh was 19.7 months(95%CI:2.9 months–not reached[NR]),and median duration of response(DoR)was 14.3 months(95%CI:6.4 months–NR).Consistent clinical benefits and safety of ivosidenib were consistently observed at the final data cutoff with median follow-up time 26.0 months,as compared with primary data cutoff,and the data from Chinese R/R mIDH1 AML patients were also consistent with results from pivotal study.

关键词： China IDH1 mutation Ivosidenib Relapsed or refractory acute myeloid leukemia

基于动态哈夫模型及双边匹配的电动汽车充电引导策略

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电力系统自动化 2024年第7期48卷 181-189页

作者：苏粟王建祥王磊李玉璟聂晓波向文旭北京交通大学电气工程学院北京市100044 中交机电工程局有限公司北京市100012

由于充电站中充电桩数目有限且电动汽车充电耗时长,陆续产生充电需求的各电动汽车用户存在对充电站资源的竞争。这不仅增加了用户排队概率,降低了充电站收益和利用率,而且使得用户在充电站规模、价格、评价等方面的个性化需求得不到充... 详细信息

由于充电站中充电桩数目有限且电动汽车充电耗时长,陆续产生充电需求的各电动汽车用户存在对充电站资源的竞争。这不仅增加了用户排队概率,降低了充电站收益和利用率,而且使得用户在充电站规模、价格、评价等方面的个性化需求得不到充分满足。为此,提出了一种动态哈夫模型与双边匹配方法相结合的电动汽车充电引导策略。首先,对充电站客流、充电订单和充电桩详情等真实数据集进行大数据挖掘,分析公共充电站用户的充电站选择偏好和充电行为特征;然后,基于动态哈夫模型,结合用户充电站选择偏好量化不同区域用户前往不同充电站的概率,并生成充电站推荐列表;最后,将前景理论与双边匹配策略相结合,进行充电引导。算例分析表明,所提策略大幅降低了用户的排队概率,在满足用户个性化充电需求的同时,保障了充电站利益。

关键词：充电引导电动汽车哈夫模型前景理论双边匹配

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急性髓系白血病分型的演变

临床血液学杂志 2024年第3期37卷 147-149页

作者：王建祥中国医学科学院血液学研究所血液病医院天津300020

急性髓系白血病的分型历经多年的发展,从单纯的形态学分型,逐步发展为集形态学、免疫学、细胞及分子遗传学、临床特征为一体的分型体系,尤其是以遗传学为驱动,认知出许多疾病类型,并得到临床应用。本文将对急性髓系白血病分型的发展演... 详细信息

急性髓系白血病的分型历经多年的发展,从单纯的形态学分型,逐步发展为集形态学、免疫学、细胞及分子遗传学、临床特征为一体的分型体系,尤其是以遗传学为驱动,认知出许多疾病类型,并得到临床应用。本文将对急性髓系白血病分型的发展演变进行简要概述。

关键词：急性髓系白血病分型

基于网络药理学及分子对接探讨姜黄素治疗卒中后抑郁的作用机制

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神经解剖学杂志 2024年第4期40卷 464-470页

作者：王健翔殷小焦高云昆明医科大学附属甘美医院昆明650000

目的:通过网络药理学以及分子对接探讨姜黄素治疗卒中后抑郁的潜在分子作用机制。方法:运用人类基因综合数据库(GeneCards)、药物基因组知识库(PharmGKB)、瑞士靶点数据库(SwissTargetPrediction)检索姜黄素潜在作用靶点;通过在线人类... 详细信息

目的:通过网络药理学以及分子对接探讨姜黄素治疗卒中后抑郁的潜在分子作用机制。方法:运用人类基因综合数据库(GeneCards)、药物基因组知识库(PharmGKB)、瑞士靶点数据库(SwissTargetPrediction)检索姜黄素潜在作用靶点;通过在线人类孟德尔遗传数据库、GeneCards数据库检索缺血性脑卒中和抑郁的潜在靶点。利用蛋白质数据库(Uniprot)对靶点进行规范,随后导入韦恩(Venn)在线平台,得到三者之间的交集靶点。通过基因间功能关联数据库(STRING)和Cytoscape 3.7.1软件对交集靶点进行蛋白相互作用(PPI)可视化分析;Metascape数据库对交集靶点进行基因本体(GO)和基因组百科全书(KEGG)通路富集分析。最后,利用AutoDock Vina1.5.6软件对姜黄素与核心靶点进行分子对接验证。结果:共获得缺血性脑卒中及抑郁潜在靶点1452个,药物作用靶点207个,三者的交集靶点47个。GO功能富集分析得到2332个条目,KEGG通路富集分析得到138个条目。根据度值大小及富集分数筛选出白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、丝氨酸/苏氨酸蛋白激酶1(AKT1)、白细胞介素-1β(IL-1β)等核心靶点及高级糖基化终末产物-受体(AGE-RAGE)信号通路、白细胞介素-17(IL-17)信号通路、TNF信号通路等。分子对接结果显示姜黄素与IL-6、TNF、AKT1、IL-1β等核心靶点有较强的结合能力。结论:姜黄素可能作用于IL-6、TNF、AKT1、IL-1β等关键靶点,通过AGE-RAGE、IL-17、TNF等信号通路发挥重要作用。

关键词：姜黄素缺血性脑卒中抑郁卒中后抑郁网络药理学分子对接

A Peridynamic Model for the Dynamics of Defects with Asymmetric Potential Wells

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Acta Mechanica Solida Sinica 2021年第6期34卷 844-861页

作者： Jiacheng Xing jianxiang wang Linjuan wang State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking UniversityBeijing100871China School of Astronautics Beihang UniversityBeijing100191China

The peridynamic model of a solid is suitable for studying the dynamics of defects in *** use the bond-based peridynamic theory to propose a one-dimensional nonlocal continuum model to study a defect in equilibrium and in steady *** the defect propagates,the material particles undergo a transition between two *** using the Wiener–Hopf method,an explicit analytical solution of the problem is *** relation between the applied force and the propagation speed of the defect is determined;our results show that the defect does not propagate if the applied force is less than a critical value,whereas propagation occurs when the force exceeds that *** energy properties of the system are investigated.

关键词： Peridynamic theory Defect propagation Phase transformation The Wiener-Hopf method

Finite Indentation of Pressurized Elastic Fluid Nano vesicles by a Rigid Cylindrical Indenter

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Acta Mechanica Solida Sinica 2019年第5期32卷 633-642页

作者： Xingyi Tang jianxiang wang Xin Yi Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China CAPT HEDPS and IFSA Collaborative Innovation Center of MoEPeking UniversityBeijing 100871China Beijing Innovation Center for Engineering Science and Advanced Technology Peking UniversityBeijing 100871China

Nanovesicles have been demonstrated to be the key agents in therapeutic encapsulations for drug delivery and diagnostic area,and the effectiveness and efficiency of these applications strongly depend on the mechanical properties of *** on the Helfrich membrane theory,a theoretical investigation is conducted to explore the mechanical behaviors of pressurized elastic fluid nanovesicles during the indentation by a rigid cylindrical *** effects of osmotic pressure,membrane bending rigidity,energy of adhesion bet ween the vesicle and substrate on the mechanical responses of the vesicle to the indentation are *** is found that the osmotic pressure dominates the mechanical behaviors of strongly pressurized nanovesicles as well as the effective vesicle stiffness and Young's *** results may have important implications on regulating the mechanical behaviors of inter-and intracellular nanovesicles which are crucial for particle-based drug delivery systems.

关键词： Nanovesicles Indentation Osmotic pressure Young's modulus Stiffness Forcedepth curves

Nonlocal thermo-elastic constitutive relation of fibre-reinforced composites

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Acta Mechanica Sinica 2020年第1期36卷 176-187页

作者： Linjuan wang Jifeng Xu jianxiang wang Bhushan LKarihaloo State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking UniversityBeijing100871China CAPT-HEDPS and IFSA Collaborative Innovation Center of MoECollege of EngineeringPeking UniversityBeijing100871China Beijing Aeronautical Science and Technology Research Institute Beijing100083China School of Engineering Cardiff UniversityCardiffCF243AAUK

The effective properties of composite materials have been predicted by various micromechanical *** composite materials of constituents which are described by the classical governing equations of the local form,the conventional micromechanical schemes usually give effective properties of the local ***,it is recognized that under general loading conditions,spatiotemporal nonlocal constitutive equations may better depict the macroscopic behavior of these *** this paper,we derive the thermo-elastic dynamic effective governing equations of a fibre-reinforced composite in a coupled spatiotemporal integral *** coupled equations reduce to the spatial nonlocal peridynamic formulation when the microstructural inertial effects are *** static deformation and steady-state heat conduction,we show that the integral formulation is superior at capturing the variations of the average displacement and temperature in regions of high gradients than the conventional micromechanical *** approach can be applied to analogous multi-field coupled problems of composites.

关键词： Nonlocal theory Thermoelasticity Composite materials Constitutive equations

基于单细胞测序技术探讨柴胡清肝汤干预三阴性乳腺癌免疫微环境潜在分子机制

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中医学报 2024年第6期39卷 1301-1313页

作者：王建湘沈浮杨雷湖南中医药大学第一附属医院湖南长沙410007 湖南医药学院附属永州市中医医院湖南永州425000

目的:采用单细胞RNA测序相关的生物信息学技术分析柴胡清肝汤干预三阴性乳腺癌(triple negative breast cancer,TNBC)免疫微环境的潜在分子机制。方法:收集TNBC相关的单细胞RNA测序数据,利用R语言中的Seurat程序对其进行主成分分析及t... 详细信息

目的:采用单细胞RNA测序相关的生物信息学技术分析柴胡清肝汤干预三阴性乳腺癌(triple negative breast cancer,TNBC)免疫微环境的潜在分子机制。方法:收集TNBC相关的单细胞RNA测序数据,利用R语言中的Seurat程序对其进行主成分分析及t分布和随机近邻嵌入聚类。通过多数据库及文献获取柴胡清肝汤活性成分,对其干预TNBC中各细胞亚群的特异性基因进行交集靶标的提取并进行基因本体论(Gene Ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes enrichment analysis,KEGG)富集分析,利用癌症基因组图谱数据库中TNBC的免疫细胞矩阵进行免疫浸润细胞水平分析,最后将柴胡清肝汤中关键活性成分与免疫相关的靶蛋白进行分子对接验证。结果:共获得了14个细胞簇,柴胡清肝汤中的槲皮素、牛蒡酚、牛蒡子苷元、山柰酚等活性成分可能作用于CD14、IL-1β、SYK、ITGA等靶点干预M2巨噬细胞,涉及核因子-kappa B(nuclear factor-kappa B,NF-κB)信号通路、磷脂酰肌醇3-激酶-蛋白激酶B(phosphatidylinositol 3-kinase-protein kinase B,PI3K-Akt)信号通路、Toll样受体信号等通路;作用于CXCR3、非受体型蛋白酪氨酸激酶(Janus kinase,JAK)、信号转导与转录激活因子(signal transducer and activator of transcription,STAT)、ITGA等靶点干预CD4^(+)T淋巴细胞,涉及JAK-STAT信号通路、趋化因子信号通路、程序性死亡受体1等相关通路,且多数靶基因在TCGA的免疫矩阵中与对应免疫浸润细胞水平具有相关性。槲皮素、白杨黄素、山柰酚主要通过干预JUN、CALM1、JAK1、IL-6、INSR等蛋白调节MAPK、Wnt、肿瘤坏死因子、cAMP、AGE-ARGE以及PI3K-Akt信号通路而发挥干预TNBC微环境中的其他细胞亚群。在分子对接结果中,50%以上的活性成分与靶蛋白具有较强的对接活性。结论:柴胡清肝汤中关键活性成分干预TNBC的免疫微环境的分子机制涉及多靶点多细胞组分,涉及肿瘤、免疫、炎症反应等多类型通路。

关键词：柴胡清肝汤三阴性乳腺癌单细胞测序技术网络药理学免疫微环境生物信息