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Biomedical and Environmental Sciences 2022年第8期35卷 699-710页

作者： wang geng fu YUAN Meng Yuan CHANG Jun Jie LI Yong Han SU Pu Yu Department of Maternal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People's Republic of ChinaHefei 230032AnhuiChina NHC Key Laboratory of study onabnormal gametes and reproductive tract Hefei 230032AnhuiChina

ObjectiveTo present an approach to phenotyping ACEs and explore the association between ACEs and adolescent health risky behaviors based on the social context of *** Totally,5,726 adolescents aged 12-18 years were investigated about their ACEs in the family,peer,school,and personal domains and the occurrence of six types of risky health behaviors(i.e.,smoking,drinking,sexual intercourse,self-harm,and suicidal ideation and attempts).Latent class analysis(LCA)was used to explore the ACE *** Six latent classes of ACEs were identified,including low adversity,school adversity,school adversity and peer victimization,peer victimization,maltreatment and peer victimization,and high adversity,and associated with risky health behaviors in *** physically punished by a teacher,experiencing sexual abuse,and experiencing family trauma most strongly differentiated from the six AcE classes and were correlated with an increased risk for risky adolescent health *** study supports a positive association between ACEs and risky adolescent health *** victimization,school adversity and associated contexts need to be considered in future ACEstudies.

关键词： Adverse childhood experiences Adolescents Healthy risky behaviors Sexual abuse Peer victimization China

Gender Differences in the Relationships between Pubertal Stages and the Perpetration of Self-inflicted and Interpersonal Violence among Middle School Students in China

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Biomedical and Environmental Sciences 2020年第6期33卷 464-469页

作者： SU PuYu wang geng fu REN Hao Yang CHEN Li Ru ZHANG Guo Bao SUN Ying Department of Maternal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People's Republic of ChinaHefei 230032AnhuiChina NHC Key Laboratory of study on abnormal gametes and reproductive tract Hefei 230032AnhuiChina Department of Clinical Medicine The second School of Clinical MedicineAnhui Medical UniversityHefei 230032AnhuiChina

Self-inflicted and interpersonal violence are the two main types of adolescent *** involved in self-inflicted violence both cause and receive the harm,while those who engage in interpersonal violence often aim to harm ***-harm and suicide are common types of selfinflicted ***-fatal violence,such as aggression,bullying,and physical fighting,are common forms of interpersonal violence between adolescents[1].

关键词： such while among

Childhood Sexual Abuse and Quality of Life in Chinese Undergraduates: the Mediating Role of Resilience

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Biomedical and Environmental Sciences 2023年第7期36卷 658-662页

作者： WEN Xue LI Yuan LI Yong Han CHANG Jun Jie YUAN Meng Yuan CAO Lei Lei wang Shao Jie SU Pu Yu wang geng fu Department of Maternal Childand Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei 230032AnhuiChina

Childhood sexual abuse(CSA)is a widespread and serious public health concern,with long-term impacts on overall health in *** to a systematic review published in 2018,the prevalence of CSA in China ranges from 11.6%to 20.2%[1].A longitudinal study from New Zealand demonstrated that CSA negatively influences a broad range of adult developmental outcomes,including mental disorders,psychological wellbeing,sexual risk-taking,physical health,and socioeconomic wellbeing[2].Therefore,CSA is considered a longterm hazard to the overall health of adults and is associated with poor quality of life(QoL).

关键词： Childhood hazard widespread

Ceruloplasmin or Fibronectin Synergism with Quartz Dust on Stimulating Collagen Gene Transcription in Human 2BS Fibroblast

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Biomedical and Environmental Sciences 1995年第3期8卷 246-253页

作者： LIU BING-CI YOU BAO-RONG LIU YU-YING wang geng-fu MIAO QIN AND LI YU-RUI (Institute of Occupational Medicine, Chinese Academy of Preventive Medicine,Beijing 100050, China) Institute of Occupational Medicine Chinese Academy of Preventive Medicine Beijing China.

Human α1(Ⅰ), α2(Ⅰ) and α1(Ⅲ) cDNA probes and RNA dot hybridization were employed to quantitate collagen mRNA changes after adding silica dust into the media of human 2BS fibroblasts. At all dosages used (100, 200, 500 and 1000μg), the α1(Ⅰ), α2(Ⅰ)and α1(Ⅲ) mRNA levels increased one day after dusting. At the same dosage of silica (100μg), α1(Ⅲ) mRNA increased earlier than type Ⅰ collagen mRNA did. The type Ⅰ and type Ⅲ collagen mRNA contents in the experimental groups were higher than those in control on days 3, 5, 7 and 9. The effect of ceruloplasmin (Cp) and fibronectin (Fn) on collagen mRNA synthesis was also studied, after adding silica dust, Cp or Fn into the media of human 2BS fibroblast. The results showed that Cp and Fn have stimulating effect on collagen mRNA production. When both Cp and silica dust were added into cell culture media, the collagen mRNA level was increased more than those of adding either Cp or silica dust alone. Similar situations were found for Fn. Cp (or Fn) synergism with silica dust on stimulating transcription of human collagen gene was suggested

关键词： Res Gene Ceruloplasmin or Fibronectin Synergism with Quartz Dust on Stimulating Collagen Gene Transcription in Human 2BS Fibroblast Chen length BS Fn Figure Li

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高频电源变压器磁芯的设计原理

磁性材料及器件 2000年第4期31卷 26-31页

作者：王耕福国营第八九八厂江苏南京210028

开关电源正向高频化发展 ,作为主变压器使用的软磁铁氧体磁芯 ,从材料性能、尺寸形状等均应作相应改进。讨论了磁芯设计中应考虑的通过功率、性能因子、热阻系数等参数 ,并提出了降低材料高频损耗的微观设计方法。

关键词：开关电源变压器磁芯高频设计

异丙酚和异氟醚用于维持颅脑手术后期麻醉效果的观察

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医学信息（手术学分册） 2007年第5期20卷 413-415页

作者：赵伟王更富新乡医学院第一附属医院麻醉科河南卫辉453100

目的比较静脉输注异丙酚与吸入异氟醚用于颅内手术后期麻醉时病人应激及苏醒过程的差异。方法择期颅内手术38例,随机分成异氟醚组(A组)和异丙酚组(B组),每组各19例,当手术开始缝合硬脑膜时停用一切静脉麻醉药,A组继续吸入异氟醚维持麻... 详细信息

目的比较静脉输注异丙酚与吸入异氟醚用于颅内手术后期麻醉时病人应激及苏醒过程的差异。方法择期颅内手术38例,随机分成异氟醚组(A组)和异丙酚组(B组),每组各19例,当手术开始缝合硬脑膜时停用一切静脉麻醉药,A组继续吸入异氟醚维持麻醉,B组停用吸入麻醉药,加用异丙酚维持麻醉,两组病人均监测围术期的收缩压、舒张压、心率、脉搏血氧饱和度、呼吸频率,记录术后拔管时间,并统计苏醒时的副反应及使用拮抗药的情况。结果A组术后拔管时间明显长于B组,且A组使用拮抗药的剂量明显大于B组;A组在拔管时及拔管后5min的心率明显高于B组,A组拔管时收缩压明显高于术前;A组苏醒时的副反应(恶心、呕吐)的发生率明显高于B组。结论异丙酚用于颅内手术麻醉,既能维持麻醉平稳,同时术后又能迅速完全苏醒,苏醒时副反应少。

关键词：异丙酚异氟醚麻醉颅内手术

异丙酚对体外循环下心脏瓣膜置换术患者血清白细胞介素-6及白细胞介素-10含量的影响

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中国实用医刊 2011年第7期38卷 65-67页

作者：王更富姚前进新乡医学院第一附属医院麻醉科河南卫辉453100

目的探讨体外循环过程中异丙酚对心脏瓣膜置换术患者血清白细胞介素（IL）-6及IL-10含量的影响。方法选择ASA Ⅲ级，预计主动脉阻断时间和体外循环时间分别在30、60min以上的风湿性心脏瓣膜病患者30例，随机分为对照组（C组）和异丙酚组... 详细信息

目的探讨体外循环过程中异丙酚对心脏瓣膜置换术患者血清白细胞介素（IL）-6及IL-10含量的影响。方法选择ASA Ⅲ级，预计主动脉阻断时间和体外循环时间分别在30、60min以上的风湿性心脏瓣膜病患者30例，随机分为对照组（C组）和异丙酚组（P组），每组15例。P组在中心静脉置管后以5mg／（kg·h）的速度输注异丙酚，分别于切皮前（T1）、主动脉阻断后30min（T2）、CPB停机后90min（T3）采集两组上腔静脉血检测血清IL-6和IL—10含量。结果两组IL-6含量在T2、T3均较T1升高（P〈0．05），并于T3达峰值，C组T3高于T2,差异有统计学意义（P〈0．05），P组T3与T2差异无统计学意义（P〉0．05）；两组IL-10在T2均较T1呈下降趋势，但仅C组T2与T1之间差异有统计学意义（P〈0．05），在T3均较T1、T2升高，两组T3与．T2比较差异均有统计学意义（P〈0．05）。两组患者血清IL-6、IL-10含量，在T1、T2差异均无统计学意义（P〉0．05），在T3时，P组IL-6高于C组，IL-10低于C组，差异均有统计学意义（P〈0．05）。结论心脏瓣膜置换术患者围术期使用异丙酚可以抑制IL-6的释放．促进IL-10的分泌．有效地抑制体外循环引起的炎性反应。

关键词：异丙酚体外循环白细胞介素-6 白细胞介素-10 心脏瓣膜置换术

葛根素对大鼠体外循环后心肌缺血再灌注损伤的保护作用及抗氧化应激机制的探讨

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中国实验方剂学杂志 2012年第1期18卷 165-168页

作者：巩红岩秦元旭王更富王庆志新乡医学院第一附属医院麻醉科河南新乡453100 新乡医学院解剖教研室河南新乡453100

目的:探讨葛根素对大鼠体外循环后心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MIRI)的保护作用及抗氧化应激机制。方法:取健康雄性SD大鼠75只,随机分为5组:即假手术组(给予等体积的生理盐水)、MIRI模型组(给予等体积... 详细信息

目的:探讨葛根素对大鼠体外循环后心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MIRI)的保护作用及抗氧化应激机制。方法:取健康雄性SD大鼠75只,随机分为5组:即假手术组(给予等体积的生理盐水)、MIRI模型组(给予等体积的生理盐水)、葛根素低、中、高剂量组(2,5,10 ***-1 3个剂量)。于再灌注开始时在储血槽内加入稀释葛根素10mL。在全麻手术下制造大鼠体外循环模型后,随即阻断大鼠升主动脉造成心肌缺血30 min然后开放升主动脉后再灌注180 min造成大鼠心肌缺血再灌注损伤模型(灌注24 h,用于测定心肌梗死面积)。实验组和对照组分别给予葛根素和生理盐水。实验完成后留取大鼠心脏标本,观察大鼠心肌缺血区的心肌细胞凋亡情况;收集血清测定其抗氧化应激的指标:超氧化物歧化酶(SOD),丙二醛(MDA),谷胱甘肽(GSH),谷胱甘肽过氧化物酶(GSH-Px)。结果:与模型组相比,葛根素的应用减少了MIRI大鼠的心肌细胞凋亡、心梗面积和血清中丙二醛的含量,增加了血清中超氧化物歧化酶、谷胱甘肽过氧化物酶的活性和谷胱甘肽的含量,并且随着剂量的增加保护效果尤为明显。结论:葛根素对MIRI大鼠具有抗氧化应激的作用,它能够剂量依赖性的减少心肌细胞凋亡,最终减少心肌梗死面积。

关键词：葛根素心肌缺血再灌注损伤抗氧化应激心肌细胞凋亡

小剂量芬太尼复合丙泊酚在电子胃镜检查中的应用

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实用全科医学 2007年第4期5卷 290-291页

作者：王更富巩红岩河南省新乡医学院第一附属医院麻醉科 453100

目的探讨小剂量芬太尼复合丙泊酚用于无痛胃镜检查的可行性。方法选择80例传统胃镜检查为对照组,80例为无痛胃镜组,两组患者均于检查前、检查中、检查后连续监测血压、心率和SPaO2,记录不良反应及术中舒适度并进行比较。结果两组比较,... 详细信息

目的探讨小剂量芬太尼复合丙泊酚用于无痛胃镜检查的可行性。方法选择80例传统胃镜检查为对照组,80例为无痛胃镜组,两组患者均于检查前、检查中、检查后连续监测血压、心率和SPaO2,记录不良反应及术中舒适度并进行比较。结果两组比较,检查时与检查前后的血压、心率变化差异有统计学意义(P<0.01)。结论小剂量芬太尼复合丙泊酚用于无痛胃镜检查安全有效,值得推广。

关键词：芬太尼丙泊酚麻醉电子胃镜

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非体外循环下冠状动脉搭桥术的麻醉管理

新乡医学院学报 2005年第4期22卷 340-342页

作者：王妍心王更富张永强新乡医学院第一附属医院麻醉科河南卫辉453100

目的探讨非体外循环下冠状动脉搭桥术的麻醉处理方法。方法25例冠心病患者,均在静脉复合麻醉常温下完成手术。麻醉诱导采用静脉注射咪唑安定10mg,芬太尼8～10μg·kg1,丙泊酚1～1.5mg·kg1,阿曲库铵0.2mg·kg1。麻醉维持采取连续泵入丙... 详细信息

目的探讨非体外循环下冠状动脉搭桥术的麻醉处理方法。方法25例冠心病患者,均在静脉复合麻醉常温下完成手术。麻醉诱导采用静脉注射咪唑安定10mg,芬太尼8～10μg·kg1,丙泊酚1～1.5mg·kg1,阿曲库铵0.2mg·kg1。麻醉维持采取连续泵入丙泊酚50～100μg·kg1·min1+芬太尼5～10μg·kg1,术中间断追加咪唑安定5～20mg,阿曲库铵4mg。手术开始后,根据心率变化情况必要时泵入艾司洛尔0.5μg·kg1·min1。结果本组患者麻醉过程平稳,手术中顺利度过,麻醉诱导气管插管时,心率、血压波动不明显,无术中改为体外循环下完成手术,无麻醉并发症及死亡。结论非体外循环下冠状动脉搭桥术的麻醉管理的重点在于防止心率过快和血压的较大波动,以避免增加心脏氧耗。

关键词：体外循环冠脉搭桥麻醉