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Journal of Materiomics 2023年第3期9卷 464-471页

作者： Shuai Cheng boping Zhang Shengjie Ai Hongbao Yu Xin wang Jiahao Yang Changrong Zhou Jingtai Zhao Guanghui Rao Guangxi Key Laboratory of Information Materials&School of Materials Science and Engineering Guilin University of Electronic TechnologyGuilin541004China Foshan(Southern China)Institute for New Materials Foshan528200GuangdongChina School of Materials Science and Engineering Shanghai UniversityShanghai200444China School of Materials Science and Engineering University of Science and Technology Beijing100083BeijingChina

Morphotropic phase boundary(MPB)plays a key role in tuning piezoelectric responses of ferroelectric ***,Bi_(0.5)Na_(0.5)TiO_(3)modified BiFeO_(3)-BaTiO_(3)ternary solid solutions of 0.7BiFeO_(3)-(0.3-x)BaTiO_(3)-xBi_(0.5)Na_(0.5)TiO_(3)(referred to as BF-BT-xBNT,0.00≤x≤0.04)were prepared for lead-free *** the ceramics exhibit an MPB with coexisting rhombohedral(R)and tetragonal(T)phases,and the R/T phase ratio decreases upon increasing *** increment of BNT promotes the grain growth,lowers the leakage current and Curie temperature(TC),and gradually drives the ferroelectric to relaxor *** of the MPB with appropriate R/T phase ratio,increased grain size and density,and decreased leakage current,the well-balanced performance between d_(33)=206 pC/N and TC=488℃is obtained in x=0.01 *** addition,the further enhanced in-situ d_(33)=286e347 pC/N is obtained in BF-BT-xBNT ceramics along with the improved depolarization temperature T_(d)from 280 to 312℃,showing a potential application for lead-free piezoceramics at high temperature.

关键词： Ferroelectrics Piezoelectric property Curie temperature Phase transitions Thermal stability

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有取向硅钢片开关磁阻电机研究

大电机技术 2024年第3期 57-62页

作者：孙宇亮王九崇朱浩铭李义忠孟伯平哈尔滨电机厂有限责任公司哈尔滨150040 天津国能盘山发电有限责任公司天津301900

开关磁阻电机结构简单、可靠性高,已在一些驱动场合得到应用,但为获得更大转矩和开关磁阻电机的双凸极结构,使开关磁阻电机铁芯磁密较为饱和。为提高开关磁阻电机定子磁极抗饱和能力,降低励磁电流,结合开关磁阻电机磁路特点,提出有取向... 详细信息

开关磁阻电机结构简单、可靠性高,已在一些驱动场合得到应用,但为获得更大转矩和开关磁阻电机的双凸极结构,使开关磁阻电机铁芯磁密较为饱和。为提高开关磁阻电机定子磁极抗饱和能力,降低励磁电流,结合开关磁阻电机磁路特点,提出有取向硅钢拼块式定子铁芯结构,利用有取向硅钢材料优异的导磁性能,缓解定子磁极饱和情况,仿真结果表明,有取向硅钢片开关磁阻电机可以降低定子磁极饱和程度、降低励磁电流、减小转矩脉动。

关键词：开关磁阻电机有取向硅钢片饱和拼块式定子

肺有效动脉弹性在心力衰竭患者风险评估中的预测价值

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中华心血管病杂志 2024年第4期52卷 397-404页

作者：吴易航黄博平冯佳禹黄丽燕赵雪梅王静关敬元李心晴张宇辉张健中国医学科学院北京协和医学院国家心血管病中心阜外医院心力衰竭中心心血管疾病国家重点实验室北京100037

目的评估肺有效动脉弹性(Ea)在心力衰竭(心衰)患者长期预后评估中的潜在价值。方法该研究为回顾性队列研究,纳入2013年9月至2022年2月在阜外医院心衰中心行漂浮导管检查的284例心衰患者。收集患者的基线临床资料、血流动力学数据及预后... 详细信息

目的评估肺有效动脉弹性(Ea)在心力衰竭(心衰)患者长期预后评估中的潜在价值。方法该研究为回顾性队列研究,纳入2013年9月至2022年2月在阜外医院心衰中心行漂浮导管检查的284例心衰患者。收集患者的基线临床资料、血流动力学数据及预后信息。Ea的计算公式为平均肺动脉压/每搏输出量。根据Ea的中位数值(0.555 mmHg/ml,1 mmHg=0.133 kPa)将患者分为Ea<0.555组和Ea≥0.555组。主要终点为主要临床事件,设定为包括全因死亡、心脏移植、左心室辅助装置植入和因心衰再住院的复合事件。无事件生存定义为未发生主要临床事件。采用Spearman相关性分析Ea与右心功能指标的相关性。采用Kaplan-Meier法进行生存分析,log-rank法比较两组间无事件生存率差异。采用Cox比例风险回归模型分析Ea与主要临床事件的关联,并根据研究对象的年龄、性别、纽约心脏协会(NYHA)心功能分级、左心室射血分数、是否合并肺动脉高压以及N末端B型利钠肽原(NT-proBNP)水平进行亚组分析。采用受试者工作特征(ROC)曲线计算Ea预测心衰患者无事件生存的曲线下面积(AUC)。结果所有患者的中位年龄为51岁,男性206例(72.5%)。Ea与肺动脉顺应性(r=-0.888,P<0.001)和肺血管阻力(r=0.698,P<0.001)显著相关。与Ea<0.555组相比,Ea≥0.555组患者的NT-proBNP水平[4443(1792,8554)ng/L比1721(480,4528)ng/L,P<0.001]、肺血管阻力[3.4(2.5,4.7)Wood比1.4(0.9,2.2)Wood,P<0.001]更高,心输出量[3.0(2.3,3.9)L/min比4.3(3.8,4.9)L/min,P<0.001]、肺动脉顺应性[1.6(1.3,2.0)ml/mmHg比4.0(3.0,6.0)ml/mmHg,P<0.001]更低。中位随访时间392(166,811)d,Kaplan-Meier生存曲线显示,Ea≥0.555组的无事件生存率低于Ea<0.555组(P_(log-rank)<0.001)。多因素Cox回归分析结果显示,Ea是主要终点的独立预测因子(HR=1.734,95%CI 1.314~2.289,P<0.001)。亚组分析表明,Ea对各类心衰人群均存在预测价值(P均<0.05)。Ea预测心衰患者无事件生存的AUC为0.724(P<0.001)。结论Ea与右心室后负荷指标密切相关,Ea升高是心衰患者不良预后的独立预测因子。

关键词：心力衰竭右心功能肺有效动脉弹性血流动力学预后

2018年至2022年某中医院第二类精神药品使用情况分析

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中国药业 2024年第7期33卷 17-21页

作者：汪江涛丁伯平范琳琳叶鸣蒋慧莲安徽省芜湖市中医医院安徽芜湖241000 皖南医学院药学院安徽芜湖241000 皖南医学院弋矶山医院安徽芜湖241000

目的促进中医院第二类精神药品的合理使用。方法利用医院信息系统收集安徽省芜湖市中医医院2018年至2022年第二类精神药品的销售数据,分析用药频度(DDDs)、限定日费用(DDC)、排序比(B/A);按第二类精神药品门急诊处方150张/年和病历医嘱5... 详细信息

目的促进中医院第二类精神药品的合理使用。方法利用医院信息系统收集安徽省芜湖市中医医院2018年至2022年第二类精神药品的销售数据,分析用药频度(DDDs)、限定日费用(DDC)、排序比(B/A);按第二类精神药品门急诊处方150张/年和病历医嘱50份/年,根据药品说明书、相关指南及专家共识进行处方点评。结果2020年,第二类精神药品销售金额最大,占全院药品销售总金额的1.86%;地佐辛注射液、盐酸曲马多缓释片、咪达唑仑注射液销售金额排名前3;阿普唑仑片、艾司唑仑片、地佐辛注射液的DDDs排名前3;阿普唑仑片的DDC最低;地佐辛注射液的B/A在0.33~1.00之间。共收集1000张处方/医嘱,其中合理处方709张,合理医嘱228条,合理率为93.70%;不合理类型包括用药不规范、不适宜。结论该院2018年至2022年第二类精神药品的使用存在不合理现象,应继续加强对其的管理和监控,确保临床用药安全、合理。

关键词：中医院第二类精神药品合理用药处方点评

Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales

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Science Bulletin 2019年第7期64卷 422-424页

作者： Liping Zhu Junbo wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu boping Han Linshan Liu Mingda wang Qingfeng Ma Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Ecology Jinan University Institute of Geographic Sciences and Natural Resource Research Chinese Academy of Sciences

The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions.

关键词： Co Ti Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales

QuantiFERON-TB Gold Plus与QuantiFERON-TB Gold In-Tube在骨关节结核辅助诊断中的比较研究

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中国防痨杂志 2024年第6期46卷 648-653页

作者：贾红彦范俊孙琦宋瑞雪杜博平董静王颖超邢爱英朱传智李自慧潘丽萍耐药结核病研究北京市重点实验室/首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所北京101149

目的:评价QuantiFERON-TB Gold Plus(简称“QFT-Plus”)和QuantiFERON-TB Gold In-Tube(简称“QFT-GIT”)检测辅助诊断骨关节结核的应用价值及其检测结果的一致性。方法:选取2023年4—9月于首都医科大学附属北京胸科医院就诊的骨关节结... 详细信息

目的:评价QuantiFERON-TB Gold Plus(简称“QFT-Plus”)和QuantiFERON-TB Gold In-Tube(简称“QFT-GIT”)检测辅助诊断骨关节结核的应用价值及其检测结果的一致性。方法:选取2023年4—9月于首都医科大学附属北京胸科医院就诊的骨关节结核患者88例作为观察组,非结核性骨关节疾病患者123例作为对照组。所有研究对象同时行外周血QFT-Plus和QFT-GIT检测。分析QFT-Plus和QFT-GIT辅助诊断骨关节结核的价值,评价两种方法检测结果的一致性。结果:211例研究对象中,剔除4例检测为不确定结果者,最终将207例研究对象检测结果纳入诊断性能评估(观察组86例,对照组121例)。QFT-Plus检测的敏感度为95.3%(95%CI:87.9%~98.5%),特异度为70.2%(95%CI:61.2%~78.0%),阳性预测值为65.5%(95%CI:60.2%~77.5%),阴性预测值为95.5%(95%CI:88.3%~98.6%);QFT-GIT检测的敏感度为91.9%(95%CI:83.4%~96.4%),特异度为66.9%(95%CI:57.7%~75.1%),阳性预测值为66.4%(95%CI:57.1%~74.6%),阴性预测值为92.0%(95%CI:83.8%~96.5%)。QFT-Plus和QFT-GIT检测结果的总一致率为91.8%(95%CI:88.1%~95.5%),阳性一致率为92.4%(95%CI:87.7%~97.2%),阴性一致率为90.9%(95%CI:84.9%~96.9%),一致性检验Kappa值为0.832(95%CI:0.756~0.908,P<0.001)。结论:QFT-Plus与QFT-GIT检测结果具有良好的一致性,在骨关节结核诊断中具有相似的辅助诊断效能。

关键词：结核,骨关节诊断,鉴别免疫学试验评价研究

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结核分枝杆菌潜伏感染者外周血单个核细胞转录组学研究

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中国防痨杂志 2024年第4期46卷 449-460页

作者：尚雪恬董静黄麦玲孙琦贾红彦张蓝月刘秋月姚明旭王颖超姬秀秀杜博平邢爱英潘丽萍首都医科大学附属北京胸科医院耐药结核病研究北京市重点实验室/北京市结核病胸部肿瘤研究所北京101149 首都医科大学附属北京胸科医院结核科/北京市结核病胸部肿瘤研究所北京101149 首都医科大学附属北京胸科医院重症医学科/北京市结核病胸部肿瘤研究所北京101149

目的:通过对比分析结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)者和健康人的外周血单个核细胞(peripheral blood mononuclear cells,PBMC)经结核特异性抗原刺激后的转录组,寻找LTBI人群中结核抗原特异的免疫应答重要基... 详细信息

目的:通过对比分析结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)者和健康人的外周血单个核细胞(peripheral blood mononuclear cells,PBMC)经结核特异性抗原刺激后的转录组,寻找LTBI人群中结核抗原特异的免疫应答重要基因及可能发挥功能的信号通路,绘制LTBI基因表达谱。方法:应用微阵列芯片检测2009年12月在首都医科大学附属北京胸科医院招募的4例LTBI者(LTBI组)和4名健康人(健康对照组)经结核抗原刺激后的PBMC转录组,并对部分差异基因进行qPCR检测以验证芯片数据。应用加权基因共表达网络分析(weighted gene co-expression network analysis,WGCNA)筛选与LTBI最相关模块,并对模块中的基因分别进行基因本体论(geneontology,GO)分析、京都基因与基因组百科全书(Kyoto encylopedia of genes and genomes,KEGG)通路分析。通过基因集富集分析(gene set enrichment analysis,GSEA)从全转录组水平筛选信号通路。通过免疫浸润分析寻找与LTBI相关的免疫细胞。通过STRING数据库蛋白相互作用(protein-protein interaction,PPI)网络分析绘制两模块中差异基因相互作用网络图。结果:LTBI组与健康对照组间共发现393个差异表达基因(差异倍数>2或<0.5,P<0.05),LTBI中112个表达下调,281个表达上调。针对10个差异基因的实时荧光定量PCR(quantitative real-time PCR,qPCR)检测证实基因表达趋势与芯片数据一致,即CAMK1G、IL2、SPINK1、SUCNR1、HCAR3、IL18BP、CHI3L1、TNF均上调;RASGRP2、TPM2均下调。通过WGCNA分析确定与LTBI最相关的正相关蓝色模块(cor=0.88,P=0.004)和负相关蓝绿色模块(cor=―0.93,P=0.001)。对上述模块内基因进行KEGG富集分析,并行基于全转录组的GSEA分析,发现趋化因子信号通路(P<0.001)和凋亡信号通路(P=0.003)在两种分析中均明显富集。对两模块中的差异基因通过STRING数据库构建PPI网络图,通过内置插件计算得到每个模块中的前10个关键基因,即蓝色模块中的PTPRC、CD40、IL10、IRF8、CCR1、CD80、TLR8、CLEC7A、CD83和CD274;蓝绿色模块中的TNF、ICAM1、TNFRSF4、HAVCR2、CD276、CCL4、CD33、IL1RN、NCF1和FGR。免疫浸润分析发现,M1型巨噬细胞(P=0.029)和M2型巨噬细胞(P=0.001)等固有免疫细胞的比例在LTBI组和健康对照组间存在明显差异。结论:经结核特异性抗原刺激后的PBMC转录组在LTBI人群和健康人群间存在明显差异,这些差异基因主要聚集于凋亡信号通路和趋化因子信号通路,其中巨噬细胞介导的免疫应答在其中发挥了重要作用,揭示了固有免疫应答在LTBI中的重要作用。

关键词：分枝杆菌,结核分枝杆菌感染转录因子生物学标记免疫

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Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging

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Nuclear Science and Techniques 2009年第1期20卷 37-41页

作者： ZHU Jie MA Wenyan ZHU Yufeng MA Hongguang WU Yuelei HU Huasi ZHANG boping HUO Yonggang LIU Silu JIAN Bin wang Zhaomin The Second Artillery Engineering College Xi＇an 710025 China Nuclear Engineering Department School of Energy ＆ Engineering Xi＇an Jiaotong University Xi＇an 710049 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China Department of Electric Information Engineering Wuhan Polytechnic University Wuhan 430023 China

Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole *** the ideal pinhole collimator must keep a compromise between spatial resolution and *** order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole *** results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 *** chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution.

关键词：氢硼聚变衰变原子核模拟能谱

Identification of a Novel Universal Potential Epitope on the Cytoplasmic Tail of H7N9 Virus Hemagglutinin

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Virologica Sinica 2019年第3期34卷 334-337页

作者： Xi Liu Li Ding Jing Yuan Jian Liao Lian Duan Wenfei wang Weiguo Tan Weiye Yu boping Zhou Xinchun Chen Zheng Yang Department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 51900China Lab for Tuberculosis Research Shenzhen Center for Chronic Disease ControlShenzhen 518020China Department of Infectious Diseases The Third People's Hospital of Shenzhen (The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000China Shenzhen Key Laboratory of Infection and Immunity The Third People's Hospital of Shenzhen (The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000China Department of Pathogen Biology School of MedicineShenzhen UniversityShenzhen 518000China Longhua Branch of Shenzhen People's Hospital Shenzhen 518000China

Dear Editor,H7N9 is a recently identified subtype of influenza A virus that caused a major outbreak in humans in China in *** to the latest data provided by the Chinese Center for Disease Control and Prevention(http://***/zwgk/yqbb3/***,updated on October 31,2018),the mortality rate of H7N9 infections in China amounts to 39.7%(611/1536).Thus,H7N9 poses a serious public health threat.

关键词： Identification Novel Universal Potential Epitope Cytoplasmic Tail

Wastewater surveillance and an automated robot:effectively tracking SARS-CoV-2 transmission in the post-epidemic era

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National Science Review 2023年第6期10卷 86-95页

作者： Guanyong Ou Yuxuan Tang Shiyu Niu Liwen Wu Shaxi Li Yang Yang Jun wang Yun Peng Chuanfu Huang Wei Hu Qinghua Hu Yinghui Li Yang Ping Chao Lin boping Yu Qi Han Yabin Hao Zhiguang Luo Wende Tian Han Zhang Yingxia Liu National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease The Third People's Hospital of Shenzhen Second Hospital Affiliated to Southern University of Science and Technology School of Medicine Southern University of Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen Longhua Drainage Co. Ltd. Shenzhen Center for Disease Control and Prevention Microbiology Laboratory Shenzhen Center for Disease Control and Prevention Power China Eco-Environmental Group Co. Ltd. Shenzhen Water Planning & Design Institute Co. Ltd. Shenzhen Academy of Environmental Sciences School of Civil and Environmental Engineering Harbin Institute of Technology (Shenzhen) 1Institute of Solid Wastes and Physical Environment Research Shenzhen Academy of Environmental Sciences Shenzhen Metasensing Technology Co. Ltd. 13. Zhongmin (Shenzhen) intelligent ecology Co. Ltd. Research Centre for Eco-Environmental Sciences Chinese Academy of Sciences

Wastewater-based epidemiology(WBE) has exhibited great utility in the early and rapid identification of SARS-C ***,the efficacy of wastewater surveillance under China’ s previous strict epidemic prevention policy remains to be *** collected the WBE data of wastewater treatment plants(WWTPs) in the Third People’s Hospital of Shenzhen and several communities to determine the significant effectiveness of routine wastewater surveillance in monitoring the local spread of SARS-C oV-2under tight containment of the *** results of 1 month of continuous wastewater surveillance showed that positive signals for SARS-C oV-2 RNA were detected in the wastewater samples,and a significant positive correlation was observed between the virus concentration and the number of daily *** addition,the community’ s domestic wastewater surveillance results were confirmed even 3 days before,or simultaneously with,the infected patient being confirmed as having the ***,an automated sewage virus detection robot,ShenNong No.l robot,was developed,showing a high degree of agreement with experimental data,offering the possibility of large-scale multi-point ***,our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.

关键词： SARS-CoV-2 wastewater surveillance wastewater-based epidemiology WWTP automated robot