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Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species

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Chinese Journal of Natural Medicines 2024年第4期22卷 375-384页

作者： ZENG Zhen ZHANG Chen HU Jiadong wang feiyan WU Ziding wang Jing ZHANG Jun YANG Shuda CHEN Junfeng LI Mingming TONG Qi QIU Shi CHEN Wansheng The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Second Affiliated Hospital of Navy Medical UniversityShanghai 200003China Kunming Plant Classification Biotechnology Co. Ltd.Kunming 650500China School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing100700China

The aerial parts of Mosla chinensis *** Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as ***,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and *** challenge in distinguishing between these genera arises from their similar morphological and metabolic *** address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based *** detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203 identified compounds,as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia *** methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal *** findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants.

关键词： Genus Elsholtzia Genus Mosla Traditional Chinese medicine Xiang-ru Non-volatile phenolic compounds Liquid chromatography-mass spectrometry

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预算与内部控制的关系研究

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商业观察 2024年第7期10卷 53-56页

作者：王飞燕海口开源水务有限公司海南海口570000

文章旨在研究预算与内部控制之间的关系,并探讨其对组织绩效的影响。预算作为管理会计的重要工具被广泛运用于组织的规划与控制中。内部控制是组织为了实现目标、管理风险和确保运营效率而采取的一系列措施和程序。通过文献综述和理论分... 详细信息

文章旨在研究预算与内部控制之间的关系,并探讨其对组织绩效的影响。预算作为管理会计的重要工具被广泛运用于组织的规划与控制中。内部控制是组织为了实现目标、管理风险和确保运营效率而采取的一系列措施和程序。通过文献综述和理论分析,研究首先回顾预算和内部控制的相关概念和特点;其次探讨预算制度与内部控制的密切关联,强调预算在促进内部控制过程中的作用;接着讨论影响预算与内部控制关系的因素,包括组织文化、管理层行为和信息技术支持等;最后综合分析预算与内部控制的关系对组织绩效的影响机制,并提出相关的经验和建议。

关键词：内部控制组织绩效管理会计

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新农科背景下作物育种学教学模式探索

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热带农业工程 2024年第3期48卷 141-144页

作者：鲍亚宁王飞雁刘洋贵州大学烟草学院贵州贵阳550025

随着农业现代化进程的加快,新农科逐渐成为农业发展的主流模式。作物育种学作为新农科建设中的重要环节,肩负着培养高素质农业人才的重要使命。然而,传统的作物育种学教学模式已经不能满足新农科需求,亟需进行教学模式的创新。本文以新... 详细信息

随着农业现代化进程的加快,新农科逐渐成为农业发展的主流模式。作物育种学作为新农科建设中的重要环节,肩负着培养高素质农业人才的重要使命。然而,传统的作物育种学教学模式已经不能满足新农科需求,亟需进行教学模式的创新。本文以新农科建设为导向,探索新型作物育种学教学模式的构建,通过分析课程中的痛点问题、新农科背景下作物育种学教学模式的特点以及教学模式的实践应用,旨在探索新农科背景下作物育种学教学模式,以期提高教学质量,培养适应新农科需求的人才。

关键词：作物育种学新农科教学模式教学改革

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Experimental study on failure evolution mechanism of clastic rock considering cementation and intermediate principal stress

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1636-1650页

作者： feiyan wang Xia-Ting Feng Yangyi Zhou Xiaojun Yu Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

The study of clastic rock failure evolution under true triaxial stress is an important research topic;however,it is rarely studied systematically due to the limitation of monitoring *** this study,true triaxial compression tests were conducted on clastic rock specimens to investigate the effect of cementation and intermediate principal stress(s2)on the failure *** complete stressestrain curves were obtained,while the acoustic emission(AE)was monitored to indirectly evaluate the evo-lution of tensile and shear cracks,and crack evolution under true triaxial compression was imaged in real time by a high-speed *** results showed that the deformation and failure characteristics of clastic rock were closely related to the cementation type and intermediate principal *** the basis of the distribution characteristics of the ratio of rise time to amplitude(RA)and the average frequency(AF)of AE signals,tensile cracks of the contact cementation specimen propagated ***,the enhancement of specimen cementation promoted the evolution of shear cracks,and the increase inσ_(2)promoted the evolution of tensile ***,the mesoscale cracking mechanism of clastic rock caused by cementation andσ_(2)under true triaxial compression was *** failure patterns of clastic rock under true triaxial compression were divided into three modes:structure-induced,structure-stress-induced and stress-induced *** study confirms the feasibility of high-speed camera technology in true triaxial testing,and has important implications for elucidating the disaster mechanism of deep tunnels in weak rocks.

关键词： True triaxial compression Cementation Failure evolution Acoustic emission(AE) High-speed camera

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A rigid true triaxial apparatus for analyses of deformation and failure features of deep weak rock under excavation stress paths

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第5期15卷 1065-1075页

作者： Xia-Ting Feng Xiaojun Yu Yangyi Zhou Chengxiang Yang feiyan wang Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

The squeezing scenario in deep weak rock tunnels can hinder underground ***,due to the limitations of test technologies at hand,the real excavation stress path cannot be mimicked in the ***,the large deformation mechanism of deep weak rocks still remains *** this,a true triaxial apparatus(TTA)to investigate the mechanical responses of deep weak rock under excavation stress paths in field and reveal the squeezing mechanism of deep tunnels is assembled and developed at Northeastern University,*** apparatus can perform instantaneous unloading in s3 direction based on electromagnetism *** addition,uniform loading and deformation measurements can be carried out based on the proposed linked interlocking clamp and antifriction device,even if the sample has a strong dilatation deformation ***,a bore trepanning is designed to capture noiseless acoustic emission(AE)signals for deep weak rock at a low ***,two tests were are conducted using this instrument to preliminarily understand the failure and deformation features of deep weak rock based on fractured *** results show that the complete stressestrain curves of fractured marble have the characteristics of low strengths and large deformations,and the larger deformation and the more serious failure occur when the fractured marble enters the post-peak state after *** results show that the developed apparatus is likely to be applicable for deep weak rock engineering.

关键词： True triaxial apparatus(TTA) Deep weak rock Large deformation Excavation stress path Instantaneous unloading

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毒害艾美耳球虫谷胱甘肽过氧化物酶EnGPX的原核表达与分析

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畜牧兽医学报 2024年第2期55卷 846-853页

作者：彭月梅叶状汪飞燕王礼跃冯永翠王乐乐候照峰许金俊陶建平刘丹丹扬州大学兽医学院扬州225009 扬州大学江苏高校动物重要疫病与人兽共患病防控协同创新中心扬州225009

旨在研究毒害艾美耳球虫谷胱甘肽过氧化物酶EnGPX的反应原性及其在虫体内的亚细胞定位。提取毒害艾美耳球虫(扬州株)配子体总RNA,RT-PCR扩增En GPX的ORF编码序列,构建原核表达质粒pET-28a(+)-En GPX,转化至BL21(DE3)进行体外诱导表达,... 详细信息

旨在研究毒害艾美耳球虫谷胱甘肽过氧化物酶EnGPX的反应原性及其在虫体内的亚细胞定位。提取毒害艾美耳球虫(扬州株)配子体总RNA,RT-PCR扩增En GPX的ORF编码序列,构建原核表达质粒pET-28a(+)-En GPX,转化至BL21(DE3)进行体外诱导表达,同时制备鼠抗rEnGPX多克隆抗体,对重组蛋白进行Western blot反应原性分析和激光共聚焦免疫荧光定位分析。结果表明,En GPX ORF序列全长753 bp,编码250个氨基酸,体外重组表达蛋白大小约30 ku,主要以包涵体形式存在。该重组蛋白能被6×HIS标签单克隆抗体,鼠抗rEnGPX多克隆抗体,毒害艾美耳球虫、巨型艾美耳球虫和柔嫩艾美耳球虫病鸡康复血清所识别,表明其具有较好的反应原性和交叉反应原性。在天然配子体蛋白中检测出EnGPX,其编码蛋白主要分布于配子体内的Ⅱ型成壁体(WFBII)及卵囊壁上。本研究成功克隆表达了毒害艾美耳球虫谷胱甘肽过氧化物酶EnGPX,验证其具有良好的反应原性,并定位于配子体及卵囊壁上。以期为研究En GPX参与卵囊壁形成的分子机制提供新的线索,也为研制新型球虫亚单位疫苗提供新的靶标。

关键词：毒害艾美耳球虫 EnGPX 克隆表达反应原性免疫荧光定位

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新时代背景下的“针织学”课程思政建设探索

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纺织科技进展 2024年第1期46卷 58-60,64页

作者：张丽哲王飞艳南通大学纺织服装学院江苏南通226019

纺织行业是我国国民经济支柱产业之一,对纺织工程专业课程进行思政建设是实现专业人才培养的有效途径。依托丰厚的纺织工业历史发展背景与地方产业文化特色,充分发掘思政元素,并结合精心设计的课程思政教学体系,采用多元化的教学方法与... 详细信息

纺织行业是我国国民经济支柱产业之一,对纺织工程专业课程进行思政建设是实现专业人才培养的有效途径。依托丰厚的纺织工业历史发展背景与地方产业文化特色,充分发掘思政元素,并结合精心设计的课程思政教学体系,采用多元化的教学方法与教学形式,对针织学课程思政建设进行初步探索,以期为培养德才兼备、全面发展的专业人才提供教学参考。

关键词：纺织工程针织学课程思政地方产业文化

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Recent progress of hybrid cathode interface layer for organic solar cells

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Journal of Energy Chemistry 2024年第4期91卷 383-406页

作者： Jianru wang Dan Zhou Zhentian Xu Yujie Pu Senmei Lan Fang wang feiyan Wu Bin Hu Yongfen Tong Ruizhi Lv Honglin Chu Lie Chen Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources RecycleNanchang Hangkong UniversityNanchang 330063JiangxiChina College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031JiangxiChina

Organic solar cells(OSCs)have gained conspicuous progress during the past few decades due to the development of materials and upgrading of the device *** power conversion efficiency(PCE)of the single-junction device had surpassed 19%.The cathode interface layer(CIL),by optimizing the connection between the active layer and the cathode electrode,has become a momentous part to strengthen the performances of the ***,CIL is also indispensable to illustrating the working mechanism of OSCs and enhancing the stability of the *** this essay,hybrid CILs in OSCs have been ***,the advancement and operating mechanism of OSCs,and the effects and relevant design rules of CIL are briefly concluded;secondly,the significant influence of CIL on enhancing the stability and PCE of OSCs is presented;thirdly,the characteristics of organic hybrid CIL and organic-inorganic hybrid CIL are ***,the conclusion and outlook of CIL are summarized.

关键词： Organic solar cells Theoperation mechanism Organic hybrid cathode interface layer Organic-inorganic hybrid CIL

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A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy

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Acupuncture and Herbal Medicine 2024年第1期4卷 113-121页

作者： Dandan Huang Zhongjie Tang Xiao Pu Tianqi wang feiyan Gao Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqingChina Department of Pharmacy National University of SingaporeSingapore 117545Singapore

Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk1/CTX-Lip).Methods:Physical and chemical properties of Rk1/CTX-Lip were *** evaluated the biological functions of Rk1/CTXLip,both in vitro and in vivo.A subcutaneous prostate cancer(RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in ***,a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/***,biocompatibility and in vivo safety of Rk1/CTX-Lip were ***:We successfully prepared Rk1/CTX-Lip,achieving high CTX encapsulation efficiency(97.24±0.75)%and physical ***1/CTX-Lip demonstrated evasion of macrophage phagocytosis,effective tumor tissue targeting,and a significant reduction(>50%)in average tumor volume compared with Chol/***,it relieved the concurrent infection burden and effectively regulated immune organs and cells,demonstrating superior ***:Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity.

关键词： Cabazitaxel Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer

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Fine-mapping of a candidate gene for web blotch resistance in Arachis hypogaea L.

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Journal of Integrative Agriculture 2024年第5期23卷 1494-1506页

作者： Xiaohui Wu Mengyuan Zhang Zheng Zheng Ziqi Sun feiyan Qi Hua Liu Juan wang Mengmeng wang Ruifang Zhao Yue Wu Xiao wang Hongfei Liu Wenzhao Dong Xinyou Zhang College of Agronomy Henan Agricultural UniversityZhengzhou 450046China Henan Academy of Agricultural Sciences/Henan Academy of Crop Molecular Breeding/Key Laboratory of Oil Crops in Huang-Huai-Hai Plain Ministry of Agriculture and Rural Affairs/Henan Provincial Key Laboratory for Oil Crop ImprovementZhengzhou 450002China The Shennong Laboratory Zhengzhou 450002China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000China

Peanut(Arachis hypogaea L.)is a globally important oil *** blotch is one of the most important foliar diseases affecting peanut,which results in serious yield losses *** web blotch-resistant peanut varieties is the most effective and economically viable method for minimizing yield losses due to web *** the current study,a bulked segregant analysis with next-generation sequencing was used to analyze an F2:3 segregating population and identify candidate loci related to web blotch *** on the fine-mapping of the candidate genomic interval using kompetitive allele-specific PCR(KASP)markers,we identified a novel web blotch resistance-related locus spanning approximately 169 kb on chromosome *** region included four annotated genes,of which only Arahy.35VVQ3 had a non-synonymous single nucleotide polymorphism in the coding region between the two *** markers(Chr.16.12872635 and Chr.16.12966357)linked to this gene were shown to be co-segregated with the resistance of peanut web blotch by 72 randomly selected recombinant inbred lines(RIL),which could be used in marker-assisted breeding of resistant peanut varieties.

关键词： peanut web blotch bulked segregant analysis KAsP markers resistant gene

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