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Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism

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Science Bulletin 2025年第3期70卷 342-346页

作者： Nana Yang Jiahong Chen Yujie Zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi Ding huiqing wang Yaobo Zhao Liang Ji Rui Zhan Yufei Wu Zhaomeng wang Manyuan Dong Lemin Zheng School of Bioscience and Technology Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular DiseasesShandong Second Medical UniversityWeifang 261053China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China Beijing Tiantan Hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionBeijing Institute of Brain DisordersThe Capital Medical UniversityBeijing 100050China Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdao 266071China

Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart ***(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关键词： metabolism cardiovascular diseases

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基于标签依赖性的多功能活性肽预测模型

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陕西师范大学学报(自然科学版) 2025年第1期53卷 22-32页

作者：任建雪韩笑程昊石晋雪王会青太原理工大学计算机科学与技术学院(大数据学院) 山西晋中030600

多功能活性肽是一种源于蛋白质的化合物,能够作用于多个靶标并传递多种生理效应,对多种疾病具有显著的治疗效果。现有多功能活性肽预测模型在特征表示阶段未能充分考虑到氨基酸之间存在的关联性,使得模型的特征表示能力降低;现有方法采... 详细信息

多功能活性肽是一种源于蛋白质的化合物,能够作用于多个靶标并传递多种生理效应,对多种疾病具有显著的治疗效果。现有多功能活性肽预测模型在特征表示阶段未能充分考虑到氨基酸之间存在的关联性,使得模型的特征表示能力降低;现有方法采用将多标签分类问题转换为多个二分类预测问题的策略,导致模型在预测阶段无法考虑活性肽多个功能之间的依赖性,使得模型对多功能活性肽的预测准确度下降。针对以上问题,提出一种基于标签依赖性的多功能活性肽预测模型TCLD,通过Transformer编码器提取活性肽序列中氨基酸之间的关联性,利用ZLPR损失函数来捕获多个功能之间对应的标签依赖性,用于提高多功能活性肽预测模型的性能。实验结果表明,TCLD的预测性能优于现有的多功能活性肽预测方法,有助于研究人员快速筛选出具有潜在治疗价值的多功能活性肽候选物,从而加速新型药物的研发进程。

关键词：多功能活性肽 Transformer 多尺度卷积网络混合池化标签依赖性

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International Experience, China's Development and Prospect of Carbon Market Construction

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2022年第2期17卷 345-367页

作者： wang huiqing Research Institute of Bank of China Beijing 100818China

Carbon market,which is capable of scientific quantifying and marked-based pricing of carbon emission,is an important way for countries to achieve the target of carbon emission *** global carbon market,after more than ten years of development,has developed a mature *** started the trial of carbon market in *** ten years of exploration,the national carbon trading market was officially launched in mid-July *** the backdrop of carbon neutrality,the national carbon market will shoulder a greater mission of carbon emission reduction and speed up its financialization and ***,it should take a dialectical attitude toward the opportunities and risks of carbon market *** the future,China can promote the development of carbon market through efforts to develop market participants,clarify the attributes of carbon finance,prevent potential risks of carbon finance,improve the connection mechanism with the international carbon market,and innovate carbon finance services.

关键词： carbon market international experience carbon trading risk of carbon finance

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Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

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Frontiers of Medicine 2024年第1期18卷 31-45页

作者： Yaonan Song Haoran Wei Zhitong Zhou huiqing wang Weijian Hang Junfang Wu Dao Wen wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

Phenylacetylglutamine(PAGln)is an amino acid derivate that comes from the amino acid *** are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular *** this review,we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of *** summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases,such as heart failure,coronary heart disease/atherosclerosis,and cardiac *** underlying mechanism of PAGln is now considered to be related to the thrombotic potential of platelets via adrenergic ***,other possible mechanisms such as inflammatory response and oxidative stress could also be induced by ***,since PAGln is produced across different organs including the intestine,liver,and kidney,the cross-talk among multiple organs focused on the function of this uremic toxic ***,the prognostic value of PAGln compared to the classical biomarker was discussed and we also highlighted important gaps in knowledge and areas requiring future investigation of PAGln in cardiovascular diseases.

关键词： PAGln cardiovascular disease gut microbiota uremic metabolite biomarker

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噻呋酰胺和种菌唑复配对大豆白绢病和立枯病的防治效果

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植物保护 2025年第1期51卷 304-310页

作者：迟元凯任琛荣叶梦迪刘菲曹舜戚仁德王惠卿赵伟安徽省农业科学院植物保护与农产品质量安全研究所合肥230031 新疆维吾尔自治区植物保护站乌鲁木齐830000 新疆伊犁哈萨克自治州农业技术推广总站伊宁835099

室内测定了噻呋酰胺和种菌唑及其不同配比对大豆白绢病的病原菌齐整小核菌Sclerotium rolfsii和立枯病的病原菌立枯丝核菌Rhizoctonia solani的毒力,结果表明,噻呋酰胺和种菌唑对大豆齐整小核菌的EC _(50)分别为0.120μg/mL和0.033μg/... 详细信息

室内测定了噻呋酰胺和种菌唑及其不同配比对大豆白绢病的病原菌齐整小核菌Sclerotium rolfsii和立枯病的病原菌立枯丝核菌Rhizoctonia solani的毒力,结果表明,噻呋酰胺和种菌唑对大豆齐整小核菌的EC _(50)分别为0.120μg/mL和0.033μg/mL,对立枯丝核菌的EC _(50)分别为0.164μg/mL和0.022μg/mL,二者有效成分比例在1∶1,1∶5和1∶10时对大豆白绢病菌抑制效果好,表现为增效作用,增效系数分别为1.670,1.787和1.606,在5∶1,1∶1和1∶5时对立枯病菌抑制效果好,表现为增效作用,增效系数分别是1.756,1.616,和1.512。室内盆栽和田间试验表明,噻呋酰胺和种菌唑在1∶5配比下对大豆白绢病和立枯病防控效果分别达93.6%和88.3%,且能促进大豆苗期生长,增产率为39.1%~59.1%。综合考虑药剂对大豆出苗的安全性、对大豆白绢病和立枯病的防效及大豆增产效果,噻呋酰胺和种菌唑在1∶5配比下对大豆白绢病和立枯病具有明显的防治效果,适合防治大豆根茎部病害。

关键词：噻呋酰胺种菌唑大豆白绢病立枯病增效作用

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Effects of micro-oxygenation on the aroma of Cabernet Sauvignon wine from Ningxia,China

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 251-263页

作者： Zhong Zhang Qingchen Zhang huiqing wang Hongchuan Xia Lijun Sun Junxiang Zhang School of Life Sciences Ningxia UniversityYinchuan 750021China College of Pharmacy University of FloridaGainesville FL32610USA School of Agriculture Ningxia UniversityYinchuan 750021China School of Food and Wine Ningxia UniversityYinchuan 750021China China Wine Industry Technology Institute Yinchuan 750021China

Micro-oxygenation (MOX) is an effective post-harvest technique for the flavor improvement of grape wine. This study investigated the effect of MOX on the aroma quality of Ningxia wine for the first time. Three sub-region Cabernet Sauvignon dry red wines were treated with different levels of oxygen before or after malolactic fermentation. The wine aroma was analyzed through gas chromatography-mass spectrometry (GC-MS) and quantitative descriptive analysis (QDA) after six months of aging. The data obtained demonstrated that the dose and timing of oxygen addition were key factors influencing the effectiveness of MOX. The most noticeable modifications in wine aroma compounds were generated by an oxygen dosage of 30 (mL/L)/month added before malolactic fermentation. Predominantly, the concentrations of 2-phenylethanol, benzaldehyde, diacetyl, and 2,3-pentanedione showed an increased pattern upon MOX treatments. The sensory analysis revealed that MOX improved the aroma quality of wine by decreasing green and animal odors, meanwhile enhancing the olfactory intensities of dried fruits, flowers, and nuts. This work confirmed that MOX was suitable for aroma modification of Cabernet Sauvignon dry red wine from Ningxia and established a preliminary MOX procedure that can serve as a reference for future applications.

关键词： grape wine micro-oxygenation volatile organic compounds aroma profiles Ningxia

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基于阳虚致消理论探讨2型糖尿病胰岛素抵抗患者的中医治疗

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广州中医药大学学报 2025年第1期42卷 243-248页

作者：汪慧青谢长才王翰林尹丽红范文菲广州中医药大学第二临床医学院广东广州510006 广东省中医院针灸科广东广州510120

2型糖尿病(T2DM)是以胰岛素抵抗为特征的代谢性疾病,是目前世界范围内最常见的慢性非传染性疾病之一。中医认为,阳虚致消是T2DM的重要发病机制之一,也是胰岛素抵抗的核心病理基础。该文以阳虚致消理论为指导,通过查阅近年来国内相关文献... 详细信息

2型糖尿病(T2DM)是以胰岛素抵抗为特征的代谢性疾病,是目前世界范围内最常见的慢性非传染性疾病之一。中医认为,阳虚致消是T2DM的重要发病机制之一,也是胰岛素抵抗的核心病理基础。该文以阳虚致消理论为指导,通过查阅近年来国内相关文献,梳理2型糖尿病胰岛素抵抗的西医发病机制与治疗、中医阳虚致消的理论与治疗应用、中医治疗胰岛素抵抗的临床效用,分析阳虚致消理论在中医治疗T2DM胰岛素抵抗中的适用性。认为基于阳虚致消理论的中医治疗T2DM胰岛素抵抗具有显著的效果和优势,既考虑了西医的科学性和规范性,又可以发挥中医治疗的整体观和个体化的优势,实现了两种医学的优势互补和协同作用。中医治疗胰岛素抵抗能够通过多种途径和多个靶点改善胰岛素信号传导、胰岛素分泌功能和其他相关代谢异常指标,进而改善机体健康状态。中医治疗胰岛素抵抗具有较好的安全性和耐受性,能够减少西药治疗所致的不良反应。但中医治疗胰岛素抵抗也存在临床试验质量有待提高、作用机制有待深入探讨、创新性和前沿性有待提升等问题。未来需进一步深入开展相关研究,以期为中医药在防治代谢性疾病方面发挥更大的作用提供科学依据。

关键词： 2型糖尿病胰岛素抵抗阳虚致消胰岛素信号传导胰岛素分泌功能中医治疗

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The Long-Term Impacts of COVID-19 on Physical and Psychological Health—Beijing Municipality,China,December 2022–April 2023

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China CDC weekly 2023年第40期5卷 894-899页

作者： Tian Tian Chuan Yang Xiaoyu Long Fei Kong Yu Fu Fang Liu Ling Tuo Xiujun Guo Lei Li Xingxing Zhao Qun wang Guangti Yuan huiqing wang Yuanyuan wang Jie Qiao Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina State Key Laboratory of Female Fertility Promotion BeijingChina National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital) BeijingChina Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijingChina Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology BeijingChina Personnel Department Peking University Third HospitalBeijingChina Office of Hospital Management Peking University Health Science CenterBeijingChina The Second Outpatient Department of Peking University Third Hospital BeijingChina Capital Airport sub-district DongPingLi Community Health Center BeijingChina Zizhuyuan Community Service Station in Haidian District BeijingChina Beijing Advanced Innovation Center for Genomics BeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina.

Summary What is already known about this topic?Reports detailing the clinical presentation of coronavirus disease 2019(COVID-19)are extensive in ***,data remains limited regarding the long-term effects of the 2022 outbreak on the community and healthcare workers(HCWs).What is added by this report?In the follow-up study conducted with 1,069 community members and 3,309 HCWs infected with COVID-19,we observed that five months postoutbreak,39.2%of community members and 28.7%of HCWs reported experiencing at least one *** symptoms most frequently reported included fatigue or muscle weakness,insomnia,cognitive dysfunction,hair loss,joint or muscle pain,and persistent *** tended to experience fewer long-term physical consequences and their symptoms had an expedited recovery time compared to the community ***,HCWs displayed a higher prevalence of moderate to severe depression and anxiety.

关键词： clinical consequences COV

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An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie Tang Shengjun Sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng wang Yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun huiqing wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

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Facile synthesis of UCNPs/Zn_xCd_(1-x)S nanocomposites excited by near-infrared light for photochemical reduction and removal of Cr(Ⅵ)

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Chinese Journal of Catalysis 2018年第7期39卷 1240-1248页

作者： Mengli Zhao Wanni wang Chenxi Huang wang Dong Yang wang Sheng Cheng huiqing wang Haisheng Qian School of Biological and Medical Engineering Hefei University of TechnologyHefei 230009AnhuiChina Instrumental Analysis Center Hefei University of TechnologyHefei 230009AnhuiChina School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009AnhuiChina

Photocatalysis driven by near-infrared（NIR）light is of scientific and technological interest for ex-ploiting solar *** this study,we demonstrate a facile hydrothermal process to synthesize core-shell nanoparticles combining upconversion nanoparticles（UCNPs）and alloyed ZnxCwhich can be excited using NIR or visible ***,phase,and chemical composition have been investigated using field-emission scanning electron microscopy,transmission electron mi-croscopy,X-ray diffraction analysis,and atomic absorption ***,we found that amorphous TiO2 layers existing in the final samples play an important role in formation ofyolk-shell nanoparticles,which bind the as-prepared ZnxCnanoparticlescan be tuna-ble by adjusting the amount of the Cd and Zn source *** photochemical reduction of Cr（Ⅵ）in water has been performed to study the photocatalytic performance under irradiation by NIR light or a simulated solar light,showing efficient photoreduction and Cr（Ⅵ）removal over the/TiO2 yolk-shell *** as-prepared UCNPs@ZnxC/TiO2 nanoparticles show excellent production of hydroxyl radicals,which are responsible for the photochemical reduction of Cr（Ⅵ）to Cr（Ⅲ）.This study will provide an alternative strategy for en-vironmental wastewater treatment,making full use of solar energy.

关键词： Upconversion nanoparticle ZnxCd1-xS alloyed semiconductor Yolk-shell Photocatalysis Hydrothermal synthesis

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