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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao wang Jia Zeng Donglin Gan kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

Efficient and Stable Photoassisted Lithium‑Ion Battery Enabled by Photocathode with Synergistically Boosted Carriers Dynamics

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Nano-Micro Letters 2025年第3期17卷 440-454页

作者： Zelin Ma Shiyao wang Zhuangzhuang Ma Juan Li Luomeng Zhao Zhihuan Li Shiyuan wang Yazhou Shuang Jiulong wang fang wang Weiwei Xia Jie Jian Yibo He Junjie wang Pengfei Guo Hongqiang wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an 710072People’s Republic of China State Key Laboratory of Solidification Processing School of Materials Science and Engineering DepartmentNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063People’s Republic of China Key Laboratory of Applied Surface and Colloid Chemistry Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringNational Ministry of EducationShaanxi Normal UniversityXi’an 710119People’s Republic of China

Efficient and stable photocathodes with versatility are of significance in photoassisted lithium-ion batteries(PLIBs),while there is always a request on fast carrier transport in electrochemical active *** work proposes a general approach of creating bulk heterojunction to boost the carrier mobility of photocathodes by simply laser assisted embedding of plasmonic *** employed in PLIBs,it was found effective for synchronously enhanced photocharge separation and transport in light charging ***,experimental photon spectroscopy,finite difference time domain method simulation and theoretical analyses demonstrate that the improved carrier dynamics are driven by the plasmonic-induced hot electron injection from metal to TiO_(2),as well as the enhanced conductivity in TiO2 matrix due to the formation of oxygen vacancies after Schottky *** from these merits,several benchmark values in performance of TiO2-based photocathode applied in PLIBs are set,including the capacity of 276 mAh g^(−1)at 0.2 A g^(−1)under illumination,photoconversion efficiency of 1.276%at 3 A g^(−1),less capacity and Columbic efficiency loss even through 200 *** results exemplify the potential of the bulk heterojunction strategy in developing highly efficient and stable photoassisted energy storage systems.

关键词： Photoassisted lithium-ion batteries Bulk heterojunction Carrier dynamics TiO2 nanofiber Plasmonic metal nanocrystals

动物源性人畜共患细菌流行特征、致病机制及防治新措施

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中国预防兽医学报 2021年第10期43卷 1132-1132页

作者： wang fang-kun ZHANG WAN-JIANG NIU DONG-YAN Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention College of Veterinary Medicine Shandong Agricultural University Tai’an China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin China Ecosystem and Public Health Faculty of Veterinary Medicine University of Calgary Calgary AB Canada

食源性人畜共患病细菌引起的感染与世界范围内人畜细菌性疾病的高发病率直接相关。许多国家每年报告数百万例食源性疾病和/或慢性并发症。据估计,食源性细菌性疾病影响全球2-6亿人,每年有42万人死于食源性胃肠道疾病。食源性人畜共患细... 详细信息

食源性人畜共患病细菌引起的感染与世界范围内人畜细菌性疾病的高发病率直接相关。许多国家每年报告数百万例食源性疾病和/或慢性并发症。据估计,食源性细菌性疾病影响全球2-6亿人,每年有42万人死于食源性胃肠道疾病。食源性人畜共患细菌被认为是人类肠道的主要病原体,也是畜禽及其加工产品中常见的食源性病原体。畜禽是这些肠道病原体的主要携带者,在疾病的传播中发挥了重要作用。此外,这些肠道病原体在全球造成人畜共患细菌的持续流行和巨大的经济损失。

关键词：细菌性疾病人畜共患病胃肠道疾病携带者致病机制肠道病原体食源性疾病流行特征

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关联理论视阈下大学英语阅读教学研究

教育教学论坛 2020年第47期 365-367页

作者：王昆芳浙江越秀外国语学院浙江绍兴312000

外语学习中阅读理解是一块重要的内容,人们通常通过阅读获取信息,它也是一项较为复杂的心理活动。大学英语课程中,英语阅读教学是极其重要的一门课程,近年来,基于对阅读理解的研究不断发展,阅读理论和技巧的大量引入,大学英语教学发生... 详细信息

外语学习中阅读理解是一块重要的内容,人们通常通过阅读获取信息,它也是一项较为复杂的心理活动。大学英语课程中,英语阅读教学是极其重要的一门课程,近年来,基于对阅读理解的研究不断发展,阅读理论和技巧的大量引入,大学英语教学发生了很大变化。斯波伯(Sperber)、威尔逊(Wilson)合著的《关联:交际与认知》(Relevance:Communication and Cognition)书中详细论述了关联理论,引起很多研究者的关注,有被用来解释翻译学、语用学和语篇分析等语言现象的,也有分析阅读教学的。论文在关联理论框架的基础上,首先分析了阅读理解拥有关联理论相同的本质,在阅读中,作者和读者展开了交际,这个过程是一个明示推理的过程,读者可以通过语境找到和作者之间的最佳关联;然后详细探讨了关联理论视阈下大学英语阅读教学的策略,以加强学生语用能力的培养。

关键词：关联理论大学英语阅读语境教学

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词源策略在英语词汇习得中的应用研究

佳木斯职业学院学报 2016年第5期32卷 376-377,379页

作者：王昆芳浙江越秀外国语学院浙江绍兴312000

词汇习得是学习英语的基础,学习者经常被复杂的词汇来源所困扰,主要是英语词汇发展过程中流入了很多外来语。从词源学角度出发,追溯词汇的来源和发展,可以促进语言和文化学习的有效性。本文基于词源学理论,引入词汇词源学策略,研究其在... 详细信息

词汇习得是学习英语的基础,学习者经常被复杂的词汇来源所困扰,主要是英语词汇发展过程中流入了很多外来语。从词源学角度出发,追溯词汇的来源和发展,可以促进语言和文化学习的有效性。本文基于词源学理论,引入词汇词源学策略,研究其在英语词汇习得中的应用,以此优化学习者策略,提高词汇习得效率。

关键词：词源策略词汇习得应用

入侵植物少花蒺藜草及其伴生植物的光合特性研究

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河北农业大学学报 2016年第1期39卷 43-48页

作者：王坤芳彭爽纪明山沈阳农业大学植物保护学院辽宁沈阳110161 辽宁省草原监理站辽宁沈阳110161 辽宁省彰武县草原监理站辽宁彰武123200

为探讨少花蒺藜草的入侵机制和制定有效的治理措施,本试验对其入侵地植物群落构成进行了调查。调查地全部植物种类为20种,隶属8科18属。在此基础上,选定了少花蒺藜草及其常见伴生植物马唐和圆叶藜进行了光合特性研究。结果表明:在自然... 详细信息

为探讨少花蒺藜草的入侵机制和制定有效的治理措施,本试验对其入侵地植物群落构成进行了调查。调查地全部植物种类为20种,隶属8科18属。在此基础上,选定了少花蒺藜草及其常见伴生植物马唐和圆叶藜进行了光合特性研究。结果表明:在自然条件下,少花蒺藜草的净光合速率为14.33μmol/(m2·s),明显高于马唐和圆叶藜;少花蒺藜草的光饱和点为1 573.74μmol/(m2·s),均大于马唐的1 321.21μmol/(m2·s)和圆叶藜的1 226.94μmol/(m2·s);在光饱和点下的最大净光合速率为20.39μmol/(m2·s),也显著高于2种伴生植物。有效光合辐射的变化对少花蒺藜草及其伴生植物的气孔导度、蒸腾速率和水分利用率均有显著影响。少花蒺藜草具有较高的光合速率和物质积累能力,较高的生产力是其成功入侵的重要因素之一。

关键词：生物入侵少花蒺藜草群落组成伴生植物光合特性

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei Liu Shilong fang Weiwei wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia Xu Chengcheng Zhou Kaimei Lu Bin fang Lijuan wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons