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Nano Research 2024年第6期17卷 5409-5423页

作者： Ding wang Qi Jiang Ruoyu Shen Lijun Peng Wentao Zhou Tingting Meng fuqiang Hu Jianwei wang Hong Yuan College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009China

The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological *** studies have demonstrated that intestinal barrier function plays an important role in the occurrence and development of inflammatory bowel disease(IBD).Oral administration is the most common route for intestinal *** this study,a synergistic strategy is proposed for IBD management through active barrier repair combined with anti-inflammatory treatment,which can interrupt the pathological process of IBD,resulting in the significantly improved efficacy of existing *** on the specific pH values and high reactive oxygen species(ROS)levels in inflammatory sites of IBD,an orally administrated ROS-responsive drug delivery system targeting inflamed colon has been designed,and confirmed in vitro and in *** anti-inflammatory drug dexamethasone acetate(Dex)and the barrier function regulator LY294002 are delivered by the synthesized nanocarrier to treat IBD synergistically by inhibiting inflammation and actively repairing the intestinal barrier through tight junctions(TJs).The accumulation of nanocarriers in the inflamed colon and synergistic efficacy has been validated in mice with *** brief,a drug delivery system and a therapeutic strategy for IBD are successfully developed.

关键词： nanotechnology reactive oxygen species(ROS)-responsive targeted delivery inflammatory bowel disease(IBD) intestinal barrier combination treatment

基于逆向传递策略的直流锅炉主汽温网络化预测控制

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中国电机工程学报 2015年第19期35卷 4981-4990页

作者：王富强神华国华(北京)电力研究院有限公司北京市朝阳区100000

针对直流锅炉主蒸汽温度控制系统复杂,控制链跨度大的问题,在分析了主汽温控制系统特点的基础上,提出一种基于逆向传递策略的串级系统网络化预测控制方法,并采用遗忘因子递推最小二乘法(RLS)对子系统进行在线辨识,适应直流锅炉变工况需... 详细信息

针对直流锅炉主蒸汽温度控制系统复杂,控制链跨度大的问题,在分析了主汽温控制系统特点的基础上,提出一种基于逆向传递策略的串级系统网络化预测控制方法,并采用遗忘因子递推最小二乘法(RLS)对子系统进行在线辨识,适应直流锅炉变工况需要。为了使喷水减温具有较大的调整范围,通过主汽温导前区在线辨识结果实现对逆向传递策略中设定值的设计;并用预测控制的约束条件,保证中间点温度和各级过热器出口具有足够的过热度。将该方法应用于电厂过热汽温控制系统进行仿真研究,结果表明该方法能较好地适应对象特性的变化,且控制效果明显优于常规串级控制系统。

关键词：直流锅炉主汽温度网络化预测控制带遗忘因子的递推最小二乘法在线辨识逆向传递策略约束条件

复杂重型装备产品设计/制造/运维服务一体化技术

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重型机械 2024年第2期 8-15,23页

作者：张嘉睿杨妮董波宋美萱王富强冯连强鄢萍重庆大学机械与运载工程学院重庆400044 中国重型机械研究院股份公司陕西西安710018

深入剖析了复杂重型装备产品设计制造运维一体化过程中的数据一体化、任务分解与跟踪、资源匹配与动态调度等关键问题,针对每一类问题提出了创新性的解决方法。通过数据主题域划分与一体化建模,实现了数据的高效管理与利用;借助任务分... 详细信息

深入剖析了复杂重型装备产品设计制造运维一体化过程中的数据一体化、任务分解与跟踪、资源匹配与动态调度等关键问题,针对每一类问题提出了创新性的解决方法。通过数据主题域划分与一体化建模,实现了数据的高效管理与利用;借助任务分解技术、粒度评价及设计、任务耦合以及变更重组,优化了任务执行流程和提高了工作效率;建立了任务时间、质量、成本的预测模型,并优化了“任务-资源”的匹配方法,提升了资源利用效率。这些一体化优化技术为设计制造运维服务提供了坚实支撑,有效提升了生产效率和协同合作效果,为后续网络化协同设计、制造研究奠定了坚实基础。

关键词：一体化任务分解任务匹配动态调度

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DNA of neutrophil extracellular traps promote NF-κBdependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3040-3055页

作者： Jun Chen Tao wang Xiaoou Li Lijuan Gao Ke wang Mengxin Cheng Zijian Zeng Lei Chen Yongchun Shen fuqiang Wen Department of Respiratory and Critical Care Medicine West China HospitalWest China School of Medicineand Division of Pulmonary DiseasesState Key Laboratory of BiotherapySichuan UniversityChengduSichuan 610041China

Chronic obstructive pulmonary disease(COPD)is characterised by persistent airway inflammation even after cigarette smoking *** extracellular traps(NETs)have been implicated in COPD severity and acute airway inflammation induced by short-term cigarette smoke(CS).However,whether and how NETs contribute to sustained airway inflammation in COPD remain *** study aimed to elucidate the immunoregulatory mechanism of NETs in COPD,employing human neutrophils,airway epithelial cells(AECs),dendritic cells(DCs),and a long-term CS-induced COPD mouse model,alongside cyclic guanosine monophosphate-adenosine monophosphate synthase and toll-like receptor 9 knockout mice(cGAS-^(−/−)TLR9^(−/−));Additionally,bronchoalveolar lavage fluid(BALF)of COPD patients was *** from COPD patients released greater cigarette smoke extract(CSE)-induced NETs(CSE-NETs)due to mitochondrial respiratory chain *** CSE-NETs,containing oxidatively-damaged DNA(NETs-DNA),promoted AECs proliferation,nuclear factor kappa B(NF-κB)activation,NF-κB-dependent cytokines and type-I interferons production,and DC maturation,which were ameliorated/reversed by silencing/inhibition of cGAS/*** the COPD mouse model,blocking NETs-DNA-sensing via cGAS^(−/−)and TLR9^(−/−)mice,inhibiting NETosis using mitoTEMPO,and degrading NETs-DNA with DNase-I,respectively,reduced NETs infiltrations,airway inflammation,NF-κB activation and NF-κBdependent cytokines,but not type-I interferons due to IFN-α/βreceptor *** NETs components(myeloperoxidase and neutrophil elastase activity)in BALF of COPD smokers correlated with disease severity and NF-κB-dependent cytokine levels,but not type-I interferon *** conclusion,NETs-DNA promotes NF-κB-dependent autoimmunity via cGAS/TLR9 in long-term CS exposure-induced ***,targeting NETs-DNA and cGAS/TLR9 emerges as a potential strategy to alleviate persistent airway inflammation in COPD.

关键词： inflammation TLR9 neutrophil

Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 120-135页

作者： Xiaomei Wu Renxiang Yuan Yichong Xu Kai wang Hong Yuan Tingting Meng fuqiang Hu Department of Pharmacy Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China

The challenge in the clinical treatment of Parkinson's disease lies in the lack of disease-modifying therapies that can halt or slow down the progression. Peptide drugs, such as exenatide (Exe), with potential disease-modifying efficacy, have difficulty in crossing the blood-brain barrier (BBB) due to their large molecular weight. Herein, we fabricate multi-functionalized lipid nanoparticles (LNP) Lpc-BoSA/CSO with BBB targeting, permeability-increasing and responsive release functions. Borneol is chemically bonded with stearic acid and, as one of the components of Lpc-BoSA/CSO, is used to increase BBB permeability. Immunofluorescence results of brain tissue of 15-month-old C57BL/6 mice show that Lpc-BoSA/CSO disperses across the BBB into brain parenchyma, and the amount is 4.21 times greater than that of conventional LNP. Motor symptoms of mice in Lpc-BoSA/CSO-Exe group are significantly improved, and the content of dopamine is 1.85 times (substantia nigra compacta) and 1.49 times (striatum) that of PD mice. α-Synuclein expression and Lewy bodies deposition are reduced to 51.85% and 44.72% of PD mice, respectively. Immunohistochemical mechanism studies show AKT expression in Lpc-BoSA/CSO-Exe is 4.23 times that of PD mice and GSK-3β expression is reduced to 18.41%. Lpc-BoSA/CSO-Exe could reduce the production of α-synuclein and Lewy bodies through AKT/GSK-3β pathway, and effectively prevent the progressive deterioration of Parkinson's disease. In summary, Lpc-BoSA/CSO-Exe increases the entry of exenatide into brain and promotes its clinical application for Parkinson's disease therapy.

关键词： Blood-brain barrier Lipid nanoparticles Brain delivery facilitation α-Symuclein Parkinson's disease

风浪流单独及耦合作用下15 MW级浮式基础动力特性研究

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水力发电 2024年第7期50卷 93-100页

作者：李帅李筹胜任亚君王富强武明鑫李清石郝军刚水电水利规划设计总院北京100120 清华大学北京100084

了解风浪流等环境荷载效应对浮式基础设计及优化至关重要,为此,以15 MW级漂浮式基础为研究对象,系统性定量分析风浪流环境荷载单独及耦合作用下对浮式基础运动及系泊系统受力的影响。首先,以INOWINDMOOR 12 MW和TaiDa 15 MW浮式基础为... 详细信息

了解风浪流等环境荷载效应对浮式基础设计及优化至关重要,为此,以15 MW级漂浮式基础为研究对象,系统性定量分析风浪流环境荷载单独及耦合作用下对浮式基础运动及系泊系统受力的影响。首先,以INOWINDMOOR 12 MW和TaiDa 15 MW浮式基础为原型设计新的15 MW级浮式基础,并在ANSYS-AQWA建立水动力分析模型,风力荷载及海流荷载通过风力系数、流力系数添加;其次,针对风浪流等环境荷载单独及耦合作用下浮式基础运动和系泊受力等特征开展分析。结果表明:浮式基础运动及系泊受力主要受风力和流力的影响,波浪会加剧浮式基础运动及系泊受力的往复性,并加大运动幅度及系泊受力;流荷载对浮式基础运动及系泊受力影响较大,特别是风、浪与流耦合作用时会导致系泊受力明显增加,实际工程设计时,流荷载应给与重点关注。

关键词： 15 MW级浮式基础风浪流环境荷载单独及耦合作用基础运动特性系泊受力

Hydrogen gas:a novel antioxidant for chronic obstructive pulmonary disease?

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Journal of Medical Colleges of PLA(China) 2011年第2期26卷 94-97页

作者： Shen Yongchun Yang Ting wang Tao Wen fuqiang Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu 610041 China

Oxidative stress therapy targeted on ox plays idativ critical role in the pathogenesis of chronic obstructive e stress is of great importance for COPD. However, since pu the lmonary disease （COPD）, so current used antioxidants are not satisfying, scientists have to find more effective antioxidants for COPD. Hydrogen, the most abundant chemical element in the universe, was recently discovered as a novel therapeutic medical gas, and has shown great antioxidant potential in a series of recent published researches for its feature of selectively reducing toxic reactive oxygen species. Based on these findings, we hypothesize that hydrogen gas therapy might be a novel, effective, safe, and economic treatment for COPD patients in one day

关键词： Hydrogen Chronic obstructive pulmonary disease

Investigation of Corrosion Resistance Using Positron Annihilation for an Amorphous Alloy

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Journal of Materials Science & Technology 2001年第4期17卷 482-484页

作者： Jingcheng wang, fuqiang YOU,Junlin YIN and Guohua GAO Testing Center, Shanghai Iron & Steel Research Institute, Shanghai Bao Steel Group Corporation, Shanghai City Key Laboratory of Metal Functional Materials, Shanghai 200940, China Testing Cent. Shanghai Iron and Steel Res. Inst. Shanghai Bao Steel Group Corp. Shanghai 200940 China

An amorphous alloy with Ni-(17-19) at. pct P prepared by electrodeposition process was studied using positron annihilation technique (PAT) associated with X-ray diffraction and the measurement of corrosion rate. It is suggested that defect or the interface between precipitates and matrix is one of the important factors which decrease corrosion resistance of the alloy after crystallization.

关键词： Nickel alloys

Energy Efficiency Time Synchronization Protocol for Wireless Sensor Networks

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Energy Efficiency Time Synchronization Protocol for Wireless...

铝电解槽中局部阴极电流增大对电解质-铝液两相流场的影响

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作者： fuqiang wang Xiaoming Wu Zhiyong Liu Qilu University of Technology （Shandong Academy of Sciences） Shandong Computer Science Center （National Supercomputing Center in Jinan）Shandong Provincial Key Laboratory of Computer Networks

The main cost of time synchronization in Wireless Sensor Networks（WSN） is to interact information with each other through wireless transceivers,so reducing the frequency of synchronous transmission is an important way to reduce the cost of *** the paper,we propose an Energy Efficiency Time Synchronization Protocol（EETS） for *** exploits the combination of ARMA（Auto Regressive Moving Average） model and Kalman filter model in time series to predict,which can not only solve the shortcoming of low prediction accuracy of ARMA in complex environment,but also make up for the shortcoming of Kalman filter prediction that cannot adapt to the non-linear change of time *** realizes the energy efficiency of time synchronization by adjusting the feedback of synchronization cycle adaptively under certain error *** further build a prototype system and the validation results confirm the effectiveness of EETS and show energy efficiency for WSNs.

关键词： Time Synchronization Wireless Sensor Networks Energy Efficiency Time Cycle

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金属学报 2020年第7期56卷 1047-1056页

作者：王富强刘伟王兆文东北大学冶金学院沈阳110819 沈阳铝镁设计研究院有限公司沈阳110001

采用数值模拟方法建立了三维非稳态电解质-铝液两相流500 kA全槽模型,并通过铝液流速和电解质/铝液的界面变形测试数据验证了模型的准确性。在此基础上模拟并定量评估了6种实际电解生产中存在的局部阴极电流增大60%对铝液流场和界面变... 详细信息

采用数值模拟方法建立了三维非稳态电解质-铝液两相流500 kA全槽模型,并通过铝液流速和电解质/铝液的界面变形测试数据验证了模型的准确性。在此基础上模拟并定量评估了6种实际电解生产中存在的局部阴极电流增大60%对铝液流场和界面变形产生的影响程度。结果表明,局部阴极电流增大并不能改变全槽的铝液流场和界面变形的整体趋势,只是局部位置的铝液流速和界面变形幅度略有差异,其中A2A3阴极电流增大有利于抑制B侧中部的界面隆起,极距平均改善幅度为3.0%。分别通过增大电解槽两端部,中部和A、B两侧的部分阴极电流比例对比分析了两相流场变化规律。结果表明,适当增加电解槽两端部的阴极电流有利于抑制界面变形,尤其是A1~A4和A21~A34阴极电流增加28%可将界面隆起最大值降低2.4 mm,B7~B18的极距平均拉高9.5%。该研究为母线优化和改善电解槽磁流体稳定性提供了一条新思路。

关键词：铝电解槽两相流场局部阴极电流增大界面变形数值模拟优化