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Frontiers of Environmental Science & Engineering 2009年第4期3卷 387-392页

作者： guanghong ZHENG Zhuhui KANG Yifan QIAN Lei wang State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

NH^(+)_(4)is typically an inhibitor to hydrogen production from organic wastewater by *** this experiment,biohydrogen generation with wild-type anoxygenic phototrophic bacterium Rhodobacter sphaeroideswas found to be sensitive to NH^(+)_(4)due to the significant inhibition of NH^(+)_(4)to its *** order to avoid the inhibition of NH^(+)_(4)to biohydrogen generation by ***,a glutamine auxotrophic mutant *** AR-3 was obtained by mutagenizing with ethyl methane *** AR-3 mutant could generate biohydrogen efficiently in the hydrogen production medium with a higher NH^(+)_(4)concentration,because the inhibition of NH^(+)_(4)to nitrogenase of AR-3 was *** suitable conditions,AR-3 effectively produced biohydrogen from tofu wastewater,which normally contains 50–60 mg/L NH^(+)_(4),with an average generation rate of 14.2 mL/L$*** generation rate was increased by more than 100%compared with that from wild-type ***.

关键词： ammonium anoxygenic phototrophic bacterium biohydrogen glutamine auxotrophic tofu wastewater

Energetics and structures of hydrogen-vacancy clusters in tungsten based on genetic algorithm

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Science China(Physics,Mechanics & Astronomy) 2018年第10期61卷 100-103页

作者： LiFang wang XiaoLin Shu guanghong Lu Fei Gao Department of Physics Beihang University Department of Nuclear Engineering and Radiological Sciences University of Michigan

The behavior of hydrogen （H） in metals has been a long- standing research topic in materials science. One of the most compelling subjects is the deleterious effects of H on the microstructural evolution of materials; these effects include H embrittlement, superabundant vacancy formation, and blistering. Vacancies have been demonstrated through both experiments and computational simulations to have strong H trapping effects [1], resulting in increased H retention [2], gas-filled bubble formation [3-5], and surface modification [6-9]. In addition, at high temperatures and high H pressures, superabundant vacancy formation induced by H is observed [ 10,11 ]. Unfortunately, even though substantial research has been conducted on the interplay between H and vacancies [12-14], the detailed processes by which H-vacancy com- plexes nucleate, grow, and agglomerate remain unclear. In these processes, the energetics and structures of H-vacancy clusters are undoubtedly important.

关键词：微结构基因算法聚类氢材料科学计算模拟表面修正钨

Numerical Analyses of Idealized Total Cavopulmonary Connection Physiologies with Single and Bilateral Superior Vena Cava Assisted by an Axial Blood Pump

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Computer Modeling in Engineering & Sciences 2018年第8期116卷 215-228页

作者： Xudong Liu Yunhan Cai Bing Jia Shengzhang wang guanghong Ding Institute of Biomechanics Department of Aeronautics and AstronauticsFudan UniversityShanghai200433China. Cardiovascular Center Children’s HospitalFudan UniversityShanghai201102China.

Our study evaluated the hemodynamic performance of an axial flow blood pump surgically implanted in idealized total cavopulmonary connection(TCPC)*** blood pump was designed to augment pressure from the inferior vena cava(IVC)to the pulmonary *** Fontan procedures with single and bilateral superior vena cava(SVC)were compared to fit the mechanical supported TCPC *** fluid dynamics(CFD)analyses of two Pump-TCPC models were performed in the ***-flow characteristics,energy efficiency,fluid streamlines,hemolysis and thrombosis analyses were *** simulations indicate that the pump produces pressure generations of 1 mm to 24 mm Hg for rotational speeds ranging from 2000 RPM to 5000 RPM and flow rates of 2 LPM to 4 *** surgical models incorporated with the pump were found to be insignificant in pressure augmentation and energy *** risk assessment of blood trauma and thrombosis generation was evaluated representatively through blood damage index(BDI),particle resident time(PRT)and relative resistant time(RRT).The hemolysis and thrombosis analyses declare the advantage of the pump supported bilateral SVC surgical scheme in balancing flow distribution and reducing the risk of endothelial cell destruction and trauma generation.

关键词： Computational fluid dynamics total cavopulmonary connection bilateral superior vena cava axial flow blood pump blood trauma thrombosis probability

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我国城市土地集约利用评价研究综述

山东师范大学学报（自然科学版） 2008年第3期23卷 89-93,98页

作者：郑泽庆黄贤金钟太洋王广洪南京大学国土资源与旅游学系南京210093

文章从城市土地集约利用的内涵、评价尺度、指标体系的构建、评价方法等方面对我国开展土地集约利用的研究及评价工作进行了总结和归纳,得出了对内涵认识多元化、评价尺度广泛、评价指标和理想值均难以选取等特点,并对我国未来城市土地... 详细信息

文章从城市土地集约利用的内涵、评价尺度、指标体系的构建、评价方法等方面对我国开展土地集约利用的研究及评价工作进行了总结和归纳,得出了对内涵认识多元化、评价尺度广泛、评价指标和理想值均难以选取等特点,并对我国未来城市土地集约利用评价应加强新方法新技术的应用,并充分发挥评价结果在现实应用中的趋势展望.

关键词：土地集约利用评价方法研究综述城市土地

EAST极向场电源本地控制器软件设计与实现

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计算机测量与控制 2018年第1期26卷 157-160页

作者：王广红何诗英高格傅鹏黄连生中国科学院合肥物质科学研究院等离子体物理研究所合肥230031

本地控制器是EAST(experimental advanced super-conducting tokamak)极向场电源控制系统重要的子系统,实现对12套电源系统的实时控制,设备状态监控以及系统保护;本地控制器采用主从结构的实时控制软件架构,共享内存实现内部数据传输,... 详细信息

本地控制器是EAST(experimental advanced super-conducting tokamak)极向场电源控制系统重要的子系统,实现对12套电源系统的实时控制,设备状态监控以及系统保护;本地控制器采用主从结构的实时控制软件架构,共享内存实现内部数据传输,脉冲式消息传递触发进程执行;通过现场总线、硬件板卡、反射内存网络等与现场设备和主控制器进行数据传输;通过数字移相板卡实现对整流器的环流、四象限等运行控制。经实验测试,该设计运行稳定,能满足极向场电源控制系统对本地控制器的实时性可靠性的需求。

关键词：极向场电源控制系统本地控制器整流器实时控制

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肝病诊疗中肝活检病理诊断的临床应用价值

中国继续医学教育 2017年第14期9卷 86-88页

作者：李雪燕张太科王广宏王浩枣庄矿业集团中心医院内科山东枣庄277100

目的探析肝病诊疗中肝活检病理诊断的临床应用价值。方法2016年1月—2017年1月,我院共收治140例肝病患者,依照其入院前后双次序将其分为对照组(n=70)与观察组(n=70)。对照组进行常规检查,观察组进行肝穿刺活检。通过对两组患者检查有效... 详细信息

目的探析肝病诊疗中肝活检病理诊断的临床应用价值。方法2016年1月—2017年1月,我院共收治140例肝病患者,依照其入院前后双次序将其分为对照组(n=70)与观察组(n=70)。对照组进行常规检查,观察组进行肝穿刺活检。通过对两组患者检查有效性以及诊断准确性进行相应对比。结果在临床检查有效率上,对照组低于观察组(80.00%<97.14%,P<0.05)。在诊断准确率上,对照组低于观察组(85.71%<98.57%,P<0.05)。结论肝活检病理检查有利于肝病的临床诊断。

关键词：肝病肝穿刺活检病理诊断

不同布孔方式下梳状定向长钻孔水力压裂数值模拟及工程应用

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煤矿安全 2021年第5期52卷 72-77页

作者：李文王广宏欧聪李守瑞李向往赵华军刘建华赵壁中煤科工集团重庆研究院有限公司重庆400037

为了避免新疆焦煤集团2130煤矿定向长钻孔水力压裂的盲目性,准确掌握不同布孔方式下水力压裂裂隙延伸扩展规律,基于数值模拟方法对2130煤矿4号煤层埋深500 m水平开展梳状定向长钻孔水力压裂数值模拟,模拟结果表明钻孔布孔方式的不同对... 详细信息

为了避免新疆焦煤集团2130煤矿定向长钻孔水力压裂的盲目性,准确掌握不同布孔方式下水力压裂裂隙延伸扩展规律,基于数值模拟方法对2130煤矿4号煤层埋深500 m水平开展梳状定向长钻孔水力压裂数值模拟,模拟结果表明钻孔布孔方式的不同对水力压裂起裂压力、起裂位置、破裂方式及裂隙延伸扩展规律有明显的影响,结合2130煤矿4号煤层实际赋存条件,优选最佳钻孔布孔方式及压裂参数应用于工程实践,取得了良好的压裂效果,相比于前期该水平沿煤层巷道走向布孔水力压裂措施,抽采浓度提高了2.7倍,抽采纯量提高了11.8倍。

关键词：定向长钻孔水力压裂数值模拟瓦斯抽采地应力

Gli1小分子干扰RNA对人胰腺癌细胞增殖和凋亡的影响

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陕西医学杂志 2010年第3期39卷 291-294页

作者：王烜王忠琼杜光红夏国栋邓明明泸州医学院附属医院消化内科泸州646000

目的:研究锌指转录因子Gli1小分子干扰RNA(siRNA)对人胰腺癌PC-2细胞的增殖和凋亡的影响。方法:筛选出最佳的靶向Gli1siRNA转染人胰腺癌PC-2细胞,采用逆转录-聚合酶链反应(RT-PCR)和Western印迹分别从mRNA和蛋白水平检测抑制效果,四甲... 详细信息

目的:研究锌指转录因子Gli1小分子干扰RNA(siRNA)对人胰腺癌PC-2细胞的增殖和凋亡的影响。方法:筛选出最佳的靶向Gli1siRNA转染人胰腺癌PC-2细胞,采用逆转录-聚合酶链反应(RT-PCR)和Western印迹分别从mRNA和蛋白水平检测抑制效果,四甲基偶氮唑蓝(MTT)和TUNEL+PI双染流式细胞检测Gli1被抑制后细胞增殖和细胞凋亡的情况。结果:Gli1siRNA能在mRNA和蛋白水平下调人胰腺癌细胞株PC-2中Gli1基因的表达,以转染72h时最显著。Gli1表达被抑制后,转染后72h时PC-2细胞生长受到明显抑制,凋亡细胞显著增多。结论:Gli1与胰腺癌细胞的生长和凋亡密切相关,抑制胰腺癌细胞中Gli1表达可抑制胰腺癌细胞生长,促进胰腺癌细胞凋亡。

关键词：胰腺肿瘤细胞分裂细胞凋亡锌指转录因子/分析 @SiRNA干扰

Variability of the currents in the Luzon Strait during spring of 2002 obtained from observations and satellite geostrophic currents and spectral analyses

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Science China Earth Sciences 2009年第4期52卷 519-531页

作者： YUAN YaoChu LIAO guanghong wang HuiQun LOU RuYun CHEN Hong State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China

The structure and variability of the currents in the Luzon Strait during spring of 2002 are studied, based on the current measurements at the average position of the mooring station (20°49′57"N, 120°48′12"E) from March 17 to April 15, 2002, satellite geostrophic currents in the Luzon Strait, and the spectral analyses, using the maximum entropy method. The subtidal currents at the mooring station show de-creased amplitudes downward with an anti-cyclonic rotation, suggesting that the currents enter and exit the South China Sea in the upper and intermediate layers, respectively. The vertical structure of the currents in the Luzon Strait suggests strongly the sandwiched structure of the LST, even though the bottom part of the profile is not resolved by the observational grid. The spectral analyses show the following periods of significant spectral peaks: (1) the tidal currents variability in the vertical direction; (2) the period about 4-6 d for the two cases of frequency f >0 and f0; (3) The fluctuation in the period range is about 2-3 days for the two cases of f >0 and f<0 at the 200, 500 and 800 m levels, namely the Luzon Strait currents exhibit significant synoptical variability throughout the water column up to 800 m deep. Both direct current measurements and in situ hydrographic and satellite survey suggest no Kuroshio loop current in the Luzon Strait during the spring of 2002.

关键词： currents in the Luzon Strait tidal currents and synoptical variability satellite geostrophic currents sandwiched structure Kuroshio loop current

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多发性骨髓瘤的维持治疗方案

现代仪器与医疗 2017年第4期23卷 125-127页

作者：王光红黄国军李张维吴攀黄长玉成都市郫都区人民医院肿瘤血液科

目的 :比较来那度胺与硼替佐米维持治疗多发性骨髓瘤(Multiple myeloma,MM)的临床疗效与安全性。方法 :2013年3月至2015年3月124例初治缓解的MM患者按照随机数字表法分为来那度胺组、硼替佐米组各62例,记录其无进展生存期(PFS)、总生存... 详细信息

目的 :比较来那度胺与硼替佐米维持治疗多发性骨髓瘤(Multiple myeloma,MM)的临床疗效与安全性。方法 :2013年3月至2015年3月124例初治缓解的MM患者按照随机数字表法分为来那度胺组、硼替佐米组各62例,记录其无进展生存期(PFS)、总生存期(OS),评价两组患者客观疗效并比较其治疗期间不良反应、第二肿瘤发生情况。结果:两组患者PFS比较,差异无统计学意义(P>0.05),来那度胺组OS、SCR率、CR率低于硼替佐米组,差异均有统计学意义。来那度胺组血液学毒性、感染发生率高于硼替佐米组,其外周神经毒性发生率低于后者,差异有统计学意义。来那度胺组第二肿瘤发生率为17.74%(11/62),高于硼替佐米组的8.06%(5/62),差异有统计学意义。结论 :来那度胺与硼替佐米维持治疗MM均可取得良好的临床效果,硼替佐米可提高患者OS、降低第二肿瘤发生风险。

关键词：多发性骨髓瘤维持治疗硼替佐米生存时间