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Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang wang Zheng-Yu wang jin Li Zhu-bo wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-Ling Zou yun-Feng Xiao Wen-Fu zhang Chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao wang jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao jin Ling Kang bo Li Gong Li Xiao Li Yang Li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang Lin‑Hao zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

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Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG Jian wang Fei Fei liu Yang Qing PU Ji DONG Ling Zhi zhang Si Hui HUANG Zhen Zhou HUANG Yu Yuan LI Ya Ben YANG Cai Xin TAO Yuan Meihui ZHAO Li Jun jin Dong liu Li yun YANG jing LU Shan Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-borne Diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and Huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella

Exploring the therapeutic effect of Xiaoyan d ecoction on lung cancer cachexia skeletal muscle atrophy based on L3-SMI

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Cancer Advances 2024年第15期7卷 1-9页

作者： Qing-Peng jin yun-Chao zhang Shi-Yu wang Hao-Jian zhang Shang-Heng liu Wen-Hao liu Na Lu Graduate School of Tianjin University of Traditional Chinese Medicine Tianjin 301617China Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China

Background:Lung cancer cachexia has received widespread attention as one of the most common complications in patients with advanced lung *** a multifactorial syndrome,lung cancer cachexia is characterized by a persistent decline in muscle mass that cannot be reversed by conventional nutrition Xiaoyan d ecoction can promote appetite and improve skeletal muscle mass in patients with lung cancer cachexia,while the third lumbar skeletal muscle index(L3-SMI)is able to determine whole-body skeletal muscle *** analyze the relationship between L3-SMI and hematological indexes and lung cancer cachexia,and to study the clinical efficacy of Xiaoyan decoction on skeletal muscle atrophy in lung cancer cachexia patients,with the aim of providing a reference basis for the early diagnosis and treatment of lung cancer cachexia patients and skeletal muscle ***:148 patients who were diagnosed with lung cancer in the Department of Oncology of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 2020 to December 2022 were included,and were divided into cachexia and non-cachexia groups according to the diagnostic criteria of cachexia,and analyzed the differences of hematological indexes and L3-SMI between cachexia patients and non-cachexia *** the patients with cachexia were divided into control group and treatment group,analyzed and compared the changes of body mass index(BMI),L 3-SMI,Karnofsky functional status score,albumin and other hematological indexes of the two groups before and after the treatment,and evaluated the safety of the Xiaoyan decoction in the treatment of ***:A total of 148 lung cancer patients were included in this study,including 67 patients in the cachexia group and 81 patients in the non-cachexia *** to the pre-treatment statistical analysis,the BMI of patients in the cachexia group was lower than that of patients in the non-cachexia group(P<0.05);among the biochemi

关键词： lung cancer cachexia Xiaoyan decoction skeletal muscle index network pharmacology

Revisiting tuberculosis as a cause of gastric outlet obstruction:Insights from a case report

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World Journal of Clinical Cases 2024年第32期12卷 6563-6565页

作者： jin Meng Li-Mei zhang Zhi-Gang wang Xiu Zhao hai-Xia Bai Ying wang De-Yu Chen De-long liu Cheng-Chun Ji Yuan liu Lei wang bo-Yang Li Zhi-Tao Yin Department of Anorectal Disease Shenyang Coloproctology HospitalShenyang 110000Liaoning ProvinceChina Department of Neurology Central Hospital of Dalian University of TechnologyDalian 116001Liaoning ProvinceChina Acupuncture and Tuina College Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

Gastroduodenal tuberculosis(GD-TB)is exceptionally *** clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high *** a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this *** patient had no family history of TB or contact with people with *** GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this *** diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.

关键词： Tuberculosis Gastrointestinal tuberculosis Gastric outlet obstruction Gastroduodenal tuberculosis X pert Interferon-γrelease assay

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

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Journal of Integrative Plant Biology 2024年第8期66卷 1703-1717页

作者： Qishuang Li Xiang Jiao Xinyi Li Wenlong Shi Ying Ma Xiangmei Tan jingyi Gan Jimei liu Jian Yang Jian wang Baolong jin Tong Chen Ping Su Yujun Zhao Yifeng zhang jinfu Tang Guanghong Cui yun Chen Juan Guo Luqi Huang School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Life Sciences Chalmers University of TechnologyGothenburg SE-41296Sweden State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaThe Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Aporphine alkaloids have diverse pharmacological activities;however,our understanding of their biosynthesis is relatively *** studies have classified aporphine alkaloids into two categories based on the configuration and number of substituents of the D-ring and have proposed preliminary biosynthetic pathways for each *** this study,we identified two specific cytochrome P450 enzymes(CYP80G6 and CYP80Q5)with distinct activities toward(S)-configured and(R)-configured substrates from the herbaceous perennial vine Stephania tetrandra,shedding light on the biosynthetic mechanisms and stereochemical features of these two aporphine alkaloid ***,we characterized two CYP719C enzymes(CYP719C3 and CYP719C4)that catalyzed the formation of the methylenedioxy bridge,an essential pharmacophoric group,on the A-and D-rings,respectively,of aporphine *** the functional characterization of these crucial cytochrome P450 enzymes,we reconstructed the biosynthetic pathways for the two types of aporphine alkaloids in budding yeast(Saccharomyces cerevisiae)for the de novo production of compounds such as(R)-glaziovine,(S)-glaziovine,and *** study provides key insight into the biosynthesis of aporphine alkaloids and lays a foundation for producing these valuable compounds through synthetic biology.

关键词： aporphine alkaloids biosynthesis CYP719C CYP80 engineered yeast

Silica nanoparticle design for colorectal cancer treatment:Recent progress and clinical potential

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World Journal of Clinical Oncology 2024年第6期15卷 667-673页

作者： jin Meng Zhi-Gang wang Xiu Zhao Ying wang De-Yu Chen De-long liu Cheng-Chun Ji Tian-Fu wang Li-Mei zhang hai-Xia Bai bo-Yang Li Yuan liu Lei wang Wei-Gang Yu Zhi-Tao Yin Department of Anorectal Disease Shenyang Coloproctology HospitalShenyang 110000Liaoning ProvinceChina Acupuncture and Tuina College Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina Department of Neurology Central Hospital of Dalian University of TechnologyDalian 116001Liaoning ProvinceChina

Colorectal cancer(CRC)is the third most common cancer worldwide and the second most common cause of cancer *** are able to selectively target the delivery of cancer therapeutics,thus improving overall antitumor eff-iciency and reducing conventional chemotherapy side *** silica nanoparticles(MSNs)have attracted the attention of many researchers due to their remarkable advantages and *** offer insights into the recent advances of MSNs in CRC treatment and their potential clinical application value.

关键词： Colorectal cancer Treatment Silica nanoparticles Mesoporous silica Mesoporous silica nanoparticles

Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023 edition)

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Chinese Herbal Medicines 2024年第1期16卷 3-12页

作者： Qing Zhao Tong wang Hongbin wang Peng Cao Chengyu Jiang Hongzhi Qiao Lihua Peng Xingdong Lin yunyao Jiang Honglei jin Huantian zhang Shengpeng wang Yang wang Ying wang Xi Chen Junbing Fan bo Li Geng Li Bifeng liu Zhiyang Li Suhua Qi Mingzhen zhang Jianjian Zheng Jiuyao Zhou Lei Zheng Kewei Zhao Guangdong Engineering Research Center of Chinese Herbal Vesicles The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Institute of Life and Health Engineering the First Affiliated HospitalJinan UniversityGuangzhou 510630China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Institute of Basic Medicine Chinese Academy of Medical SciencesBeijing 100005China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310030China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of bone and Joint Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAomen 999078China Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233China School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515China School of Life Sciences Nanjing UniversityNanjing 210008China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Laboratory Animal Center Guangzhou University of Chinese MedicineGuangzhou 510405China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Nanjing 210008China School of Medical and Technology Xuzhou Medical UniversityXuzhou 221004China School of Basic Medical Sciences Xi’an Jiaotong UniversityXi’an 710065China The First Affiliated Hospital of Wenzhou Medical University WenZhou 325035China

To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization,led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles,research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles,Professional Committee on Extracellular Vesicle Research and Application,Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal *** on the collation of relevant literature,we have adopted the Delphi method,the consensus meeting method combined with the nominal group method to form a discussion draft of“Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023)”.The first draft was discussed in online and offline meetings on October 12,14,November 2,2022 and April and May 2023 on the current status of research,nomenclature,isolation methods,quality standards and research applications of extracellular vesicles of Chinese herbal medicines,and 13 consensus opinions were finally *** the Third Academic Conference on Research and Application of Chinese Herbal Vesicles,held on May 26,2023,Kewei Zhao,convenor of the consensus,presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal *** consensus highlights the characteristics and advantages of Chinese medicine,inherits the essence,and keeps the righteousness and innovation,aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad,decode the mystery behind Chinese herbal vesicles together,establish a safe,effective and controllable accurate Chinese herbal vesicle prevention and treatment system,and build a bridge for Chinese medicine to the world.

关键词： Chinese herbal medicine extracellular vesicles research application consensus

Endocrine therapy of short duration prevents local and contralateral recurrence of ductal carcinoma in situ of the breast: A multicenter retrospective cohort study in China

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中华医学杂志(英文版) 2024年第14期137卷 1756-1758页

作者： wang Zhen jin Zining zhang Huanrui Xu guiying zhang Dianlong Fang Fengqi Xing Hua wang Jia Guo Baoliang Zhu Guolian liu Yongzhi Li Jieqing Cai Zhengang Sun Liang zhang Yuting Zhou Tianyang liu Chang Zhou Baosen jin Feng zhang Yan Song Dong Chen bo Department of Breast Surgery The First Hospital of China Medical University Shenyang Liaoning China Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China Department of Geriatric Medicine The First Hospital of China Medical University Shenyang Liaoning China Department of Breast Surgery Jilin Cancer Hospital Changchun Jilin China Department of Breast and Thyroid Surgery Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning China Department of Oncology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning China Department of Breast Surgery China-Japan Union Hospital Affiliated to Jilin University Changchun Jilin China Department of Breast Surgery The Second Hospital of Dalian Medical University Dalian Liaoning China Department of Breast Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Department of Breast Surgery The Fifth People’s Hospital of Shenyang Shenyang Liaoning China Department of Breast Surgery General Hospital of Benxi Iron &amp Steel Industry Group of Liaoning Health Industry Group Benxi Liaoning China Department of Breast Surgery The Fourth People’s Hospital of Shenyang Shenyang Liaoning China Department of Breast Surgery The First Affiliated Hospital of Dalian Medical University Dalian Liaoning China Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang Liaoning China Department of Breast Surgery The Second Hospital of Jilin University Changchun Jilin China Department of Breast Surgery General Surgery Center The First Hospital of Jilin University Changchun Jilin China

To the Editor: De-escalating the treatment of ductal carcinoma in situ (DCIS) of the breast has been investigated in recent years. A 5-year adjuvant endocrine therapy (AET) regimen is the recommended treatment for hormone receptor-positive DCIS. Selective estrogen receptor modulators (such as the commonly used tamoxifen and toremifene) and aromatase inhibitors (AIs) are the currently used AET drugs. However, long-term AET is accompanied by severe side effects such as menopausal symptoms, endometrial carcinoma, cardiovascular events, venous thromboembolic events, osteoporosis, and joint pain that can significantly reduce patients’ quality of life. It was reported that only 50% of the patients completed the recommended 5-year AET mainly because of side effects, while higher adherence rates were observed with shorter-duration regimens. Therefore, de-escalation of AET should be considered to reduce the side effects of AET and improve adherence.

关键词： ADHERENCE