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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang mei-feng Ruan Guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

Evolution mechanism and quantitative characterization of initial micro-cracks in marble under triaxial compression

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 586-595页

作者： Zhiliang wang Songyu LI Jianguo wang Ao LI Weixiang wang Chenchen feng Jingjing FU School of Civil Engineering Hefei University of TechnologyHefei230009China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou221116China

The initial micro-cracks affect the evolution characteristics of macroscopic deformation and failure of rock but are often ignored in theoretical calculation,numerical simulation,and mechanical *** this study,we propose a quantitative analysis model to investigate the effects of initial micro-cracks on the evolution of marble deformation and *** relationship between the micro-crack propagation and the marble failure characteristics was comprehensively studied by combining theoretical analysis with a micro-computed tomography(micro-CT)scanning *** found that with the increase of confining pressure,the matrix elastic modulus of the marble first increased and then tended to be stable,while the micro-cracks increased *** sensitivity ranges of the marble sample matrix elastic modulus and micro-cracks to confining pressure were 0–30 MPa and 30–50 MPa,*** porosity and Poisson’s ratio decreased *** increasing proportion of internal micro-cracks led to an increase in the sample *** samples presented mainly shear failure under triaxial compression,and the failure angle decreased linearly with the increase of confining *** convergence direction of cracks decreased *** quantitative analysis model could accurately portray the relationship between the overall macroscopic deformation and the deviatoric stress of the samples at the compaction and the linear elastic stages,thus deepening the understanding of the stress–strain behavior of rocks.

关键词： Marble Initial micro-cracks Triaxial compression Constitutive relationship Crack evolution

Machine learning model based on non-convex penalized huberized-SVM

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Journal of Electronic Science and Technology 2024年第1期22卷 81-94页

作者： Peng wang Ji Guo Lin-feng Li School of Finance and Economics Xizang Minzu UniversityXianyang712082China Research Center for Quality Development of Xizang Special Industries Xianyang712082China School of Computer Science and Technology Xinjiang UniversityUrumqi830017China

The support vector machine(SVM)is a classical machine learning *** the hinge loss and least absolute shrinkage and selection operator(LASSO)penalty are usually used in traditional ***,the hinge loss is not differentiable,and the LASSO penalty does not have the Oracle *** this paper,the huberized loss is combined with non-convex penalties to obtain a model that has the advantages of both the computational simplicity and the Oracle property,contributing to higher accuracy than traditional *** is experimentally demonstrated that the two non-convex huberized-SVM methods,smoothly clipped absolute deviation huberized-SVM(SCAD-HSVM)and minimax concave penalty huberized-SVM(MCP-HSVM),outperform the traditional SVM method in terms of the prediction accuracy and classifier *** are also superior in terms of variable selection,especially when there is a high linear correlation between the *** they are applied to the prediction of listed companies,the variables that can affect and predict financial distress are accurately filtered *** all the indicators,the indicators per share have the greatest influence while those of solvency have the weakest *** companies can assess the financial situation with the indicators screened by our algorithm and make an early warning of their possible financial distress in advance with higher precision.

关键词： Huberized loss Machine learning Non-convex penalties Support vector machine(SVM)

PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan wang feng Li Shuang wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

Application of Bionic Technology in Marine Cruise Equipment:Research Progress and Development Trends

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Journal of Bionic Engineering 2024年第3期21卷 1117-1155页

作者： Kunhui Luo Lan Yan Zhiyi Zhu Zhongqiu wang Hongru wang feng Jiang School of Electromechanical and Automation Huaqiao UniversityXiamen36102China National Local Joint Engineering Research Center for Intelligent Manufacturing Technology of Brittle Material Products Xiamen361021China Institute of Oceanographic Instrumentation Shandong Academy of SciencesQilu University of Technology(Shandong Academy of Sciences)Qingdao266100China Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment Technology Qingdao266100China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao266100China Institute of Manufacturing Engineering Huaqiao UniversityXiamen361021China

This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development *** cruising is a crucial means of gaining insights into the marine environment and conducting scientific ***,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine *** technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread *** article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface *** summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising ***,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising *** application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.

关键词： Marine cruising equipment Bionic technology Propulsion methods Drag reduction Surface antifouling

Simulation and analysis of soil homogenization drills based on discrete element method and response surface methodology

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Particuology 2024年第5期88卷 128-148页

作者： Zhipeng wang Tong Zhu Youzhao wang Song Yang feng Ma Xu Li Institute of Process Equipment and Environmental Engineering School of Mechanical Engineering and AutomationNortheastern UniversityShenyang110819China Liaoning Coning Testing Co. Ltd.Shenyang110170 China

Currently,rotary drilling is one of the main pieces of equipment used for in-situ remediation of contaminated ***,this equipment has problems such as uneven mixing and low utilization efficiency,which affect the efficiency of in-situ soil *** improve the efficiency of in-situ soil remediation,this paper takes contaminated black soil as the research object,and the structural design of the new three-stage soil remediation auger is carried out based on *** mixing process of soil and heavy metal passivator under different motion and structural parameters was investigated by the discrete element method(DEM)and response surface *** experimental design was based on rotational speed,homogenizing mixing time,crushing section pitch,and homogenizing section pitch as factors,and soil fragmentation ratio,the coefficient of dispersion,and torque as optimization *** kinematic and structural parameters of the three-stage auger drill bit were then optimized using the one-factor method,the orthogonal test,and the response surface methodology,*** test method uses a one-way test to determine the central level value of the orthogonal test and a comprehensive balance method to determine the best combination of parameters for the orthogonal test,which is then used as the central value of the response surface test for parameter *** optimal combinations of kinematic and structural parameters of the three-stage auger drill bit are determined and validated using response surface *** optimum combination of parameters was found to be a speed of 129 rpm,a homogenizing mixing time of 24 s,a pitch of 165 mm in the crushing section,and a pitch of 132 mm in the homogenizing *** error between the optimal value of the predicted model using the response surface method and the actual simulated value under the optimal parameters is 4.2%,4.9%,and 5.3%,*** optimized factor parameters provide a refe

关键词： Black soil Mixing homogeneity Orthogonal method Response surface methodology Discrete element method Soil remediation

High efficiency photothermal cyclic self-healing antibacterial coating based on in-situ dual-functional BiOI@Bi_(2)S_(3)

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Journal of Materials Science & Technology 2024年第6期173卷 121-136页

作者： Huimeng feng Tong wang Wei wang Chengcheng Ma Yanan Pu Shougang Chen School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

Although extremely challenging,it is highly desirable to develop self-healing materials that exhibit high efficiency under environmental conditions for marine protection *** this work,polyurethane elastomers with hydrogen bond and dimethylglyoxime-urethane(DOU)coordination complex were combined with in-situ dual-functional BiOI@Bi_(2)S_(3) to synthesize high-efficiency photothermal cyclic self-healing antibacterial *** photothermal efficiency of BiOI@Bi_(2)S_(3) is improved by 38% through interfacial ***@Bi_(2)S_(3)/PU rapidly rises by 50.2℃ within 300 s under near-infrared(NIR)light,which can trigger the hydrogen bond of polyurethane coating and recover the barrier properties of the coating through *** functional theory was used to simulate and analyze the generation of multiple electron transfer paths after the vulcanization of BiOI,which improves the interfacial mobility of photogenerated carriers and generates more ***,molecular dynamics verified the self-healing mechanism of hydrogen bond and the photothermal lifting mechanism of the *** 5th scratches and self-healing cycle tests,the coating has a self-healing efficiency of more than 80%,which can ensure the self-healing and anticorrosion protection performance of the coating for multiple *** photocatalytic and photothermal properties of BiOI@Bi_(2)S_(3) enhance the antibacterial rate of the coating up to 99%.This work provides heuristic perspectives for the design of coatings with anti-corrosion,antibacterial and self-healing properties.

关键词： Self-healing Photothermal Interfacial regulation Dual-functional BiOI@Bi_(2)S_(3) Antibacterial

Exploration on electrical resistance tomography in characterizing the slurry spatial distribution in cemented granular materials

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 365-379页

作者： Bohao wang Wei wang feng JIN Handong TAN Ning LIU Duruo HUANG State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China Institute of Science and Technology China Three Gorges CorporationBeijing 100038China School of Geophysics and Information Technology China University of GeosciencesBeijing 100083China

This study investigated the application of electrical resistance tomography(ERT)in characterizing the slurry spatial distribution in cemented granular materials(CGMs).For CGM formed by self-flow grouting,the voids in the accumulation are only partially filled and the bond strength is often limited,which results in difficulty in obtaining in situ samples for quality ***,it is usually infeasible to evaluate the grouting effect or monitor the slurry spatial distribution by a mechanical *** this research,the process of grouting cement paste into high alumina ceramic beads(HACB)accumulation is reliably monitored with *** shows that ERT results can be used to calculate the cement paste volume in the HACB accumulation,based on calibrating the saturation exponent n in Archie’s *** results support the feasibility of ERT as an imaging tool in CGM characterization and may provide guidance for engineering applications in the future.

关键词： electrical resistance tomography cemented granular material grouting spatial distribution Archie’s law

Path signature-based XAI-enabled network time series classification

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Science China(Information Sciences) 2024年第7期67卷 91-106页

作者： Le SUN Yueyuan wang Yongjun REN feng XIA Department of Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science and Technology School of Computing Technologies Royal Melbourne Institute of Technology

Classifying network time series(NTS) is crucial for automating network administration and ensuring cyberspace security. It enables the detection of anomalies, the identification of network attacks,and the monitoring of performance issues, thereby providing valuable support for network protection and optimization. However, modern communication networks pose challenges for NTS classification *** include handling large-scale and complex NTS data, extracting features from intricate datasets, and addressing explainability requirements. These challenges are particularly pronounced for complex 5G networks. Notably, explainability has become crucial for the widespread deployment of network automation for 5G networks and beyond. To tackle these challenges, we propose a path-signature-based NTS classification model called recurrent signature(Recur Sig). This innovative model is designed to overcome the time-consuming feature selection problem by utilizing deep-learning(DL) techniques. Additionally, it provides a solution for addressing the black-box issue associated with DL models in network automation systems(NAS) by incorporating an explainable classification approach. Extensive experimentation on various public datasets demonstrates that Recur Sig outperforms existing models in accuracy and explainability. The results indicate its potential for application in cyberspace security and automated network management, offering an explainable solution for network protection and optimization.

关键词： network time series classification explainable artificial intelligence path signature automated network management recurrent neural network

Theoretical and Experimental Study on the Performance of Hermetic Diaphragm Squeeze Film Dampers for Gas-Lubricated Bearings

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 151-169页

作者： Jianwei wang Haoxi Zhang Shaocun Han Hang Li Peng wang Kai feng State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

Low damping characteristics have always been a key sticking points in the development of gas *** application of squeeze film dampers can significantly improve the damping performance of gas lubricated *** paper proposed a novel hermetic diaphragm squeeze film damper(HDSFD)for oil-free turbomachinery supported by gas lubricated *** types of HDSFDs with symmetrical structure were proposed for good damping *** considering the compressibility of the damper fluid,based on hydraulic fluid mechanics theory,a dynamic model of HDSFDs under medium is proposed,which successfully reflects the frequency dependence of force *** on the dynamic model,the effects of damper fluid viscosity,bulk modulus of damper fluid,thickness of damper fluid film and plunger thickness on the dynamic stiffness and damping of HDSFDs were *** experimental test rig was assembled and series of experimental studies on HDSFDs were *** damper fluid transverse flow is added to the existing HDSFD concept,which aims to make the dynamic force coefficients independent of *** the force coefficient is still frequency dependent,the damping coefficient at high frequency excitation with damper fluid supply twice as that without damper fluid *** results serve as a benchmark for the calibration of analytical tools under development.

关键词： Hermetic diaphragm squeeze film damper Compressibility Dynamic model Experimental studies