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The relationship between serum amyloid A and apolipoprotein A-I in high-density lipoprotein isolated from patients with coronary heart disease

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Chinese Medical Journal 2013年第19期126卷 3656-3661页

作者： wang dong-xue liu hong yan li-rong zhang ye-ping guan xiao-yuan xu zhi-min jia you-hong li yi-shi zKey Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health State Key Laboratory of Cardiovascular DiseasesFuwai Hospital National Center for Cardiovascular DiseasesPeking Union Medical College and Chinese Academy of MedicalSciences Beijing 100037China

Background Alteration in the protein composition of high-density lipoprotein （HDL） has been proposed as a mechanism for the development of coronary heart disease （CHD）.In HDL,an increase in serum amyloid A protein （SAA） accompanying the decrease in apolipoprotein A-I （apoA-I） has been found during the acute inflammation ***,whether this phenomenon persists in CHD patients,a disease related to inflammation,is *** purpose of the present study was to explore the relationship between SAA and apoA-I in HDL isolated from CHD *** Overall,98 patients with confirmed stable CHD and 90 control subjects matched for age and gender were enrolled in this case-control *** bromide （KBr） density gradient ultracentrifugation was used to isolate HDL from *** levels of SAA and apoA-I in the HDL samples were detected by enzyme-linked immunosorbent assay ***＇s correlation and general linear models were used in the *** Compared with controls,patients with CHD had a significant decrease in the amount of apoA-I （（14.21±8.44） μg/ml vs.（10.95±5.95） μg/ml,P =0.003） in HDL and a significant increase in the amount of log SAA （1.21±0.46 vs.1.51±0.55,P 〈0.00001）.Differences were independent of age,body mass index （BMI）,HDL cholesterol （HDL-C）,and other *** independently and statistically significant positive correlation between log SAA and apoA-I in HDL was observed only in the CHD group （β =2.0,P =0.026）.In the general linear model,changes in Iog（SAA）,age,age2,gender,BMI and HDL-C could explain a statistically significant 43% of the variance in *** This study provides direct evidence for the first time that there was an independent positive correlation between log SAA and apoA-I in the HDL of CHD patients,indicating the alteration of protein composition in ***,the question of whether this alteration in HDL is associated with impairment of HDL functions requires further research.

关键词： coronary heart disease lipoproteins high-density lipoprotein serum amyloid A protein apolipoprotein A-I

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Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 218-236页

作者： Wenda zhang Weimin yuan zhixing ling Yong Chen Nanda Rea Arne Rau zhiming Cai Huaqing Cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei jia Chichuan Jin dongyue li Paul O’Brien rongfeng Shen Xinwen Shu Shengli Sun xiaojin Sun xiaofeng wang Lei yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu mingjun liu Xing liu yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng wang Song wang Tinggui wang Zhongxiang wang Qingwen Wu xuefeng Wu dong xu yanjun xu Suijian xue Yongquan xue Zijian zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen yehai Chen yifan Chen Chenzhou Cui Weiwei Cui yanfeng Dai dongwei Fan Ju guan Dawei Han dongjie Hou Haibo Hu Maohai Huang jia Huo Zhenqing jia Bowen jiang Ge Jin Chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo jia Ma xuan Mao Haiwu Pan Xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang yihan Tao Hao wang Juan wang Lei wang Wenxin wang yilong wang Yusa wang Qinyu Wu Haitao xu Jingjing xu Xinpeng xu Yunfei xu Zhao xu Changbin xue Yulong xue Ailiang yan Haonan yang Xiongtao yang yanji yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang donghua Zhao Haisheng Zhao xiaofan Zhao Zijian Zhao hongyan Zhou yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institute of Space Sciences(ICE) CSICBarcelona E-08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) Barcelona E-08034Spain Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China Department of Physics University of Hong KongHong Kong 999077China School of Physics and Astronomy University of LeicesterLeicester LE17RHUK School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Department of Physics Anhui Normal UniversityWuhu 241002China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Physics Department Tsinghua UniversityBeijing 100084China Nevada Center for Astrophysics University of Nevada Las VegasLas Vegas NV 89154USA Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA South African Astronomical Observatory Cape Town 7935South Africa Department of Astronomy University of Cape TownRondebosch 7701South Africa Department of Physics University of the Free StateBloemfontein 9300South Africa Universit´e Paris Cit´e CNRSAstroparticule et CosmologieParis F-75013France Universit´e Paris Cit´e CEA Paris-SaclayIRFU/DAp-AIMGif-sur-Yvette 91191France Department of Astronomy Guangzhou UniversityGuangzhou 510006China Cosmic Dawn Center(DAWN) Copenhagen 2200Denmark Niels Bohr Institute University of CopenhagenCopenhagen 2200Denmark Department of Physics and Astronomy Rutgersthe State University of New JerseyPiscataway NJ 08854-8019USA Institute for Cosmic Ray Research The University of TokyoKashiwa City 277-8582Japan ESA/ESTEC Noordwijk 2201 AZThe Netherlands Department of Astronom

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope(WXT)on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for 12 *** flare reached a peak flux of 3:9×10^(−9) erg cm^(−2) s^(−1) in 0.5-4 keV,∼300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying within *** X-ray light curve shows a plateau lasting for∼4 d,followed by a steep decay till becoming undetectable∼10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of∼10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients Einstein Probe

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Prediction of energy resolution in the JUNO experiment

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Chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Marco Beretta Antonio Bergnoli Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai xiao Cai yanke Cai zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone Jinfan Chang Yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen pingping Chen Shaomin Chen Xin Chen yiming Chen yixue Chen Yu Chen Zelin Chen zhangming Chen zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng YuChin Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti yen-Ting Chin Po-lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Marta Colomer Molla Selma Conforti Di Lorenzo Alberto Coppi Daniele Corti Simon Csakli Chenyang Cui Flavio Dal Corso Olivia Dalager Jaydeep Datta Christophe De La Taille zhi Deng Ziyan Deng xiaoyu Ding xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko jianmeng dong Evgeny Doroshkevich Wei Dou Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Katherine Dugas Stefano Dusini hongyue Duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan jian Fang Wenxing Fang Dmitry Fedoseev li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng Gao Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar guanghua Gong Hui Gong Yuri Gornushkin Marco Grassi Maxim Gromov Vasily Gromov minghao G yerevan Physics Institute YerevanArmenia Université libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Millennium Institute for SubAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full JUNO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector JUNO simulation reconstruction

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Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

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Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： lin Zhu jian‑rong Zhou yuan‑guang Xia liang xiao hong Luo xiao‑Juan Zhou Wen‑Qin yang Bei‑Ju guan Xing‑Fen jiang yan‑Feng wang hong xu Hai‑Yun Teng li‑Xin Zeng jia‑Jie li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑xun Shen Jun xu li‑jiang liao xiao‑Zhuang wang Gui‑An yang Huai‑Chan Chen Ju‑ping xu zhi‑Duo li Song‑lin wang jian Zhuang Yu‑Bin Zhao Jun‑rong zhang Wen yin zhi‑jia Sun yuan‑Bo Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to facilitate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： ying-Shuo wang Yun-lian Zhou guan-Nan Bai Shu-Xian li Dan xu li-Na Chen Xing Chen xiao-yan dong hong-min Fu Zhou Fu Chuang-li Hao jian-Guo hong En-Mei liu Han-min liu xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong yin xiao-Bo zhang jian-Hua zhang Hai-lin zhang De-Yu Zhao Shun-ying Zhao Guo-hong Zhu ying-xue Zou Quan Lu yuan-yuan zhang zhi-min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao dong li Shao-lin Xiong yan-Qiu zhang yang Su Wei Chen yi Zhao xiao-Bo li jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-yang Wen li-ming Song shi-Jie Zheng Xin-ying Song xiao-Yun Zhao Yue Huang Shuang-Nan zhang Shuo xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du min Gao Ke Gong dong-Ya Guo zhi-Wei Guo jian-jian He Bin li Chao li Chao-yang li Gang li jian-Hui li Lu li Qing-Xin li yan-Guo li Jing liang xiao-Hua liang Jin-yuan liao xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou dong-li shi Jing-yan shi Gong-Xing Sun Xi-Lei Sun you-li Tuo Chen-Wei wang Hui wang Jin wang Jin-Zhou wang ping wang Wen-Shuai wang hong Wu Sheng-Lun Xie yan-Bing xu Yu-Peng xu wang-Chen xue Sheng yang min Yao jian-ying ye Qi-Bin yi Chao-Yue zhang Da-li zhang Fan zhang Fei zhang hong-Mei zhang Kai zhang Peng zhang xiao-Lu zhang Zhen zhang Guo-ying Zhao shi-yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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3-to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： wang Jing Ya ZONG Xing Yu WU Gui Hui QI yuan lin li Hui Zhen JI Xin Yu TONG lin zhang Lei yanG ming Bo yanG Pu ye li Ji Ke xiao Fu rong zhang lin Song HU Yun hong liu hong De xu Shou Fang SUN Sheng WU Wei MAO Ya li min Qing HOU Hao Hua GONG Zhao yuan GUO yang jiaO li Wen QIN Jin wang Ding yi wang Fang guan li liN Gang MA yan wang yan ping shi Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of Chinese Medicine Xingtai 054000HebeiChina shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of Traditional Chinese Medicine Chengde 067040HebeiChina Hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of Traditional Chinese Medicine Ankang 725000ShaanxiChina Department of Traditional Chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China National Medicines Corporation Ltd Beijing 100077China Beijing University of Chinese Medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues *** long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is *** study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB *** From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in *** outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after *** Thirty-two COVID-19 with PTB survivors were *** median age was 52(45,59)years,and 23(71.9%)were *** them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a *** and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after ***,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up *** The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of *** recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.

关键词： COVID-19 Pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

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Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3925-3939页

作者： guan-Nan li xue-jiao Zhao Zhen wang Meng-shi Luo Shen-Nan shi Dan-Mei yan Hua-yi li jia-Hao liu yang yang jia-hong Tan Ze-Yu zhang Ru-Qi Chen Hui-ling Lai xiao-yuan Huang jian-Feng Zhou Ding Ma Yong Fang Qing-Lei Gao Cancer Biology Research Center(Key Laboratory of the ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina National Clinical Research Center for Obstetrics and Gynecology Department of Gynecological OncologyTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina Department of Gynecology the Sixth Affiliated HospitalSun Yat-Sen University510000 GuangzhouGuangdongChina

Finely tuned mitogen-activated protein kinase(MAPK)signaling is important for cancer cell *** that push cells out of the MAPK fitness zone result in cell ***,in a screen of the North China Pharmaceutical Group Corporation’s pure compound library of microbial origin,we identified elaiophylin as an autophagy ***,we demonstrated a new role for elaiophylin in inducing excessive endoplasmic reticulum(ER)stress,ER-derived cytoplasmic vacuolization,and consequent paraptosis by hyperactivating the MAPK pathway in multiple cancer ***-wide CRISPR/Cas9 knockout library screening identified SHP2,an upstream intermediary of the MAPK pathway,as a critical target in elaiophylin-induced *** cellular thermal shift assay(CETSA)and surface plasmon resonance(SPR)assay further confirmed the direct binding between the SHP2 and *** of the SHP2/SOS1/MAPK pathway through SHP2 knockdown or pharmacological inhibitors distinctly attenuated elaiophylin-induced paraptosis and autophagy ***,elaiophylin markedly increased the alreadyelevated MAPK levels and preferentially killed drug-resistant cells with enhanced basal MAPK *** overcame drug resistance by triggering paraptosis in multiple tumor-bearing mouse models resistant to platinum,taxane,or PARPi,suggesting that elaiophylin might offer a reasonable therapeutic strategy for refractory ovarian cancer.

关键词： cancer activation elevated

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-li zhang Xi zhang wang Hua Zheng-De Xie Han-min liu Hai-lin zhang Bi-Quan Chen yuan Chen Xin Sun yi xu Sai-Nan Shu Shun-ying Zhao Yun-xiao Shang ling Cao yan-Hui jia Luo-Na lin Jiong li Chuang-li Hao xiao-yan dong Dao-Jiong lin hong-Mei xu De-Yu Zhao Mei Zeng zhi-min Chen li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan liao yan-Qiu zhang Yue Huang Lu li Xing Wen Fei zhang Jing Duan Chen-Wei wang dong-li shi Peng zhang Qi-Bin yi Chao-yang li yan-Bing xu xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu wang Sheng yang xiao-Jing liu min Gao Mao-Shun li Jin-Zhou wang Xing Zhou yi Zhao wang-Chen xue Chao Zheng jia-Cong liu Xing-Bo Han Jin-ling Qi jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma xiao-Bo li ping wang Xin-ying Song li-ming Song shi-Jie Zheng Bing li hong-Mei zhang Yue Zhu Wei Chen jian-jian He Zhen zhang Jin Hou hong-Jun wang yan-Chao Hao Xiang-Yu wang Zong-yuan yang zhi-Long Wen zhi Chang yuan-yuan Du Rui Gao xiao-Fei Lan yan-Guo li Gang li xu-Fang li Fang-Jun Lu hong Lu Bin Meng Feng shi Hui wang Hui-Zhen wang Yu-Peng xu jia-Wei yang xue-Juan yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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