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模糊模态逻辑系统M■uk中的可达广义重言式

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山东大学学报（理学版） 2009年第8期44卷 80-85页

作者：邹尚田王国俊陕西师范大学数学与信息科学学院陕西西安710062

将赋值格取为单位区间并将二元关系R模糊化,研究了模糊模态逻辑系统M■uk,然后将其赋值格离散化研究了多值模态逻辑系统M■n;证明了在M■n中,对任一可能的赋值α都存在可达α-重言式;在M■uk中对任一有理数α∈[0,1]都存在可达α-重言式... 详细信息

将赋值格取为单位区间并将二元关系R模糊化,研究了模糊模态逻辑系统M■uk,然后将其赋值格离散化研究了多值模态逻辑系统M■n;证明了在M■n中,对任一可能的赋值α都存在可达α-重言式;在M■uk中对任一有理数α∈[0,1]都存在可达α-重言式;指出了在R0系统中起关键作用的升级算法对M■n系统已不再适用,并分析了其原因。

关键词：模糊模态逻辑模糊模态逻辑系统MLuk 可达广义重言式可达广义矛盾式类类不空定理

Transcription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines

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World Journal of Gastroenterology 2002年第2期8卷 203-207页

作者： Miao-wang Hao Li Liu,Department of Internal Medicine,Tangdu Hospital,xi’an 710038,shaanxi Province,china Ying-Rui Liang Ming-Yao Wu Huan-xing Yang,Department of Pathology,Medical College of Shantou university,Shantou 515031,Guangdong Province,china Yan-Fang Liu,Department of Pathology,Fourth Military Medical university,xi’an 710032,shaanxi Province,china Department of Internal Medicine Tangdu Hospital Fourth Military Medical University Xi'an 710038 Shaanxi Province China. haomwg@***

AIM: The transcription factor EGR-1 (early growth response gene-1) plays an important role in cell growth, differentiation and development. It has identified that EGR-1 has significant transformation suppression activity in some neoplasms, such as fibrosarcoma, breast carcinoma. This experiment was designed to investigate the role of egr-1 in the cancerous process of hepatocellular carcinoma (HCC) and esophageal carcinoma (EC), and then to appraise the effects of EGR-1 on the growth of these tumor cells. METHODS: Firstly, the transcription and expression of egr-1 in HCC and EC, paracancerous tissues and their normal counterpart parts were detected by in situ hybridization and immunohistochemistry, with normal human breast and mouse brain tissues as positive controls. Egr-1 gene was then transfected into HCC (HHCC, SMMC7721) and EC (ECa109) cell lines in which no egr-1 transcription and expression were present. The cell growth speed, FCM cell cycle, plate clone formation and tumorigenicity in nude mice were observed and the controls were the cell lines transfected with vector only. RESULTS: Little or no egr-1 transcription and expression were detected in HCC, EC and normal liver tissues. The expression of egr-1 were found higher in hepatocellular paracancerous tissue (transcription level P=0.000; expression level P=0.143, probably because fewer in number of cases) and dysplastic tissue of esophageal cancer (transcription level P=0.000; expression level P=0.001). The growth rate of egr-1-transfected HHCC (HCC cell line) cells and ECa109 (EC cell line) cells was much slower than that of the controls. The proportion of S phase cell, clone formation and tumorigenicity were significantly lower than these of the controls' (decreased 45.5% in HHCC cells and 34.1% in ECa109 cells; 46.6% and 41.8%; 80.4% and 72.6% respectively). There were no obvious differences between SMMC7721 (HCC) egr-1-transfected cells and the controls with regard to the above items. CONCLUSION: The dec

关键词： Animals Carcinoma, Hepatocellular Cell Division Cell Transplantation DNA-Binding Proteins Early Growth Response Protein 1 Esophageal Neoplasms Humans Immediate-Early Proteins In Situ Hybridization Liver Neoplasms Mice Mice, Nude Neoplasm Transplantation Research Support, Non-U.S. Gov't Transcription Factors Tumor Cells, Cultured

Empirical Analysis on The Competitiveness of The Logistics Industry Cluster in Zhengzhou City

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Empirical Analysis on The Competitiveness of The Logistics I...

2011 3rd IEEE International Conference on Information Management and Engineering(ICIME 2011)

作者： wang Qinmei International Business School Shanxi normal university xi’an 710062 china ZHENG Yeqing International Business School Shanxi normal university xi’an 710062 china

In this paper,based on the concept of the industry clusters competitiveness,the focus is establishing the logistics industry cluster competitiveness model based on "Diamond Model" and "GEM Model ".According to this model of the logistics industry cluster competitiveness,we set up the index system to evaluate the logistics industry cluster competitiveness in urban,and used the method--Principal Component Analysis to calculate the competitiveness of Zhengzhou s logistics industry *** analyzed the reasons that competitiveness of logistics industry cluster in Zhengzhou City is weak,mainly due to lack of resources,business backwardness and lack of market demand and so ***,we made a summary of the full-text,and gave some recommendations to improve the competitiveness of the logistics industry clusters of Zhengzhou City.

关键词： Zhengzhou logistics industry cluster competitiveness empirical analysis

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盛唐手工业简论

陕西师范大学学报（哲学社会科学版） 2000年第1期29卷 106-113页

作者：王双怀陕西师范大学历史学系陕西西安710062

手工业是唐代重要的经济部门之一。盛唐时期 ,由于统治者采取了鼓励手工业的措施 ,加之社会消费的良性刺激 ,各种手工业都在不同程度上得到了发展。从文献资料和考古资料看 ,盛唐时期丝织、制瓷、铸造等手工业分布广泛 ,专业化程度明显... 详细信息

手工业是唐代重要的经济部门之一。盛唐时期 ,由于统治者采取了鼓励手工业的措施 ,加之社会消费的良性刺激 ,各种手工业都在不同程度上得到了发展。从文献资料和考古资料看 ,盛唐时期丝织、制瓷、铸造等手工业分布广泛 ,专业化程度明显提高 ,产品的数量和质量都大大超过了前代。可以肯定 ,盛唐手工业的发展促进了当时社会经济的繁荣。

关键词：盛唐时期手工业物质文明专业化产品数量质量

How to Coadd Images.Ⅱ.Anti-aliasing and PSF Deconvolution

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Research in Astronomy and Astrophysics 2024年第4期24卷 103-113页

作者： Lei wang Huanyuan Shan Lin Nie Dezi Liu Zhaojun Yan Guoliang Li Cheng Cheng Yushan xie Han Qu Wenwen Zheng xi Kang Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China National Basic Science Data Center Beijing 100190China Zhejiang university-Purple Mountain Observatory Joint Research Center for Astronomy Zhejiang UniversityHangzhou 310030China Shanghai Astronomical Observatory Shanghai 200030China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China Department of Information Engineering Wuhan Institute of CityWuhan 430083China South-Westem Institute for Astronomy Research Yunnan UniversityKunming 650500China The Shanghai Key Lab for Astrophysics.Shanghai normal university Shanghai200234China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

We have developed a novel method for co-adding multiple under-sampled images that combines the iteratively reweighted least squares and divide-and-conquer *** approach not only allows for the anti-aliasing of the images but also enables Point-Spread Function(PSF)deconvolution,resulting in enhanced restoration of extended sources,the highest peak signal-to-noise ratio,and reduced ringing *** test our method,we conducted numerical simulations that replicated observation runs of the china Space Station Telescope/the VLT Survey Telescope(VST)and compared our results to those obtained using previous *** simulation showed that our method outperforms previous approaches in several ways,such as restoring the profile of extended sources and minimizing ringing ***,because our method relies on the inherent advantages of least squares fitting,it is more versatile and does not depend on the local uniformity hypothesis for the ***,the new method consumes much more computation than the other approaches.

关键词： methods:analytical techniques:image processing gravitational lensing:weak (ISM:)cosmic rays

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3449-3466页

作者： xixi Guo xiaosa Zhao xi Lu Liping Zhao Qingxuan Zeng Fenbei Chen Zhimeng Zhang Mengyi Xu Shijiao Feng Tianyun Fan Wei Wei xin Zhang Jing Pang xuefu You Danqing Song Yanxiang wang Jiandong Jiang Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College100050 BeijingChina School of Information Science and Technology Northeast Normal UniversityChangchun 130117China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272029 ShandongChina Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei230601AnhuiChina

Helicobacter pylori(***)is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis,and its high prevalence and resistance make it difficult to tackle.A graph neural network-based deep learning model,employing different training sets of 13,638 molecules for pre-training and fine-tuning,was aided in predicting and exploring novel molecules against ***.A positively predicted novel berberine derivative 8 with 3,13-disubstituted alkene exhibited a potency against all tested drug-susceptible and resistant *** strains with minimum inhibitory concentrations(MICs)of 0.25-0.5μg/*** studies demonstrated an ideal gastric retention of 8,with the stomach concentration significantly higher than its MIC at 24 h post *** administration of 8 and omeprazole(OPZ)showed a comparable gastric bacterial reduction(2.2-log reduction)to the triple-therapy,namely OPZ+amoxicillin(AMX)+clarithromycin(CLA)without obvious disturbance on the intestinal flora.A combination of OPZ,AMX,CLA,and 8 could further decrease the bacteria load(2.8-log reduction).More importantly,the mono-therapy of 8 exhibited comparable eradication to both triple-therapy(OPZ+AMX+CLA)and quadrupletherapy(OPZ+AMX+CLA+bismuth citrate)*** and BamD,playing a major role in outer membrane protein(OMP)transport and assembling,were identified and verified as the direct targets of 8 by employing the chemoproteomics technique.n summary,by targeting the relatively conserved OMPs transport and assembling system,8 has the potential to be developed as a novel *** candidate,especially for the eradication of drug-resistant strains.

关键词： berberine stomach retention

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一类代数上的逻辑学(Ⅱ)

陕西师范大学学报（自然科学版） 1997年第1期25卷 1-8页

作者：王国俊陕西师范大学数学研究所

Ｚａｄｅｈ的复合命题演算方法（简称ＣＲＩ方法）虽然已被广泛采纳并在应用上取得了很大成功，然而ＣＲＩ方法至今尚未有严格的理论基础．本文在一类模糊公式代数Ｆ（Ｓ）上通过特殊的赋值方法为模糊取式（ＦｕｚｙＭｏｄｕｓＰｏｎｅ... 详细信息

Ｚａｄｅｈ的复合命题演算方法（简称ＣＲＩ方法）虽然已被广泛采纳并在应用上取得了很大成功，然而ＣＲＩ方法至今尚未有严格的理论基础．本文在一类模糊公式代数Ｆ（Ｓ）上通过特殊的赋值方法为模糊取式（ＦｕｚｙＭｏｄｕｓＰｏｎｅｎｓ）与模糊拒取式（ＦｕｚｙＭｏｄｕｓＴｏｌｅｎｓ）建立了严格的逻辑基础．其中关于ＦＭＰ的一个结果不只是Ｚａｄｅｈ的ＣＲＩ方法相应结果的改进，而且也是首次把ＣＲＩ方法纳入了模糊逻辑的框架之中，沿此途径，进一步提出并研究了前提与结论之间的支持度与相似度的理论．

关键词：模糊公式代数模糊取式模糊推理逻辑学

Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan wang xiang-Yang Zhai Zheng wang Chun-Ling Gao Sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-Fei Li Sheng-Yan xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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中国古代的水利设施及其特征

陕西师范大学学报（哲学社会科学版） 2010年第2期39卷 109-117页

作者：王双怀陕西师范大学历史文化学院陕西西安710062

中国古代以农业立国,对水利建设比较重视,在数千年的历史岁月中,兴建过数以万计的水利设施。这些水利设施涉及生活用水、农田灌溉、防洪排涝、漕运航运等诸多领域,在经济社会生活中发挥过重要作用。从大量资料来看,中国古代的水利设施... 详细信息

中国古代以农业立国,对水利建设比较重视,在数千年的历史岁月中,兴建过数以万计的水利设施。这些水利设施涉及生活用水、农田灌溉、防洪排涝、漕运航运等诸多领域,在经济社会生活中发挥过重要作用。从大量资料来看,中国古代的水利设施经历了发展变化的过程,并在不同的时段和不同的地区呈现出不同的特点。尽管这些水利设施并不是持续发展的,有些设施甚至经历了由先进到落后的转变,但毋庸置疑,许多设施起源甚早,科技含量甚高,在一定程度上体现了中国古代的农业文明,至今仍有一定的借鉴意义。

关键词：中国古代水利农田灌溉设施生活用水设施防洪水利设施漕运水利设施