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World Journal of Gastroenterology 2024年第9期30卷 1224-1236页

作者： Hai-Yang Li Lin-Lin Zheng Nan Hu Zhi-Hao wang Chang-Cheng Tao Ya-Ru wang Yue Liu Zulihumaer Aizimuaji Hong-Wei wang Rui-Qi Zheng Ting Xiao Wei-Qi Rong Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Hernia Surgery Liaocheng Dongcangfu People’s HospitalLiaocheng 252000Shandong ProvinceChina State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND As a critical early event in hepatocellular carcinogenesis,telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma(HCC)patients,and its function in the genesis and treatment of HCC has gained much attention over the past two *** To perform a bibliometric analysis to systematically assess the current state of research on HCC-related *** The Web of Science Core Collection and PubMed were systematically searched to retrieve publications pertaining to HCC/telomerase limited to“articles”and“reviews”published in English.A total of 873 relevant publications related to HCC and telomerase were *** employed the Bibliometrix package in R to extract and analyze the fundamental information of the publications,such as the trends in the publications,citation counts,most prolific or influential writers,and most popular journals;to screen for keywords occurring at high frequency;and to draw collaboration and cluster analysis charts on the basis of coauthorship and *** was utilized to compile and visualize the bibliometric *** A surge of 51 publications on HCC/telomerase research occurred in 2016,the most productive year from 1996 to 2023,accompanied by the peak citation count recorded in *** to December 2023,35226 citations were made to all publications,an average of 46.6 citations to each *** United States received the most citations(n=13531),followed by China(n=7427)and Japan(n=5754).In terms of national cooperation,China presented the highest centrality,its strongest bonds being to the United States and *** the 20 academic institutions with the most publications,ten came from China and the rest of Asia,though the University of Paris Cité,Public Assistance-Hospitals of Paris,and the National Institute of Health and Medical Research(INSERM)were the most *** for individual contributions,Hisatomi H,Kaneko S,and Ide T were the three most prolific a

关键词： Telomerase Bibliometric analysis Telomerase reverse transcriptase Prognosis Treatment Hepatocellular carcinoma

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Numerical Simulation Study of Oil-Water Emulsion Separation in an Ultrasonic Field:Effect of Coupling between Acoustic and Flow Field Parameters

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 116-125页

作者： wang Heping Lin Yinchao Li Yanggui Zhang Xiaohang Wu Yi Key Laboratory of Engineering Mathematics and Advanced Computing of Nanchang Institute of Technology School of SciencesNanchang Institute of TechnologyNanchang 330099People’s Republic of China Dongguan Key Laboratory of Kunpeng Computing School of Computer ScienceGuangdong University of Science&TechnologyDongguan 523083China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China

In this study,the separation and coalescence of oil-in-water emulsions are explored in an ultrasonic field using the lattice Boltzmann *** simulating the propagation of ultrasonic waves,this study focuses on examining the effects of acoustic wave frequency,the ratio of oil to water components,and the aspect ratio of the boundary on the emulsification and separation processes of oil-water *** following conclusions are drawn.①Frequency affects the speed of oil droplet separation,leading to an increase in droplet size over *** droplets are found near the source,while smaller droplets are distributed throughout the wave web.②As the boundary aspect ratio increases,the emulsification efficiency of the droplets weakens,and the system takes longer to stabilize.③Emulsions with a higher component of oil can better resist acoustic waves.④At the same acoustic frequency,longer wavelength ultrasonic fields promote the formation of uniformly distributed,smaller oil droplets,which is beneficial to the storage of *** numerical simulation results offer insights for optimizing conditions for oil-in-water separation and serve as a numerical reference for the study of oil-in-water emulsion separation in ultrasonic environments.

关键词： lattice Boltzmann method phase separation ultrasound field

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A highly sensitive ratiometric near-infrared nanosensor based on erbium-hyperdoped silicon quantum dots for iron(Ⅲ) detection

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Journal of Semiconductors 2024年第8期45卷 49-58页

作者： Kun wang Wenxuan Lai Zhenyi Ni Deren Yang Xiaodong Pi State Key Laboratory of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Advanced Semiconductors&Zhejiang Provincial Key Laboratory of Power Semiconductor Materials and Devices ZJ-UHangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China

Ratiometric fluorescent detection of iron(Ⅲ)(Fe^(3+))offers inherent self-calibration and contactless analytic ***,realizing a dual-emission near-infrared(NIR)nanosensor with a low limit of detection(LOD)is rather *** this work,we report the synthesis of water-dispersible erbium-hyperdoped silicon quantum dots(Si QDs:Er),which emit NIR light at the wavelengths of 810 and 1540 nm.A dual-emission NIR nanosensor based on water-dispersible Si QDs:Er enables ratiometric Fe^(3+)detection with a very low LOD(0.06μM).The effects of pH,recyclability,and the interplay between static and dynamic quenching mechanisms for Fe^(3+)detection have been systematically *** addition,we demonstrate that the nanosensor may be used to construct a sequential logic circuit with memory functions.

关键词： erbium-hyperdoped silicon quantum dots dual-emission near-infrared nanosensor Fe^(3+)detection sequential logic circuit

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Fluorine-Doped High-Performance Li_(6)PS_(5)Cl Electrolyte by Lithium Fluoride Nanoparticles for All-Solid-State Lithium-Metal Batteries

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Transactions of Tianjin University 2024年第3期30卷 250-261页

作者： Xiaorou Cao Shijie Xu Yuzhe Zhang Xiaohu Hu Yifan Yan Yanru wang Haoran Qian Jiakai wang Haolong Chang Fangyi Cheng Yongan Yang Institute of Molecular Plus School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

All-solid-state lithium-metal batteries(ASSLMBs)are widely considered as the ultimately advanced lithium batteries owing to their improved energy density and enhanced safety *** various solid electrolytes,sulfide solid electrolyte(SSE)Li_(6)PS_(5)Cl has garnered significant ***,its application is limited by its poor cyclability and low critical current density(CCD).In this study,we introduce a novel approach to enhance the performance of Li_(6)PS_(5)Cl by doping it with fluorine,using lithium fluoride nanoparticles(LiFs)as the doping *** F-doped electrolyte Li_(6)PS_(5)Cl-0.2LiF(nano)shows a doubled CCD,from 0.5 to 1.0 mA/cm^(2) without compromising the ionic conductivity;in fact,conductivity is enhanced from 2.82 to 3.30 mS/cm,contrary to the typical performance decline seen in conventionally doped Li_(6)PS_(5)Cl *** symmetric Li|SSE|Li cells,the lifetime of Li_(6)PS_(5)Cl-0.2LiF(nano)is 4 times longer than that of Li_(6)PS_(5)Cl,achieving 1500 h vs.371 h under a charging/discharging current density of 0.2 mA/cm^(2).In Li|SSE|LiNbO_(3)@NCM721 full cells,which are tested under a cycling rate of 0.1 C at 30℃,the lifetime of Li_(6)PS_(5)Cl-0.2LiF(nano)is four times that of Li_(6)PS_(5)Cl,reaching 100 cycles vs.26 ***,the doping of nano-LiF off ers a promising approach to developing high-performance Li_(6)PS_(5)Cl for ASSLMBs.

关键词： Sulfide solid electrolyte All-solid-state lithium batteries Li_(6)PS_(5)Cl Lithium fluoride F-doping

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Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2024年第3期9卷 194-201,I0001-I0103页

作者： Wei Li Hao Li Chaoxia Lu Jialu Zhao Huichun Xu Zhe Xu Braxton Mitchell Yong Jiang Hong-Qiu Gu Qin Xu Anxin wang Xia Meng Jinxi Lin Jing Jing Zixiao Li Wanlin Zhu Zhigang Liang Mengxing wang Yongjun wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Division of Endocrinology Diabetes and NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMarylandUSA Department of Neurology Qindao University Medical College Affiliated Yantai Yuhuangding HospitalYantaiShandongChina Clinical Center for Precision Medicine in Stroke Capital Medical UniversityBeijingChina

Background and purpose Multiple factors play important roles in the occurrence and prognosis of ***,the roles of monogenic variants in all-cause ischaemic stroke have not been systematically *** aim to identify underdiagnosed monogenic stroke in an adult ischaemic stroke/transient ischaemic attack(TIA)cohort(the Third China National Stroke Registry,CNSR-III).Methods Targeted next-generation sequencing for 181 genes associated with stroke was conducted on DNA samples from 10428 patients recruited through *** genetic and clinical data from electronic health records(EHRs)were reviewed for completion of the diagnostic *** assessed the percentages of individuals with pathogenic or likely pathogenic(P/LP)variants,and the diagnostic yield of pathogenic variants in known monogenic disease genes with associated *** In total,1953 individuals harboured at least one P/LP variant out of 10428 ***,792(7.6%)individuals(comprising 759 individuals harbouring one P/LP variant in one gene,29 individuals harbouring two or more P/LP variants in different genes and 4 individuals with two P/LP variants in ABCC6)were predicted to be at risk for one or more monogenic diseases based on the inheritance ***,230 of 792 individuals manifested a clinical phenotype in the EHR data to support the diagnosis of stroke with a monogenic *** most diagnosed Mendelian cause of stroke in the cohort was cerebral autosomal dominant arteriopathy with subcortical infarcts and *** were no relationships between age or family history and the incidence of first symptomatic monogenic stroke in *** The rate of monogenic cause of stroke was 2.2%after reviewing the clinical *** reasons that Mendelian causes of stroke may be missed in adult patients who had an ischaemic stroke/TIA include a late onset of stroke symptoms,combination with common vascular risks and the absence of a promine

关键词： patients transient likely

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Digital economy and carbon dioxide emissions:Examining the role of threshold variables

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Geoscience Frontiers 2024年第3期15卷 389-400页

作者： Qiang wang Jiayi Sun Ugur Korkut Pata Rongrong Li Mustafa Tevfik Kartal School of Economics and Management China University of Petroleum(East China)Qingdao 266580China Osmaniye Korkut Ata University Faculty of Economics and Administrative Sciences Department of EconomicsMerkez80000 OsmaniyeTurkey Department of Banking and Finance European University of LefkeLefkeNorthern CyprusTR-10 MersinTürkiye Adnan Kassar School of Business Lebanese American UniversityBeirutLebanon Department of Economics and Management Khazar UniversityBakuAzerbaijan

Considering that previous literature has mainly focused on the impact of the digital economy(DE)on environmental degradation,ignoring the role of natural resources,this study uses two key factors(natural resource rent and anticorruption regulation)as threshold variables to reveal the effect of natural resources on the association between DE and carbon dioxide(CO_(2))*** doing so,the study covers 97 countries,uses annual data between 2003 and 2019,and applies a panel threshold *** outcomes present that the influence of the DE on CO_(2)emissions has a single-threshold effect(i.e.,there is an inverted U-shaped link between the DE and CO_(2)emissions)when natural resource rent is the threshold ***,the DE significantly increases CO_(2)emissions when the natural resource rent is at a low-to-medium level,but the DE suppresses CO_(2)emissions growth when natural resource rent exceeds the ***,the DE drives overall CO_(2)emissions growth when anticorruption regulation is the threshold variable and there are double thresholds for its impact on CO_(2)***,a rise in anticorruption regulation initially exacerbates the contribution of DE impact on CO_(2)emissions and then weakens it over *** on the results,the study proposes various implications,such as formulating a DE development strategy,considering natural resources in the development of the DE,and strengthening anti-corruption efforts in the field of environmental protection.

关键词： Digital economy Natural resource rent Anticorruption regulation CO_(2)emissions Threshold regression

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A Secure Communicating While Jamming Approach for End-to-End Multi-Hop Wireless Communication Network

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Chinese Journal of Electronics 2024年第3期33卷 833-846页

作者： Xiao MA Dan LI Liang wang Weijia HAN Nan ZHAO School of Physics and Information Technology Shaanxi Normal University Beijing Aerospace Science and Industry Century Satellite Hi-tech Co. Ltd.Xi'an Branch School of Computer Science Shaanxi Normal University School of Telecommunications Engineering Xidian University

With the rapid development of wireless communications,cellular communication and distributed wireless network are fragile to eavesdropping due to distributed users and transparent ***,to adopt bigger transmit power at a given area to interfere potential eavesdroppers not only incurs huge energy waste but also may suppresses regular communication in this *** this end,we focus on secure communication in multi-hop wireless communication network,and propose two communicating while jamming schemes for secure communication in presence of potential eavesdroppers for the narrow band and broad band point-to-point(P2P) systems respectively with the aid of artificial noise transmitted by a chosen cooperative ***,to achieve the end-to-end(E2E) multi-hop secure communication,we devise the secure network topology discovering *** constructing a proper network topology with at least one proper node as the cooperative interferer in each hop,and then propose the secure transmission path planning scheme to find an E2E secure transmission route from source to destination,*** on the wireless open-access research platform demonstrate the feasibility of the proposed ***,simulations results validate that the proposed schemes can achieve better performance compared with existing methods in both the P2P communication case and E2E multi-hop communication network scenario.

关键词： Wireless communication Network topology Law Simulation Wireless networks Noise Spread spectrum communication

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Experimental research on the launching system of auxiliary charge with filter cartridge structure

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Defence Technology（防务技术） 2024年第1期31卷 41-48页

作者： Zi-Jun Chen Ze He Hong-Hao Ma Lu-Qing wang Zhao-Wu Shen CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefeiAnhui230027PR China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefeiAnhui230026PR China

A launching system with a filter cartridge structure was proposed to improve the muzzle velocity of the *** combustion chamber of the launching system is divided into two fixed chambers,one is located in the breech chamber,and the other is arranged in the *** breech chamber charge was ignited first,and the charges in the auxiliary chambers were ignited by the high-temperature,highpressure combustible gas trailing the *** this way,the combustible gas in the auxiliary chambers could compensate for the pressure drop caused by the movement of the *** proposed device features the advantage of launching a projectile with high muzzle velocity without exceeding the maximum pressure in the *** order to obtain some internal ballistic characteristics of the launch system,some critical structure,such as the length of the filter cartridge auxiliary charge,the combustion degree of the propellant in the chamber,and the length of the barrel,are *** experimental results show that with the increased auxiliary charge length,a pressure plateau or even a secondary peak pressure can be formed,which is less than the peak *** projectile velocity increased by 23.57%,14.64%,and 7.65%when the diaphragm thickness was 0 mm,1 mm,and2 mm,*** muzzle velocity of the projectile can be increased by 13.42%by increasing the length of the *** the same charge condition,with the increase of barrel length,the energy utilization rate of propellant increases by 28.64%.

关键词： Interior ballistics Charge structures Launch system Charge design

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Versatile MXene Gels Assisted by Brief and Low‑Strength Centrifugation

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Nano-Micro Letters 2024年第5期16卷 231-247页

作者： Weiyan Yu Yi Yang Yunjing wang Lulin Hu Jingcheng Hao Lu Xu Weimin Liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006People’s Republic of China Key Laboratory of Colloid and Interface Chemistry and Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100People’s Republic of China

Due to the mutual repulsion between their hydrophilic surface terminations and the high surface energy facilitating their ran-dom restacking,2D MXene nanosheets usually cannot self-assemble into 3D macroscopic gels with various applications in the absence of proper linking *** this work,a rapid spontaneous gelation of Ti3C2Tx MXene with a very low dispersion concentration of 0.5 mg mL^(-1) into multifunctional architectures under moderate centrifugation is *** as-prepared MXene gels exhibit reconfigurable internal structures and tunable rheological,tribological,electrochemical,infrared-emissive and photothermal-conversion properties based on the pH-induced changes in the surface chemistry of Ti_(3)C_(2)T_(x) *** adopting a gel with optimized pH value,high lubrication,exceptional specific capacitances(~635 and~408 F g^(-1) at 5 and 100 mV s^(-1),respectively),long-term capacitance retention(~96.7%after 10,000 cycles)and high-precision screen-or extrusion-printing into different high-resolution anticounterfeiting patterns can be achieved,thus displaying extensive potential applications in the fields of semi-solid lubrication,control-lable devices,supercapacitors,information encryption and infrared camouflaging.

关键词： MXene Centrifugation-assisted rapid gelation Lubrication Supercapacitor Anti-counterfeiting applications

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Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu Cao Xi-Min wang Qi-Wen wang Yi-Ting wang Zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

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