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The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum

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Biomedical and Environmental Sciences 2023年第11期36卷 1005-1014页

作者： YANG Ke WEN Ya ZHU Lei BAO Jia Yu LI Shang wang ying hui FENG Jun TIAN Lei JIE ying Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key LabBeijing 100730China

Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic *** Patients with chronic hordeolum who underwent IPL treatment were enrolled in this *** to the severity of hordeolum,the patients were treated with IPL 3 to 5 ***’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were *** number,congestion,long diameter,short diameter and area of nodules were also recorded and ***,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were *** 20 patients were enrolled in this *** eyelid margins were congestive and swollen,with blunt rounding or *** meibum was cloudy or *** meibomian gland expressibility,meibomian gland dropout and tear meniscus height were *** cornea showed scattered fluorescein *** treatment,score of visual analog scale,congestion and size of nodules were significantly *** margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were *** gland dropout had no significant *** side effects occurred during *** IPL is beneficial for the treatment of chronic hordeolum.

关键词： Intense pulsed light Hordeolum Chronic

The Quality of Life of Chinese Middle-Aged Male Patients with Gastric Carcinoma After Total Gastrectomy and Nursing Intervention

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Clinical oncology and cancer researeh 2010年第2期7卷 151-156页

作者： Yan wang hui-ying wang Guo-hong YIN hui-zi TIAN Dan wang Department of Gastroenterological Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China.

OBJECTIVE The purpose of this study was to evaluate the quality of life （QOL） in Chinese middle-aged male patients with gastric carcinoma after total gastrectomy, to investigate the factors affecting their QOL, and to Study the effectiveness of nursing *** Structured questionnaire （EORTC QLQ-C30） was used among 162 middle-aged male patients after total gastrectomy （the patients finished the whole process of chemotherapy, and returned home, and society） for data collection and reevaluate the patients＇ aualitv of life with 2 months nursing *** The patient＇s quality of life was related to their education level, economic condition, family support, and pathological staging. This study showed that patients got higher scores in Functional scales （except for CF）, and lower scores in Symptom scales and single items （except for FI） after receiving intervention than before it was received *** The study revealed that the QOL in middleaged male patients after total gastrectomy was worse when there was inadequate attention. After implementing pertinent nursing intervention implementing, patients＇ mental attitude and negative behavior were improved, and their QOL was enhanced after returning home and into society.

关键词： middle-aged patients gastrectomy quality oflife nursing.

Direct electrochemistry and electrocatalysis of myoglobin in dodecyltrimethylammonium bromide film modified carbon ceramic electrode

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Chinese Chemical Letters 2011年第4期22卷 465-468页

作者： Yuan Zhen Zhou hui wang She ying Dong An Xiang Tian Zhi Xian He Bin Chen School of Science Xi'an University of Architecture and TechnologyXi'an 710055China

Direct electrochemistry and electrocatalysis of myoglobin（Mb） were studied with Mb immobilized on dodecyltrimethylammonium bromide（DTAB） film modified carbon ceramic（CC） *** voltammetry showed a pair of well-defined and nearly reversible redox peaks of Mb（Fe~Ⅱ/Fe~Ⅲ） at about—0.3 V ***（pH = 6.98）.The currents of the redox peak were linear to scan rate,and rate constant（Ks） was estimated to be 3.03 s^（-1）.The formal potential（E°＇） of Mb in the DTAB/CC electrodes shifted linearly with pH with a slope of -36.44 mV/pH,implying that the electron transfer between DTAB and CC electrodes is accompanied by proton *** immobilized Mb exhibited excellent electrocatalytic response to the reduction of hydrogen peroxide（H2O2）.

关键词： Electrocatalysis Direct electron transfer DTAB H_2O_2 Myoglobin

Direct-acting Antiviral Agents Resistance-associated Polymorphisms in Chinese Treatment-na（i）ve Patients Infected with Genotype 1b Hepatitis C Virus

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Chinese Medical Journal 2015年第19期128卷 2625-2631页

作者： Ye wang hui-ying Rao Xing-wang Xie Lai Wei Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory for Hepatitis C and Immunotherapy for Liver DiseaseBeijing 100044China

Background：It has been reported that several baseline polymorphisms of direct-acting antivirals （DAAs） agents resistance-associated variants （RAVs） would affect the treatment outcomes of patients chronically infected with hepatitis C virus （CHC）.The aim of this study is to investigate the prevalence of DAAs RAVs in treatment-na（i）ve GT1b CHC ***：Direct sequencing and ultra-deep sequencing of the HCV NS3,NS5A,and NS5B gene were performed in baseline serum samples of treatment-ha（i）ve patients infected with genotype lb hepatitis C virus （HCVs）.Results：One hundred and sixty CHC patients were *** sequence information was obtained for 145 patients （NS3）,148 patients （NS5A）,and 137 patients （NS5B）.Treatment-failure associated variants of DAAs were detected：56.6％（82/145） of the patients presented S122G for simeprevir （NS3 protease inhibitor）;10.1％（14/148） of the patients presented Y93H for daclatasvir and ledipasvir （NS5A protein inhibitors）;94.2％（129/137） of the patients presented C316N for sofosbuvir （NS5B polymerase inhibitor）.Nearly,all of the DAAs RAVs detected by ultra-deep sequencing could be detected by direct ***：The majority of genotype lb CHC patients in China present a virus population carrying HCV DAAs *** sequencing of HCV genome might need to be performed when patients infected with GTlb HCV receiving DAAs-containing regimens in *** sequencing would be quite quantified for the work.

关键词： Antiviral Resistance Direct Antiviral Agents Hepatitis C Virus

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软件功能需求变化传播机理分析

计算机学报 2007年第11期30卷 2025-2032页

作者：王映辉西安理工大学计算机科学与工程学院西安710048

软件变化控制是软件开发者历来追求的目标,也是研究软件演化的基础.基于功能需求变化,描述了变化用况和变化对象的标识,阐明了变化构件的界定策略,给出了SA(Software Architecture)中变化信息的追踪方法;同时分析了软件变化转播在软件... 详细信息

软件变化控制是软件开发者历来追求的目标,也是研究软件演化的基础.基于功能需求变化,描述了变化用况和变化对象的标识,阐明了变化构件的界定策略,给出了SA(Software Architecture)中变化信息的追踪方法;同时分析了软件变化转播在软件生命周期中的一些重要性质;最后描绘了本文研究的整体框架和一个应用实例.对软件演化与维护具有一定的借鉴意义.

关键词：用况对象模型变化传播软件演化变化分析

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

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Chinese Medical Journal 2006年第23期119卷 1983-1990页

作者： wang hui-ying SHEN Hua-hao James J Lee Nancy A Lee Department of Respiratory Medicine Second Affiliated Hospital ofZhejiang University Medical College Institute of RespiratoryDiseases of Zhejiang University Hangzhou 310009 China Department of Biochemistry and Molecular Biology Mayo ClinicScottsdale Scottsdale Arizona 85259 USA

Background Asthma is a chronic airway disease with inflammation characterized by physiological changes （airway hyper-responsiveness, AHR） and pathological changes （inflammatory cells infiltration and mucus production）. Eosinophils play a key role in the allergic inflammation. But the causative relationship between eosinophils and airway inflammation is hard to prove. One of the reasons is lack of activation marker of murine eosinophils. We investigated the expression of CD69 on murine eosinophils in vitro, the relationship between the expression of CD69 on eosinophils from peripheral blood and bronchoalveolar lavage fluid and on airway inflammation in asthmatic mice. Methods Eosinophils from peripheral blood of IL-5 transgenic mice （NJ.1638） were purified. Mice were divided into five groups： wild type mice sensitized and challenged with saline （WS group）, wild type mice sensitized and challenged with ovalbumin （WO group）, IL-5^-/- mice sensitized and challenged with saline and transferred with purified eosinophils （ISE group）, IL-5^-/- mice sensitized and challenged with OVA and transferred with purified eosinophils （IOE group）, IL-5^-/- mice sensitized and challenged with OVA and transferred with purified eosinophils, pretreated with anti CD4 monoclonal antibody （IOE＋antiCD4mAb group）. IL-5^-/- mice were sensitized with OVA at day 0 and day 14, then challenged with OVA aerosol. On days 24, 25, 26 and 27 purified eosinophils were transferred intratracheally to IL-5^-/- mice. On day 28, blood and BALF were collected and CD69 expression on eosinophils measured by flowcytometry. Results Purified eosinophils did not express CD69. But eosinophils cultured with PMA＋MA, IFN- T, IL-5 or GM-CSF expressed CD69 strongly. Eosinophils from blood of WO, WS group did not express CD69 at all. The numbers of eosinophils in BALF of WO group, IOE group, ISE group and IOE＋antiCD4mAb group were significantly higher than in mice of WS group which did not have eosinophils at all. CD69

关键词： asthma eosinophils CD69 airway inflammation murine model

Small-medium sized enterprise cluster and small town economic development

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Chinese Business Review 2007年第4期6卷 25-28,34页

作者： wang hui-ying MENG Shan-shan School of Economics Tianjin Polytechnic University Tianjin 300384 China

The small-medium sized enterprise （SME） in China has made considerable progress and been the main power to promote the regional economic development. SME cluster at the small town in the developed areas along the east coast of China. This paper analyses the relationship between SME cluster and the economic development of small towns. The conclusion is that SME cluster is the direction of the small town＇s development. The special cultural tradition and value conception are the important location conditions to develop SME cluster. In the end, the author provides some countermeasures to develop SME clusters in the small towns.

关键词： SME cluster small town economic development countermeasures

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软件体系结构演化模型

电子学报 2005年第8期33卷 1381-1386页

作者：王映辉王立福北京大学软件工程国家工程研究中心

软件演化包括静态演化和动态演化两个方面.作为软件的蓝图的SA(软件体系结构),为人们宏观把握软件的整体结构和软件演化提供了一条有效的途径.在描述SA的构件-连接件模型的基础上,首先针对SA的静态演化,建立了SA邻接矩阵和可达矩阵,凭... 详细信息

软件演化包括静态演化和动态演化两个方面.作为软件的蓝图的SA(软件体系结构),为人们宏观把握软件的整体结构和软件演化提供了一条有效的途径.在描述SA的构件-连接件模型的基础上,首先针对SA的静态演化,建立了SA邻接矩阵和可达矩阵,凭借矩阵变换与运算对SA静态演化中的波及效应进行了深入地分析和量化界定,同时给出了构件在SA中贡献大小相对量的计算方法.其次,针对SA的动态演化,给出了SA动态语义网络模型,分析了SA动态语义网络中基于不动点的浸润过程收敛的判定,提出了邻接矩阵原子过滤的概念,进而指出,SA动态演化过程可用一系列邻接矩阵原子过滤在时刻上的逻辑衔接来描述.最后给出了两个层面上对SA演化波及效应的分析框架.为SA演化的管理、控制、利用、评价和量化描述奠定了基础.

关键词：软件体系结构软件演化可达矩阵波及效应浸润

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基于改进搜索策略的混合蜂群算法

系统工程与电子技术 2014年第10期36卷 2094-2101页

作者：王慧颖王文彬北京科技大学东凌经济管理学院复杂系统故障预测和管理研究所北京100083

针对人工蜂群算法搜索效率低、易陷入局部最优和精度低等缺点,提出混合蜂群(hybrid bee colony,HBC)算法。将人工蜂群(artificial bee colony,ABC)算法局部收敛性与模拟退火(simulated annealing,SA)算法全局收敛性结合,为ABC算法提供... 详细信息

针对人工蜂群算法搜索效率低、易陷入局部最优和精度低等缺点,提出混合蜂群(hybrid bee colony,HBC)算法。将人工蜂群(artificial bee colony,ABC)算法局部收敛性与模拟退火(simulated annealing,SA)算法全局收敛性结合,为ABC算法提供了一种新机制。根据SA算法中Metropolis接受准则,通过调整温度依概率确定全局最优解的替代值,并利用全局最优解的替代值和个体极值来改进ABC算法的引领蜂搜索模式。其次,改进侦察蜂搜索方式,根据迭代次数非线性减小侦察蜂搜索范围和以一定概率反向搜索更新方式,能够有效地提高算法的全局搜索能力,并加快算法的后期收敛速度。通过对8个复杂函数仿真测试,结果表明,HBC算法在搜索性能和精度方面均有明显提高。

关键词：人工蜂群算法模拟退火算法混合蜂群算法函数优化