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Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor

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Chinese Chemical Letters 2009年第4期20卷 420-422页

作者： Fei Ma Gang Lu Wei Fen Zhou Qiu Juan wang yi hua Zhang Qi Zheng Yao School of Pharmacy China Pharmaceutical University Nanjing 210009 China

A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory activities similar to that of methotrexate （MTX）, while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.

关键词： Nitric oxide Tetrahydrobiopterin Nitric oxide synthase Synthesis Inhibitive activity

OsHemA gene, encoding glutamyl-tRNA reductase(GluTR) is essential for chlorophyll biosynthesis in rice(Oryza sativa)

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Journal of Integrative Agriculture 2020年第3期19卷 612-623页

作者： ZENG Zhao-qiong LIN Tian-zi ZHAO Jie-yu ZHENG Tian-hui XU Le-feng wang yi-hua LIU Ling-long JIANG Ling CHEN Sai-hua WAN Jian-min State Key Laboratory for Crop Genetics&Germplasm Enhancement/Jiangsu Provincial Center of Plant Gene Engineering/College of Agriculture Nanjing Agricultural UniversityNanjing 210095P.R.China Nanchong Academy of Agricultural Sciences Nanchong 637000P.R.China Key Laboratory of Plant Functional Genomics Ministry of Education/CoInnovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhou 225009P.R.China

Chlorophyll(Chl) biosynthesis is essential for photosynthesis and plant ***-tRNA reductase(GluTR) catalyzes glutamyl-tRNA into glutamate-1-semialdehyde(GSA) and initiates the chlorophyll *** though the main role of GluTR has been established,the effects caused by natural variations in its corresponding gene remain largely ***,we characterized a spontaneous mutant in paddy field with Chl biosynthesis deficiency,designated as *** intact thylakoid lamellar structure,the cbd1 plant showed light green leaves and reduced Chl and carotenoids(Cars) content significantly compared to the wild *** map-based gene cloning,the mutation was restricted within a 57-kb region on chromosome 10,in which an mPingA miniature inverted-repeat transposable element(MITE) inserted in the promoter region of OsHemA *** leaf color and the pigment contents in cbd1 were recovered in a complementation test,confirming OsHemA was responsible for the mutant *** was uniquely predicted to encode GluTR and its expression level was dramatically repressed in *** transformation in protoplasts demonstrated that GluTR localized in chloroplasts and a signal peptide exists in its N-terminus.A majority of Chl biosynthesis genes,except for POR and CHLG,were down-regulated synchronously by the repression of OsHemA,suggesting that an attenuation occurred in the Chl biosynthesis ***,we found major agronomic traits involved in rice yield were statistically unaffected,except for the number of full grains per panicle was increased in ***,OsHemA plays an essential role in Chl biosynthesis in rice and its weak allele can adjust leaf color and Chls content without compromise to rice yield.

关键词： OsHemA GluTR chlorophyll biosynthesis

Penetrating Depth of Comet SL9 Fragments into Jovian Atmosphere

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紫金山天文台台刊 1996年第2期15卷 20-25页

作者： Ma Yue-hua wang yi-ping Xu Pin-xin wang Si-cbao Purple Mountaion Observatory,Academia Sinica,Nanjing 210008

Comet Shoemaker-Levy 9 entering the Jovian atmosphere was suffered ablation and dissociation as a result of interaction with the *** comet fragments are modeled as 1012,1013 and 1014kg with density of 3.0,1.0,0.8,0.5 and 0.2g/cm3,*** results show that these fragments explode below the ammonia cloud layer,near the 1-bar level,consisting with the resnlt of Mac Low & Zahnle.

关键词：山口

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从生产实际谈竹材原料的控制问题

中国造纸 2010年第10期29卷 75-76页

作者：汪义华赤天化集团纸业股份有限公司贵州赤水564707

竹浆生产中应加强对原料种类、原料的中间流通环节和加工质量等方面的控制,达到降低生产成本,提高企业经营效益的目的。

关键词：原料竹子竹种控制

竹浆企业利用竹子生产再生纤维浆粕和燃料乙醇

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中国造纸 2011年第9期30卷 59-63页

作者：汪义华贵州赤天化纸业股份有限公司贵州赤水564707

竹浆企业利用丰富的竹资源开发并生产再生纤维浆粕和生物燃料乙醇,可以实现竹资源的充分利用和低碳生态循环。在纺织行业的再生纤维浆粕生产过程中,依托大型竹浆企业,利用优势的资源配置,能够解决再生纤维浆粕制造过程中的环保问题。

关键词：竹子低碳竹浆燃料乙醇再生竹纤维浆粕低碳生态循环

Laparoscopic splenectomy by secondary pedicle division strategy： a highly cost-effective method

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Chinese Medical Journal 2008年第2期121卷 105-107页

作者： CAI Xiu-jun SHEN Bo YU Hong LIANG Xiao ZHU Lin-hua wang yi-fan DAI yi YANG Jin Institute of Micro-Invasive Surgery of Zhejiang University Department of General Surgery Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Background Laparoscopic splenectomy （LS） shows many advantages compared with open surgery except for the high cost. This study was aimed to recommend secondary pedicle division strategy as a method with high cost-effectiveness. Methods From January 2003 to June 2005, 14 consecutive patients underwent laparoscopic splenectomy. The splenic pedicle was controlled by secondary pedicle division strategy in 8 cases and by Endo-GIA in the other 6 cases. A retrospective study was carried out to evaluate the operative time, blood loss, time to diet, operative morbidity, postoperative stay, and operative cost.Results LS was performed successfully in a total of 14 cases. There was no significant difference between the two strategies in operative time, blood loss, time to diet, operative morbidity and postoperative stay. The operative cost of secondary pedicle division strategy group （RMB 8354.38±752,10） was significantly lower than that of Endo-GIA group （RMB 11053.33±602.27）（P〈0.01）.Conclusions Laparoscopic splenectomy by secondary pedicle division strategy is a safe, effective and economical procedure with the value of popularization in developing countries.

关键词： laparoscopic surgery splenectomy spleen

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上海锻压生产技术及设备的进步

锻压技术 2005年第Z1期30卷 7-10页

作者：王以华上海交通大学中京锻压有限公司上海200240

本文概括了近5年来上海锻压生产及科研水平的现状.较详细地介绍了代表上海近年水平的4条生产线及教学科研情况.

关键词：锻压生产技术设备楔横轧

Pulmonary alveolar proteinosis in an indium-processing worker

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Chinese Medical Journal 2010年第10期123卷 1347-1350页

作者： XIAO Yong-long CAI Hou-rong wang yi-hua MENG Fan-qing ZHANG De-ping Department of Respiratory Medicine Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Pathology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

With the increasing number of workers engaged in liquid-crystal displays （LCD） manufacturer, lung diseases related to this occupational exposure are attracting more attention. Herein we report a case of interstitial lung disease in a LCD processing worker, which was pathologically confirmed as pulmonary alveolar proteinosis （PAP）.

关键词： cholesterol indium lung lavage pulmonary alveolar proteinosis

Influence of Vitamin D Level in the Second Trimester of Pregnancy on the Complications of Chinese Pregnant Women and Fetuses

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Reproductive and Developmental Medicine 2017年第2期1卷 77-79页

作者： Yang Ling Song Li-Ge wang yi-hua Zhao Dong Department of obstetrical Changning Maternity and Infant Health HospitalShanghai 200335China Department of Endocrine Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Gynecology Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China

Background:Vitamin D has been found to have more biological effects beyond the traditional research range,which involve in immunoregulation,occurrence,and development of tumor,reproduction,cell differentiation,and so ***,the influence of Vitamin D level in the second trimester of pregnancy on the Chinese pregnant women and fetal weight was ***:Totally 1,612 pregnant women were followed up during the study,the 25-hydroxyvitamin D(25(OH)D)level was measured with ELISA at the 16th gestational week,and the fasting blood glucose was measured with hexokinase method using an automatic biochemistry analyzer at the same *** week 24,oral glucose tolerance test(OGTT)was performed to test the blood glucose level(fasting blood glucose,1 h and 2 h after oral administration of glucose).Besides,other indices(e.g.,fetal birth weight)were recorded and analyzed by SPSS version 19.0 ***:Pearson’s correlation analysis indicated that the serum 25(OH)D had a negative correlation with blood glucose at 1 h after oral glucose administration at week 24 in OGTT(correlation coefficient:−0.03,P=0.01).However,it did not have correlations with the fasting blood glucose at weeks 16 and 24 as well as the blood glucose at 2 h after oral glucose administration at week *** Pearson’s correlation analysis was used to analyze the correlation between Vitamin D level in the pregnant women and fetal birth weight,and there was no correlation between ***:The Vitamin D level in the second trimester of pregnancy had a negative correlation with blood glucose glucose at 1 h after oral glucose administration and had no correlation with fetal birth weight.

关键词： Blood Glucose Low Birth Weight Second Trimester of Pregnancy Vitamin D

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