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Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages

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World Journal of Gastroenterology 2003年第9期9卷 2060-2064页

作者： Li wang jian Li qing Li jian Zhang Xiang-Lin Duan Life Science College,Hebei Normal University,Shijiazhuang 050016,Hebei Province,China Life Science College Hebei Normal University Shijiazhuang 050016 Hebei Province China.

AIM: To study the changes of cell proliferation and apoptosis in rat jejunal epithelium at different ***: Cell proliferation and apoptosis of the jejunal mucosal and glandulous epithelia from birth to postnatal 12th month were observed using immunocytochemistry (ICC), and TUNEL method. The height of villus, the thickness of muscle layer and the number of goblet cells in jejunal mucosal and glandulous epithelia were measured by BeiHang analytic software and analyzed by ***: (1) Proliferating cell nuclear antigen (PCNA) positive cells of jejunal glandulous recess were found and increased in number from birth to the postnatal 3rd month. The number of PCNA positive cells peaked in the postnatal 3rd month, and decreased from then on. (2) The number of apoptotic cells also peaked in the postnatal 3rd month, showing a similar trend to that of the PCNA positive cells. (3) The height of jejunal villus increased after birth, peaked in the postnatal 3rd month and decreased from then on. The jejunal muscle layer became thicker in the postnatal 3rd week and the postnatal 12th *** number of goblet cells of the jejunal mucosal and glandulous epithelia had a linear correlation with ***: (1) PCNA positive cells are distributed in the jejunal glandulous recess. (2) Apoptotic cell number peaks in the postnatal 3rd month, indicating that cell proliferation and apoptosis are developed with the formation of digestive metabolism as rat grows to maturity. (3) The thickness of jejunal muscle layer increases to a maximum in the postnatal 3rd week, which may be related to the change in diet from milk to solid food. (4) The number of goblet cells increases rapidly in the postnatal 3rd week, probably due to ingestion of solid food.

关键词：细胞增殖细胞凋亡空肠黏膜年龄细胞形态学

Mediation Effects of Placental Inflammatory Transcriptional Biomarkers on the Sex-Dependent Associations between Maternal Phthalate Exposure and Infant Allergic Rhinitis: A Population-Based Cohort Study

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Biomedical and Environmental Sciences 2022年第8期35卷 711-721页

作者： wang jian qing LI Zhi Juan GAO Hui SHENG Jie LIANG Chun Mei HU Ya Bin XIA Xun HUANG Kun wang Su Fang ZHU Peng HAO Jia Hu TAO Fang Biao Department of Maiernal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina MOE Key Laboratory of Popularion Health across Life Cycle Hefei 230032AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Anhui Medical UniversityHefei 230032AnhuiChina The Fourth Affiliated Hospital Anhui Medical UniversiyHefei 230022AnhuiChina Department of Pediatrics First Afiliated Hospital of Anhui Medical UniversityHefei 230022AnhuiChina

Objective Prenatal phthalate exposure has been associated with placental inflammatory factors and infant allergic rhinitis(AR).However,the results are *** designed a population-based cohort study to examine the effects of placental inflammatory biomarkers on the sex-dependent associations between maternal phthalate exposure and infant *** A total of 2,348 pregnant women from Ma’anshan,Anhui Province,China,who were screened before antenatal visits and met the inclusion criteria,were included in the present *** assessed AR in their offspring aged 36 months with a *** PCR was performed to measure placental inflammatory factor m *** independent samples t-test and multivariable logistic regression were used to determine the associations between infant AR and maternal *** Childhood AR may be related to education and family monthly income(P = 0.01).The phthalate metabolites,mono(2-ethylhexyl) phthalate(MEHP),mono(2-ethyl-5-hydroxyl) phthalate(MEHHP),in pregnant women were associated with a significantly increased risk for infant AR in males[P < 0.05;odds ratio(OR):1.285;95% confidence interval(CI):1.037-1.591,and OR:1.232,95% CI:1.008-1.507,respectively],but not ***,irritably-increased expression levels of HO-1 and IL-4 were associated with AR in male infants(OR:1.175;95% CI:1.038-1.329 and OR:1.181;95% CI:1.056-1.322,respectively).The association between maternal urinary MEHHP and placental HO-1 was marginally significant according to mediation *** The associations of maternal MEHHP and MEOHP levels with fetal AR in males were *** HO-1 was a fractional mediator in the associations between MEHHP and ***,the placenta should be further investigated as a potential mediator of maternal exposure-induced disease risk in children.

关键词： Phthalate Infants Allergic rhinitis Inflammation Sex difference

Acaroid mite,intestinal and urinary acariasis

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World Journal of Gastroenterology 2003年第4期9卷 874-877页

作者： Chao-Pin Li Yu-Bao Cui jian wang qing-Gui Yang Ye Tian Department of Etiology and Immunology,School of Medicine,Anhui University of Science & Technology,Huainan 232001,Anhui Province,China Department of Etiology and Immunology School of Medicine Anhui University of Science and Technology Huainan 232001 Anhui Province China. yxfy@***

AIM: To investigate epidemiology and pathogenic mite species of intestinal and urinary acariasis in individuals with different ***: A total of 1994 individuals were tested in this study. History collection, skin prick test and pathogen identification were conducted. The mites were isolated from stool and urine samples by saturated saline flotation methods and sieving following centrifugation, ***: Among the 1994 individuals examined, responses to the skin prick test of '+++', '++', '+','±' and '-' were observed at frequencies of 3.96 % (79), 3.21% (64), 2.31%(46), 1.25 % (25) and 89.27 % (1780), respectively. A total number of 161 (8.07 %) individuals were shown to carry mites, with 92 (4.61%) positive only for stool samples, 37(1.86 %) positive only for urine samples and 32 (1.60 %)for both. The positive rate of mites in stool samples was 6.22 % (124/1994), being 6.84 % (78/1140) for males and 5.39 % (46/854) for females. No gender difference was observed in this study (χ2=1.77, P＞0.05). The mites from stool samples included Acarus siro, TynoPhagus putrescentiae,Dermatophagoides farinae, D. pteronyssinus, Glycyphagus domesticus, ***, Carpoglyphus lactis and Tarsonemus granaries. The positive rate of mites in urine samples was 3.46 % (69/1994). The positive rates for male and female subjects were found to be 3.95 % (45/1140) and 2.81%(24/854) respectively, with no gender difference observed (χ2=1.89, P＞0.05). Mites species in urine samples included Acar us siro, Tynophagus putrescentiae, T. longior, Aleunocglyphus ovatus, Caloglyphus berlesei, C mycophagus, Suidasia nesbitti, Lardoglyphus konoi, Glycyphagus domesticus,Carpoglyphus lactis, Lepidoglyphus destructor,Dermatophagoides farinae, D. pteronyssinus, Euroglyphus magnei, Caloglyphus hughesi, Tarsonemus granarus and ***. The species of mites in stool and urine samples were consistent with those separated from working environment. A significant difference was found amo

关键词：恙虫病流行病学肠内感染尿路感染微生物检测病原体

Diarrhea and acaroid mites:A clinical study

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World Journal of Gastroenterology 2003年第7期9卷 1621-1624页

作者： Chao-Pin Li Yu-Bao Cui jian wang qing-Gui Yang Ye Tian, Department of Etiology and Immunology, School of Medicine, Anhui University of Science & Technology, Huainan 232001, Anhui Province, China Department of Etiology and Immunology School of Medicine Anhui University of Science Technology Huainan 232001 Anhui Province China. cpli@***

AIM: To explore the characteristics of diarrhea caused by acaroid ***: Acaroid mites in fresh stools of 241 patients with diarrhea were separated by flotation in saturated ***, skin prick test, total IgE and mite-specific IgE were detected in all ***: The total positive rate of mites in stool samples of the patients was 17.01% (41/241), the positive rates of mites in male and female patients were 15.86 % (23/145)and 18.75 % (18/96), respectively, without significant difference (P＞0.05). The percentage of skin prick test as ″+++″″++ ″″+ ″″±″″-″ was″+++, ″++″,″ +″, ″±″ and ″-″was 9.13 % (22/241), 7.47 %(18/241), 5.81% (14/241), 4.98 % (12/241) and 72.61%(175/241), respectively. The serum levels of total IgE, mitespecific IgE in patients with and without mites in stool samples were (165.72±78.55) IU/ml, (132.44±26.80) IU/ml and (145.22±82.47) IU/ml, (67.35±45.28) IU/ml,respectively, with significant difference (P＜0.01). The positive rate of mites in stool samples in staffs working in traditional Chinese medicine storehouses or rice storehouses (experimental group) was 26.74 % (23/86), which was significantly higher than that (11.61%, 18/155) in people engaged in other professions (X2=8.97, P＜0.01).CONCLUSION: Acaroid mites cause diarrhea and increase serum levels of total IgE and mite-specific IgE of patients,and the prevalence of diarrhea caused by acaroid mites is associated with occupations rather than the gender of patients.

关键词：腹泻螨类免疫球蛋白E 病因学

基于混合粒子群优化的巡航导弹低空突防航迹规划

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应用科学学报 2012年第3期30卷 317-323页

作者：王建青李帆赵建辉北京航空航天大学仪器科学与光电工程学院北京100191

将模拟退火算法嵌入到粒子群优化(paRtical swarm optimization,PSO)算法中,并对PSO产生的最优适应值进行重新评价,以此构成混合粒子群优化算法(PSO-SA).将PSO-SA算法应用于巡航导弹的航迹规划,不仅可以避免PSO陷入局部最优,而且能快速... 详细信息

将模拟退火算法嵌入到粒子群优化(paRtical swarm optimization,PSO)算法中,并对PSO产生的最优适应值进行重新评价,以此构成混合粒子群优化算法(PSO-SA).将PSO-SA算法应用于巡航导弹的航迹规划,不仅可以避免PSO陷入局部最优,而且能快速有效地完成离线和在线规划任务,获得理想的三维航迹.仿真结果验证了该算法的有效性,且对同一起始位置所规划出的航程较PSO算法短,可有效节约导弹燃料.

关键词：低空突防离线规划在线规划粒子群优化模拟退火

A Phase Ⅱ Clinical Trial of Celecoxib Combined with Platinum-Based Regimen as First-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer Patients with Cyclooxygenase-2 Positive Expression

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Chinese Journal of Cancer Research 2009年第1期21卷 1-12页

作者： Jun Zhao Zhi-jie wang jian-chun Duan qing-zhi Guo Hua Bai Lu Yang Tong-tong An Xin wang Yu-yan wang Mei-na Wu Xu-yi Liu Jie wang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Thoracic Medical Oncology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To evaluate the efficacy and safety of celecoxib treatment of advanced non-small cell lung cancer （NSCLC）, and combined therapy by molecular analysis. plus platinum-doublet as first-line chemotherapy in to determine the subgroup benefiting from celecoxib Methods： A total of 44 treatment-naive patients of advanced NSCLC with positive cyclooxygenase-2 （COX-2） expression confirmed by immunohistochemical （IHC） staining were designed to receive celecoxib plus platinum-doublet chemotherapy （cisplatin plus gemcitabine, novelbine or docetaxol） from February 2005 to May 2007. On 5-7 day before chemotherapy, 400 mg celecoxib was administered twice a day orally until obvious evidence of disease progression or intolerable toxicity was found. Adverse events were recorded according to NCI-CTC criteria. The primary endpoint was overall survival （OS）. The secondary endpoints included progression-free survival （PFS）, 1-year survival rate, response rate （RR） and safety. Additionally, we detected epithelial growth factor receptor （EGFR） status including EGFR gene amplification by real-time PCR and gene mutations by DHPLC followed by sequencing. Results： The response rate was 45% （20/44）, and the disease control rate （DCR） was 59% （26/44）. The median progression-free survival time and median survival time were 6 m and 18 m, respectively. The l-year survival rate was 68%. Chemotherapy cycle numbers and best response were found to be the predictive factors for PFS by COX model analysis （P=0.023 and P=0.000, respectively）. No factor was found to affect OS. The most common toxicities included neutropenia and nausea/vomit. EGFR gene amplification was an independent prognostic factor influencing OS （P=0.0002）. Patients with EGFR mutations （exon 21） had a tendency of disease progression （P=0.041）. Conclusion： Encouraging activities of celecoxib combined with platinum-doublet chemotherapy were demonstrated in treatment-naive patients with advanced NSCLC, with good tolerances. For

关键词： Cyclooxygenase-2 Epithelial growth factor receptor Non-small-cell lung cancer

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品牌视觉识别系统的建构

包装工程 2005年第3期26卷 137-138,158页

作者：王青剑广州大学广州510029

本文论述了在建构品牌视觉识别系统时,在运用品牌视觉识别系统中要注意和考虑的重要因素,使建构品牌视觉识别系统时采取更加科学、更加合理,正确而全面的方法。

关键词：品牌品牌视觉识别系统建构

4πβ-4πγ相加效率外推法测量^(60)Co、^(134)Cs活度

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原子能科学技术 2009年第4期43卷 300-303页

作者：郭晓清汪建清姚顺和中国原子能科学研究院国防科工委放射性计量一级站北京102413

阐述了由4πβ(PC)流气式正比计数器及大体积井型4πγNaI(Tl)晶体组成的4π-β4πγ活度测量装置,从理论上建立了相加效率外推方程,并利用相加效率外推方法测量了60Co1、34Cs活度,其相对标准不确定度分别为0.29%、0.19%。将测量结果与... 详细信息

阐述了由4πβ(PC)流气式正比计数器及大体积井型4πγNaI(Tl)晶体组成的4π-β4πγ活度测量装置,从理论上建立了相加效率外推方程,并利用相加效率外推方法测量了60Co1、34Cs活度,其相对标准不确定度分别为0.29%、0.19%。将测量结果与符合效率外推测量结果进行了比较验证。分析表明,此方法适于复杂衰变核素的活度测量。

关键词： 4πβ-4πγ装置相加效率外推 60Co 134Cs 活度

One-phase treatment for calculous pyonephrosis by percutaneous nephrolithotomy assisted by EMS LithoClast master

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Chinese Medical Journal 2013年第8期126卷 1584-1586页

作者： wang jian ZHOU Da-qing HE Meng LI Wen-gang PANG Xiang YU Xiao-xiang jianG Bo Department of Urology 303th Hospital of People's LiberationArmy Nanning Guangxi 530021 China

The one-phase therapy for calculous pyonephrosis through percutaneous nephrolithotomy （PCNL） iscurrently vigorously debated. After a definite preoperative diagnosis of pyonephrosis, the traditional approach1 has been initial drainage through puncture and nephrostomy. Upon the stabilization of symptoms, a second-phase operation is performed. If pus is discovered during an intra-operative puncture, a nephrostomy tube is deposited until a second elective operation. With the advancements of science and technology, the third generation EMS LithoClast master is capable of not only efficiently crushing and removing the stones, but also lowering the intra-pelvic pressure through vacuum suction. Thus the surgical risks have been greatly reduced so that many one-phase operations for calculous pyonephrosis may be completed.2

关键词： percutaneous nephrolithotomy calculi pyonephrosis pressure