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Impact of land-use change on hydrological processes in the Maying River basin, china

Science china Earth {1. 2006年第10期49卷 1098-1110页

作者： wang genxu1.3, zhang yu2, liu guimin2 & chen lin3 1. institute of Mountain hazards and environment, chinese academy of sciences, chengdu 610041, china 2. Cold and Arid Regions environmental and Engineering Research institute, chinese academy of sciences, Lanzhou 730000, china 3. Resource and environment School, Lanzhou University, Lanzhou 730000, china institute of Mountain {1. and environment Chinese Academy of Sciences Chengdu China Resource and environment School Lanzhou University Lanzhou China Cold and Arid Regions environmental and Engineering Research {1. Chinese Academy of Sciences Lanzhou China

Since the 1.60s, dramatic changes have taken place in land-use patterns characterized by the persistent expansion of cultivated land and a continuous decrease in natural woodland and grassland in the arid inland river basins of china. It is very important to assess the effects of such land-use changes on the hydrological processes so vital for water resource management and sustainable development on the catchment scale. The Maying River catchment, a typical arid inland watershed located in the middle of the Hexi Corridor in northwest china, was the site chosen to investigate the hydrological responses to land-use changes. The annual runoff, base flow, maximum peak flow, and typical seasonal runoff in both spring and autumn flood periods were selected as the variables in the hydrological processes. Statistical-trend analysis and curvilinear regression were utilized to detect the trends in hydrological variables while eliminating the climatic influence. The relationship between cultivated land-use and hydrological variables was analyzed based on four periods of land-use variation data collected since 1.65. A runoff model was established composed of two factors, i.e., cultivated land use and precipitation. The impact of land use changes, especially in the large ar- eas of upstream woodland and grassland turned into cultivated lands since 1.67, has resulted in a mean annual runoff decrease of 28.1.%, a base flow decline of 35.32%, a drop in the maximum peak discharge of 35.77%, and mean discharge decreases in spring and autumn of 36.05% and 24.87% respectively, of which the contribution of cultivated land expansion to the influence of annual runoff amounts to 77%-80%, with the contribution to the influence of spring discharge being 73%-81., and that to the influence of base flow reaching 62%-65%. Thus, a rational regulation policy of land use patterns is vitally important to the sustainable use of water resources and the proper development of the entire catchment.

关键词： land-use change, arid inland river catchment, hydrological process, impact, Maying River.

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Malignant glaucoma treated by low-dose laser cycloplasty: a 1.year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing {1. Su-Jie Fan Zuo-HongWu Su-Mian cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan zhang Shan-Shan liu Ai-Guo Lyu Ying zhang Hong chen Dan-Ni Jiang Wu-Liang Li Nathan Congdon Clement C Tham Ming-Guang He yuan-Bo Liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of Suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1.k,1.3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1.1..5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P1.with 2.9±1.6 medications(P=0.046)at 1.,and 1..4±6.7 mm Hg(P1.with 1.3±1.7 medications(P1.at *** ACD increased from 1.1.0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1. and 1.mo,respectively.A total of 32(94.1.)eyes achieved initial anatomical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 1.-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

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浙江省台州市海岛和山区中老年人群衰弱患病率与相关因素研究

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中华流行病学杂志 2024年第1期45卷 139-147页

作者：梁欣悦周琼桂王良友汪剡灵谢亚莉杨萱何佳谕张志一王妙辰何淑娴张韵秋陈泰霖吴烜赫王婷婷林海江陈潇潇何纳复旦大学公共卫生学院流行病学教研室上海200032 复旦大学义乌研究院义乌322000 浙江省台州市疾病预防控制中心台州318000

目的比较浙江省台州市海岛和山区≥45岁中老年社区人群衰弱现况及其相关因素。方法基于横断面研究,采取分层整群抽样及配额抽样的方法。2022年7-8月在台州市沿海6个行政区和3个内陆行政区中各随机抽取1.行政区(椒江区和仙居县),作为两... 详细信息

目的比较浙江省台州市海岛和山区≥45岁中老年社区人群衰弱现况及其相关因素。方法基于横断面研究,采取分层整群抽样及配额抽样的方法。2022年7-8月在台州市沿海6个行政区和3个内陆行政区中各随机抽取1.行政区(椒江区和仙居县),作为两类地形代表地区。整群抽样纳入椒江区海岛所有≥45岁的常住人口,在仙居县山区按年龄和性别1.1.行配额抽样,通过问卷调查和实验室检查收集其人口学特征、生活方式及健康状况相关数据,以Fried衰弱表型量表评估衰弱状况。采用分层分析和多元logistic回归分析海岛和山区研究对象衰弱的相关因素。结果研究对象共1.1.人,其中海岛和山区人群分别占48.1.(486/1.1.),和51.9%(525/1.1.);男性和女性分别占45.9%(464/1.1.)和54.1.(547/1.1.);45~、60~、≥75岁年龄组分别占38.6%(390/1.1.)、44.6%(451.1.1.)和1..8%(1.0/1.1.)。研究对象的衰弱患病率为3.6%(36/1.1.),男性和女性的衰弱率分别为3.7%(1./464)和3.5%(1./547)。45~、60~和≥75岁年龄组衰弱患病率分别为0.3%(1.390)、2.2%(1./451.、1..7%(25/1.0)。海岛的衰弱和衰弱前期患病率分别为6.0%(29/486)和39.1.(1.0/486),高于山区的1.3%(7/525)和30.9%(1.2/525)。调整潜在混杂因素后,海岛研究对象的衰弱患病风险显著高于山区(aOR=1.55,95%CI:1.07~2.25,P=0.01.)。海岛研究对象的衰弱症状相关因素包括增龄(60~岁组:aOR=2.52,95%CI:1.56~4.1.;≥75岁组:aOR=1..65,95%CI:5.38~26.70)、女性(aOR=1.94,95%CI:1.20~3.1.)和抑郁(aOR=1.09,95%CI:1.02~1.1.)。山区研究对象的衰老症状相关因素为增龄,但OR值低于海岛(60~岁组:aOR=1.74,95%CI:1.04~2.94;≥75岁组:aOR=4.78,95%CI:2.45~9.50)。山区研究对象的多重用药(aOR=2.08,95%CI:1.1.~3.80)和抑郁(aOR=1.1.,95%CI:1.02~1.1.)与衰弱症状呈显著正相关;山区研究对象的文化程度与衰弱症状者显著负相关(初中:aOR=0.40,95%CI:0.21.0.75;高中/中专:aOR=0.29,95%CI:0.1.~0.53;大专及以上:aOR=0.22,95%CI:0.1.~0.42)。结论台州市海岛中老年人群衰弱患病率显著高于山区,海岛和山区的衰弱相关因素存在差异。海岛≥75岁高龄老年人和女性的衰弱患病风险较高,增龄和抑郁是衰弱的独立危险因素。需关注海岛的健康危险因素及环境特殊性,采取综合干预措施,延缓衰弱进程,提高中老年人群生命质量。

关键词：衰弱中老年人群海岛山区相关因素

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3’-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels

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chinese Journal of Natural Medicines 2019年第6期17卷 413-423页

作者： XU Run-Jia FEI Shuo-Han chen {1.-Yan wang Gan liu Ming zhang Wen-Sheng YAN Xiu-Wen LAI Ren SHEN Chuan-Bin Life sciences College of Nanjing Agricultural University Nanjing 210095China Key Laboratory of bioactive peptides of yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of{1. Kunming Institute of ZoologyKunming 650223China Department of Molecular and Cell Biology School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Laboratory of Anesthesia and Critical Care Medicine Translational Neuroscience CenterWest China HospitalSichuan UniversityChengdu 610041China Sino-African Joint Research Center CASKunming Institute of ZoologyKunming 650223China

Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains unclear. Voltage-gated sodium channels(VGSCs) play important roles in excitability of pain sensing neurons and many of them are important nociceptors. Here, we report that several isoflavones including 3’-methoxydaidzein(3 MOD), genistein(GEN) and daidzein(DAI) show abilities to block VGSCs and thus to attenuate chemicals and heat induced acute pain or chronic constriction injury(CCI) induced pain hypersensitivity in mice. Especially, 3 MOD shows strong analgesic potential without inducing addiction through inhibiting subtypes NaV1.7, NaV1.8 and NaV1.3 with the IC50 of 1.1.± 1., 397 ± 26, and 505 ± 46 nmol·L–1. respectively, providing a promising compound or parent structure for the treatment of pain pathologies. This study reveals a pain-alleviating mechanism of dietary isoflavones and may provide a convenient avenue to alleviate pain.

关键词： 3’-Methoxydaidzein Analgesic Isoflavone Chronic pain Sodium channel

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3型哺乳动物正呼肠孤病毒SYBR Green I荧光定量PCR方法的建立及应用

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中国预防兽医学报 2024年第8期46卷 819-824页

作者：汤文菲罗宇航董覃婷朱鑫玥王杨林韦祖樟陈樱欧阳康覃一峰钟舒红谢江陈集成王小玲黄伟坚潘艳广西大学动物科学技术学院广西南宁530004 广西农业职业技术大学广西南宁530007 广西壮族自治区兽医研究所广西南宁530001 广西壮族自治区兽用生物制品工程研究中心广西南宁530004 广西畜禽繁育与疾病防控重点实验室广西南宁530004 广西高校动物疫病预防与控制重点实验室广西南宁530004

哺乳动物正呼肠孤病毒(MRV)是双链RNA病毒,可以感染自然宿主的哺乳动物和脊椎动物。为建立一种针对3型哺乳动物正呼肠孤病毒(MRV-3)的特异且快速的检测方法,本研究根据Genbank登录的MRV-3(OQ627746-OQ627755)S1.因保守区设计1.特异性... 详细信息

哺乳动物正呼肠孤病毒(MRV)是双链RNA病毒,可以感染自然宿主的哺乳动物和脊椎动物。为建立一种针对3型哺乳动物正呼肠孤病毒(MRV-3)的特异且快速的检测方法,本研究根据Genbank登录的MRV-3(OQ627746-OQ627755)S1.因保守区设计1.特异性引物,并从MRV-3中扩增S1.因,构建重组质粒p MD1.-S1.经PCR和测序鉴定正确后作为质粒标准品,经反应体系及反应条件优化后首次初步建立了检测MRV-3的SYBR Green I荧光定量PCR(q PCR)方法。将质粒标准品1.倍倍比稀释后作为模板经该q PCR扩增,建立标准曲线,结果显示,质粒标准品在1.3×1.~8拷贝/μL~1.3×1.~3拷贝/μL与各自的Ct值均呈良好的线性关系,斜率为-3.1.06,R~2为0.9999,熔解曲线为单峰。以牛病毒性腹泻病毒(BVDV)、牛肠道病毒(BEV)、水牛匈爱病毒(Buf Hu V)、牛冠状病毒(BCo V)、牛细小病毒(BPV)和MRV-3的基因组DNA/c DNA为模板,利用本研究建立的q PCR方法检测,评估该方法的特异性;将质粒标准品1.倍倍比稀释至1.3×1.~2拷贝/μL~1.3×1.~8拷贝/μL后作为模板,分别利用本研究建立的q PCR和常规PCR检测,比较两种方法的检测结果,评估本研究建立q PCR方法的敏感性;以1.3×1.~3拷贝/μL~1.3×1.~7拷贝/μL 5个不同浓度的质粒标准品为模板,利用该方法分别进行批内和批间的重复性试验,评估该方法的重复性。结果显示,该方法只能检测出MRV-3,其他相关病原的检测结果均为阴性;该q PCR对质粒标准品的检测限为1.3×1.~3拷贝/μL,比常规PCR敏感性高1. 000倍;批内和批间重复性试验的变异系数均小于或等于1.0%,表明该q PCR方法特异性强、敏感性高、重复性好。利用该方法检测220份牛粪便样品,结果显示MRV-3的检出率(3.64%,8/220)高于常规PCR的检出率(1.36%,3/220),两种检测方法的阳性符合率达1.0%,阴性符合率为97.75%,总符合率为97.78%。综上所述,本研究首次建立的检测MRV-3的SYBR Green I q PCR方法可以用于临床牛腹泻病原的检测,为MRV-3尤其是牛源MRV-3提供了一种快速灵敏的检测手段,也为MRV-3的后续研究奠定了基础。

关键词：哺乳动物正呼肠孤病毒 SYBR Green I 荧光定量PCR 病毒检测

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Nitrogen doping/infusion of 650 MHz cavities for CEPC

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Nuclear Science and Techniques 2021年第5期32卷 17-23页

作者： Peng Sha Jian-Kui Hao Wei-Min Pan lin lin Hong-Juan Zheng Xin-Ying zhang Fang wang Ji-yuan Zhai Zheng-Hui Mi Fei-Si He Shu chen Bai-Qi liu Zhi-Tao Yang Chao Dong Zhong-Quan Li State Key Laboratory of Nuclear Physics and Technology&institute of Heavy Ion Physics Peking UniversityBeijing 100871China institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Acceleration Physics and Technology Chinese Academy of SciencesBeijing 100049China Center for Superconducting RF and Cryogenics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China

The nitrogen doping/infusion of 650 MHz cavities for the circular electron positron collider(CEPC)is investigated in this *** 650 MHz 1.cell cavities are first treated via buffered chemical polishing(BCP),followed by nitrogen doping.A"2/6"condition is adopted,similar to that for 1.3 GHz cavities of {1.ear Coherent Light Source *** quality factor of both cavities improved to 7×1.^(1.)in low fields,i.e.,higher than that obtained from the base{1.e *** 650 MHz two-cell cavity is nitrogen infused at 1.5℃for 48 h with a BCP surface *** intrinsic quality factor(Q0)reached6×1.^(1.)at 22 MV/m in the vertical test,and the maximum gradient is 25 MV/m,which exceeds the specification of the CEPC(4×1.^(1.)at 22 MV/m).

关键词： Superconducting radio frequency cavity Nitrogen doping Nitrogen infusion Quality factor Accelerating gradient

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High-Performance Ru_(2)P Anodic Catalyst for Alkaline Polymer Electrolyte Fuel Cells

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CCS Chemistry 2022年第5期4卷 1732-1744页

作者： yuanmeng Zhao Fu{1. Yang Wei zhang Qihao Li Xuewei wang Lixin Su Xuemei Hu Yan wang Zizhun wang {1. Zhuang Shengli chen Wei Luo Hubei Electrochemical Power Sources Key Laboratory College of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei 430072 Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringElectron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012 Suzhou institute of Wuhan University SuzhouJiangsu 215123

Exploring efficient and economical electrocatalysts and understanding the mechanism for alkaline hydrogen oxidation reaction(HOR)are crucial to facilitate the development of alkaline polymer electrolyte fuel cells(APEFCs).Herein,Ru_(2)P was synthesized and used as an anodic HOR electrocatalyst for APEFC,achieving a peak power density of 1.3 W cm^(−2),the highest value among Pt-free anode electrocatalysts reported under the same *** density functional theory(DFT)calculations and experimental results,it was found that besides the optimized hydrogen binding energy,the enhanced adsorption strength of oxygenated species(OH*)and the reduced work function of Ru_(2)P contributed to the enhanced HOR *** normalized exchange current densities of Ru_(2)P/C were 0.37 mA cm_(ECSA)^(−2) and 0.27 mAμgRu^(−1.,respectively,both approximately three times higher than those of Ru when conducted in the rotating disk electrode(RDE)*** work provides a new pathway for exploring highly active Pt-free HOR electrocatalysts and expanding the family of anodic electrocatalysts for APEFCs.

关键词： anodic alkaline rotating

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2022年全国血流感染细菌耐药监测报告:革兰阴性菌

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中华临床感染病杂志 2024年第1期17卷 42-57页

作者：刘志盈陈云波嵇金如应超群杨青孔海深茆海丰丁卉田鹏鹏宋江勤刘永云王际亮金炎戴媛媛周义正耿燕陈凤訇王璐李岩岩刘丹张鹏曹俊敏李小燕宋迪静强鑫华李艳红张秋莹廖国林黄颖张保华郭良李爱云康海全黄东红满思金李卓尹佑东梁坤鹏董海新刘东华徐红云董银樵徐荣郑琳虎淑妍李建刘强栾亮沈继录张利侠全博颜小平戚晓燕乔登嫣刘卫平夏修三孟灵梁金花沈萍肖永红浙江大学医学院附属第一医院传染病重症诊治全国重点实验室杭州310003 感染性疾病诊治协同创新中心杭州310003 江苏省连云港市第一人民医院检验科连云港222002 浙江省丽水市中心医院检验科丽水323000 湖北省荆州市第一人民医院检验科荆州434000 湖北省天门市第一人民医院检验科天门431799 山东省滨州医学院附属医院检验科滨州256603 山东省胜利油田中心医院检验科东营257034 山东省立医院检验科济南250021 安徽省立医院检验科合肥230036 湖北省荆州市中心医院检验科荆州434020 西安交通大学第二附属医院检验科西安710004 福建省莆田市第一医院检验科莆田351100 安徽省六安市人民医院检验科六安237000 山东省淄博市中心医院检验科淄博255036 江西省九江市第一人民医院检验科九江332000 安徽省皖南医学院第一附属医院检验科芜湖241001 浙江省中医院检验科杭州310006 南方医科大学第五附属医院检验科广州510900 浙江省海宁市人民医院检验科海宁314400 浙江省湖州市第一人民医院检验科湖州313099 河南省安阳地区医院检验科安阳455000 湖北省随州市中心医院检验科随州441300 湖北省武汉市普仁医院检验科武汉430081 安徽医科大学第一附属医院检验科合肥230022 安徽省黄山市人民医院检验科黄山245000 福建省宁德市闽东医院检验科福安355000 浙江大学医学院附属妇产科医院检验科杭州310006 江苏省徐州医科大学附属医院检验科徐州220005 福建医科大学附属第二医院检验科泉州362002 山东省滕州市中心人民医院检验科滕州277500 西安医学院第一附属医院检验科西安710077 云南省盈江县人民医院检验科盈江679301 安徽省蚌埠医科大学第二附属医院检验科蚌埠233040 山东省济宁医学院附属医院检验科济宁272000 湖北省孝感市中心医院检验科孝感432009 云南省第二人民医院检验科昆明650021 安徽省天长市人民医院检验科天长239300 江西省宜春市人民医院检验科宜春336000 浙江省宁波大学附属第一医院检验科宁波315211 甘肃省庆阳市人民医院检验科庆阳745000 安徽省六安世立医院检验科六安237000 河南大学淮河医院检验科开封475000 中国人民解放军北部战区总医院检验科沈阳110015 安徽医科大学第一附属医院北区检验科合肥230041 陕西省人民医院检验科西安710068 湖北省荆州市第二人民医院检验科荆州530031 四川省自贡市第三人民医院检验科自贡643000 安徽省六安市金安区妇幼保健院检验科六安237006 甘肃省中医院检验科兰州730000 内蒙古自治区人民医院检验科呼和浩特010000 安徽省庐江县人民医院检验科巢湖231500 兰州大学第二医院检验科兰州730099 黑龙江省牡丹江医学院附属红旗医院检验科牡丹江157011

目的监测全国血流感染革兰阴性菌病原谱分布及其耐药趋势,为临床血流感染治疗及细菌耐药防控提供参考。方法收集全国血流感染细菌耐药监测联盟成员单位2022年1.1.月所有分离自血培养阳性的革兰阴性菌,按照美国临床和实验室标准化研究所... 详细信息

目的监测全国血流感染革兰阴性菌病原谱分布及其耐药趋势,为临床血流感染治疗及细菌耐药防控提供参考。方法收集全国血流感染细菌耐药监测联盟成员单位2022年1.1.月所有分离自血培养阳性的革兰阴性菌,按照美国临床和实验室标准化研究所(CLSI)推荐的稀释法进行抗菌药物敏感性测定。采用WHONET 5.6和SPSS 25.0软件进行统计分析。结果共收集51.医院革兰阴性菌9035株,其中肠杆菌目细菌7895株(87.4%),非发酵菌1.40株(1..6%);排在前5位的病原菌为大肠埃希菌451.株(49.9%)、肺炎克雷伯菌2340株(25.9%)、铜绿假单胞菌534株(5.9%)、鲍曼不动杆菌复合体405株(4.5%)及阴沟肠杆菌327株(3.6%)。产超广谱β-内酰胺酶(EBSLs)大肠埃希菌、EBSLs(+)肺炎克雷伯菌和EBSLs(+)变形杆菌属检出率分别为47.1.(2095/4452)、21.0%(427/2033)和41.1.(58/1.1.;耐碳青霉烯类大肠埃希菌(CREC)、耐碳青霉烯类肺炎克雷伯菌(CRKP)检出率分别为1.3%(58/451.)和1..1.(307/2340);CREC和CRKP对头孢他啶/阿维巴坦的耐药率分别为62.1.(36/58)和9.8%(30/307)。耐碳青霉烯类鲍曼不动杆菌(CRAB)复合体的检出率为59.5%(241.405),鲍曼不动杆菌复合体对替加环素和多黏菌素B的耐药率均1..4%(98/534)。血流感染革兰阴性菌构成比及主要耐药菌在不同地区的检出率存在差异,其中CRKP和CRPA检出率差异有统计学意义(χ^(2)=20.489和20.252,P1.。省级医院的CREC、CRKP、CRPA、CRAB、ESBLs(+)大肠埃希菌及ESBLs(+)肺炎克雷伯菌检出率均高于地市级医院(χ^(2)=1..953、81.1.3、1..404、5.91.、1..41.和6.459,P1.1.)。结论我国血流感染革兰阴性菌分离率呈上升趋势,其中大肠埃希菌占首位,肺炎克雷伯菌分离率上升明显;ESBLs(+)大肠埃希菌和ESBLs(+)肺炎克雷伯菌的流行率呈下降趋势,CREC保持低水平流行,CRKP流行率呈下降趋势,CRAB复合体仍保持高水平流行率;我国不同地域的血流感染革兰阴性菌构成比和耐药株略有不同,主要耐药菌在省级医院较为突出。

关键词：革兰氏阴性菌抗药性血流感染全国范围耐药监测

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Enabling 2.4-V aqueous supercapacitors through the rational design of an integrated electrode of hollow vanadium trioxide/carbon nanospheres

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Science china Materials 2021年第9期64卷 2163-2172页

作者： Kaiyang zhang Yingchun {1. {1.gfang chen Jun Huang Li wang Mengke Peng Xiannong Tang Ting Hu Kai yuan Yiwang chen institute of Polymers and Energy Chemistry(IPEC) College of ChemistryNanchang UniversityNanchang 330031China School of Materials Science and Engineering Nanchang UniversityNanchang 330031China institute of Advanced Scientific Research(iASR) Jiangxi Normal UniversityNanchang 330022China

Aqueous supercapacitors(SCs)exhibit several advantages,including high-power density,cycling durability,and safety;however,the shortage of low energy density inhibits their further *** an excellent performance upon using simple strategies would be beneficial,but remains ***,an integrated electrode of hollow V_(2)O_(3)/carbon nanospheres(H-V_(2)O_(3)/C)was designed and synthesized for *** introduction of carbon can increase the conductivity and stability,whereas the hollow structure endows H-V_(2)O_(3)/C with a high specific surface area and rapid transport of ***,the H-V_(2)O_(3)/C integrated electrode can simultaneously work in both negative and positive potential *** from these advantages,the H-V_(2)O_(3)/C integrated electrode exhibits a specific capacitance as high as 708.6 F g^(-1. in a wide voltage window of-1.1.{1. ***,stemming from the multiple energy storage mechanisms,the aqueous integrated full SC device exhibits a wider potential window and higher energy density than the traditional(a)symmetric ***,the proposed device delivers a wide voltage window of 2.4 V with an energy density of 96.8 W h kg^(-1. at a power density of 1.04.6 W kg^(-1.,as well as superior cycling *** study enlightens the design and preparation of electrode materials,opening up a possible approach for developing wide-voltage aqueous SCs.

关键词： hollow nanosphere integrated electrode supercapacitor voltage window energy density

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Efficacy and safety of LY01.05 versus goserelin implant in {1. patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

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chinese Medical Journal 2023年第10期136卷 1207-1215页

作者： cheng{1.an Gu Zengjun wang Tianxin lin Zhi{1. liu Weiqing Han Xuhui zhang Chao Liang Hao liu Yang {1. Zhenzhou Xu Shuang liu Jingen wang linghua Jia Xin Yao Wenfeng Liao cheng Fu Zhaohui Tan Guohua He Guoxi Zhu Rui Fan Wenzeng Yang Xin chen Zhizhong liu Liqiang Zhong Benkang Shi Degang Ding Shubo chen Junli Wei Xudong Yao Ming chen Zhanpeng Lu Qun Xie Zhiquan Hu Yinhuai wang Hongqian Guo Tiwu Fan Zhaozhao Liang Peng chen Wei wang Tao Xu Chunsheng Li Jinchun Xing Hong Liao Dalin He Zhibin Wu Jiandi {1. Zhongwen Feng Mengxiang Yang Qifeng Dou Quan Zeng {1.anwei Li Xin Gou Guangchen Zhou Xiaofeng wang Rujian Zhu Zhonghua zhang Bo zhang Wanlong Tan Xueling Qu Hongliang Sun Tianyi Gan Dingwei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Urology The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityHunan Cancer CenterChangshaHunan 410013China Department of Urology First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of Urology Jiangxi Provincial People’s HospitalSchool of MedicineNanchang UniversityNanchangJiangxi 330006China Department of Urology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Urology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110043China Department of Urology Inner Mongolia People’s HospitalHohhotInner Mongolia 010010China Department of Urinary Surgery Taizhou Hospital of Traditional Chinese MedicineTaizhouJiangsu 225300China Department of Urology Linfen People’s HospitalLinfenShanxi 041000China Department of Urology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450006China Department of Urology The Affiliated Hospital of Hebei UniversityBaodingHebei 071000China Department of Urology Chifeng Municipal HospitalChifeng Clinical Medical College of Inner Mongolia Medical UniversityChifengInner Mongolia 024000China Department of Urology Baogang HospitalBaotouInner Mongolia 014010China Department of Oncology The Second People’s Hospital of YibinYibinSichuan 644000China Department of Urology Qilu Hospital of Shandong UniversityJinanShandong 250014China Department of Urology Henan Provincial People’s Hos

Background:LY01.05(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected *** phase III trial study aimed to evaluated the efficacy and safety of LY01.05 in {1. patients with prostate ***:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in *** study included 290 patients with prostate cancer who received either LY01.05 or goserelin implants every 28 days for three *** primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to ***-inferiority was prespecified at a margin of-1.%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen ***:On day 29,in the LY01.05 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(1.2/1.3)and 1.0%(1.0/1.0)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two *** cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for *** endpoints were similar between *** treatments were ***01.05 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/1.5]).Conclusion:LY01.05 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety *** registration:***,NCT04563936.

关键词： Prostatic neoplasms LY01.05 Gonadotropin-releasing hormone agonist Efficacy Safety

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