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Qingchi San(青赤散)treats ulcerative colitis in mice by inhibiting the nuclear factor-kappa B signaling pathway and Nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3 inflammasome formation

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Journal of Traditional Chinese Medicine 2023年第1期43卷 68-77页

作者： ZHOU Zhenghua JI Jianbin wang hongxia YAN Lin KANG Hongchang Department of Gastroenterology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

OBJECTIVE:To investigate the efficacy of Qingchi San(青赤散,QCS),a preparation of Traditional Chinese Medicine,on ulcerative colitis(UC)in mice by inhibiting the nuclearfactor-kappa B(NF-κB)signaling pathway and nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3(NLRP3)inflammasome ***:The UC model was established with male C57BL/6J as the animal ***,Disease Activity Index(DAI),colon length and weight were ***,colonic histology was performed by hematoxylin-eosin(HE)***-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),myeloperoxidase(MPO)and superoxide dismutase(SOD)were performed by enzyme-linked immunosorbent *** 2(COX2)and inducible nitric oxide synthase(iNOS)mRNA expression were conducted by real-time quantitative polymerase chain reaction(RT-qPCR).NF-κB,inhibitor of NF-κBα(iκBα),Phosphorylated inhibitor of NF-κBα(p-iκBα),caspase-1,NLRP3 and Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC)protein expression were conducted by Western ***:Compared with UC model group,Bodyweight was significantly increased in QCS *** the same time,DAI was significantly decreased in QCS *** length and weight and colonic histology were significantly improved in QCS ***,the expression of IL-1β,IL-6,TNF-α,MPO,SOD,COX2,and iN OS were significantly decreased in QCS ***,the expression of NF-κB signaling pathway-related proteins NF-κB,iκBα,p-iκBα,and the expression of NLRP3 inflammasome related proteins caspase-1,NLRP3 and ASC were significantly decreased in QCS ***:Traditional Chinese drug QCS could treat UC by inhibiting the NF-κB signaling pathway and NLRP3 inflammasome formation in mice.

关键词： colitis ulcerative NF-kappa B disease activity index NLR family pyrin domain-containing 3 protein inflammasomes Qingchi San

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Yummy Art!Chinese Mooncakes Feast for Eyes,Stomach

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Women of China 2021年第9期 56-59页

作者： wang hongxia 无不详 VCG

Millions upon millions of Chinese customarily eat mooncakes during the Mid-Autumn Festival(15th day of the eighth lunar month).The pastries,shaped like a full moon,symbolize a family reunion and a full,happy *** tasty delicacies are also exquisite works of art,with auspicious patterns,such as a dragon and a phoenix,to represent prosperity and good luck,and the abundant harvest of all food crops.

关键词：农历八月十五相思之情月饼团圆

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Folk Customs Evolve Through Time Chinese Celebrate Dragon Boat Festioal

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Women of China 2021年第6期 56-59页

作者： wang hongxia 无不详 VCG and Quanjing

The Dragon Boat Festival(on the fifth day of the fifth lunar month),one of China'straditional festivals,was added to the list of UNESCO(United Nations Educational,Scientific and Cultural Organization)'s intangible cultural heritage in *** iswidely known that Chinese,across the country,host dragon-boat races and eat zongzi(pyramid-shaped dumplings made from glutinous rice wrapped in bamboo or reed leaves)during the *** how many people realize the traditions,including the activities,can vary from one region of China to another?During the past millennium,the customs used to celebrate theDragon Boat Festival have evolved;as such they offer a glimpseinto China's fascinating cultural development.

关键词：端午节民俗记忆联合国教科文组织民俗活动吃粽子赛龙舟中国传统文化传统节日

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First observation of Karlodinium venef icum from the East China Sea and the coastal waters of Germany

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Acta Oceanologica Sinica 2011年第6期30卷 112-121页

作者： wang hongxia LU Douding HUANG Haiyan GOBEL Jeaaette DAI Xinfeng XIA Ping State Key Laboratory of Satellite Ocean Environment Dynamics the Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China Landesamt fiir Landwirtschaft Umwelt und landliche Raume Flintbek 24220 Germany

Harmful algal blooms often occurred in the East China Sea （ECS） and the German coastal waters of the North Sea but Karlodinium veneficum had not been taxonomically reported. Two strains of Karlodinium （LAMB090611 and LAMB010601） were isolated from the two areas in 2009. The morphological characteristics and molecular phylogeny of two strains are compared on the basis of observation of a light microscope, a scanning electron microscope （SEM）, a laser scanning micro-scope （LSM） and an internal transcribed spacer （ITS） sequence data. The mean cell length of strain LAMB090611 is （14.2 ± 1.8） μm （range 11.1–18.7 μm） and mean width is （10.8 ± 1.5） μm （range 8.2– 14.7 μm）. The mean cell length of strain LAMB010601 is （15.1 ± 1.2） μm （range 12.7–17.9 μm） and the mean width is （11.4 ± 1.1） μm （range 9.1–14.7 μm）, respectively. The two strains are similar in morphological characteristics, including a straight apical groove, distinct ventral pore, sulcal extension, cingulum displacement, two or four irregular shaped chloroplasts within the cell and almost equal sized epicone and hypocone. The large and round nucleus is located at the center or at the hypocone of the cell. The sequence length of the ECS strain LAMB090611 and the German strain LAMB010601 is 640 and 646 bp, respectively. The GC content is 49%. The nucleotide similarity of the two strains is 98.1%. The sequence divergence is 0.003. Both strains are confirmed as Karlo-dinium veneficum （D. Ballantine） J. Larsen and this is the first taxonomic report from China and Germany coastal waters. The population dynamics of this toxic species in the ECS and German coastal waters needs to be investigated in the near future.

关键词： Karlodinium veneficum East China Sea morphological characteristic scanning electron microscope internal transcribed spacer phylogeny

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All-solid-state flexible asymmetric supercapacitors with high energy and power densities based on NiCo_2S_4@MnS and active carbon

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Journal of Energy Chemistry 2017年第6期26卷 1260-1266页

作者： Zhiguo Zhang Xiao Huang Huan Li hongxia wang Yingyuan Zhao Tingli Ma Department of Life Science and System Engineering Kyushu Institute of Technology School of Chemistry Physics and Mechanical Engineering Queensland University of Technology School of Petroleum and Chemical Engineering Dalian University of Technology

Electrode material based on a novel core–shell structure consisting of NiCoS（NCS） solid fiber core and Mn S（MS） sheet shell（NCS@MS） in situ grown on carbon cloth（CC） has been successfully prepared by a simple sulfurization-assisted hydrothermal method for high performance supercapacitor. The synthesized NiCoS@Mn S/CC electrode shows high capacitance of 1908.3 F gat a current density of 0.5 A gwhich is higher than those of NiCoSand Mn S at the same current density. A flexible all-solid-state asymmetric supercapacitor（ASC） is constructed by using NiCoS@Mn S/CC as positive electrode, active carbon/CC as negative electrode and KOH/poly（vinyl alcohol）(PVA) as electrolyte. The optimized ASC shows a maximum energy density of 23.3 Wh kgat 1 A g, a maximum power density of about7.5 kw kgat 10 A gand remarkable cycling stability. After 9000 cycles, the ASC still exhibited67.8% retention rate and largely unchanged charge/discharge curves. The excellent electrochemical properties are resulted from the novel core–shell structure of the NiCoS@Mn S/CC electrode, which possesses both high surface area for Faraday redox reaction and superior kinetics of charge transport. The NiCoS@Mn S/CC electrode shows a promising potential for energy storage applications in the future.

关键词： NiCo_2S_4@MnS core–shell structure Flexible All-solid-state supercapacitor High energy and power densities

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Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

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Molecular Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming Li Yunze wang Xinyi wang M-Hossein Moeinzadeh Dora G.Quispe-Huamanquispe Weijuan Fan Yijie Fang Yuqin wang Haozhen Nie Zhangying wang Aiko Tanaka Bettina Heider Jan F.Kreuze Godelieve Gheysen hongxia wang Martin Vingron Ralph Bock Jun Yang Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Department of Computational Molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAS Center for Excellence of Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops ***,its genetic origin remains controversial,and its domestication history remains *** this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of *** diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to *** tetraploid progenitor of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast *** most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome *** analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA

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Volatile of alkyd varnish inhibits the expression of neuronal growth associated protein-43 in mice

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Neural Regeneration Research 2007年第6期2卷 331-334页

作者： Qian Huang hongxia wang Wei Zou College of Life Science Liaoning Normal University Dalian 116029 Liaoning Province China Department of Biology Liupanshui College of Guizhou Province Liupanshui 553004 Guizhou Province China

BACKGROUND： Studies have demonstrated that coating materials used commonly in the interior decoration contain volatile of alkyd varnish, which has obvious effects on the structure of endothelial cells of respiratory tract. OBJECTIVE： To observe the effects of volatile of alkyd varnish in the decoration materials on the expression of neuronal growth associated protein-43 （GAP-43） in mice, and to analyze the influencing mechanism of interior environmental pollutants for brain mechanism. DESIGN： A randomized grouping and controlled experiment. SETTING： College of Life Science, Liaoning Normal University. MATERIALS： This study was carried out in the College of Life Science, Liaoning Normal University between February and December 2006. Twenty one-month-old Kunming mice, weighing （20 ± 2 ） g, male and female in half, were involved in this study. The involved mice were divided into 2 groups by random lot method： chronic poisoning group （n =10） and control group （n =10）. Alkyd varnish used commonly for house decoration was purchased from Furnishing World of Liberation Plaza of Dalian City. Alkyd varnish used commonly for house decoration was purchased from Furnishing World of Liberation Plaza of Dalian City. Rabbit GAP-43 polyclonal antibody, rat β -actin monoclonal antibody, goat anti-rat IgG-HRP and goat ant-rabbit IgG-HRP were purchased from Boster Company （Wuhan）. ECL was purchased from Amersham Company （Britain）, other related reagents were all purchased from Sigma Company and Promega Company （USA）. All the other reagents were home-made analytical pure. METHODS： ①Poisoning test： The mice were poisoned by static inhalation poisoning method. Mice in the chronic poisoning group were placed in the 0.024 m^3 poisoning cabinet. Alkyd varnish （8 g, 3-time dosage of house decoration） was daily spread once on a 40 cm × 21 cm kraft paper evenly. Mice were poisoned for 14 hours within 3 weeks successively. Mice in the control group were placed in the same environment without alk

关键词： alkyd varnish hippocampus growth associated protein mice

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A Study on the Integration of Chinese Excellent Traditional Culture and College English Teaching

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教育研究前沿（中英文版） 2019年第3期9卷 142-146页

作者： Zhao Weihong Xu Daoping wang hongxia Qingdao Huanghai University QingdaoShandong266427China

At present, the education of English curriculum has become one of the main courses of higher education in China. The purpose ofEnglish teaching is to enable students to master the language and use it for intercultural communication. As the main body offoreign exchange in the new era, college students are facing the heavy responsibility of the development of the new era and theimportant carrier of foreign exchange. The infiltration of Chinese excellent traditional culture into college English teaching can notonly deepen students'understanding of Western culture, but also enable them to appreciate the vastness and depth of their ownnational culture, thus promoting cultural integration and improving students' English cognitive and application level. Infiltration inEnglish teaching is an innovation in the ways and methods of ideological and moral education. Strengthen the teaching of Chinesetraditional Chinese culture in college English, encourage English teachers to integrate into the teaching innovation of Chineseexcellent traditional culture, create a classroom teaching atmosphere of Chinese excellent traditional culture, and innovate teachingmethods to create an environment for the introduction of Chinese excellent traditional culture.

关键词： Chinese Excellent Traditional Culture College English Integration

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Low-Temperature Fabricated Self-Charging Photocapacitors based on Integrated Perovskite Solar Cells and Quasi-Solid-State Supercapacitors

Low-Temperature Fabricated Self-Charging Photocapacitors bas...

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第八届新型太阳能材料科学与技术学术研讨会

作者： Yang Yang hongxia wang School of Chemistry and Physics Science and Engineering FacultyQueensland University of Technology Centre for Materials Science Queensland University of Technology

Self-charging perovskite photocapacitors(SCPPs) that has dual functions of solar energy harvest and storage can provide reliable, sustainable and off-grid power supply for electrical devices. Currently the majority of reported SCPPs are fabricated on heavy and rigid conductive glass substrates due to the high annealing temperature requirement of making electron transport layer such as TiO in the perovskite solar cells(PSCs). Practically, flexible and lightweight photocapacitors are highly desirable for applications such as portable and wearable electronics. Herein, we demonstrate a monolithic SCPP with parallel structure by integrating a PSC using amorphous WO based electron transport layer deposited at room temperature and a quasi-solid-state carbon based symmetrical supercapacitor(SC). The WO film with 26 nm thickness yielded a champion power conversion efficiency of 14.14% and 10.80% with the FTO/glass rigid and the ITO/PEN flexible PSCs, respectively. Investigation of the performance for the photocapacitors with the rigid substrate(r-SCPP) and the flexible substrate(f-SCPP) exhibited that the r-SCPP could be photo-charged to 0.68 V within 20 s while the f-SCPP required 25 s to be charged to 0.65 V. Consequently, an overall conversion efficiency of 2.13% and 1.27% were obtained with the r-SCPP and the f-SCPP, respectively. This work paves a new way towards making SCPPs that may serve as off-grid electrical power supply in the future.[1]

关键词： self-charging perovskite photocapacitors amorphous WOx perovskite solar cells low temperature supercapacitors

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SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer

SOX9 is a critical regulator of TSPAN8-mediated metastasis i...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Junjian Li hongxia wang Shanghai General Hospital

Pancreatic ductal adenocarcinoma(PDAC) is the deadliest cancer mainly due to its proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence, understanding the molecular mechanisms underlying early invasion and metastasis by PDAC is imperative for improving patient outcomes. The present study identified that upregulation of TSPAN8 expression in PDAC facilitates metastasis in vivo and in vitro. We found SOX9 as a key transcriptional regulator of TSPAN8 expression in response to EGF stimulation. SOX9 modulation was sufficient to positively regulate endogenous expression of TSPAN8, with concomitant in vitro phenotypic changes such as loss of cell–matrix adherence and increased invasion. Moreover, increased SOX9 and TSPAN8 levels were shown to correlate in human pancreatic cancer specimens, and downregulated in vitro by EGFR tyrosine kinase inhibitors. High expression of SOX9 and TSPAN8 has been associated with tumour stage, poor prognosis and poor patient survival in PDAC. In conclusion, this study highlights the importance of the EGF-SOX9-TSPAN8 signalling cascade in the control of PDAC invasion and implies that TSPAN8 may be a promising novel therapeutic target for the treatment of PDAC.

关键词： SOX9 TSPAN8 metastasis PDAC

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