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血清PTX3、CK-MB水平对慢性失代偿心力衰竭患者容量负荷的评估价值

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中国医师杂志 2024年第1期26卷 87-92页

作者：曹明善王春娣胡小倩孟令慧武瑜丰刘欢杨华邢台市中心医院检验科邢台054000 临西县人民医院心内科临西054900 邢台市人民医院检验科邢台054031

目的探讨血清正五聚蛋白3(PTX3)、肌酸激酶同工酶MB(CK-MB)水平对慢性失代偿心力衰竭(CDHF)患者容量负荷的评估价值。方法选取2019年7月至2022年7月于邢台市中心医院就诊的300例CDHF患者,根据患者容量平衡水平将其分为容量负荷过载组(n=... 详细信息

目的探讨血清正五聚蛋白3(PTX3)、肌酸激酶同工酶MB(CK-MB)水平对慢性失代偿心力衰竭(CDHF)患者容量负荷的评估价值。方法选取2019年7月至2022年7月于邢台市中心医院就诊的300例CDHF患者,根据患者容量平衡水平将其分为容量负荷过载组(n=182)和非容量负荷过载组(n=118)。对比分析两组临床资料,利用受试者工作特征(ROC)曲线分析血清PTX3、CK-MB水平对CDHF患者容量负荷的评估价值,利用单因素分析两组患者的临床疾病特征,采用logistic回归分析CDHF患者容量负荷的影响因素,构建列线图模型并验证。结果容量负荷过载组患者BMI、腰围、收缩压、舒张压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、C反应蛋白(CRP)、尿酸(UA)、胰岛素抵抗指数(HOMA-IR)均高于非容量负荷过载组,差异均有统计学意义(均P<0.05)。容量负荷过载组患者的PTX3、CK-MB、肺毛细血管楔压(PCWP)、CVP水平高于非容量负荷过载组,清蛋白、血红蛋白、红细胞比容低于非容量负荷过载组,差异均有统计学意义(均P<0.05)。ROC曲线显示,PTX3、CK-MB预测CDHF患者容量负荷过载的曲线下面积(AUC)为0.795、0.718,灵敏度分别为86.2%、83.7%,特异度分别为65.4%、68.6%,预测准确性较高;两项联合预测的AUC为0.817、灵敏度为92.5%、特异度为70.6%,预测准确性高于PTX3(Z=3.812,P<0.05)和CK-MB(Z=3.365,P<0.05)。PTX3、CK-MB、清蛋白、血红蛋白、红细胞比容、PCWP、中心静脉压(CVP)均为CDHF患者的容量负荷状态的影响因素(均P<0.05),据此建立的列线图风险预测模型在临床治疗上有着高准确性和强适用性。结论血清PTX3、CK-MB水平为CDHF患者发生容量过载的影响因素,联合清蛋白、血红蛋白、红细胞比容、PCWP、CVP等指标构建的列线图模型对CDHF的容量负荷状态具有较高的预测价值。

关键词：心力衰竭正五聚蛋白3 肌酸激酶,MB型容量负荷

HRCT关于肺腺癌磨玻璃结节浸润性的研究进展

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影像研究与医学应用 2024年第13期8卷 1-3,6页

作者：王玉秀周建立解丙坤王春笛滨州医学院医学影像学院山东烟台264003 平原县第一人民医院影像科山东德州253100 山东大学齐鲁医院德州医院核医学科山东德州253000 山东大学齐鲁医院德州医院放射科山东德州253000

本文综述了高分辨率CT(HRCT)在评估肺腺癌磨玻璃结节(GGN)浸润性方面的研究进展。通过对GGN的定量参数(如大小、密度、质量等)和定性征象(如分叶征、毛刺征、胸膜凹陷征等)的分析,预测GGN的浸润程度。然而,现有方法主观性强、效率低,且... 详细信息

本文综述了高分辨率CT(HRCT)在评估肺腺癌磨玻璃结节(GGN)浸润性方面的研究进展。通过对GGN的定量参数(如大小、密度、质量等)和定性征象(如分叶征、毛刺征、胸膜凹陷征等)的分析,预测GGN的浸润程度。然而,现有方法主观性强、效率低,且易漏诊、误诊。近年来,人工智能(AI)辅助肺结节诊断的应用取得了显著效果,其可迅速识别肺结节,提高准确率,减少漏诊和误诊。未来,随着临床评估标准的统一和AI技术的进一步发展,对GGN浸润性的预判将更加准确,以实现患者的精准医疗。

关键词： GGN 腺癌浸润

Invasion by exogenous RNA:cellular defense strategies and implications for RNA inference

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Marine Life Science & Technology 2023年第4期5卷 573-584页

作者： Danxu Tang Yan Liu chundi wang Lifang Li Saleh AAl‑Farraj Xiao Chen Ying Yan Laboratory of Marine Protozoan Biodiversity and Evolution Marine CollegeShandong UniversityWeihai 264209China Key Laboratory of Evolution and Marine Biodiversity(Ministry of Education)and Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Zoology Department College of ScienceKing Saud University11451 RiyadhSaudi Arabia Suzhou Research Institute Shandong UniversitySuzhou 215123China

Exogenous RNA poses a continuous threat to genome stability and integrity across various *** evidence reveals complex mechanisms underlying the cellular response to exogenous RNA,including endo-lysosomal degradation,RNA-dependent repression and innate immune *** a variety of mechanisms,the natural anti-sense RNAdependent defensive strategy has been utilized both as a powerful gene manipulation tool and gene therapy strategy named RNA-interference(RNAi).To optimize the efficiency of RNAi silencing,a comprehensive understanding of the whole life cycle of exogenous RNA,from cellular entry to its decay,is *** this paper,we review recent progress in comprehending the recognition and elimination of foreign RNA by cells,focusing on cellular entrance,intracellular transportation,and immune-inflammatory *** leveraging these insights,we highlight the potential implications of these insights for advancing RNA interference efficiency,underscore the need for future studies to elucidate the pathways and fates of various exogenous RNA forms,and provide foundational information for more efficient RNA delivery methods in both genetic manipulation and therapy in different organisms.

关键词： Endocytosis Exogenous RNA Innate immune response RNA inference

Report and Phylogeny of a Novel Euplotes Species from China:*** ***.,and Review of ***(Alveolata,Ciliophora)

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Journal of Ocean University of China 2023年第3期22卷 831-841页

作者： LIAN Chunyu JIANG Jiamei XI Muchen DONG Jingyi MA Honggang AL-FARRAJ Saleh A STOECK Thorsten wang chundi SHAO Chen Laboratory of Protozoological Biodiversity and Evolution in Wetland College of Life SciencesShaanxi Normal UniversityXi’an 710119China Shanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution Shanghai Ocean UniversityShanghai 201306China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Zoology Department College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Ecology University of KaiserslauternKaiserslautern 67663Germany Marine College Shandong UniversityWeihai 264209China

The freshwater species,Euplotes mazeii ***.,and the marine species,***(Dujardin,1841)Diesing,1850 were collected from China and investigated based on their living morphology,ciliary pattern,and small subunit ribosomal RNA(SSU rRNA)gene sequence *** mazeii *** characterized by its small cell size((40-55)μm×(25-35)μm),nine frontoventral cirri,one marginal and two caudal cirri,seven dorsal kineties,and a double-eurystomus type of dorsal silverline *** analyses based on molecular data confirmed the branching position of this new taxa within the genus Euplotes,with 5.01%(84 nucleotides)sequence variation,supporting the identification of a new *** re-examined all described and supposedly conspecific populations and give a review of Euplotes *** has been reported frequently;however,*** sensu Agamaliev,1968 is different from other populations in the number of marginal cirri or the type of silverline system,which suggests there might be a *** SSU rRNA gene sequences of two populations of *** from the studies of Chen et al.(2013)and Pan et al.(2012)differ from each other by more than 135 nucleotides,implying that the identity of the species currently associated with the SSU rRNA gene sequence in molecular databases requires further confirmation.

关键词： biodiversity molecular analysis morphology systematic placement

New considerations on the phylogeny of Sessilida(Protista:Ciliophora:Peritrichia)based on multiple-gene information,with emphasis on colonial taxa

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Marine Life Science & Technology 2022年第4期4卷 569-583页

作者： Zhe wang Xiaoting Feng Lifang Li Khaled A.S.Al-Rasheid Alan Warren chundi wang Zemao Gu Marine College Shandong UniversityWeihai264209China College of Fisheries/Shuangshui ShuanglüInstitute Huazhong Agricultural UniversityWuhan430070China Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention Wuhan430070China Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Life Sciences Natural History MuseumLondonSW75BDUK

The subclass Peritrichia,containing two orders Sessilida and Mobilida,is a major group of ciliates with worldwide distribution and high species *** studies have investigated the phylogeny of peritrichs;however,the evolutionary relationships and classification of some families and genera within the Sessilida remain *** the present study,we isolated and identified 22 peritrich populations representing four families and six genera and obtained 64 rDNA sequences to perform phylogenetic analyses and assess their systematic *** character reconstruction was also carried out to infer evolutionary routes within the *** results indicate:(1)family Vaginicolidae is monophyletic and acquisition of the typical peritrich lorica represents a single evolutionary divergence;(2)core epistylidids evolved from a Zoothamnium-like ancestor and experienced spasmoneme loss during evolution;(3)Campanella clusters with species in the basal clade and shows stable morphological differences with other epistylidids,supporting its assignment to a separate family;(4)the structure of the peristomial lip may be a genus-level character rather than a diagnostic character for discriminating Epistylididae and Operculariidae,thus a redefinition of Operculariidae should be carried out when more species have been investigated;(5)some characters,such as lifestyle(solitary or colonial),spasmoneme and living habit(sessile or free-swimming),evolved repeatedly among sessilids indicating that species with non-contractile stalks or that are free-swimming have multiple evolutionary routes and might derive from any sessilid lineage without a *** close phylogenetic relationships of some morphologically distinct sessilids imply that the diagnoses of some genera and families should be improved.

关键词： Ancestral state reconstruction Ciliates Morphology Peritrichs Phylogenetic analyses

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精神分裂症与抑郁障碍患者振动触觉损害分析

四川精神卫生 2024年第1期37卷 11-15页

作者：庄芸月朱嘉琪邓虎王春地陈景旭承德医学院河北承德067000 北京回龙观医院/北京大学回龙观临床医学院北京100096 北京航空航天大学人文社会科学学院北京100191

背景精神分裂症患者与抑郁障碍患者均存在感知觉异常的表现,既往关于感知觉的研究多采用问卷调查法,对精神分裂症与抑郁障碍患者在客观行为学上的研究尚不足。目的探讨精神分裂症患者与抑郁障碍患者振动触觉的差异,充实与此部分患者有... 详细信息

背景精神分裂症患者与抑郁障碍患者均存在感知觉异常的表现,既往关于感知觉的研究多采用问卷调查法,对精神分裂症与抑郁障碍患者在客观行为学上的研究尚不足。目的探讨精神分裂症患者与抑郁障碍患者振动触觉的差异,充实与此部分患者有关的行为学上的研究结果。方法于2021年3月—2023年9月,在北京回龙观医院门诊部和住院部选择符合《精神障碍诊断与统计手册(第5版)》(DSM-5)诊断标准的33例精神分裂症患者和31例抑郁障碍患者,同期在北京航空航天大学与北京回龙观医院招募34名健康对照组。采用阳性和阴性症状量表(PANSS)评定精神分裂症患者的临床症状,采用汉密尔顿抑郁量表17项版(HAMD-17)评定抑郁障碍患者的抑郁症状。通过改编的振动触觉形式的单样本延迟匹配任务,对三组被试的左手振动触觉情况进行检测,并比较三组被试在单样本延迟匹配任务中振动触觉的正确率。结果精神分裂症患者在食指、中指与无名指上的正确率均低于健康对照组(P均0.05)。精神分裂症患者组振动触觉平均正确率与病程、首发年龄、氯丙嗪当量和PANSS总评分的相关性均无统计学意义(r=0.058、0.045、0.114、-0.194,P均>0.05);抑郁障碍患者组振动触觉平均正确率与首发年龄呈负相关(r=-0.415,P=0.020),与病程和HAMD-17评分的相关性均无统计学意义(r=-0.044、0.142,P均>0.05)。结论精神分裂症与抑郁障碍患者均存在振动触觉损害,其中精神分裂症患者在食指、中指与无名指上的振动触觉受到严重损伤,抑郁障碍患者在大拇指上的振动触觉受到严重损伤,此外,抑郁障碍患者振动触觉损伤可能与首发年龄存在关联。

关键词：精神分裂症抑郁障碍振动触觉

Timing and characteristics of nuclear events during conjugation and genomic exclusion in Paramecium multimicronucleatum

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Marine Life Science & Technology 2022年第3期4卷 317-328页

作者： Xue Zhang Xiaoteng Lu Yong Chi Yaohan Jiang chundi wang Saleh AAl‑Farraj Adriana Vallesi Feng Gao Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Mariculture(OUC) Ministry of EducationQingdao 266003China Department of Biology Shenzhen MSU-BIT UniversityShenzhen 518172China Laboratory of Marine Protozoan Biodiversity and Evolution Shandong UniversityWeihai 264209China Zoology Department College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Laboratory of Eukaryotic Microbiology and Animal Biology University of Camerino62032 CamerinoItaly Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Ciliated protists are ideal material for studying the origin and evolution of sex,because of their nuclear dimorphism(containing both germline micronucleus and somatic macronucleus in the same cytoplasm),special sexual processes(conjugation and autogamy),and high diversity of mating-type ***,the study of sexual process is limited to only a few species,due to the difficulties in inducing or observing *** the present study,we investigate the conjugation process in Paramecium multimicronucleatum:(1)of the three prezygotic divisions,all micronuclei undergo the first two divisions(meiosis I,II),while a variable number of nuclei undergo the third division(mitosis);(2)the synkaryon divides three times after fertilization,giving rise to eight products that differentiate into four macronuclear anlagen and four micronuclei;(3)cells restore the vegetative stage after two successive cell fissions during which the macronuclear anlagen are distributed into daughter cells without division,while micronuclei divide mitotically;(4)the parental macronucleus begins to fragment following the first meiotic division and finally degenerates completely;(5)the entire process takes about 110 h,of which about 85 h are required for macronuclear *** addition,we describe for the first time the process of genomic exclusion occurring between amicronucleate and micronucleate cells of ***,during which the micronucleate cell contributes a pronucleus to the amicronucleate cell,resulting in both exconjugants being *** results provide new insights into the diversity of sexual processes and lay an important cytological basis for future in-depth studies of mating systems in ciliates.

关键词： Amicronucleate cells Nuclear development Ciliate Life cycle Sexual reproduction

Restoring Vision Naturally and Noninvasively

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Neuroscience Bulletin 2021年第11期37卷 1642-1644页

作者： chundi wang Hu Deng Shenbing Kuang Department of Psychology and Research Centre of Aeronautic Psychology and Behavior Beihang UniversityBeijing 100191China Peking University HuiLongGuan Clinical Medical School Beijing HuiLongGuan Hospital.Beijing 100096China State Key Laboratory of Brain and Cognitive Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China

More than 200 million people across the world suffer from moderate to severe visual impairments,mostly due to retinal degeneration or damage to the eyes[1].Methods of reprogramming the cells in the eyes or electrical ... 详细信息

关键词： programming mostly damage

A paradox： rapid evolution rates of germline-limited sequences are associated with conserved patterns of rearrangements in cryptic species of Chilodonella uncinata(Protista, Ciliophora)

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Science China(Life Sciences) 2018年第9期61卷 1071-1078页

作者： Tengteng Zhang chundi wang Laura A.Katz Feng Gao Institute of Evolution & Marine Biodiversity Ocean University of ChinaQingdao 266003 China Key Laboratory of Mariculture (Ocean University of China) Ministry of EducationQingdao 266003 China Department of Biological Sciences Smith CollegeNorthampton MA 01063 USA Program in Organismic and Evolutionary Biology UMass-Amherst Amherst MA 01003 USA

Some of the most extreme genome wide rearrangements are found in ciliates, which are unique in possessing both germline micronucleus and somatic macronucleus in every cell/organism. A series of DNA rearrangement events, including DNA elimination, chromosomal fragmentation, gene unscrambling and alternative processing, happen during macronuclear development. To assess the molecular evolution of macronuclear and germline-limited sequences in different cryptic species of Chilodonella uncinata, we characterized the actin, α-tubulin and β-tubulin genes in the micronucleus and macronucleus genomes of USA-SC2 strain and compared them with other strains(i.e. cryptic species). Three main results are:(i) rearrangement patterns between germline and soma are conserved for each gene among the cryptic species of C. uncinata;(ii) in contrast, the germlinelimited regions are highly divergent in sequence and length among the cryptic species;(iii) pointer shifting is frequent among the cryptic species. We speculate that pointer sequences may serve as the buffer between the conserved macronuclear destined sequences and rapidly-evolving internal eliminated sequences. The data combined with previous studies demonstrate the plasticity of gene rearrangement among different groups of ciliates and add to the growing data for the role of genome rearrangements in species differentiation.

关键词：整理种类序列保存进化染色体描绘悖论 DNA