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Single-cell multi-omics sequencing and its applications in studying the nervous system

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Biophysics Reports 2022年第3期8卷 136-149页

作者： chaoyang wang Xiaoying Fan Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) The Fifth Affiliated Hospital of Guangzhou Medical University

Single-cell sequencing has become one of the most powerful and popular techniques in dissecting molecular heterogeneity and modeling the cellular architecture of a biological system. During the past twenty years, the throughput of single-cell sequencing has increased from hundreds of cells to over tens of thousands of cells in parallel. Moreover, this technology has been developed from sequencing transcriptome to measure different omics such as DNA methylome, chromatin accessibility, and so ***, multi-omics which can analyze different omics in the same cell is rapidly advancing. This work advances the study of many biosystems, including the nervous system. Here, we review current single-cell multi-omics sequencing techniques and describe how they improve our understanding of the nervous system. Finally, we discuss the open scientific questions in neural research that may be answered through further improvement of single-cell multi-omics sequencing technology.

关键词： Single-cell sequencing Multi-omics Cell heterogeneity Nervous system

Development targets and tasks of China’s financial industry in the“13th Five-Year”period

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China Finance and Economic Review 2015年第4期4卷 71-89页

作者： wang chaoyang National Academy of Economic Strategy Chinese Academy of Social Sciences

As for financial development based on the dual attributes of function and industry,China,in the“13th Five-Year”period,should build a more mature and better-established modern financial system and transform from a major financial country to a major world financial *** proportion of financial industrial value-added should be maintained at around 7.5%during the“13th Five-Year”period,and by the end of the period,the proportion of direct financing in social financing should surpass 25%.The main tasks of financial development include improving the interest rate and exchange rate mechanisms,and promoting the market to play a decisive role in the allocation of resources,holding onto the bottom line of preventing systematic and regional risks,and making full use of government function,enhancing financial reform,and opening-up in a concerted effort for the purpose of building a global financial powerhouse,and putting more efforts into developing diverse financial patterns to better serve the development of the real *** this end,China should promote coordination among different economic policies,continue to advance the reform of financial institutions,push forward the development of multi-level capital markets,strengthen the financial security network,and prepare emergency plans to prevent potential financial crises.

关键词： financial service industry social financing scale RMB internationalization financial crisis

Exploring porous zeolitic imidazolate frame work-8(ZIF-8)as an efficient filler for high-performance poly(ethyleneoxide)-based solid polymer electrolytes

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Nano Research 2020年第8期13卷 2259-2267页

作者： Zhiwen Lei Jinlai Shen Weide Zhang Qingrong wang Jun wang Yonghong Deng chaoyang wang Research Institute of Materials Science South China University of TechnologyGuangzhou510640China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640China Department of Materials Science and Engineering Academy for Advanced Interdisciplinary StudiesGuangdong Provincial Key Laboratory of Energy Materials for Electric PowerShenzhen518055China

Nano Research volume 13,pages2259–2267(2020)Cite this article 277 Accesses 1 Altmetric Metrics details Abstract The incorporation of inorganic fillers into poly(ethyleneoxide)(PEO)-based solid polymer electrolytes(SPEs)is well known as a low-cost and effective method to improve their mechanical and electrochemical *** zeolitic imidazolate framework-8(ZIF-8)is firstly used as the filler for PEO-based SPEs in this *** to the introduction of ZIF-8,an ionic conductivity of 2.2×10^−5 S/cm(30℃)is achieved for the composite SPE,which is one order of magnitude higher than that of the pure ***-8 also accounts for the broader electrochemical stability window and lithium ion transference number(0.36 at 60℃)of the composite ***,the improved mechanism of ZIF-8 to the composite SPE is investigated by zeta potential and Fourier transform infrared spectrograph *** stability at the composite SPE/lithium interface is greatly *** LiFePO4||Li cells using the composite SPE exhibit high capacity and excellent cycling performance at 60℃,i.e.,85%capacity retention with 111 mA·h/g capacity retained after 350 cycles at 0.5 *** comparison,the cells using the pure PEO show fast capacity decay to 74 mA·h/g maintaining only 68 *** results indicate that the PEO-based SPEs with ZIF-8 are of great promise for the application in solid-state lithium metal batteries.

关键词： zeolitic imidazolate framework inorganic fillers solid polymer electrolytes poly(ethyleneoxide) solid-state lithium metal batteries

A three-dimensional crosslinked chitosan sulfate network binder for high-performance Li-S batteries

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Journal of Energy Chemistry 2021年第5期30卷 171-178页

作者： Jianwen Feng Huan Yi Zhiwen Lei Jun wang Hongbo Zeng Yonghong Deng chaoyang wang Research Institute of Materials Science South China University of TechnologyGuangzhou 510640GuangdongChina Department of Materials Science&Engineering Academy for Advanced Interdisciplinary StudiesGuangdong Provincial Key Laboratory of Energy Materials for Electric PowerSouthern University of Science and Technology(SUSTech)Shenzhen 518055GuangdongChina Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada

Poor cycling performance caused by the shuttle effect of polysulfides is the main obstacle in the development of advanced lithium-sulfur(Li-S)*** polymer binders with polar groups can effectively adsorb polysulfides chemically,thereby suppressing the shuttle ***,a robust three-dimensional crosslinked polymer network,which demonstrates excellent mechanical property and strong affinity for polysulfides,is prepared by the aldimine condensation and coordination *** crosslinked chitosan sulfate network(CCSN)significantly enhances the cycling performance and rate capability of the sulfur *** CCSN-based sulfur cathode exhibits a high initial discharge capacity of 824 m Ah g^(-1) with only 0.082%average capacity loss per cycle at 1 *** a high rate of 4 C,the cathode exhibits a high capacity retention of 84.8%after 300 ***,the CCSN-based sulfur cathode exhibits an excellent cycling performance at a high sulfur loading of 2.5 mg cm^(-2),which indicates the excellent mechanical strength and binding performance of the CCSN binder for high-energy density Li-S *** study demonstrates a viable approach for developing high-performance Li-S batteries for practical application.

关键词： Chitosan Crosslinked binder Polysulfide Lithium-sulfur battery

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Risks and Causes of Financial Sector’s High Growth in China

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China Finance and Economic Review 2018年第1期7卷 3-29页

作者： Dexu He chaoyang wang National Academy of Economic Strategy Chinese Academy of Social Sciences

In recent years,China’s financial sector has witnessed a high growth *** trend has been caused by several reasons:the traditional macro-control tools do not match the new normal characteristics of China’s economy growth,the regulatory reform is lagging behind the rapid progress of financial innovation,and the drastic fluctuations of the stock market are combined with a new round of increase in real estate *** particular,this round of high growth in the financial sector occurs in the context of a rapid decline of manufacturing sector,which reflects the low efficiency of financial *** also means the foundation of financial stability and sustainable development is losing and high risks are *** deal with this change properly,we need to further deepen financial reform and improve financial supervision,and create a favorable financial environment for the real *** the same time,researchers should also reflect on and study the characteristics of China’s financial development,and provide the theoretical basis for maintaining financial security.

关键词： value-added of the financial sector financial innovation financial supervision financial risks

TAXOL INDUCES CELL DEATH WITH CYTOPLASM VACUOLIZATION IN PARAPTOSIS-LIKE BUT NOT ONCOSIS FASHION IN ASTC-a-1 CELLS

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 70-76页

作者： YING-YAO QUAN chaoyang wang XIAO-PING wang TONG-SHENG CHEN Department of Pain Management The First A±liated Hospital of Jinan University Guangzhou 510632 P.R.China Lab of Chinese Medicine and Photonics Technology&MOE Key Lab of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510630P.R.China

Recently,we found that high concentration of taxol(70μM)induced cell death with cytoplasm vacuolization,the typical characteristic of both paraptosis and oncosis,in human lung carcinoma(ASTC-a-1)*** report was designed to further deternine the form of taxo-induced cell death with cytoplasm *** is generally coneidered that the cytoplasm vacuolization in oncosis due to the sweling of endoplasmic reticulum(ER),mitochondria,lysosomes and muclei occurs after the loss of mitochondrial mermbrane potential(△ψm).However,flow cytometry(FCM)analysis showed that taxol induced cy toplsm vacuolization preceded the loss of(△ψm).Moreover,taxol treatment did not induce the collapse of microtubule,the ty pical characteristic of *** data demonstrated that taxol-induced cell death with cytoplasm vacuolization is not *** analysis by Annexin V-FTTC/PI apoptosis detection kit further demoustrated that taxol-induced cell death with cytoplasm vacuolization is not *** conclusion,in combination with our recent in ritro and in vito data,this report further demonstrates that high concentration of taxol induces cell death with cytoplasm vacuolization in paraptosis like but not oncosis fashion.

关键词： Taxol human lung adenocarcinoma cancer cells paraptosis onocosis microtubules endoplasmic reticulum

Fast Numerical Simulation of Two-Phase Transport Model in the Cathode of a Polymer Electrolyte Fuel Cell

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Communications in Computational Physics 2009年第6期6卷 49-71页

作者： Pengtao Sun Guangri Xue chaoyang wang Jinchao Xu Department of Mathematical Sciences University of NevadaLas Vegas4505 Maryland ParkwayLas VegasNV 89154USA Department of Mathematics The Pennsylvania State UniversityUniversity ParkPA 16802USA Departments of Mechanical Engineering and Materials Science and Engineering Electrochemical Engine Center(ECEC)The Pennsylvania State UniversityUniversity ParkPA 16802USA Laboratory of Mathematics and Applied Mathematics School of Mathematical SciencesPeking UniversityBeijing 100871China

In this paper,we apply streamline-diffusion and Galerkin-least-squares fi-nite element methods for 2D steady-state two-phase model in the cathode of polymer electrolyte fuel cell(PEFC)that contains a gas channel and a gas diffusion layer(GDL).This two-phase PEFC model is typically modeled by a modified Navier-Stokes equation for the mass and momentum,with Darcy’s drag as an additional source term in momentum for flows through GDL,and a discontinuous and degenerate convectiondiffusion equation for water *** on the mixed finite element method for the modified Navier-Stokes equation and standard finite element method for water equation,we design streamline-diffusion and Galerkin-least-squares to overcome the dominant convection arising from the gas ***,we employ Kirchhoff transformation to deal with the discontinuous and degenerate diffusivity in water *** experiments demonstrate that our finite element methods,together with these numerical techniques,are able to get accurate physical solutions with fast convergence.

关键词： Two-phase model polymer electrolyte fuel cell Kirchhoff transformation convection dominated diffusion problem streamline diffusion Galerkin-least-squares

Grand canonical Monte Carlo simulation for hydrogen uptakes based on nanoporous NaBH_4

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Science China(Physics,Mechanics & Astronomy) 2013年第8期56卷 1525-1532页

作者： REN Juan ZHANG Hong TANG YongJian WU WeiDong wang chaoyang College of Physical Science and Technology Sichuan University Research Center of Laser Fusion China Academy of Engineering Physics

A new hydrogen storage route of 3D nanoporous sodium borohydride (NPSB) generated by removing special atoms is proposed in this work. Three different size pores of NPSB-1 (7), NPSB-2 (10) and NPSB-3 (14) are presented, and the hydrogen storage capacities of these NPSBs are simulated by employing a grand canonical Monte Carlo (GCMC) procedure for a temperature range of 77-298 K and a pressure range of 0.1-100 bar. The effects of pore diameter, temperature and pressure on the hydrogen adsorption have been examined. The results show that the adsorption of hydrogen decreases and increases with increasing temperature and hydrogen pressure, respectively. It also reflects that the hydrogen adsorption capacities at higher pressures are dependent on pore diameter, while independent of pore diameter at lower pressures.

关键词： nanoporous hydrogen storage GCMC NaBH4

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Voluminous continental growth of the Altaids and its control on metallogeny

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National Science Review 2023年第2期10卷 69-84页

作者： Tao wang He Huang Jianjun Zhang chaoyang wang Guangyue Cao Wenjiao Xiao Qidi Yang Xuewei Bao Beijing SHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Key Laboratory of Earth Probe and Geodynamics Chinese Academy of Geological Sciences National Key Laboratory of Arid Area Ecological Security and Sustainable Development Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Wuhan Center of China Geological Survey School of Earth Sciences Zhejiang University

The Altaids is generally considered to be the largest Phanerozoic accretionary orogen on Earth,but it is unclear whether it was associated with extensive continental crustal growth and whether there is a link between the crustal growth and ore *** paper reviews whole-rock Nd and zircon Hf isotope data for felsic-intermediate-mafic igneous rocks in the Altaids and presents Nd+Hf isotopic contour maps for this *** maps highlight the 3D lithospheric compositional architecture of the Altaids and make it possible to quantitatively evaluate the crustal growth and its relationship with ore *** Altaids hosts ～4 107 350 km2and ～184 830 750 km3(assuming a crustal thickness of 40-50 km) juvenile crust(εNd(t)> 0),accounting for 58% by isotope-mapped area(～7 010 375 km2) of almost all outcrops of the Altaids(～8 745 000 km2) and formed during 1000-150 Ma(mainly 600-150 Ma).The juvenile crustal,slightly juvenile-reworked crustal and slightly reworked crustal provinces controlled the Cu-Au,the Pb-Zn-Ag and the Li-Be,Nb-Ta and W-Sn ore *** to the crustal architecture and background of deep compositions,we propose that the ore deposits can be grouped into three types:juvenile crust-related,mixed-source(or slightly juvenile crust)-related and reworked *** highlights the close relationship between accretion,continental growth and mineralization,and will facilitate exploration for specific ore-deposit types in the Altaids.

关键词： 3D lithospheric architecture architecture evolution juvenile crust igneous rocks isotopic mapping metallogeny Central Asian Orogenic Belt(CAOB)