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基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

科学通报:英文版 2023年第18期68卷 2106-2114,M0004页

作者： zhuo-Yu An Ye-jun wu Yu Hou Heng Mei wei-Xia Nong Wen-qian Li Hu Zhou Ru feng Jian-Ping Shen jun Peng Hai Zhou yi Liu yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-yong Li Yun-feng Cheng Peng Liu Ya-Jing Xu Zhao wang yi Luo Zhen Cai Hui Liu Jing-Wen wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu zhu Xin wang Rong Fu Liang Huang Shao-Yuan wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng wang Xu-Liang Shen Yangjin Baima Yue-ying Li qian-Fei wang qiu-Sha Huang Hai-Xia Fu Xiao-Lu zhu Yun He qian Jiang Hao Jiang Jin Lu Xiang-Yu Zhao ying-jun Chang Tao wu Yao-zhu Pan Lin qiu Da Gao A-Rong Jin wei Li Su-jun Gao Lei Zhang Ming Hou Xiao-jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

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中国多巴胺能PET联合葡萄糖代谢PET脑显像在帕金森病临床应用专家共识

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中国临床神经科学 2024年第4期32卷 361-372页

作者：左传涛刘丰韬田梅管一晖张宏鲁佳荧李欣忆琚紫昭葛璟洁吴平张军罗巍豆晓锋于聪聪钟燕金晨涛周瑞侯海峰占宏伟卢洁王瑞民李彪尹雅芙李雪娜朱小华朱元凯兰晓莉姜磊何勇田蓉范岩孙夕林赵军富丽萍蒋韩马晓芬张丽霞丁正同王坚中国认知科学学会分子影像分会复旦大学附属华山医院核医学/PET中心复旦大学附属华山医院神经内科浙江大学医学院附属第二医院核医学科/PET中心复旦大学附属华山医院放射科浙江大学医学院附属第二医院神经内科首都医科大学宣武医院放射与核医学科中国人民解放军总医院第一医学中心核医学科上海交通大学医学院附属瑞金医院核医学科上海交通大学医学院附属新华医院核医学科中国医科大学附属第一医院核医学科华中科技大学同济医学院附属同济医院核医学科华中科技大学同济医学院附属协和医院核医学科广东省人民医院核医学科武汉大学中南医院核医学科四川大学华西医院核医学科北京大学第一医院核医学科哈尔滨医科大学附属第四医院核医学科同济大学附属东方医院核医学科中日友好医院核医学科福建医科大学附属协和医院PET/CT室广东省第二人民医院核医学科浙江省中医院核医学科中国认知科学学会分子影像分会

多巴胺能正电子发射断层扫描(PET)脑显像是目前诊断帕金森病的重要依据，但其对帕金森综合征的鉴别能力有限。葡萄糖代谢PET显像中不同的脑代谢模式为进一步鉴别诊断提供可能。文中在前期PET脑显像相关技术操作和临床应用专家共识的基... 详细信息

多巴胺能正电子发射断层扫描(PET)脑显像是目前诊断帕金森病的重要依据，但其对帕金森综合征的鉴别能力有限。葡萄糖代谢PET显像中不同的脑代谢模式为进一步鉴别诊断提供可能。文中在前期PET脑显像相关技术操作和临床应用专家共识的基础上，对开展多巴胺能联合葡萄糖代谢显像进行系统梳理，征求专家意见后形成本专家共识。旨在规范帕金森综合征患者的多巴胺能显像及葡萄糖代谢显像的技术操作，为医生提供报告解读建议，进一步指导多巴胺能与葡萄糖代谢PET脑显像联合应用在帕金森相关疾病中的临床实践流程。

关键词：帕金森综合征帕金森病正电子发射断层扫描多巴胺能显像葡萄糖代谢显像联合应用

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Optimization of performance of the KM2A full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

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Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients

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Journal of Nutritional Oncology 2018年第4期3卷 182-188页

作者： Zhen Ming Fu Hong Xia Xu Chun Hua Song wei Li Zeng qing Guo Yuan Lin ying ying Shi Wen Hu yi Ba Su yi Li Zeng Ning Li Kun Hua wang Jing wu ying He Jia jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou wei wang qi Luo yong Mei Shi Yu Mei qi Hai Ping Jiang Wen Xian Guan jun qiang Chen Jia Xin Chen Yu Fang Lan Zhou yong Dong feng Rong Shao Tan Tao Li jun Wen Ou qing Chuan Zhao Jian Xiong wu Chang wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui 230031 China Department of Clinical Nutrition The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China Department of Gastrointestinal Surgery Institute of Gastroenterology The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department of Clinical Nutrition The First People's Hospital of Kashi Xinjiang 844000 China Department of Clinical Nutrition Chongqing General Hospital Chongqing 400014 China Department of Colorectal and Anal Surgery Huizhou Municipal Central Hospital Huizhou Guangdong 516001 China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China Department of Oncology Xingtai People’s Hospital Hebei Medical University Xingtai Hebei 054031 China The First Department of the Tumor Hospital of Harbin Medical University Harbin Heilongjiang 150085 China Department of Nutrition Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Department of Nutrition Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing 400042 China Department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan 450008 China Department of General Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China Comprehensive Oncology Department Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 China Department of Oncology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 China The Fourth Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150001 China Cancer center The First People's Hospital of Foshan Foshan Guangdong 528000 China Department of Gastrointestinal Tumor Surge

Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients.

关键词： Validation Nutrition status Chinese version Cancer

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Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients

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Journal of Nutritional Oncology 2016年第1期1卷 52-58页

The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the P

关键词： Validation Nutrition status PG-SGA Chinese version Cancer

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu Hui-Xian Li Xue-ying Li Yu-wei wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen wei Chen Yu-qi Cheng Shi-Xian Cui Zhao-Yu Deng yi-Ru Fang qi-yong Gong Wen-Bin Guo Zheng-Jia-yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu qing-Hua Luo Hua-qing Meng Dai-Hui Peng Jiang qiu Yue-Di Shen Tian-Mei Si Yan-qing Tang Chuan-Yue wang Fei wang Hua-Ning wang Kai wang Xiang wang ying wang Zi-Han wang Xiao-Ping wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-feng Xu Hong Yang Jian Yang Shu-qiao Yao yong-qiang Yu yong-Gui Yuan Ke-Rang Zhang wei Zhang Zhi-jun Zhang jun-Juan zhu Xi-Nian Zuo Jing-Ping Zhao Yu-feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects

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Journal of Nutritional Oncology 2021年第1期6卷 16-32页

作者： Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang wang Zeng qing Guo Yuan Lin ying ying Shi Wen Hu yi Ba Su yi Li Zeng Ning Li Kun Hua wang Jing wu ying He Jia jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou wei wang qi Luo yong Mei Shi Yu Mei qi Hai Ping Jiang Wen Xian Guan jun qiang Chen Jia Xin Chen Yu Fang Lan Zhou yong Dong feng Rong Shao Tan Tao Li jun Wen Ou qing Chuan Zhao Jian Xiong wu Min Weng qing Hua Yao Jiu wei Cui wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Cancer Center of the First Hospital of Jilin University Changchun 130021JilinChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal Surgery Cancer Hospital Affiliated to Guangxi Medical UniversityNanning 530021GuangxiChina Department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina Department of Clinical Nutrition the First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical University 650032KunmingYunnanChina Department of Clinical Nutrition the First People's Hospital of KashiKashi 844000XinjiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtai 054031HebeiChina Harbin Medical University Cancer Hospital Harbin 150085HeilongjiangChina

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even ***,there is currently no large data available on the prevalence of malnutrition in Chinese cancer *** study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic *** We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)*** of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal *** patients were enrolled from 72 hospitals located in different regions of *** patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)*** cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,*** From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the *** patients included 12,494(52.9%)males and 11,124(47.1%)*** mean age was 55.8±13.7 *** proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,*** the 23,994 inpatients,the proportions of patients who were underweight(BMIweight(24 kg/m2≤BMI<28 kg/m2)and obese(BMI≥2

关键词： Nutritional status Nutritional assessment Malnutrition Patient generated subjective global assessment Body mass index Body weight loss Karnofsky Performance Status score Quality of life

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南方离子吸附型稀土尾矿不同土层氮污染现状的垂向特征

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稀土 2021年第1期42卷 30-44页

作者：王启沛张萌冯兵朱秋平姚娜杨兵李发东张依章吴俊伟吴少林南昌航空大学环境与化学工程学院江西南昌330063 江西省环境保护科学研究院江西南昌330039 南昌大学生命科学学院江西南昌330031 中国环境科学研究院北京100012 中国科学院地理科学与资源研究所北京100101

江西赣州地区分布着全球稀有的离子吸附型稀土矿,其开采工艺主要为原地浸矿,提取过程中主要使用硫酸铵,长期的原位浸提对当地的土壤环境造成的污染风险亟待评估。本研究以定南县原地浸矿工艺的典型离子吸附型稀土尾矿为研究对象,开展了... 详细信息

江西赣州地区分布着全球稀有的离子吸附型稀土矿,其开采工艺主要为原地浸矿,提取过程中主要使用硫酸铵,长期的原位浸提对当地的土壤环境造成的污染风险亟待评估。本研究以定南县原地浸矿工艺的典型离子吸附型稀土尾矿为研究对象,开展了矿区不同土层氮污染现状研究,设置了不同高程的采矿区(山顶、山腰、山脚)及附近未受浸矿干扰的山体对应深度的土柱进行对比研究,运用描述性统计、均值分析、Pearson相关性和主成分分析等方法,探索了定南原地浸矿的离子型稀土尾矿氨氮含量赋存现状,分析了定南该类稀土尾矿深层土壤氮化物污染特征。结果表明:顶子脑稀土矿山土壤Kj-N、NH+4-N和NO-3-N含量平均值分别为339.26 mg/kg、156.29 mg/kg和27.63 mg/kg,下茶坑稀土矿山土壤Kj-N、NH+4-N和NO-3-N含量平均值分别为226.42 mg/kg、100.46 mg/kg和18.20 mg/kg,两个对照区土壤Kj-N、NH+4-N和NO-3-N含量平均值为157.69 mg/kg、2.55 mg/kg和2.74 mg/kg;稀土矿山开采后山体深层土壤(4 m~12 m)中氨氮污染严重(顶子脑:744 mg/kg,下茶坑:374 mg/kg);顶子脑稀土矿山的山顶氮化物污染程度比山腰和山脚污染程度高(P0.05);两座矿山山顶处凯氏氮与铵态氮含量之间存在显著的正相关性(P<0.01),山腰和山脚处铵态氮与硝态氮含量显著正相关性(P<0.01),两座矿山的铵态氮与土层深度之间存在显著的正相关性(P<0.01);稀土矿山中氮化物的存在形式主要是铵态氮,且铵态氮是稀土矿区判别污染的主要影响因素。

关键词：赣州离子吸附型稀土矿硫酸铵土柱氮化物土层污染特征

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Sex differences in the scored Patient-Generated Subjective Global Assessment in 19,528 cancer patients

引用

Journal of Nutritional Oncology 2023年第1期8卷 38-46页

作者： wang Yan-Li wu Tian-Tian Fu Zhen-Ming Guo Zeng-qing Lin Yuan Shi ying-ying Hu Wen Ba yi Li Su-yi Li Zeng-Ning wang Kun-Hua wu Jing He ying Yang Jia-jun Xie Cong-Hua Zhou Fu-Xiang Song Xin-Xia Chen Gong-Yan Ma Wen-jun Luo Su-Xia Chen Zi-Hua Cong Ming-Hua Ma Hu Zhou Chun-Ling wang wei Luo qi Shi yong-Mei qi Yu-Mei Jiang Hai-Ping Guan Wen-Xian Chen jun-qiang Chen Jia-Xin Fang Yu Zhou Lan feng yong-Dong Tan Rong-Shao Li Tao Ou jun-Wen Zhao qing-Chuan wu Jian-Xiong Lin Xin Yang Liu-qing Zhang qi Jia Ping-Ping Li wei Xu Hong-Xia Shi Han-Ping Song Chun-Hua The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Chinese Society of Nutritional Oncology Department of Epidemiology and Statistics College of Public HealthZhengzhou UniversityZhengzhouHenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianChina Department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina Department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Zhongshan Chenxinghai Hospital(Affiliated Zhongshan Chenxinghai Hospital of Guangdong Medical University) ZhongshanGuangdongChina Department of Clinical Nutrition The First People's Hospital of KashiKashiXinjiangChina Department of Clinical Nutrition Chongqing General HospitalChongqingChina Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebeiChina The First Department of the Tumor Hospital of Harbin Medical University HarbinHeilongjiangChina Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Oncology Affiliated

Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer *** purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer ***:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common *** PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this *** t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain *** Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related ***:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified *** causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer *** of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function *** sex differences in PG-SGA scores might be due to the differences i

关键词： PG-SGA Sex differences Malnutrition Cancer patients TCGA database

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Ti/nano-TiO_2膜电极制备的影响因素分析

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淮南师范学院学报 2013年第3期15卷 7-9页

作者：严晓云王凤武徐迈魏亦军朱其永安徽理工大学化学工程学院淮南师范学院化学与化工系安徽淮南232001

采用溶胶凝胶法(sol-gel)法,以钛酸丁酯为起始原料制备纳米二氧化钛溶胶;研究了水分含量、分散剂种类和煅烧温度等因素对溶胶-凝胶(sol-gel)制备钛基二氧化钛电极催化活性的影响,运用扫描电镜(SEM)、循环伏安曲线(CV)表征了所制得纳米T... 详细信息

采用溶胶凝胶法(sol-gel)法,以钛酸丁酯为起始原料制备纳米二氧化钛溶胶;研究了水分含量、分散剂种类和煅烧温度等因素对溶胶-凝胶(sol-gel)制备钛基二氧化钛电极催化活性的影响,运用扫描电镜(SEM)、循环伏安曲线(CV)表征了所制得纳米TiO2电极的形貌及电催化活性。

关键词： Sol-gel 纳米二氧化钛膜电极循环伏安

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