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[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 60-67页

作者： Zi-Hao wang Meng-Fei Xu Bei-Ni Li Ping Wu wei Wu Hubei University of Chinese Medicine Wuhan 430065 China.

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs. While the concentrations of PAEs in urine reflect recent exposure levels in humans, urinary levels of phthalate metabolites (mPAEs) are commonly used as biomarkers of internal exposure owing to the relatively short biological half-lives of PAEs (<24 h). In this study, we developed a solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method for simultaneously detecting eight mPAEs in the urine of pregnant women. Urine samples were enzymatically hydrolyzed with -glucosidase and then purified using the Bond Elut Plexa SPE column, with subsequent elution, concentration, and redissolved performed prior to HPLC-MS/MS. Separation was achieved using an Agilent Eclipse Plus C18 column (100 mm×3 mm, 3.5 μm), with gradient elution performed using 0.1% acetic acid aqueous solution and 0.1% acetic acid acetonitrile as mobile phases. Multiple reaction monitoring (MRM) mode was used for detection, with quantification performed using the internal-standard method. Good linearities were obtained in the range of 0.1-200 ng/mL for the eight mPAEs, with limits of detection (LODs) and quantification (LOQs) of 0.015-0.048 and 0.050-0.160 ng/mL, respectively. The eight mPAEs exhibited recoveries of 80.2%-99.7% at three spiked levels (1, 10, and 50 ng/mL). This method was subsequently used to analyze the eight mPAEs levels in urine samples of 497 pregnant women from the Ezhou Maternity and Child Health Care Hospital. The participants exhibited widespread exposure t

关键词： birth outcomes high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) phthalate metabolites (mPAEs) urine samples of pregnant women

甲泼尼龙冲击联合眶周注射曲安奈德治疗甲状腺相关性眼病临床研究

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中国地方病防治 2016年第12期31卷 1327-1329页

作者：郭惠宇王丹阳劳伟矫操邢健强海南省眼科学重点实验室海南海口570311

目的评价甲泼尼龙冲击治疗或联合曲安奈德眶周注射治疗甲状腺相关眼病的临床效果。方法自2013年2月-2016年8月,对28例双眼甲状腺相关眼病患者给予静滴甲泼尼龙每周1次,连续12周,前6周每次0.5g,后6周每次0.25g,同时对每例患者症状较重的... 详细信息

目的评价甲泼尼龙冲击治疗或联合曲安奈德眶周注射治疗甲状腺相关眼病的临床效果。方法自2013年2月-2016年8月,对28例双眼甲状腺相关眼病患者给予静滴甲泼尼龙每周1次,连续12周,前6周每次0.5g,后6周每次0.25g,同时对每例患者症状较重的一眼联合眶周注射曲安奈德,每次40mg,每3周一次,注射4次。结果患者双眼的炎症活动得到有效控制,眼球突出度和睑裂高度等症状改善,在联合治疗组效果更优,治疗前后差异均有统计学意义(P<0.05)。结论甲泼尼龙连续12周冲击法治疗甲状腺相关眼病有较好的疗效,联合眶周注射曲安奈德效果更佳。

关键词：甲状腺相关眼病甲泼尼龙曲安奈德疗效

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu wei Wu Xuejuan Li Chengyan wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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2019年美国冬小麦长势遥感监测分析

安徽农业科学 2020年第1期48卷 241-244页

作者：孙丽王蔚丹陈媛媛董沫农业农村部耕地利用遥感重点实验室/农业农村部规划设计研究院

美国是全球重要的小麦出口大国,其生产状况在一定程度上影响全球小麦贸易形势。利用卫星遥感技术,基于作物长势遥感监测中应用最广泛的归一化植被指数NDVI,采用同期对比法对2019年美国冬小麦进行长势监测分析。结果表明,2019年美国冬小... 详细信息

美国是全球重要的小麦出口大国,其生产状况在一定程度上影响全球小麦贸易形势。利用卫星遥感技术,基于作物长势遥感监测中应用最广泛的归一化植被指数NDVI,采用同期对比法对2019年美国冬小麦进行长势监测分析。结果表明,2019年美国冬小麦长势基本呈现持平略好趋势,且总体好于2018年同期;良好的气象条件是主产州冬小麦长势总体表现偏好的主要原因。产量有望稳中略增,进一步增加国际小麦供给。

关键词：长势监测遥感 MODIS数据美国冬小麦

Class Ⅰ graphs of nonnegative characteristic without special cycles

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Applied Mathematics(A Journal of Chinese Universities) 2012年第3期27卷 320-328页

作者： HUANG dan-jun wang wei-fan Department of Mathematics Zhejiang Normal UniversityJinhua 321004China

In this paper, we prove that every graph with maximum degree six that can be embedded in a surface of nonnegative characteristic is of Class I if it does not contain a 5- or 6-cycle with a chord, which extends some kn... 详细信息

关键词： graph Class I characteristic cycle.

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili wang Jiancheng Huang Yanan Du wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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Effects of heterogeneous adoption thresholds on contact-limited social contagions

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Chinese Physics B 2022年第6期31卷 790-800页

作者： dan-dan Zhao wang-Xin Peng Hao Peng wei wang College of Mathematics and Computer Science Zhejiang Normal UniversityJinhua 321004China College of Information Zhejiang Guangsha Vocational and Technical University of ConstructionDongyang 322100China Shanghai Key Laboratory of Integrated Administration Technologies for Information Security Shanghai 200240China School of Public Health and Management Chongqing Medical UniversityChongqing 400016China

Limited contact capacity and heterogeneous adoption thresholds have been proven to be two essential characteristics of individuals in natural complex social systems,and their impacts on social contagions exhibit complex *** this in mind,a heterogeneous contact-limited threshold model is proposed,which adopts one of four threshold distributions,namely Gaussian distribution,log-normal distribution,exponential distribution and power-law *** heterogeneous edge-based compartmental theory is developed for theoretical analysis,and the calculation methods of the final adoption size and outbreak threshold are given *** numerical simulations are performed on the Erdös-Renyi and scale-free networks to study the impact of different forms of the threshold distribution on hierarchical spreading´process,the final adoption size,the outbreak threshold and the phase transition in contact-limited propagation *** find that the spreading process of social contagions is divided into three distinct ***,different threshold distributions cause different spreading processes,especially for some threshold distributions,there is a change from a discontinuous first-order phase transition to a continuous second-order phase ***,we find that changing the standard deviation of different threshold distributions will cause the final adoption size and outbreak threshold to change,and finally tend to be stable with the increase of standard deviation.

关键词： social contagions threshold distribution heterogeneous adoption thresholds limited contact

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新文科背景下教学要素多态融合研究

黑龙江高教研究 2025年第1期43卷 66-71页

作者：冯丹娃王琪哈尔滨师范大学黑龙江哈尔滨150025

“新文科”建设为高校培养专业人才提供了新的理念,随着新文科理念和教育改革不断推进,跨学科交流、凝聚多学科的智慧和力量逐渐成为社会共识。结合新文科背景下人文社会学科融通整合的课程建设要求,基于新文科建设的契机,从教学资源、... 详细信息

“新文科”建设为高校培养专业人才提供了新的理念,随着新文科理念和教育改革不断推进,跨学科交流、凝聚多学科的智慧和力量逐渐成为社会共识。结合新文科背景下人文社会学科融通整合的课程建设要求,基于新文科建设的契机,从教学资源、教学方法、教学过程、教学媒介、学习路径等五个方面对教学要素进行阐释,并通过多态融合概念的界定,将新文科多态融合的教学要素模型进行构建,探究适合新文科发展要求的新的教学全过程重塑,在此基础上进一步阐释新文科多态融合教学模式的新保障。从该视角进行研究能够进一步体现新文科教育教学理念学科育人、课程育人的理性价值,为教育教学相关研究提供新的视角和思维方式,进而培养符合新时代经济社会发展的新文科人才。

关键词：新文科多态融合教学要素

Multi-shelled TiO2/Fe2TiO5 heterostructured hollow microspheres for enhanced solar water oxidation

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Nano Research 2017年第11期10卷 3920-3928页

作者： Muhammad Waqas Yanze wei dan Mao Jian Qi Yu Yang Bao wang dan wang State Key Laboratory of Biochemical Engineering CAS Center for Excellence in Nanoscience Institute of Process Engineering Chinese Academy of Sciences 1 North 2nd Street Zhongguancun Haidian District Beijing 100190 China Department of Physical Chemistry School of Metallurgical and Ecological Engineering University of Science & Technology Beijing No.30 Xueyuan Road Haidian District Beijing 100083 China University of Chinese Academy of Sciences Chinese Academy of Sciences No.19A Yuquanlu Beijing 100049 China

There remains a pressing challenge in the fabrication of superior photocatalysts for light-driven water ***,we designed and fabricated heterostructured TiO2/Fe2TiO5 hollow microspheres with single-,double-,closed-double-,triple-,and core-shell structures and different Fe/Ti molar ratios using a facile sequential templating *** closed-double-shelled TiO2/Fe2TiO5 hollow microspheres with 35% Fe exhibited the highest oxygen evolution reaction rate up to 375 μmol＆#183;g-1＆#183;h-1 and good stability for 5 *** high performance can be attributed to the closed-double shell,which had more reactive sites and greater light-harvesting ability,self-supported thin shells with short charge-transfer paths,and a favorable staggered band alignment between the TiO2 and Fe2TiOs.

关键词： multi-shelled hollow microsphere titanium oxide pseudo-brookite heterostructure photocatalytic water oxidation