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基于“三生”视角的黄河流域城市高质量发展测度研究

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人民黄河 2024年第1期46卷 25-31页

作者：王慧丽徐玉杰张靖妮康美佳西安财经大学统计学院陕西西安710100 西安财经大学西安统计研究院陕西西安710100

鉴于城市的高质量发展对黄河流域高质量发展具有带动和辐射作用,为了给黄河流域生态保护和高质量发展重大国家战略的全面实施提供参考,基于“三生”(生态、生产、生活)视角构建高质量发展评价指标体系,运用熵权TOPSIS法构建高质量发展... 详细信息

鉴于城市的高质量发展对黄河流域高质量发展具有带动和辐射作用,为了给黄河流域生态保护和高质量发展重大国家战略的全面实施提供参考,基于“三生”(生态、生产、生活)视角构建高质量发展评价指标体系,运用熵权TOPSIS法构建高质量发展测度模型,采用高质量发展贴近度反映高质量发展水平,对黄河流域61个地级市2011—2020年高质量发展水平进行测度,采用K均值聚类算法等分析黄河流域城市高质量发展水平时空变化情况。结果表明:1)2011—2020年黄河流域城市高质量发展水平整体上呈显著上升趋势。2)目前黄河流域高质量发展水平仍然普遍较低,从空间上看,上、下游城市高质量发展水平接近且均明显高于中游城市。3)黄河流域各市高质量发展水平差异较大。4)高质量发展水平较高的城市多为省会城市和新一线城市,其“三生”水平均较高,这类城市较少;分布于生态环境较好的上游地区和经济发展较为强劲的下游地区部分城市,高质量发展水平相对较高,这类城市“三生”中的1个或2个发展水平较高,属非全面发展,这类城市也较少;占比较大的其他城市高质量发展水平较低,这类城市“三生”水平均相对较低。建议:1)实施差异化发展策略,各城市因地制宜、发挥自身优势、补齐“三生”短板;2)进一步提高中心城市、省会城市及城市群竞争力,使其发挥更大的辐射带动作用;3)抓住发展机遇,促进经济发展、生态保护、民生改善。

关键词：高质量发展贴近度 “三生”视角城市熵权TOPSIS法黄河流域

铁死亡抑制剂Fer-1对帕金森病的影响研究

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合肥工业大学学报（自然科学版） 2024年第4期47卷 533-538,569页

作者：夏颜舟汪惠丽叶赟妍刘志华合肥工业大学食品与生物工程学院安徽合肥230601

帕金森病(Parkinson’s disease,PD)是全球第二大神经退行性疾病,近年来研究表明,帕金森病患者存在铁代谢异常。文章以果蝇为模式生物,利用Uas-Ga14系统靶向突变多巴胺能神经元(dopaminergic neuron,DA)中PINK 1基因构建果蝇帕金森病模... 详细信息

帕金森病(Parkinson’s disease,PD)是全球第二大神经退行性疾病,近年来研究表明,帕金森病患者存在铁代谢异常。文章以果蝇为模式生物,利用Uas-Ga14系统靶向突变多巴胺能神经元(dopaminergic neuron,DA)中PINK 1基因构建果蝇帕金森病模型。通过检测对照组(W^(1118))、模型组(PINK1^(B 9))和铁死亡抑制剂(Ferrostatin-1,Fer-1)干预组(PINK1^(B 9)-Fer-1)3组果蝇的运动能力、脑中铁水平、活性氧(reactive oxygen species,ROS)、脂质过氧化水平和多巴胺能神经元数目以探究铁死亡在帕金森病中的作用。结果表明:模型组果蝇运动能力下降,脑内铁质量浓度增多,ROS及脂质过氧化水平上升,多巴胺能神经元数目下降;通过Fer-1干预可以有效改善运动表型,并降低ROS及脂质过氧化水平,提高多巴胺能神经元数目。综上所述,通过突变PINK 1基因构建的帕金森病模型中存在细胞铁死亡,Fer-1治疗可以挽救相关症状。该文为后续研究帕金森病的病理机制提供新的方向。

关键词：帕金森病(PD) 铁死亡铁活性氧(ROS) 脂质过氧化多巴胺能神经元(DA)

多种两步模式的三维制图方式在丘陵区林地土壤有机碳预测中的对比

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水土保持学报 2024年第2期38卷 351-363页

作者：杨华蕾王晓晴张美薇郭倩王会利曾令涛崔宇培孙孝林中山大学地理科学与规划学院广州510006 广西壮族自治区林业科学研究院南宁530002

[目的]为了探讨多种两步模式三维制图方法的准确度影响因素及其规律。[方法]以华南典型丘陵区1个面积约5 km^(2)的林场内土壤有机碳为研究对象,分别使用样条函数、指数函数和幂函数作为深度函数,普通克里格和随机森林作为水平制图方法,... 详细信息

[目的]为了探讨多种两步模式三维制图方法的准确度影响因素及其规律。[方法]以华南典型丘陵区1个面积约5 km^(2)的林场内土壤有机碳为研究对象,分别使用样条函数、指数函数和幂函数作为深度函数,普通克里格和随机森林作为水平制图方法,以及两步模式的2种不同制图形式(称为形式A和B),进行土壤有机碳含量的三维预测制图,并探究不同的深度函数、水平制图方法或制图形式对两步模式三维制图结果的影响规律。[结果](1)深度函数在很大程度上决定制图结果在垂直和水平方向上的变异,表现在制图结果的变异在3个深度函数之间差异较大,其中指数函数上的变异最大,幂函数上最弱,而水平制图方法(普通克里格与随机森林)对制图结果的垂直变异影响不大,但对表层的空间变异影响较大;(2)样条函数由于模拟的深度曲线与实测点吻合得最好,因而准确度最好,表现在基于样条函数的三维制图一致性相关系数(CCC)为0.72~0.75,均高于同种制图形式下的其他函数(CCC为0.64~0.74),而水平制图方法中普通克里格的制图效果好于随机森林,表现在前者的CCC为0.67~0.75,后者的CCC为0.64~0.72;(3)两步模式的2种制图形式对准确度的影响较小,仅在底层的准确度上表现出形式A(即水平预测制图深度函数模拟值)好于形式B(即水平预测制图深度函数参数);(4)所有制图方式中,普通克里格与样条函数相结合的制图形式A的准确度最高,决定系数(R 2)达0.76,一致性相关系数(CCC)为0.75,均方根误差(RMSE)为3.50 g/kg。[结论]在两步模式的三维土壤制图中,首先应考虑样条函数作为深度函数,其次依据研究区的景观条件和样本量,考虑水平制图方法,最后,尽量采用两步模式的第一种制图形式。

关键词：三维制图土壤有机碳深度函数两步模式

A screening assay for thyroid hormone signaling disruption based on thyroid hormone-response gene expression analysis in the frog Pelophylax nigromaculatus

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Journal of Environmental Sciences 2015年第8期27卷 143-154页

作者： Yinfeng Zhang Yuanyuan Li Zhanfen Qin huili wang Jianzhong Li State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Department of Environmental Bio-Technology Research Center for Eco-environmental Sciences Chinese Academy of Sciences

Amphibian metamorphosis provides a wonderful model to study the thyroid hormone（TH）signaling disrupting activity of environmental chemicals, with Xenopus laevis as the most commonly used species. This study aimed to establish a rapid and sensitive screening assay based on TH-response gene expression analysis using Pelophylax nigromaculatus, a native frog species distributed widely in East Asia, especially in China. To achieve this, five candidate TH-response genes that were sensitive to T3 induction were chosen as molecular markers, and T3 induction was determined as 0.2 nmol/L T3 exposure for 48 hr. The developed assay can detect the agonistic activity of T3 with a lowest observed effective concentration of 0.001 nmol/L and EC50 at around 0.118–1.229 nmol/L, exhibiting comparable or higher sensitivity than previously reported assays. We further validated the efficiency of the developed assay by detecting the TH signaling disrupting activity of tetrabromobisphenol A（TBBPA）, a known TH signaling disruptor. In accordance with previous reports, we found a weak TH agonistic activity for TBBPA in the absence of T3,whereas a TH antagonistic activity was found for TBBPA at higher concentrations in the presence of T3, showing that the P. nigromaculatus assay is effective for detecting TH signaling disrupting activity. Importantly, we observed non-monotonic dose-dependent disrupting activity of TBBPA in the presence of T3, which is difficult to detect with in vitro reporter gene assays. Overall, the developed P. nigromaculatus assay can be used to screen TH signaling disrupting activity of environmental chemicals with high sensitivity.

关键词： Thyroid hormone signaling disruptor Pelophylax nigromaculatus TH-response gene expression Screening assay Tetrabromobisphenol A

活血通络类方剂治疗糖尿病肾脏疾病的研究进展

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世界中医药 2024年第5期19卷 736-740页

作者：王慧丽彭紫凝李冰王晨辉庞欣欣韩佳瑞河南中医药大学第二临床医学院郑州450002 河南省中医院/河南中医药大学第二附属医院肾病科郑州450002

糖尿病肾脏疾病(DKD)是导致慢性肾脏病和终末期肾病的首要病因,严重危害人类健康。中医认为血瘀是贯穿DKD全病程的重要病机,多项研究拟定了多个活血通络类方治疗DKD患者,其临床症状好转、蛋白尿减少、肾功能保护、治疗有效率提高和疾病... 详细信息

糖尿病肾脏疾病(DKD)是导致慢性肾脏病和终末期肾病的首要病因,严重危害人类健康。中医认为血瘀是贯穿DKD全病程的重要病机,多项研究拟定了多个活血通络类方治疗DKD患者,其临床症状好转、蛋白尿减少、肾功能保护、治疗有效率提高和疾病进展延缓等方面均有成效。

关键词：糖尿病肾脏疾病活血通络类方研究进展益气养阴泄浊解毒补肾活血祛风通络中医药

“全链式”信息化健康管理模式对儿童支气管哮喘的干预价值

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河南医学研究 2024年第17期33卷 3247-3250页

作者：汪慧利景钰李娜瑛郑州大学附属儿童医院/河南省儿童医院郑州儿童医院南院区急诊综合病房河南郑州450018

目的探讨“全链式”信息化健康管理模式对儿童支气管哮喘的干预价值。方法选取2021年3月至2022年10月河南省儿童医院郑州儿童医院收治的120例支气管哮喘患儿,按入院时间分为试验组(60例)和常规组(60例),常规组接受常规居家护理,试验组... 详细信息

目的探讨“全链式”信息化健康管理模式对儿童支气管哮喘的干预价值。方法选取2021年3月至2022年10月河南省儿童医院郑州儿童医院收治的120例支气管哮喘患儿,按入院时间分为试验组(60例)和常规组(60例),常规组接受常规居家护理,试验组在常规组基础上接受“全链式”信息化健康管理模式居家护理。对比两组遵医行为、症状改善时间(咳嗽、发热、肺部啰音、憋喘)、哮喘发作次数及急诊次数、肺功能[用力肺活量(FVC)、第1秒用力呼气量(FEV 1)]水平、儿童少年生活质量量表(QLSCA)及家属护理满意度。结果试验组遵医率[93.33%(56/60)]较常规组[76.67%(46/60)]高(P<0.05);试验组咳嗽、发热、肺部啰音、憋喘改善时间均较常规组短(P<0.05);试验组哮喘发作次数及急诊次数均较常规组少(P<0.05);干预后,试验组FEV 1、FVC水平均较常规组高(P<0.05);干预后,两组QLSCA评分均较干预前高,试验组QLSCA评分较常规组高(P<0.05);试验组家属护理满意度[98.33%(59/60)]较常规组[85.00%(51/60)]高(P<0.05)。结论经“全链式”信息化健康管理模式的护理可以降低支气管哮喘患儿的就诊次数,缓解病情,增强肺部功能,提高生存质量,以及让患儿家长感到满意。

关键词：儿童支气管哮喘 “全链式”信息化健康管理模式

Enantioseletive bioaccumulation of tebuconazole in earthworm Eisenia fetida

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Journal of Environmental Sciences 2012年第12期24卷 2198-2204页

作者： Dingyi Yu Jianzhong Li Yanfeng Zhang huili wang Baoyuan Guo Lin Zheng Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China

Methods of extraction and determination of tebuconazole enantiomers in earthworm （Eisenia fetida） were developed by capillary electrophoresis （CE） and high performance liquid chromatography （HPLC）. Both CE and HPLC have excellent resolution and recovery. The linearity ranges were 2.9-102.4 mg/kg and 3.0-99.6 mg/kg for （＋）-R-tebuconazole and （-）-S-tebuconazole respectively in CE, and from 0.56 to 1000 mg/kg for both enantiomers in HPLC. Enantioselective bioaccumulation in earthworms from soft was investigated under laboratory condition at concentrations of 10 and 50 mg/kg dw in soil. The uptake kinetics of （＋）-R-tebuconazole fitted the first- order kinetics well with r2 0.97 and 0.94 under 10 and 50 mg/kg dw exposure condition, respectively, while （-）-S-tebuconazole with r2 0.75 and 0.22 did not show the same. Bioaccumulation of tebuconazole in earthworm tissues was enantioselective with a preferential accumulation of （＋）-R-tebuconazole. The （＋）-R-tebuconazole might also have biomagnifying effect potential in earthworm food chain with biota-sediment accumulation factor （BSAF） of 1.64 kg OC/kg lip in 10 mg/kg dw exposure group and 2.61 kg OC/kg lip in 50 mg/kg dw exposure group from soil to earthworm after 36 days. Although （-）-S-tebuconazole shares the same physicochemical properties with （＋）-R-tebuconazole, it did not biomaguify. BSAFs of （-）-S-tebuconazole were 0.50 kg OC/kg lip （10 mg/kg dw tebuconazole exposure） and 0.28 kg OC/kg lip （50 mg/kg dw tebuconazole exposure） after 36 days, which was possibly owing to biotransformation or metabolism in earthworm tissues.

关键词： tebuconazole earthworm bioaccumulation enanfioselectivity

Characteristics of gaseous product from municipal solid waste gasification with hot blast furnace slag

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Journal of Natural Gas Chemistry 2010年第4期19卷 403-408页

作者： Lumei Zhao Hua wang Shan Qing huili Liu Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology Kunming 650093 Yunnan China

Possibility of combustible gas production from municipal solid waste （MSW） using hot blast furnace （BF） slag has been *** objective of this work is to generate combustible gas from MSW using heated BF *** this experiment,the thermal stability of the MSW was analyzed by thermogravimetric analysis,and effects of temperature,gasifying agent （air,N2,steam） and BF slag on the gas products were investigated at 600？900 ？*** thermogravimetric analysis indicates that the weight loss of MSW includes four stages：evaporation of the moisture,combustion of volatile materials,burning of carbon residue and burnout of *** contents of the combustible gas increase with increasing temperature,and the lower calorific value （LCV） increases rapidly at 600？900 ？*** is found that volume fraction of CO,H2 and CH4 at different atmospheres increases in the order N2〈air〈*** is believed that BF slag acts as the catalyst and the heat carrier,which promotes the gasification reactivity of MSW.

关键词： gas characteristics municipal solid waste gasification blast furnace slag waste heat recovery

Assessing the impact of fungicide enostroburin application on bacterial community in wheat phyllosphere

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Journal of Environmental Sciences 2010年第1期22卷 134-141页

作者： Likun Gu Zhihui Bai Bo Jin Qing Hu huili wang Guoqiang Zhuang HongxunZhang Qingdao Institute of BioEnergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China Research Centre for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China School of Earth and Environment Sciences The University of Adelaide Adelaide SA 5005 Australia Graduate University of Chinese Academy of Sciences Beijing 100039 China

Fungicides have been used extensively for controlling fungal pathogens of plants. However, little is known regarding the effects that fungicides upon the indigenous bacterial communities within the plant phyllosphere. The aims of this study were to assess the impact of fungicide enostroburin upon bacterial communities in wheat phyllosphere. Culture-independent methodologies of 16S rDNA clone library and 16S rDNA directed polymerase chain reaction with denaturing gradient gel electrophoresis （PCR-DGGE） were used for monitoring the change of bacterial community. The 16S rDNA clone library and PCR-DGGE analysis both confirmed the microbial community of wheat plant phyllosphere were predominantly of the γ-Proteobacteria phyla. Results from PCR-DGGE analysis indicated a significant change in bacterial community structure within the phyllosphere following fungicide enostroburin application. Bands sequenced within control cultures were predominantly of Pseudomonas genus, but those bands sequenced in the treated samples were predominantly strains of Pantoea genus and Pseudomonas genus. Of interest was the appearance of two DGGE bands following fungicide treatment, one of which had sequence similarities （98%） to Pantoea sp. which might be a competitor of plant pathogens. This study revealed the wheat phyllosphere bacterial community composition and a shift in the bacterial community following fungicide enostroburin application.

关键词： fungicide phyllosphere microbial community 16S rDNA clone library PCR-DGGE