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Exposure to persistent organic pollutants as potential risk factors for developing diabetes

Science China Chemistry 2010年第5期53卷 980-994页

作者： wang chunxiang,xu shunqing,lv ziquan,li yuanyuan,wang youjie & chen tian key laboratory of environment and health,ministry of education School of Public health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China key laboratory of environment and health Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China

Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food *** to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to *** growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their *** on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental *** potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or *** research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.

关键词： persistent organic pollutants diabetes dioxins polychlorinated biphenyls organochlorine pesticides

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Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang wang tian Yang Shiyou li chen xu Chong wang Yuxuan Xiong Xing wang Jiangling Wan Xiangliang Yang Zifu li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China key laboratory of Molecular Biophysics of ministry of education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei key laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging key laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

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Essential oils improve nursery pigs'performance and appetite via modulation of intestinal health and microbiota

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Animal Nutrition 2024年第1期16卷 174-188页

作者： Bi-chen Zhao tian-Hao wang Jian chen Bai-Hao Qiu Ya-Ru xu Jin-Long li College of Veterinary Medicine Northeast Agricultural UniversityHarbin150030China Heilongjiang key laboratory for laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin150030China key laboratory of the Provincial education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin150030China

Optimal intestinal health and functionality are essential for animal health and performance,and simultaneously intestinal nutrient transporters and intestinal peptides are also involved in appetite and feed intake control *** the potential of essential oil(EO)in improving animal performance and improving feed palatability,we hypothesized that dietary supplementation of cinnamaldehyde and carvacrol could improve performance and appetite of nursery pigs by modulating intestinal health and ***(100 mg/kg),carvacrol(100 mg/kg),and their mixtures(including 50 mg/kg cinnamaldehyde and 50 mg/kg carvacrol)were supplemented into the diets of 240 nursery pigs for 42 d,and data related to performance were ***,the influence of EO on intestinal health,appetite and gut microbiota and their correlations were *** supplementation increased(Plity and local *** terms of intestinal development and the mucus barrier,EO promoted intestinal development and increased(Phealth and ba

关键词： Nursery pig Essential oil Intestinal health Appetite Microbiota

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Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women — Beijing, tianjin, and Hebei PLADs, China, 2018–2019

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China CDC weekly 2024年第13期6卷 249-253,I0001-I0004页

作者： Yanlin tian Jiaonan wang Jianlong Fang chen chen Feng Zhao Yi Zhang Peng Du Yawei li Wanying Shi yuanyuan liu Enmin Ding Song Tang xu Yue Xiaoming Shi Chinese Research Academy of environmental Sciences BeijingChina Collaborative Innovation Center of Atmospheric environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC)Nanjing University of Information Science&TechnologyNanjing CityJiangsu ProvinceChina China CDC key laboratory of environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Department of Epidemiology and health Statistics School of Public HealthCapital Medical Universityand Beijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina National key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?Exposure to fine particulate matter(PM_(2.5))was linked to endocrine hormone disruption in the reproductive ***,it was unclear which specific components of PM_(2.5) were primarily responsible for these *** is added by this report?The study presented the initial epidemiological evidence that brief exposure to PM_(2.5) can elevate estradiol levels in postmenopausal *** particle components had unique effects,with watersoluble ions and specific inorganic elements like Ag,As,Cd,Hg,Ni,Sb,Se,Sn,and Tl potentially playing significant roles in increasing estradiol *** are the implications for public health practice?The study established that the prevalence of air pollution,along with its specific components,has been recognized as a novel risk factor affecting the balance of sex hormones.

关键词： pollution Particulate primarily

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Highly sensitive flexible strain sensor based on the two-dimensional semiconductor tellurium with a negative gauge factor

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Science China(Information Sciences) 2024年第7期67卷 295-304页

作者： Jiarui HE Yusong QU Shengyao chen Cong wang Lena DU Xiaoshan DU yuanyuan ZHENG Guozhong ZHAO He tian College of Mathematics and Physics Beijing University of Chemical Technology School of Integrated Circuits Tsinghua University Beijing China & The Beijing National Research Center for Information Science and Technology (BNRist)Tsinghua University CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology &University of Chinese Academy of Sciences Beijing key Lab of Terahertz Spectroscopy and Imaging Key Lab of Terahertz OptoelectronicsMinistry of Education Department of Physics Capital Normal University

Research on flexible strain sensors has advanced rapidly in recent years, with particular attention being devoted to two-dimensional(2D) semiconductor materials owing to their exceptional mechanical and electrical properties that are conducive to sophisticated sensing performance. However, resistive strain sensors based on 2D semiconductor materials typically exhibit positive gauge factors(GF), while materials for strain sensors with a negative GF remain elusive. We have identified a trend of reduction in the band gap of the emerging 2D semiconductor material tellurium(Te) under strain in simulations reported in past research,and have observed a negative GF in the Te-based strain sensor. In this study, we combined Te with a flexible polyethylene terephthalate(PET) substrate to manufacture a flexible strain sensor with a significantly negative GF. The results of tests revealed that the Te-based strain sensor achieved an impressive maximum sensitivity of-139.7 within a small range of bending-induced strain(linearity and good cyclic stability, and was successfully applied to monitor limb movements. The work here verifies the significant potential for the use of Te-based strain sensors in next-generation flexible electronics.

关键词： 2D semiconductor materials 2D tellurium flexibleelectronics strain sensors negative gauge factor high sensitivity

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Paleoclimatic application of spectral parameters to the eolian red clay of the Jianzha Basin,northeastern margin of the Tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1952-1966页

作者： Chaofeng FU Ju’e tian Xinwen xu Yougui SONG Jun ZUO Feng wang lin chen Pengfei li Xiaoke QIANG The School of Earth Science and Resources Chang’an UniversityXi’an 710054China State key laboratory of Loess and Quaternary Geology Institute of Earth and EnvironmentCASXi’an 710061China College of Urban and environmental Science Northwest UniversityXi’an 710069China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

Reflectance spectroscopy is rapid,inexpensive,and non-destructive and can provide important information about the mineralogy of rocks and *** measured the reflectance spectroscopy of Miocene red clay deposits on the northeastern margin of the Tibetan Plateau,with the aim of developing a rapid methodology for detecting paleoclimatic *** obtained visible/near-infrared(VNIR)and short-wave infrared(SWIR)spectroscopy data from the red clay in the Jianzha Basin,and analyzed their relationship with independent paleoclimatic records,including mineral contents and environmental magnetic *** results show that the VNIR parameters,including D500,D900,R500,and R900(where D and R represent the depth and reflectance of the absorption peaks around 500 and 900 nm,respectively)are temperature-sensitive and correlated with the magnetic susceptibility,frequency-dependent magnetic susceptibility,and the marine δ^(18)O *** results of frequency-domain analysis of the VNIR parameters show that they reflect climate change on orbital *** parameters,such as AS1400,D1400/D1900 and D1900(where AS represents the asymmetry of the absorption peaks around1400 nm),are correlated with the illite and montmorillonite content,and they are sensitive to the weathering *** spectral parameters of the eolian red clay in the Jianzha Basin reflect regional climatic changes caused by the uplift of the Tibetan Plateau at~8.5 Ma and global climatic cooling at~7.2 Ma,and thus they are applicable as both regional and global paleoenvironmental indicators.

关键词： Visible/near-infrared spectroscopy Short-wave infrared spectroscopy Paleoclimatic indicators Red clay Tibetan Plateau

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Plasma induced grain boundaries to boost electrochemical reduction of CO_(2)to formate

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Journal of Energy Chemistry 2024年第8期95卷 636-643,I0014页

作者： Guan wang Shengtao Zhong Xiaoqian Xiong Jing li Fangyuan wang li Huo Daoxiong Wu Xingqi Han Zhitong wang Qi chen Xinlong tian Peilin Deng School of Marine Science and Engineering State Key Laboratory of Marine Resource Utilization in South China SeaHainan UniversityHaikou 570228HainanChina

Bismuth-based catalysts are highly promising for the electrochemical carbon dioxide reduction reaction(eCO_(2)RR)to formate ***,achieving high activity and selectivity towards formate and ensuring long-term stability remains *** work reports the oxygen plasma inducing strategy to construct the abundant grain boundaries of Bi/BiO_x on ultrathin two-dimensional Bi *** oxygen plasma-treated Bi nanosheet(OP-Bi)exhibits over 90%Faradaic efficiency(FE)for formate at a wide potential range from-0.5 to-1.1 V,and maintains a great stability catalytic performance without significant decay over 30 h in flow ***,membrane electrode assembly(MEA)device with OPBi as catalyst sustains the robust current density of 100 mA cm^(-2)over 50 h,maintaining a formate FE above 90%.In addition,rechargeable Zn-CO_(2)battery presents the peak power density of1.22 mW cm^(-2)with OP-Bi as bifunctional *** mechanism experiments demonstrate that the high-density grain boundaries of OP-Bi provide more exposed active sites,faster electron transfer capacity,and the stronger intrinsic activity of Bi *** situ spectroscopy and theo retical calculations further elucidate that the unsaturated Bi coordination atoms between the grain boundaries can effectively activate CO_(2)molecules through elongating the C-O bond,and reducing the formation energy barrier of the key intermediate(^(*)OCOH),thereby enhancing the catalytic performance of eCO_(2)RR to formate product.

关键词： CO_(2)electroreduction Bi nanosheet Grain boundary Unsaturation Bi atoms MEA device

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Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator

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Nano-Micro Letters 2024年第3期16卷 351-366页

作者： Ya’nan Yang Jiaqi wang Zhe wang Changxiang Shao Yuyang Han Ying wang Xiaoting liu Xiaotong Sun liru wang yuanyuan li Qiang Guo Wenpeng Wu Nan chen liangti Qu key laboratory of Cluster Science Ministry of Education of ChinaKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019People’s Republic of China Department of Chemistry Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal ***,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information ***,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any *** research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.

关键词： Moist-electric generators Grotthuss proton hopping Fast response Durable electrical output Personal health monitoring

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Advances and perspectives in environmental health research in China

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Frontiers of environmental Science & Engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun liu shunqing xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen chen Jicheng Gong Guohua Qin Xinghua Qiu Jing Shang Haobo wang Pengpeng wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for environment and health Peking UniversityBeijing 100871China School of life and health Sciences Huainan UniversityHaikou 570228China Joint International Research laboratory of environment and health(ministry of education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke School of Public health Tsinghua UniversityBeijing 100084China Research Center of environment and health College of Environment and ResourceShanxi UniversityTaiyuan 030006China Department of environmental health School of Public HealthFudan UniversityShanghai 200032China School of environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China key laboratory of Industrial Ecology and environmental Engineering(ministry of education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Occupational and environmental health College of Public HealthZhengzhou UniversityZhengzhou 450001China

environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： environmental pollution Emerging pollutants Climate change Exposure Mechanism

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Research and development of prevention and control measures on the transmission of pathogens in compartments of passenger transport

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Transportation Safety and environment 2024年第1期6卷 1-7页

作者： Hongqi tian tiantian wang Lei xu Miao Sha Shujun chen Zeyun Yang Yan Zhu Dawei chen Hengkui li Lei Zhang Bosen Qian xudong tian key laboratory of Traffic Safety on Track of ministry of education School of Traffic&Transportation EngineeringCentral South UniversityChangshaHunan 410075China CRRC Qingdao Sifang Co. Ltd.QingdaoShandong 266111China CRRC Changchun Railway Vehicles Co. Ltd.ChangchunJilin 130062China CRRC Tangshan Co. Ltd.TangshanHebei 064000China CRRC Industrial Research Institute(Qingdao)Co. Ltd.QingdaoShandong 266109China

Contagious pathogens like COVID-19 transmitted via respiratory droplets spread effortlessly in the passenger compartments of transport,significantly jeopardizing passengers’safety when taking public *** date,studies on the fundamental theories of airborne droplet transmission and the engineering application of decontamination techniques are insufficient for the prevention and control of pathogens transmitting in the compartments of passenger *** is essential to systematically investigate the control approaches to restrain pathogens from transmitting in passenger ***,a theoretical framework for calculating the transmission of pathogens in a complex compartment environment was proposed,and experimental platforms that satisfy the Biosafety Level-2 laboratory safety level for compartment environment simulations were built based on a set of real train *** these bases,numerical investigations on the motion of pathogen-laden droplets were conducted,and decontamination techniques were examined ***,control measures on the pathogen transmission and pathogen decontamination schemes were ***,highly efficient decontamination devices were developed,and coping strategies for epidemic emergencies were *** outcomes provide theoretical and technical support for developing the next generation of transportation and the prevention and control measures cooperatively considering regular and pandemic times.

关键词： contagious pathogen airborne transmission passenger compartment of transport decontamination technique

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