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Effect of epidermal growth factor and dexamethasone on fetal rat lung development

Chinese Medical Journal 2009年第17期122卷 2013-2016页

作者： MA Lian wang Ai-hong Law Frieda HE hong-yan MA Gui-xia wang hong-wu LIN Li-min Department of Pediatrics Second Affiliated Hospital of ShantouUniversity Medical College Shantou Guangdong 515041 China Department of Surgery First Affiliated Hospital of ShantouUniversity Medical College Shantou Guangdong 515144 China Shantou University Medical College Shantou Guangdong515041 China

Background Epidermal growth factor （EGF）, a mitogenic polypeptide that binds to cell surface receptors, is an important regulator of cell differentiation and fetal lung surfactant synthesis. We investigated the preventive and therapeutic effects of EGF in respiratory distress syndrome, by administering EGF and dexamethasone （Dex） to mother rat before delivery. Methods Six female Sprague-Dawley （SD） rats were assigned to three groups （2 rats each）; EGF or Dex was given to pregnant rats （EGF group and Dex group, respectively） from gestational day 16 to day 18 by intraperitoneal injection, while the group with normal saline injection was used as negative controls. Fetal rats were taken out of womb by hysterotomy on day 19 of pregnancy, then 24 fetal rats were randomly chosen from each group. Their body weights were measured, and pulmonary surfactant protein-A and -B （SP-A and SP-B） antigens were determined by immunohistochemical staining in each group. The histologic structure was examined under a light microscope, a light microscopic image system or an electron microscope. Results The expressions of SP-A and SP-B could be detected in each group. A significant difference was observed for SP-A and SP-B in the EGF and Dex groups compared with the control group （P 〈0.01）. Image analysis showed that the relative values of air space area and interalveolar septa area in the EGF and Dex groups were significantly greater than those in the control group （P 〈0.01）, while no significant difference was found between the two groups （P 〉0.05）. The ultrastructural features of fetal lungs showed that the number of alveolar type [I cells containing lamellar bodies in the EGF and Dex groups was apparently increased compared with that in the control group. The mean body weight of fetus from the Dex group was smaller than that from the control group （（1.3192＋0.0533） g, （1.3863_＋0.0373） g）, but there was no significant difference between the EGF group and the control group （（1.3986_＋0.0730

关键词： epidermal growth factor dexamethasone fetal lung

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Evaluation of high-concentration sevoflurane for induction and nasotracheal intubation without muscle relaxant for infants with different pulmonary blood flow undergoing surgery for congenital heart diseases

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Chinese Medical Journal 2011年第24期124卷 4144-4148页

作者： wang Kai-yuan wang hong-wu XIN Lian-feng wang Yong-wang XUE Yu-liang Department of Anesthesiology TEDA International CardiovascularHospital Tianjin 300457 China

Background Inhalational anesthesia with sevoflurane for endotracheal intubation without muscle relaxant is now used widely for pediatric patients. This study assessed the efficacy and safety of induction with high concentration sevoflurane and of nasotracheal intubation without muscle relaxant in infants with increased or decreased pulmonary blood flow （PBF） and undergoing surgery for congenital heart diseases. Methods Fifty-five infants aged 2-12 months, weighing 4.7-10.0 kg, and scheduled for congenital cardiac surgery were enrolled. Subjects were divided into those with increased （IPBF group, n--29） and decreased （DPBF group, n=26） pulmonary blood flow. All infants received inhalational induction with 8% sevoflurane in 100.0% oxygen at a gas flow rate of 6 L/min. Nasotracheal intubation was performed 4 minutes after induction. Sevoflurane vaporization was decreased to 4.0% for placement of a peripheral intravenous line and invasive hemodynamic monitors. Five minutes later, sedatives and muscle relaxant were administered and the vaporizer was adjusted to 2% for maintenance of anesthesia. Bispectral index （BIS） scores, circulatory parameters, satisfactory and successful intubation ratios, adverse reactions, and complications of intubation were recorded. Results Times to loss of lash and pain reflexes were longer for the DPBF group （P 〈0.01）. Satisfactory intubation ratios were 93.1% and 61.5% for the I PBF and DPBF groups, respectively （P=0.008）. Successful intubation ratios were 96.6% and 76.9% for the IPBF and DPBF groups, respectively （P=0.044）. Following sevoflurane inhalation, blood pressures decreased significantly in the IPBF group but remained stable in the DPBF group. BIS scores declined to similar stable values, and a ＂nadir BIS＂ was recorded for both groups. No obvious adverse reactions or complications of intubation were noted perioperatively. Conclusions Induction with high concentration sevoflurane, although faster for infants with IPBF, is safe

关键词： anesthetics, inhalation infant intubation, intratracheal heart defects, congenital

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Driving Behavior Shaping Model in Road Traffic System

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Journal of Beijing Institute of Technology 2001年第3期10卷 331-336页

作者：王武宏北京理工大学车辆与交通工程学院北京100081

In order to give a new way for modeling driving behavior, identifying road traffic accident causation and solving a variety of road traffic safety problems such as driving errors prevention and driving behavior analysis, a new driving behavior shaping model is proposed, which could be used to assess the degree of effect of driving error upon road traffic safety. Driver behavior shaping model based on driving reliability and safety analysis could be used to identify the road traffic accident causation, to supply data for driver's behavior training, to evaluate driving procedures, to human factor design of road traffic system.

关键词： driving errors driving behavior shaping factors driving reliability and safety analysis road traffic safety

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A study of the employment of higher institutions based on the decision tree model

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通讯和计算机（中英文版） 2008年第10期5卷 28-32页

作者： SHEN Shi-kai wang wu hong Sun-yan Department of Computer Science Kunming University KunmingYunnan 650031 China

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晚期肺癌患者的多学科微创综合治疗现状

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中华结核和呼吸杂志 2006年第3期29卷 198-199页

作者：王洪武北京煤炭总医院肿瘤微创治疗中心 100028

自20世纪80年代始,肺癌已成为全球内发病率和病死率最高的癌症,且有逐年上升趋势.治疗肺癌的传统方法有手术、放疗、化疗、生物治疗及中医中药等.临床发现,80%以上的肺癌患者确诊时已属晚期,失去手术切除的机会.

关键词：肺癌患者治疗现状晚期微创学科手术切除 20世纪中医中药生物治疗临床发现

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On the Rational Spline Functions

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数学研究与评论 1984年第2期 31-36页

作者： wang Ren-hong wu Shun-tang(Jilin University) (Zhenjiang Nomarl College)

Since Schoenberg’s fundamental paper was published in 1946, the theory of polynomial spline functions developed rapldly and was rich in contents. Spline functions have wide range of applications to numerical *** to certain functions, for example, to the function with singular points, the interpolation by polynomial spline is not always efficient and reasonable. Since 1973 some authors have investigated the rational spline functions, and abtained a lot of results. But

关键词： Rational Spline interpolation polynomial spline rational partition preserving algebraic singular

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气管支气管内支架的种类、性能及置入技术

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中国组织工程研究与临床康复 2008年第9期12卷 1738-1744页

作者：王洪武北京煤炭总医院肿瘤微创治疗中心北京市100028

学术背景:气管内支架是目前治疗气道狭窄的重要手段。近年来,随着科学技术的发展,气管内支架的种类不断增多,性能也在不断扩展。根据气道病变的不同,所需内支架的性状和种类亦不同。目的:综述近年来国内外气管内支架的最新研究进展,以... 详细信息

学术背景:气管内支架是目前治疗气道狭窄的重要手段。近年来,随着科学技术的发展,气管内支架的种类不断增多,性能也在不断扩展。根据气道病变的不同,所需内支架的性状和种类亦不同。目的:综述近年来国内外气管内支架的最新研究进展,以指导临床正确选择内支架的种类。检索策略:应用计算机检索*** 2002-01/2007-11的相关文献,检索词"trachus,bronchus,stent",并限定文章语言种类为English。同时计算机检索中国期刊全文数据库*** 2002-01/2007-11的相关文献,检索词"气管,支气管,支架",并限定文章语言种类为中文。文献评价:共检索到英文文献363篇,从中选出代表性文章36篇;中文文献101篇,从中选出代表性文章9篇。另有2本专著作为参考。资料综合:①根据材质,气管内支架可分为金属支架和非金属支架两种。根据有无被膜,又分为被膜支架和裸支架。②原则上各种原因引起的大气道狭窄或软化失去手术机会或其他治疗方法无效时,尤其是患者处于严重呼吸困难的急症时,均适用于内支架治疗。③良性气管狭窄患者主要放置可回收支架(Z型被膜支架)或硅酮支架,近期内可予取出,慎用Wallstent裸支架或Ultraflex裸支架。恶性病变,如生存期较长的患者首选放置Z型被膜支架,生存期较短的患者可用Ultraflex支架或Wallstent,慎用Gianturco支架。累及隆突的病变可选用"Y"型支架。气道内病变还可与热消融、冷冻等方法结合应用,良性病变慎放支架,恶性病变消融术后可放置放射性粒子支架,以防肿瘤复发。结论:气管内支架置入是一种快速、安全缓解良、恶性气道狭窄的治疗方法。

关键词：内支架气管-支气管狭窄医学植入体

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支气管镜引导下的腔内CO_2冷冻治疗

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中国组织工程研究与临床康复 2008年第26期12卷 5001-5006页

作者：王洪武煤炭总医院肿瘤微创治疗中心北京市100028

CO2冷冻是根据焦耳-汤姆逊原理,在冷冻探针的前段形成一定大小的冰球,可分为冻切和冻融两种冷冻方式。对体积较大的病变可采用冻切的方法,将大部分病变粘结取出;而对比较表浅的病变,可采用冻融的方法,使病变组织慢慢坏死。冷冻治疗的效... 详细信息

CO2冷冻是根据焦耳-汤姆逊原理,在冷冻探针的前段形成一定大小的冰球,可分为冻切和冻融两种冷冻方式。对体积较大的病变可采用冻切的方法,将大部分病变粘结取出;而对比较表浅的病变,可采用冻融的方法,使病变组织慢慢坏死。冷冻治疗的效果及并发症的发生与操作者和麻醉师的技术和经验、患者情况、肿瘤性质等密切相关。但总的来说,冷冻治疗是清除支气管内阻塞性病变的安全有效方法之一。

关键词：气道内病变气道狭窄气管内肿瘤 CO2冷冻

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang Chenxin wang Xu wang Xiaoyu Zhou Wei Xiao Jie wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

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The cross-sectional and longitudinal association of the BODE index with quality of life in patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2009年第24期122卷 2939-2944页

作者： LIN Ying-xiang XU Wan-ning LIANG Li-rong PANG Bao-sen NIE Xiu-hong ZHANG Jie wang hong LIU Yu-xiang wang Dan-qi XU Zhen-yang wang hong-wu ZHANG Hu-sheng HE Zheng-yi YANG Ting wang Chen Beijing Institute of Respiratory Medicine Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Epidemiology Biostatistics and Occupational Health McGill University Montrral Qurbec H3A 2T Canada Beijing Xuanwu Hospital 100035 China Beijing Tiantan Hospital 100050 China Capital Medical University Beijing Capital Medical University Beijing Beijing Sixth Hospital Beijing 100007 China Beijing Fuxing Hospital Capital Medical University Beijing 100038 China Jishuitan Hospital Beijing 100035 China Beijing Luhe Hospital Beijing 101100 China Coal General Hospital Beijing 100028 China Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Friendship Hospital Capital Medical University Beijing 100050. China

Background The body mass index, airflow obstruction, dyspnea, and exercise capacity （BODE） index was shown at predicting the risk of death, exacerbation and disease severity among patients with COPD, but few studies verified relationship between BODE index and health related quality of life （HRQoL） among Chinese COPD patients. The objective of this study was to evaluate the relationship between BODE index and HRQoL in cross-sectional and longitudinal association analyses. Methods A multi-center prospective cohort study was initially conducted in 491 stable COPD patients in Beijing, China. Health status （HRQoL） was assessed by St. George＇s Respiratory Questionnaire （SGRQ）; the BODE index was calculated for each patient; dyspnea was assessed using the 5-grade Medical Research Council dyspnea scale. Other measurements included socio-demographic, body mass index （BMI）, lung function test and 6-minute-walk test （6MWT）. Patients were then followed monthly for 12 months. Results Only 450 patients completed the 1-year follow up and were enrolled in our present analyses. Mean age was （65.2 ±10.6）years,＇ men 309 （68.7%）. The BODE index was categorized into 4 subgroups： 0-2, 3-4, 5-6 and 7-10. At baseline BODE index was gradually increased with baseline total SGRQ and SGRQ subscales （P trend 〈0.001）. For individual components of BODE index, with the decrease of airflow limitation, and 6MWD, and with the increase of Medical Research Council （MRC） dyspnea grade, total SGRQ and SGRQ subscales were increased correspondingly, P trend 〈0.05, respectively. Similar association patterns were found between baseline BODE index and its individual components and mean SGRQ scores at the end of 1-year follow up. By multiple linear regression analyses, baseline BODE index was not only significantly associated with SGRQ score at baseline but also with SGRQ score at the end of 1-year follow up after adjustment for age, male, current smoking, 13s being 0.434 and 0.378, respectively. Conclusions

关键词： chronic obstructive pulmonary disease BODE index health-related quality of life St. George's RespiratoryQuestionnaire

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