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Constructing Nanoscale Topology on the Surface of Microfibers Inhibits Fibroblast Fibrosis

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Advanced Fiber Materials 2022年第5期4卷 1219-1232页

作者： Yongjie Jiao Xiaojing Li Jinjie Chen Chaojing Li Laijun Liu Xingxing Liu fujun wang Guang Chen Lu wang Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai 201620China Healthcare Department of Taizhou Hospital Affiliated to Wenzhou Medical University(Zhejiang Province Taizhou Hospital) Taizhou 317000China Department of Vascular Surgery Taizhou Hospital Affiliated to Wenzhou Medical University(Zhejiang Province Taizhou Hospital)Taizhou 317000China

Fibrosis is a common problem in soft tissue regeneration,often caused by the differentiation of fibroblasts into *** of the nanoscale topology that regulates the mechanical transduction of cells,nanofibers or nanoparticles are commonly used to modulate fibroblast ***,the strength of nanofibers is insufficient,and the physi-ological toxicity of nanoparticles still remains to be *** this study,self-induced crystallization was used to construct nano-protrusions on the random and aligned polycaprolactone microfibers to regulate the behavior of *** results revealed that the mechanical properties of microfibers with a nanoscale topology were *** staining manifested that nano-protrusions impeded the activation of integrins and vinculins,thereby inhibiting the nuclear transfer of Yes-associated protein,resulting in a decrease in the expression ofα-smooth muscle *** topology of microfibers hampered the activation of the Rho/ROCK signalling *** general,we used a simple process to con-struct a fibrous scaffold with a micro-nano multilevel *** structure can hinder the transformation of fibroblasts into myofibroblasts on both random and aligned fibers,which is expected to prevent fibrosis.

关键词： Electrospinning Topology Fibroblast Fibrosis

Laser Ablation and Chemical Oxidation Synergistically Induced Micro/Nano Re-entrant Structures for Super-Oleophobic Surface with Cassie State

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Nanomanufacturing and Metrology 2023年第2期6卷 79-89页

作者： Jiaqi Chao Faze Chen Lei Xia Zexin Cai fujun wang Yanling Tian Dawei Zhang School of Mechanical Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin 300072China School of Engineering University of WarwickCoventry CV47DLUK

Generally,re-entrant structures are a key part of fabricating superoleophobic surfaces,and this structure appears in almost all kinds of published research articles regarding ***,the application of related fabrication methods is usually too complex and costly in real *** this paper,we present a simple method to generate micro-cauliflower structures,which work as re-entrant structures in microcone arrays,to promote the formation of superoleophobic *** heating process after alkali-assisted surface oxidation is the main reason for the appearance of a micro-ball structure,and the oxidation time can influence the size of the *** the best of our knowledge,the influence of the heating process after alkali-assisted surface oxidation on the birth of the micro-ball structure is seldom researched.A low-surface-energy treatment was also analyzed in influencing the size of the re-entrant structure and its relative *** of 5μl of n-decane show contact angles of 155±1°on the as-prepared superoleophobic surface,and air pockets can be clearly seen underneath,indicating a stable Cassie contacting state and a promising application value in the near future.

关键词： Superoleophobic Re-entrant structure Cassie state Laser direct writing

Dynamic features of near-inertial oscillations in the Northwestern Pacific derived from mooring observations from^2015 to 2018

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Journal of Oceanology and Limnology 2020年第4期38卷 1092-1107页

作者： HU Shijian LIU Lingling GUAN Cong ZHANG Linlin wang Jianing wang Qingye MA Jie wang fujun JIA Fan FENG Junqiao LU Xi wang Fan HU Dunxin CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China College of Marine Science University of Chinese Academy of SciencesQingdao 266071China

Near-inertial oscillation is an important physical process transferring surface wind energy into deep *** investigated the near-inertial kinetic energy(NIKE)variability using acoustic Doppler current profiler measurements from a mooring array deployed in the tropical western Pacific Ocean along 130°E at 8.5°N,11°N,12.6°N,15°N,and 17.5°N from September 2015 to January *** features,decay timescales,and significant seasonal variability of the observed NIKE were *** the mooring sites of 17.5°N,15°N,and 12.6°N,the NIKE peaks occurred in boreal autumn and the NIKE troughs were observed in boreal *** contrast,the NIKE at 11°N and 8.5°N showed peaks in winter and troughs in *** cyclones and strong wind events played an important role in the emergence of high-NIKE events and explained the seasonality and latitudinal characteristics of the observed NIKE.

关键词： near-inertial kinetic energy western Pacific Ocean tropical cyclones mooring array seasonal variability

A novel spherical-headed fascial dilator is feasible for second-stage ultrasound guided percutaneous nephrolithotomy:A pilot study

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Asian Journal of Urology 2021年第4期8卷 424-429页

作者： Yiwei wang Liheng Gao Mingxi Xu Wenfeng Li Yuanshen Mao fujun wang Lu wang Jun Da Zhong wang Department of Urology Ninth People’s HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghaiChina

Objective:In second-stage percutaneous nephrolithotomy(PCNL),because the hydronephrosis has been decompressed,the dilated renal pelvis has resolved and the space is ***,introduction of the tip of the Amplatz dilator can cause injury to the opposite side of the renal-pelvic *** this study,we report the experimental and initial clinical performance of a spherical-headed fascial dilator developed specifically for second-stage ***:The novel spherical-headed dilator was compared with existing tapered-headed dilators in configuration and in puncture resistance utilizing a static puncture ***,a pilot clinical study was conducted during which patients scheduled to undergo second-stage PCNL from June 2019 to October 2019 in our center were enrolled.A typical ultrasound guided PCNL procedure was performed with the exception that the new spherical-headed fascial dilator was substituted for a tapered-headed ***:Experimentally,stab resistance against polyethylene film was significantly increased using the novel spherical-headed dilator compared to the traditional tapered-headed dilators(p<0.005).In the clinical study,the novel dilators were successfully introduced into the renal pelvis and passed down the collecting system in all eight second-stage PCNL *** were no cases of renal pelvic perforation or brisk hemorrhage nor need for transfusion.

关键词： Percutaneous nephrolithotomy Fascial dilator Ultrasound guidance Kidney stones without hydronephrosis

华南杂交稻主要不育系品质性状特点及基因分析

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中国稻米 2024年第5期30卷 84-89页

作者：熊亮曹华盛王福军顾海永李曙光何高梁世胡罗文永广东省农业科学院水稻研究所/广东省水稻育种新技术重点实验室/农业农村部华南优质稻遗传育种重点实验室(部省共建)/广东省水稻工程实验室广州510640

将广东、广西选育推广的三系不育系分成3种类型:早期高产类型、中期优质类型和后期优质高产类型。早期高产类型不育系包括博A、Y华农A、天丰A和五丰A等;中期优质类型不育系包括粤丰A、野香A、泰丰A和广8A等;后期优质高产类型不育系包括... 详细信息

将广东、广西选育推广的三系不育系分成3种类型:早期高产类型、中期优质类型和后期优质高产类型。早期高产类型不育系包括博A、Y华农A、天丰A和五丰A等;中期优质类型不育系包括粤丰A、野香A、泰丰A和广8A等;后期优质高产类型不育系包括贵A、香禾A、耕香A等。归纳分析3种类型不育系的品质性状,并对各不育系的品质基因进行检测,以期提高这些不育系的育种应用。结果表明,高产不育系的直链淀粉含量在22.4%~26.9%之间,多数不育系籽粒长宽比≤3.0,透明度≥2级,多携带不利品质的基因ALK、Chalk5、Wx-a、GS3等。优质不育系的直链淀粉含量在12.0%~18.0%之间,长宽比绝大多数在3.6~4.3之间,胶稠度≥62 mm,透明度≤2级,具有优质品质基因Wx-b、fgr、GW5、GL7、GW8等。优质高产不育系的直链淀粉含量在13.0%~16.0%之间,长宽比在3.3~3.6之间,胶稠度≥60 mm,垩白度在0~1.5%间,具有优质基因Wx-b和GW5,且产量较高。

关键词：杂交稻三系不育系品质性状品质基因华南

各向异性PCL/明胶复合人工心脏瓣膜瓣叶材料的制备及性能

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产业用纺织品 2024年第7期42卷 1-10页

作者：陈昱欣王雅娟郑小凡王富军王璐侯永泰王盛章李超婧东华大学纺织学院上海201620 东华大学纺织面料技术教育部重点实验室上海201620 复旦大学工程与应用技术研究院生物医学工程技术研究所上海200433 复旦大学航空航天系生物力学研究所上海200433 上海昊海生物科技股份有限公司上海200052

为制备模拟人体原生瓣膜层状结构及力学各向异性的人工心脏瓣膜瓣叶材料,采用静电纺丝技术,以不同质量配比的聚己内酯(PCL)和明胶为原料,通过调整各层纤维膜的纤维排列情况,顺序堆叠纺制3层结构的PCL/明胶复合支架。结果表明,PCL质量体... 详细信息

为制备模拟人体原生瓣膜层状结构及力学各向异性的人工心脏瓣膜瓣叶材料,采用静电纺丝技术,以不同质量配比的聚己内酯(PCL)和明胶为原料,通过调整各层纤维膜的纤维排列情况,顺序堆叠纺制3层结构的PCL/明胶复合支架。结果表明,PCL质量体积比为10%时,随着明胶质量分数增加,纤维直径和复合支架厚度随之增加,复合支架的弹性模量和极限抗拉强度减小。其中,PCL和明胶质量配比为5∶3的复合支架在两个相互垂直方向上的弹性模量分别为(26.98±3.01)MPa和(3.39±0.36)MPa,各向异性比约为7.96,接近原生主动脉瓣的力学各向异性比,其体外脉动流测试显示有效开口面积(EOA)为1.79 cm^(2)、平均跨瓣压差(MPD)为1.67 kPa(即12.52 mmHg)、反流分数(RF)为24.22%。同时,制备的复合支架溶血率均小于5%,细胞相对增殖率均大于80%,具有良好的血液相容性和细胞相容性,有望应用于人工心脏瓣膜瓣叶材料。

关键词：人工心脏瓣膜各向异性静电纺丝层状结构弹性模量极限抗拉强度溶血率有效开口面积(EOA) 平均跨瓣压差(MPD) 反流分数(RF)

Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment

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Bioactive Materials 2021年第9期6卷 2969-2982页

作者： Fan Zhao Jing Sun Wen Xue fujun wang Martin W.King Chenglong Yu Yongjie Jiao Kun Sun Lu wang College of Textiles Donghua UniversityShanghai201620China Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversitySongjiang DistrictShanghai201620China Department of Pediatric Cardiology Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghai200092China Wilson College of Textiles North Carolina State UniversityRaleigh27606USA

Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery ***,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy ***,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease *** cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite *** points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good *** suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing *** addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the *** in vivo results suggested the cBRS supported the vessel wall similar to that of metallic *** both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month *** in vivo degradation profile of the cBRS is consistent with static degradation results in *** is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the ***,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months.

关键词： Cardiovascular stent Bioresorbable Congenital heart disease Braided technology Thermal treatment

STUDY ON TRENDS OF TRANSLOCATION AND DISTRIBUTION OF 14C-BUTACHLOR FROM ALGINATE CRF IN SIMULATING MICRO-ECOSYSTEM

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核农学报 1992年第1期 29-34页

作者： Qi Mengwen wang fujun (Beijing Agricultural University,Beijing 100094)

The trends of transportation and distribution ofC-butachlor from alginate controlled-release formulation（CRF） were studied by contrast witch the conventional formulation in rice ecosystem. The results showed that when the CRF was applied, because butachlorwas released out from the CRF slowly and continuously, its concentrations in water would maintain a define level for longer, time and its concentrations in shoots or roots of rice plants also were lower in the ecosystem than that wnen the conventional formulation（CF）was *** soil, butachlor mainly appeared in upper（0—10cm）, and the means of distribution of the resid-

关键词： CRF C-BUTACHLOR FROM ALGINATE CRF IN SIMULATING MICRO-ECOSYSTEM STUDY ON TRENDS OF TRANSLOCATION AND DISTRIBUTION OF

Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel

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npj Flexible Electronics 2022年第1期6卷 419-429页

作者： Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo fujun wang Jifu Mao Ze Zhang Lu wang Key Laboratory of Textile Science&Technology of Ministry of Education and College of Textiles Donghua UniversityShanghai 201620China Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology Donghua UniversityShanghai 201620China Département de chirurgie Facultéde médecineUniversitéLavalAxe médecine régénératriceCentre de recherche du CHU de Québec-UniversitéLavalQuébec(QC)G1V 0A6Canada

Stretchable conductive fibers have attracted much attention due to their potential use in wearable ***,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large *** challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium *** parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human *** multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices.

关键词： conductive polypyrrole conductivity