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Response of Two Unequal-Diameter Flexible Cylinders in A Side-by-Side Arrangement:Characteristics of FIV

China Ocean engineering 2020年第4期34卷 475-487页

作者： XU Wan-hai ZHANG Qian-nan MA Wen-chen wang en-hao State Key Laboratory of Hydraulic engineering Simulation and Safety Tianjin UniversityTianjin 300072China Department of Civil and environmental engineering and Construction University of NevadaNV 89154USA

Till now,little information is available on the flow-induced vibration(FIV)of multiple flexible cylinders with unequal *** FIV characteristics of unequal-diameter cylinders can be predicted based on the knowledge of equal-diameter cylinders,while there are still other features remaining *** this paper,the FIV characteristics of two flexible cylinders with unequal diameters arranged side-by-side are experimentally *** diameter ratio of the small cylinder(Small Cyl.)to the large cylinder(Large Cyl.)is nearly *** aspect ratios and mass ratios of the two flexible cylinders are 350/181 and 1.90/1.47,*** centre-tocentre spacing ratio in the cross-flow(CF)direction is kept constant as 6.0 and the two cylinders can oscillate freely in both the CF and in-line(IL)*** towing velocity varies from 0.05 m/s to 1.00 m/*** dominant modes and frequencies,CF and IL displacement amplitudes and response trajectories are *** with the case of two identical cylinders in our previous study,the FIV responses demonstrate some similarities and *** similarities are as *** cylinders exhibit multi-mode vibration features and they interact with each ***,the IL FIV shows a more complex behaviour than that in the CF *** difference is that as the diameter of one cylinder is increased,the effect on the smaller cylinder becomes more *** Large Cyl.,the FIV response is similar to its isolated counterpart,which indicates that Small *** a negligible effect on the FIV of the larger *** Large *** the FIV of Small *** the vibration *** spacing would change when both cylinders are *** interference between the two cylinders and wake shielding effect of the Large *** *** dominant frequencies of Small *** reduced and the wake-induced flutter of Small *** observed from the response trajectories at different mea

关键词： flow-induced vibration(FIV) flexible cylinder side-by-side unequal diameter wake-induced flutter

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基于生态工程的矿山修复模式研究

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世界有色金属 2024年第15期 112-114页

作者：王恩浩赵亚杰王卉张源倍白惠文甘肃工程地质研究院

矿山活动对环境的负面影响是全球性的环境挑战之一，导致土地破坏、水体污染和生物多样性丧失等问题。为有效应对这些挑战，生态工程作为一种综合性修复方法，在矿山修复中显得尤为重要。本文探讨了生态工程在矿山修复中的关键作用和应... 详细信息

矿山活动对环境的负面影响是全球性的环境挑战之一，导致土地破坏、水体污染和生物多样性丧失等问题。为有效应对这些挑战，生态工程作为一种综合性修复方法，在矿山修复中显得尤为重要。本文探讨了生态工程在矿山修复中的关键作用和应用。首先，通过环境评估和问题诊断确定修复目标，生态工程选择合适的植被种类和土壤改良技术，有效恢复土地的生态功能和稳定性。其次，生态工程通过提升修复区域的生态服务功能，如土壤保护、水资源管理和碳吸收，支持修复区域的长期可持续性发展。社区参与和利益相关者合作是实现成功修复的关键，有效提升了修复工作的社会接受度和环境保护意识。最后，通过定期监测和评估修复效果，生态工程为持续改进修复策略提供了科学依据。

关键词：生态工程矿山修复可持续发展

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ZIF-8 modified by isocyanate as a photocatalytic antibacterial agent

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Rare Metals 2024年第6期43卷 2708-2718页

作者： Yi-Ning Zhang Zhen Pei Zi-hao wang Chong-en wang Fen-Fen Liang Li-Qiao Wei College of Architecture Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and engineering in Advanced Materials of Taiyuan University of Technology Ministry of EducationTaiyuan 030024China Department of Materials Science and engineering Shanxi Institute of TechnologyYangquan 045000China Shanxi-Zheda Institute of Advanced Materials and Chemical engineering Taiyuan 030000China

Zeolite imidazole skeleton(ZIF-8)is a promising option for self-cleaning of building exterior walls due to its large specific surface area,high antibacterial activity and low ***,it suffers from low antibacterial efficiency and yield under visible light *** address the issues,we developed the photocatalytic materials T-ZIF-8-TDI(thermally treated-ZIF-8-toluene 2,4-diisocyanate)by modifying ZIF-8 with thermal oxygen sensitization and chemical *** results show that the yield of T-ZIF-8-TDI photocatalytic antibacterial agent is increased to 11.5 times of that of T-ZIF-8,while maintaining the crystal structure of T-ZIF-8 and thermal stability up to 60℃.Furthermore,T-ZIF-8-TDI exhibits extended optical response range to the nearinfrared region,significantly narrowed band gap,improved photogenerated elec tron-hole separation efficiency,reduced recombination rate,and excellent photocatalytic *** the concentration of antibacterial agent is 600 mg·L^(-1),the antibacterial rate of Escherichia coli(***)reaches 99.99%irradiated by visible light for30 min,and when the concentration of antibacterial agent is 200 mg·L^(-1),the antibacterial rate of Staphylococcus aureus(***)reaches 99.99%irradiated by visible light for 25 *** also analyzed the reasons in detail from the aspects of bacterial species and antibacterial mechanism,and proposed the antibacterial mechanism of·O_(2)^(-)and h^(+)as the main active *** findings suggest that T-ZIF-8-TDI photocatalytic antibacterial agent has potential for use in self-cleaning of building exterior walls.

关键词： ZIF-8 Hot oxygen sensitization Modified by isocyanate Antimicrobial performance Photocatalytic antibacterial mechanism

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Relationship between dietary niacin intake and erectile dysfunction:a population-based study

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Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： Wei-Long Lin Cheng Zheng hao-Xu wang Wei Zhang Ming-en Lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

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Downregulation of Serum PTen Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING en Min YIN hao Yang DING Xue Xue wang Huan wang Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTen lowexpression models were established in vitro using 293T cells. PTen gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTen, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTen gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTen expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTen gene knockdown led to a significant decrease in PTen protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTen gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTen Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

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Deciphering the cellular heterogeneity of the insect brainwith single-cell RNA sequencing

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Insect Science 2024年第2期31卷 314-327页

作者： Xiaofei wang Yifan Zhai hao Zheng Institute of Plant Protection Shandong Academy of Agricultural SciencesJinanChina College of Food Science and Nutritional en-gineering China Agricultural UniversityBeijingChina Key Laboratory of Natural enemies Insects Ministry of Agriculture and RuralAffairsJinanChina Shandong Provincial engineering Technology Research Center on Biocontrol of Crops Diseases and In-sectPests JinanChina

Insects show highly complicated adaptive and sophisticated behaviors, includ-ing spatial orientation skills, learning ability, and social interaction. These behaviors arecontrolled by the insect brain, the central part of the nervous system. The tiny insect brainconsists of millions of highly differentiated and interconnected cells forming a complexnetwork. Decades of research has gone into an understanding of which parts of the insectbrain possess particular behaviors, but exactly how they modulate these functional conse-quences needs to be clarified. Detailed description of the brain and behavior is required todecipher the complexity of cell types, as well as their connectivity and function. Single-cell RNA-sequencing (scRNA-seq) has emerged recently as a breakthrough technologyto understand the transcriptome at cellular resolution. With scRNA-seq, it is possible touncover the cellular heterogeneity of brain cells and elucidate their specific functions andstate. In this review, we first review the basic structure of insect brains and the links toinsect behaviors mainly focusing on learning and memory. Then the scRNA applicationson insect brains are introduced by representative studies. Single-cell RNA-seq has allowedresearchers to classify cell subpopulations within different insect brain regions, pinpointsingle-cell developmental trajectories, and identify gene regulatory networks. These devel-opments empower the advances in neuroscience and shed light on the intricate problemsin understanding insect brain functions and behaviors.

关键词： behavior brain cell type insect single-cell RNA sequencing

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Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu en-Yang wang Jinbo Pang Shirong Huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk hao Jia Shu-Xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for energy and environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

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Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： hao wang Cheng-Feng Pan Chi Li Kishan S Menghrajani Markus A Schmidt Aoling Li Fu Fan Yu Zhou wang Zhang Hongtao wang Parvathi Nair Suseela Nair John You en Chan Tomohiro Mori Yueqiang Hu Guangwei Hu Stefan A Maier haoran Ren Huigao Duan Joel K W Yang College of Mechanical and Vehicle engineering Hunan UniversityChangsha 410082People's Republic of China engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Department of Electrical and Computer engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic engineering Nanyang Technological UniversitySingapore639798Singapore Department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fabricated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemblies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dimensional(3D)printing,or additive manufacturing,presents a solution to these challenges with benefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3D printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction limit via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,micro-and nanoscale capabilities,and rapid prototyping of almost arbitrary complex 3D *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capability,extensive material range,and true 3D processing,alongside advances in materials,fabrication,and design,we en

关键词： two-photon polymerization lithography 3D printing additive manufacturing imaging optics and nanophotonics

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Copper-catalyzed enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides via α-imino copper carbenes

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Science China Chemistry 2024年第9期67卷 2982-2988页

作者： en-He Huang Li-Gao Liu You-Wei Yin hao-Xuan Dong Ji-Jia Zhou Xin Lu Bo Zhou Long-Wu Ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

α-Imino metal carbenes are versatile intermediates in organic synthesis,and have broad applications in the assembly of divergent ***,the catalytic enantioselective desymmetrization based onα-imino metal carbenes has not been developed to ***,we disclose an enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides viaα-imino copper carbenes,leading to the efficient assembly of divergent chiral indoloazepines in generally moderate to excellent yields with high ***,this reaction represents the first enantioselective desymmetrization based onα-imino metal *** synthetic transformations and biological tests show the potential utility of this ***,computational studies are employed to elucidate the reaction mechanism and the origin of enantioselectivity.

关键词： enantioselective desymmetrization metal carbenes copper catalysis nitrene transfer alkynes

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应用统计分析和化学动力学参数评价生物制品的稳定性

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中国生物制品学杂志 2008年第2期21卷 126-130页

作者：朱征宇汪恩浩王媛深圳康泰生物制品股份有限公司质量管理部深圳518057

目的应用统计分析和化学动力学参数评价生物制品的稳定性。方法以重组乙型肝炎疫苗为例,拟合其效力随时间衰减的回归直线,由其95%置信曲线预测制品的有效期。根据阿伦尼乌斯方程,从较高温度下效力衰减的速率常数估算较低温度下的速率常... 详细信息

目的应用统计分析和化学动力学参数评价生物制品的稳定性。方法以重组乙型肝炎疫苗为例,拟合其效力随时间衰减的回归直线,由其95%置信曲线预测制品的有效期。根据阿伦尼乌斯方程,从较高温度下效力衰减的速率常数估算较低温度下的速率常数。由衰减速率常数计算制品的半衰期,并用于稳定性评估。结果通过对稳定性数据的统计分析能预测有效期和失活速率常数等化学动力学参数能有效地反映制品稳定性的变化。结论应用统计分析和化学动力学参数研究生物制品的稳定性,可以在设定的置信区间下预测制品的有效期,缩短临床前稳定性研究所需的时间,并对生产变更可能导致的稳定性变化进行可靠的评估。

关键词：生物制品稳定性有效期统计分析化学动力学参数

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